• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.14
• /
• pp.5691-5696
• /
• 2014

Background: Many clinical trials have been conducted to evaluate sorafenib for the treatment of advanced NSCLC, but the results for efficacy have been inconsistent. The aim of this study was to evaluate the efficacy and safety of sorafenib in patients with advanced NSCLC in more detail by meta-analysis. Methods: This meta-analysis of randomized controlled trials (RCTs) was performed after searching PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, and the proceedings of major conferences for relevant clinical trials. Two reviewers independently assessed the quality of the trials. Outcomes analysis were disease control rate (DCR), progression- free survival (PFS), overall survival (OS) with 95% confidence intervals (CI) and major toxicity. Subgroup analysis was conducted according to sorafenib monotherapy, in combination with chemotherapy or EGFR-TKI to investigate the preferred therapy strategy. Results: Results reported from 6 RCTs involving 2, 748 patients were included in the analysis. Compared to sorafenib-free group, SBT was not associated with higher DCR (RR 1.31 (0.96- 1.79), p=0.09), PFS (HR 0.82 (0.66-1.02), p=0.07) and OS (HR 1.01 (0.92-1.12), p=0.77). In terms of subgroup results, sorafenib monotherapy was associated with significant superior DCR and longer PFS, but failed to show advantage with regard to OS. Grade 3 or greater sorafenib-related adverse events included fatigue, hypertension, diarrhea, oral mucositis, rash and HFSR. Conclusions: SBT was revealed to yield no improvement in DCR, PFS and OS. However, sorafenib as monotherapy showed some activity in NSCLC. Further evaluation may be considered in subsets of patients who may benefit from this treatment. Sorafenib combined inhibition therapy should be limited unless the choice of platinum-doublet regimen, administration sequence or identification of predictive biomarkers are considered to receive better anti-tumor activity and prevention of resistance mechanisms.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.40 no.5
• /
• pp.704-711
• /
• 2011

Traditionally, mistletoes have been used as immunostimulant for the management of certain diseases such as cancer with high profile immune depleting potentials. In order to examine the safety of the 20 kGy irradiated cold water extract powder of mistletoes, we performed a 90-day repeated-dose toxicity study with ICR mice. The mice were treated with daily doses of the 20 kGy irradiated cold water extract powder of mistletoes by gavage at 0, 20, 100, and 500 mg/kg/day for 90 consecutive days. We recorded clinical signs of toxicity, body weight, organ weights, histological changes in target organs, hematology, and clinical blood chemistry analysis data for all mice. There were no significant changes in body and organ weights during the experimental period. The hematological analysis and clinical blood chemistry data revealed no toxic effects from the 20 kGy irradiated cold water extract powder of mistletoes. Pathologically, neither gross abnormalities nor histopathological changes were observed between the control and treated mice of both sexes. Collectively, these data suggest that the 20 kGy irradiated cold water extract powder of mistletoes have a high margin of safety.

• Journal of Bio-Environment Control
• /
• v.22 no.4
• /
• pp.316-321
• /
• 2013

This study was carried out to analyze heat transfer characteristics and heat flow through air-inflated double layer PO film with thermal resistance method. The experiments was conducted in the laboratory controlled air temperature between 258.0 K and 278.0 K. The experimental materials were made up two layers PO film and an inflated-air layer. The thickness of air-inflated layer was fixed at 3 types of 110, 175, 225 mm. The electrical circuit analogy for heat transfer by conduction, radiation and convection was introduced. Experimental data shows that the dominant thermal resistance in heat transfer through the air-inflated double layer film was convection. Calculation errors were 1.1~18.5 W for heat flow. In result, the method of thermal resistance could be introduced for analysis of heat flow characteristics through air-inflated double layer film.

• Korean Journal of Food Science and Technology
• /
• v.47 no.1
• /
• pp.13-19
• /
• 2015

The effects of electron beam (e-beam) irradiation at up to 10 kGy on the microbiological and physicochemical properties of dried red pepper powders were studied. Samples from Korea, China, and Vietnam were included in this study. In untreated samples, the total number of microbes, such as total aerobic bacteria, yeasts and molds, was in the range of $10^6-10^7CFU/g$. E-beam irradiation at 5 kGy reduced the microbial load by 2-4 log cycles, thus improving the hygienic quality of the samples. Moisture and pH of the samples were unchanged after e-beam irradiation. Reducing sugar content decreased at 1 kGy, followed by a gradual increase at higher radiation doses. At 5 kGy, no significant changes in the content of capsaicinoids were observed between the irradiated and control samples, while a 10 kGy dose led to a significant decrease. The content of pigments did not exhibit apparent changes with increasing dose of irradiation.

• Journal of Food Hygiene and Safety
• /
• v.4 no.2
• /
• pp.119-132
• /
• 1989

Gamma irradiation as a new physical treatment was applied to comparative investigates with a conventional ethylene oxide fumigant on the microbiological and physicochemical qualities of selected spices and dry vegetables such as powdered red pepper, black pepper, welsh onion, onion, garlic, carrot, korean cabbage and instant ramyon soup. The microorganisms contaminated in the sample, including total viable count, thermophilic bacteria, aerobic spore and fungi counts between the $10^4\;to\;10^6/g$ range. Coliforms were found only in black pepper and welsh onion powder as the $10^2\;to\;10^3/g$ level. A radiation dose of 7 to 10 KGy were sterilized completely to the contaminated microorganisms, while ehthylene oxide (E.O.) fumigation reduced of them to the $10^3/g$ level. An optimum dose of irradiation was less detrimental than E.O. fumigation to the physicochemical properties of the sample. Sensory evaluation after three months of storage at room temperatures showed that the overall acceptability of irradiated sample was higher than that of the non treated control as well as E.O. fumigated samples. Comparison gamma irradiation with E.O. gas treatment showed that E.O. treatment was less effective than radiation in cotrolling microbial contamination of spices and vegetables.

• Applied Chemistry for Engineering
• /
• v.29 no.1
• /
• pp.81-96
• /
• 2018

In this study, physicochemical properties of the natural jadeite powder were investigated and also the wash-off pack and liquid foundation containing the jadeite powder were prepared. In addition, each of these formulations was evaluated by various functional effects, sensory evaluation, stability and skin safety. In the wash-off pack, the far-infrared ray emissivity and radiation energy values increased as a function of the jadeite powder content. At a 3% jadeite powder content, the skin temperature increased by about $0.5^{\circ}C$ when the jadeite powder-containing formulation was applied to the skin. Besides, the chroma of the liquid foundation containing the jadeite powder more clearly expressed the original color of the skin. Moisture content measurements of the wash-off pack and liquid foundation containing the jadeite powder showed the highest moisture uptake of 5.0% and 63.0%, respectively. In sensorial test, the wash-off pack formulations containing the jadeite powder demonstrated improved affinities toward a skin, adherency, and moistness and combatted itching. The liquid foundation containing jadeite powder showed also improved affinities except for the coverage when compared to control formulations. Furthermore, the stability evaluation for 8 weeks revealed neither discoloration nor separation phenomenon for the formulations containing the jadeite powder. Moreover, the pH was found to be stable up to 8 weeks and the viscosity up to 4 weeks. Skin safety assessments showed that all formulations containing the jadeite powder were non-irritating. These results suggest that the jadeite powder as an inorganic pigment may serve as a new multi-functional cosmetic ingredient with stability and safety.

• Journal of electromagnetic engineering and science
• /
• v.15 no.3
• /
• pp.142-150
• /
• 2015

Several reports supported that continuous exposure to 60 Hz magnetic field (MF) induces testicular germ cell apoptosis in vivo. We recently evaluated duration- and dose-dependent effects of continuous exposure to a 60 Hz MF on the testes in mice. BALB/c male mice were exposed to a 60 Hz MF at $100{\mu}T$ for 24 hours a day for 2, 4, 6, or 8 weeks, and at 2, 20 or $200{\mu}T$ for 24 hours a day for 8 weeks. To induce the apoptosis of testicular germ cell in mice, the minimum dose is $20{\mu}T$ at continuous exposure to a 60 Hz MF for 8 weeks, and the minimum duration is 6 weeks at continuous exposure of $100{\mu}T$. Continuous exposure to a 60 Hz MF might affect duration- and dose-dependent biological processes including apoptotic cell death and spermatogenesis in the male reproductive system of mice. The safety guideline of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) indicates that the permissible maximum magnetic flux density for general public exposure is $200{\mu}T$ at 60 Hz EMF (ICNIRP Guidelines, 2010). In the present study, we aimed to examine the expression of pro- and anti-apoptotic genes regulated by the continuous exposure to 60 Hz at $200{\mu}T$ in Sprague-Dawley rats for 20 weeks. The continuous exposure to 60 Hz at $200{\mu}T$ does not affect the body and testicular weight in rats. However, exposure to 60 Hz MF significantly affects testicular germ cell apoptosis and sperm count. Further, the apoptosis-related gene was scrutinized after exposure to 60 Hz at $200{\mu}T$ for 20 weeks. We found that the message level of endonuclease G (EndoG) was greatly increased following the exposure to 60 Hz at $200{\mu}T$ compared with sham control. These data suggested that 60 Hz magnetic field induced testicular germ cell apoptosis through mitochondrial protein Endo G.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.22 no.5
• /
• pp.490-499
• /
• 2002

Recently, gamma radiographic equipments have been used about 1,000 sets manually and operated by about 2,500 persons in Korea. In order for a radiography to work effectively with avoiding any hazard of the high level radiation from the source, many field workers have expected developing a wireless automatic remote exposure controller. The KlTCO research team has developed an automatic remote exposure controller that can regulate the speed of $0.4{\sim}1.2m/s$ by BLDC motor of 24V 200W which has output of $54kgf{\cdot}cm$, suitable torque and safety factor for the work. And the developed automatic remote exposure controller can control rpm of motor, pigtail position by photo-sensor and exposure time by timer to RF sensor. Thus, the developed equipment is expected that the unit can be used in many practical applications with benefits in economical advantage to combine the use of both automatic and manual type because attachment is possible existent manual remote exposure controller, AC and DC combined use.

• Journal of the Korean Society of Radiology
• /
• v.13 no.4
• /
• pp.605-611
• /
• 2019

The purpose of this study is to manufacture a multi-function device (MFD) which can be applied to various types of weight-bearing view of the lower leg, and to compare the results with the images from the existing weight-bearing platforms (WBPs), thereby suggesting a clinical utilization. The MFD was manufactured, by considering the minimum adjustable heights of the platform for weight-bearing foot/ankle, platform for hindfoot alignment view, and X-ray tube of the X-ray device. A foot/ankle phantom was used to take the images of weight-bearing lateral foot in MFD and WBPs to compare the resolutions of the X-ray images using a quick modulation transfer function (MTF) program. Between both the images taken from the MFD and WBPs, there was no statistically significant difference found in the mean cycles per pixel (C/P) and the lines per image height (LPH) of the 50%-Contrast Spatial Frequency (MTF50), and 10-90% of Maximum Energy Rise Distance (10-90%), where p>0.05. The MFD is suggested for its clinical trial as a useful positioning device that can secure the patient's safety and manifoldly perform various inspections. Also, the recommendation of the positioning device as a policy can activate dedicated manufacturers, while also improving the quality of medical services.

• Journal of the Korean Society of Systems Engineering
• /
• v.17 no.1
• /
• pp.85-96
• /
• 2021

Radioactive mixed waste (RMW) means waste mixed with radioactive substances and hazardous substances. In Korea, there are definitions and disposal restrictions on RMW in the Nuclear Safety Management Act, but it is difficult to apply because the contents are insufficient, so this paper proposed applicable management standards. The main RMW generated from nuclear power plants is waste oil, waste asbestos, PCB, and waste fluorescent liquid, and their radiation characteristics are mostly at very low levels and some are estimated at low levels. In addition to nuclear power plants, RMW also occurs in research institutes, industries, and hospitals. The acceptance criteria of all disposal facilities in the world basically prohibit disposal of RMW unless the hazardous substances of RMW are removed or mitigated below the standard value. Cases in Korea, the United States, Japan and Europe were reviewed to propose the RMW management standards in Korea. With reference to the results of the above review, this paper clearly defined RMW and proposed detailed management standards for the separation, storage, treatment and disposal of hazardous substances by applying the Waste Control Act. It also mentioned legislation of management standards, regulatory methods, and acceptance criteria of disposal facility operator.