• Applied Biological Chemistry
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• v.51 no.2
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• pp.129-135
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• 2008

Berberine is an isoquinoline alkaloid used in traditional Chinese medicine and has been isolated from a variety of plants, such as Coptis chinensis and Phellodendron amurense. It has a wide spectrum of clinical applications such as in anti-tumor, anti-microbial, and anti-inflammatory activities. However, it is still unknown that berberine related with reactive oxygen species (ROS)-mediated apoptosis pathway in human hepatoma HepG2 cells. In the present study, we are examined the molecular mechanism of ROS- and p38 MAP kinase-mediated apoptosis by berberine in HepG2 cells. Berberine increased cytotoxicity effects by time- and does-dependent manner. $LD_{50}$ was detected 50 ${\mu}M$ at 48h of exposure to berberine. Nuclei cleavage and apoptotic DNA fragmentation were observed in cells treated with 50 ${\mu}M$ of berberine for 48h. Moreover, berberine induced the activating of caspase-3, p53, p38 and Bax expression, whereas the expression of anti-apoptotic signaling pathways, Bcl-2, was decreased. Additionally, berberine-treated cells had an increased level of generation of ROS and nitric oxide (NO). These results indicated that berberine induces apoptosis of HepG2 cells may be mediated oxidative injury acts as an early and upstream change, triggers mitochondrial dysfunction, Bcl-2 and Bax modulation, p38 and p53 activation, caspase-3 activation, and consequent leading to apoptosis.

• Journal of the Korean earth science society
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• v.40 no.2
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• pp.119-134
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• 2019

In order to analyze the observational environment of solar radiation stations operated by the Korea Meteorological Administration (KMA), we used the digital elevation model (DEM) and the solar radiation model to calculate a topographical shading, sky view factor (SVF) and solar radiation by surrounding terrain. The sky line and SVF were calculated using high resolution DEM around 25 km of the solar stations. We analyzed the topographic effect by analyzing overlapped solar map with sky line. Particularly, Incheon station has low SVF whereas Cheongsong and Chupungryong station have high SVF. In order to validation the contribution of topographic effect, the solar radiation calculated using GWNU solar radiation model according to the sky line and SVF under the same meteorological conditions. As a result, direct, diffuse and global solar radiation were decreased by 12.0, 5.6, and 4.7% compared to plane surface on Cheongsong station. The 6 stations were decreased amount of mean daily solar radiation to the annual solar radiation. Among 42 stations, eight stations were analyzed as the urgent transfer stations or moving equipment quickly and more than half of stations (24) were required to review the observational environment. Since the DEM data do not include artifacts and vegetation around the station, the stations need a detail survey of observational environment.

• Publications of The Korean Astronomical Society
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• v.27 no.4
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• pp.217-218
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• 2012

Among the AKARI all-sky survey data, the $9{\mu}m$ diffuse map is crucial to study the polycyclic aromatic hydrocarbon (PAH) emission features on large spatial scales, while the $18{\mu}m$ map is useful to trace hot dust emission. To utilize these advantages, we have improved the AKARI mid-infrared (MIR) all-sky survey diffuse maps. For example, we have established special methods to remove the effects of the ionizing radiation in the South Atlantic Anomaly (SAA) and of the scattered light from the moon. Using improved diffuse map data, we study the properties of PAHs and dust in the Galactic center region associated with high-energy phenomena.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.71.1-71.1
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• 2010

We present the FUV continuum map of The Taurus-Auriga-Perseus complex, which is one of the largest local association of dark clouds. The map is well consistent with the dust extinction and the CO emission map of the T-P-A region. The region is divided into 3 sub-regions by diffuse FUV intensities and the spectra of each region imply that the radiation field due to the Per OB2-association can be a main source of the H2 fluorescent emission of the nearby cloud region. We used the PDR H2 model, named CLOUD, developed by van Dishoeck &Black for the sake of comparing our results to the H2 model.

• Bulletin of the Korean Space Science Society
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• 2010.04a
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• pp.32.5-32.5
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• 2010

We present the FUV continuum map of The Taurus-Auriga-Perseus complex, which is one of the largest local association of dark clouds. The map is well consistent with the dust extinction and the CO emission map of the T-P-A region. The region is divided into 3 sub-regions by diffuse FUV intensities and the spectra of each region imply that the radiation field due to the Per OB2-association can be a main source of the H2 fluorescent emission of the nearby cloud region. We used the PDR H2 model, named CLOUD, developed by van Dishoeck &Black for the sake of comparing our results to the H2 model.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.7
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• pp.680-687
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• 2008

This paper presents map creation algorithm and initial attitude estimation method for the proposed optical head tracker system. The optical head tracker system consists of the IR stereo cameras and infrared LEDs as features on the helmet. In order for the stereo camera to track the luminous LEDs, it must take in to account the light radiation from the LEDs to determine the position of the center points. The proposed map creation algorithm makes map data about the position of features center points on the helmet frame. Also, initial attitude estimation method is proposed to estimate the initial attitude and position of a pilot head from the camera frame by the use of the feature pattern on the helmet. Therefore, the head motion can be expressed with respect to the body frame of a flight.

• Progress in Medical Physics
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• v.17 no.3
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• pp.173-178
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• 2006

The purpose of this study was to evaluate the radiation dose for clinical PET/CT protocols in clinical environments using Alderson phantom and TLDs. Radiation doses were evaluated for both Philips GEMINI 16 slice PET/CT system and GE DSTe 16 slice PET/CT system. Specific organ doses with $^{137}Cs$ transmission scan, high quality CT scan and topogram in philips GEMINI PET/CT system were measured. Specific organ doses with CT scan for attenuation map, CT scan for diagnosis and topogram in GE DSTe PET/CT system were also measured. The organs were selected based on ICRP60 recommendation. The TLDs used for measurements were selected for within an accuracy of ${\pm}5%$ and calibrated in 10 MV X-ray radiation field. The effective doses for $^{137}Cs$ transmission scan, high qualify scan, and topogram in Philips GEMINI PET/CT system were $0.14{\pm}0.950,\;29.49{\pm}1.508\;and\;0.72{\pm}0.032mSv$ respectively. The effective doses for CT scan to make attenuation map, CT scan to diagnose and topogram in GE DSTe PET/CT system were $20.06{\pm}1.003,\;24.83{\pm}0.805\;and\;0.27{\pm}0.008mSv$ respectively. We evaluated the total effective dose by adding effective dose for PET Image. The total PET/CT doses for Philips GEMINI PET/CT (Topogram+$^{137}Cs$ transmission scan+PET, Topogram+high qualify CT+PET) and GE DSTe PET/CT (Topogram +CT for attenuation map+ PET, Topogram+diagnostic CT+ PET) are $7.65{\pm}0.951,\;37.00{\pm}1.508,\;27.12{\pm}1.003\;and\;31.89{\pm}0.805mSv$ respectively. Further study may be needed to be peformed to find optimal PET/CT acquisition protocols for reducing the patient exposure with good image qualify.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.69.2-69.2
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• 2010

The far-ultraviolet (FUV) H2 and C IV emission images and spectra of Orion Eridanus Superbubble (OES) is hereby presented. The OES seems to consists of multiple phase through the detection of highly-ionized gas and pervasive neutral hydrogen. The former is traced by hot gas while the latter is traced by cold medium. A spectral image made with H2 fluorescent emission shows that the spatial distribution of hydrogen molecule is well correlated with the dust map. The model spectra was taken from a photodissociation region (PDR) radiation code which find a best suitable parameter such as hydrogen density, gas temperature and incident uv intensity of the radiation field. C IV emission is caused by intermediate temperature ISM about 10^4.5 K~10^6 K. Therefore we could get more clear evidence to reveal the structure of OES. Feature of spectra for the each sub region is also presented and discussed. The data were obtained with the Far-Ultraviolet Imaging Spectrograph (FIMS) and the whole data handling were followed by previous FIMS analysis.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.71.1-71.1
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• 2010

The far-ultraviolet (FUV) C IV and H2 emission spectra of Orion-Eridanus Superbubble (OES) is hereby presented. The OES seems to consist of multiple phase through the detection of highly-ionized gas and pervasive neutral hydrogen. The former is traced by hot gas while the latter is traced by cold medium. A spectral image made with H2 fluorescent emission shows that the spatial distribution of hydrogen molecule is well correlated with the dust map. The model spectra was taken from a photodissociation region (PDR) radiation code which finds a best suitable parameter such as hydrogen density and intensity of the radiation field. C IV emission is caused by intermediate temperature ISM about 10^5 K. Therefore we could get more clear evidence to reveal the morphology of OES. In this process, the hydrogen density and gas temperature were also estimated. The data were obtained with the Far-Ultraviolet Imaging Spectrograph (FIMS) and the whole data handling were followed by previous FIMS analysis.

• Nuclear Engineering and Technology
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• v.55 no.5
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• pp.1838-1854
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• 2023

This paper presents a hybrid algorithm to solve the multi-objective path planning (MOPP) problem for mobile robots in a static nuclear accident environment. The proposed algorithm mimics a real nuclear accident site by modeling the environment with a two-layer cost grid map based on geometric modeling and Monte Carlo calculations. The proposed algorithm consists of two steps. The first step optimizes a path by the hybridization of improved ant colony optimization algorithm-modified A^* (IACO-A^*) that minimizes path length, cumulative radiation dose and energy consumption. The second module is the high radiation dose rate avoidance strategy integrated with the IACO-A^* algorithm, which will work when the mobile robots sense the lethal radiation dose rate, avoiding radioactive sources with high dose levels. Simulations have been performed under environments of different complexity to evaluate the efficiency of the proposed algorithm, and the results show that IACO-A^* has better path quality than ACO and IACO. In addition, a study comparing the proposed IACO-A^* algorithm and recent path planning (PP) methods in three scenarios has been performed. The simulation results show that the proposed IACO-A^* IACO-A^* algorithm is obviously superior in terms of stability and minimization the total cost of MOPP.