• Journal of the Korean Institute of Intelligent Systems
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• v.24 no.4
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• pp.372-378
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• 2014

Noise in biomedical X-ray image degrades the quality so that it might causes to decrease the accuracy of diagnosis. Especially the noise reduction techniques is quite essential for low-dose biomedical X-ray images obtained from low radiation power in order to protect patients, because their noise level is usually high to well discriminate objects. This paper proposes an efficient method to remove the noise in low-dose X-ray images while preserving the edges with diverse resolutions. In the proposed method, a noisy image is at first decomposed into several images with different resolutions in pyramidal representation, then the stable map of edge confidence is obtained from each of analyzed image using a fuzzy logic-based edge detector. This map is used to adaptively determine the parameter for guided filters, which eliminate the noise while preserving edges in the corresponding image. The filtered images in the pyramid are extended and synthesized into a resulted image using interpolation technique. The superiority of proposed method compared to the median, bilateral, and guided filters has been experimentally shown in terms of noise removal and edge preserving properties.

• Korean Journal of Food Science and Technology
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• v.43 no.1
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• pp.30-38
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• 2011

Effects of depolymerization treatments of a carbohydrase mixture (CM), ultrasound, and irradiation on the physical properties of defatted mustard meal-based edible films (DMM films) were investigated. DMM hydrocolloids were added to CM (0.42% (w/w solution)), treated by ultrasound (500-700 W, 10-30 min) or ${\gamma}$-ray (40-100 kGy) to prepare film-forming solutions. Films were formed by drying. The CM treatment at 0.42% (w/w), pH 5.5, and 40-$50^{\circ}C$ with a 0.5 hr incubation time resulted in the highest colloidal stability in the film-forming solution. The depolymerization treatments did not dramatically change the water vapor permeability of the films. The solubility of the film decreased up to 53.1% by the CM treatment. The ultrasound treatment (700 W-30 min) decreased tensile strength and elongation. The ultrasound treatment (600 W-20 min) resulted in more compact and uniform structures of the films. Flavor profiles were differentiated by the power level and the time of the ultrasound treatment.

• Biomedical Science Letters
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• v.12 no.2
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• pp.73-79
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• 2006

Nebulin is a giant ($600{\sim}900$ kDa), modular sarcomeric protein proposed to regulate the assembly, and to specify the precise lengths of actin filamints in vertebrate skeletal muscles. Recently, There is an evidence that the nebulin also expressed in non muscle tissue, brain and liver. We identified a new isoform of nebulin from adult brain library by PCR screening. It contains two simple-repeats exon 165, 166 and linker-repeats exon $154{\sim}161$ except exon 159. The nebulin modules M160 to M170 (exon 150 to exon 161) has been shown to bind desmin. In mature striated muscle, desmin intermediate filaments surround Z-discs and link individual myofibrils laterally at their Z-discs and to other intracellular structures, including the costameres and the intercalated discs of the sarcolemma, sarcoplasmic reticulum, mitochondria, T-tubules, and nuclei. Therefore, it is an interesting possibility that the differential splice pathways within the linker region of nebulin modify the affinity of nebulin's interaction with desmin. The specific interactions of nebulin and desmin were confirmed in vivo by yeast two hybrid experiments. To verify in the cellular level the interaction between nebulin isoform and desmin, we transfected COS-7 cell with EGFP-tagged nebulin and DsRed-tagged desmin. Based on evidence showing that despite exon 159 was deleted, the new isoform of nebulin was interact with desmin. This suggest that nebulin in brain may interact with another intermediate filament. The conservation of these ligand-binding capacity in brain and skeletal nebulins suggest that nebulins may have conserved roles in brain and skeletal muscle.

• Applied Biological Chemistry
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• v.24 no.4
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• pp.230-237
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• 1981

For the investigation of efficient use of fertilizer nitrogen NPK simple trials were carried out using newly bred Tongil line(japonica indica hybrid selection) and the leading local varieties with sulfur coated area in fields for two years. The yield of Tongil line was higher than that of leading local varieties by 16% in the cool year and 23% is warm year with high solar radiation from NPK simple trials including SCU and 2-split application which were carried in 130 fields at 32 locations. Warm year increased yield by 9% in Tongil but only 3% in the local than the cool year did. Optimum nitrogen level was higher in Tongil by 3.8㎏ in the cool year and 5.5㎏ in warm year than for the local. Yearly variation of optimum nitrogen in the carne variety was greater than varietal variation in the same Year. Two-split application resulted in 1 to 2% of inconsistent yield variation. Sulfur coated urea increased yield by average 2 to 4% even at 20% reduced rate of nitrogen. It was remarkably effective in same $(27{\sim}39%)$, virgin (20%) and unmatured (10%) soils.

• Progress in Medical Physics
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• v.9 no.3
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• pp.185-192
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• 1998

It is necessarily to evaluate the energy of X-ray emitted from linear accelerator in order to determine the accurate absorbed dose. The method of direct measurement for x-ray energy is very difficult and impractical. Therefore the method of using beam quality index is generally used. Several dosimetry protocols recommend the use of quality indices such as depth of dose maximum at radiation central axis, dose gradient, and dose level. The linear accelerator manufactures follow the recommendation as dosimetry protocols. The study was performed for us to select the most suitable parameter among the Quality indices as described above. For photon beams of 4, 6, 10, 15, and 21 MV nominal energies produced by four kinds of accelerators(Mitsubishi, Scanditronix, Siemens, Varian) in eleven institutions, We evaluated the x-ray energies obtained by the Quality indices as recommended by several dosimetry protocols and manufactures. Results showed that there were energy spreads according to the same accelerators and Quality indices even though nominal energies were same. It appeared that the percent depth dose at 10 cm (D$_{10}$(%)) gave the smallest deviation and spread of energies. As energies increased, the energy deviation increased for all the quality indices. It is desirable for the use of unified quality index to compare the evaluation of beam quality at different institutions.

• Research in Plant Disease
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• v.20 no.4
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• pp.283-288
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• 2014

Citrus canker caused by Xanthomonas citri subsp. citri (Xcc) has been quarantined by many countries in the world. Recently, the usage of methyl bromide should be limited, application by gamma irradiation on the agricultural production is raised as an alternative method. In this study, the level of gamma irradiation which could decrease of population of Xcc in the suspension or on the surface of citrus fruit was investigated. The $D_{10}$ value of Xcc, which is radiation dose required to reduce the number of the microorganism, was 55 and 28 Gy in the suspension and on the surface of citrus fruit, respectively. Furthermore, disease severity was suppressed on the citrus leaves inoculated with Xcc suspension pre-treated with gamma irradiation. Based on this study, it is suggested that Xcc on the citrus fruit could be eradicated by gamma irradiation and the results of this study may be valuable for application of gamma ray in quarantine activity.

• Journal of the Korean Society of Food Culture
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• v.13 no.3
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• pp.169-182
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• 1998

This study was conducted to investigate the consumers' Dining-out preference and behavior for the chilled meat consumption strategy . A total of 328 persons in Seoul, Kyunggi areas were selected by stratified random sampling method and were responded to this study questionnaire which was composed of six parts with 65 statements about chilled meat consumption. 1. The frequency of Dining-out is characterized that 'once a month' is the highest pattern of consumers(46.3%) : In that cases, the married people showed 'once a month'(52.7%) and 'once biweekly'(23.3%), but the unmarried people showed the more frequent pattern as 'once a week'(27.3%) and 'twice a week'(27.3%). And the frequency of Dining-out in relation with the education level revealed that 'the graduate people' are the highest (37.5%). 2. Generally the first food for the Dining-out is 'Kalbi'(26.2%), and the others were 'pork grilling','chilled meat grilling','fish sasimi','chinese foods','pizza' etc.... But there were some variation in relation with incomes and housing types: For the agriculture/physical labor class, they prefers the 'pork griling'(25.0%), the office work class prefers the 'Kalbi' For the house-owner group, they prefers the 'Kalbi', but the house-renting/lodging group, they prefer the 'chinese food' or 'pork grilling' etc.... 3. In choosing the Dining-out place,'quality of food'(54.3%) and 'hygiene'(21.0%) were rated as the first important factor. 4.'Soups', 'Noodles' and 'Cooked rice in casserole' were chosen as good lunch menu : for male, they prefer the 'Soups', but females prefer 'Cooked rice in casserole'. 5. People with commercials/services(44.7%) and agriculture/physical labor(50.0%) ate their lunch in private restaurant, but peoples in the office work(57.0%)/public service personnel(70.4%) and industry use refectory; and it showed significant difference. 6. Consumers prefer the chilled meat as a Dining-out menu, but they didn't recognize the difference between chilled meat and frozen meat 7. For Dining-out menu, many people proper the beef, but the price of beef was so high than pork, agriculture/physical labor class choose the pork grilling instead of beef : commercials/services/office worker prefer the beef chilled meat . 8. The first admirable cooking method for chilled meat is direct radiation grilling with charcoal and many of consumers prefer tender, marbling, some chewy and juicy, flavor, soft as a quality of meat but physical labor class prefer the some tough and chewy texture.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.13 no.1
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• pp.21-34
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• 2015

Source term analysis should be carried out to prepare the decommissioning of the nuclear power plant. In the planning phase of decommissioning, the classification of decommissioning wastes and the cost evaluation are performed based on the results of source term analysis. In this study, the verification of MCNP/ORIGEN-2 model is carried out for preliminary source term calculation for Wolsung Unit 1. The inventories of actinide nuclides and fission products in fuel bundles with different burn-up were obtained by the depletion calculation of MCNPX code modelling the single channel. Two factors affecting the accuracy of source terms were investigated. First, the neutron spectrum effect on neutron induced activation calculation was reflected in one-group microscopic cross-sections of relevant radio-isotopes using the results of MCNP simulation, and the activation source terms calculated by ORIGEN-2 using the neutron spectrum corrected library were compared with the results of the original ORIGEN-2 library (CANDUNAU.LIB) in ORIGEN-2 code package. Second, operation history effect on activation calculation was also investigated. The source terms on both pressure tubes and calandria tubes replaced in 2010 and calandria tank were evaluated using MCNP/ORIGEN-2 with the neutron spectrum corrected library if the decommissioning wastes can be classified as a low level waste.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.1
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• pp.1-7
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• 2011

Many anticancer agents as well as ionizing radiation have been shown to induce autophagy which is originally described as a protein recycling process and recently reported to play a crucial role in various disorders. In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a marker of autophagosome degradation. Moreover, we found that curcumin caused GFP-LC3 formation puncta, a marker of autophagosome, and decrease of GFP-LC3 and SQSTM1 protein level in GFP-LC3 expressing HCT116 cells. It was further confirmed that treatment of cells with hydrogen peroxide induced increase of LC3 conversion and decrease of GFP-LC3 and SQSTM1 levels, but these changes by curcumin were almost completely blocked in the presence of antioxidant, N-acetylcystein (NAC), indicating that curcumin leads to reactive oxygen species (ROS) production, which results in autophagosome development and autolysosomal degradation. In parallel with NAC, SQSTM1 degradation was also diminished by bafilomycin A, a potent inhibitor of autophagosome-lysosome fusion, and cell viability assay was further confirmed that cucurmin-induced cell death was partially blocked by bafilomycin A as well as NAC. We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 112 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK). However, the activation of ERK1/2 and p38 MAPK seemed to have no effect on the curcumin-induced autophagy, since both the conversion of LC3 protein and SQSTM1 degradation by curcumin was not changed in the presence of NAC. Taken together, our data suggest that curcumin induced ROS production, which resulted in autophagic activation and concomitant cell death in HCT116 human colon cancer cell. However, ROS-dependent activation of ERK1/2 and p38 MAPK, but not JNK, might not be involved in the curcumin-induced autophagy.

• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.261-267
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• 1986

Development of supervoltage treatment machine may minimize skin reaction by skin-sparing effect, but skin damage is still one of "the dose limiting factor" in radiation therapy. In spite of these importance, systemic histopathologic studies of skin in similar conditions which used in clinical treatment has not been performed so far. 60mice were irradiated with conventional fraction ($200{\times}5/wk$) and whole abdominal field ($2{\times}3cm$, from symphysis pubis to xyphoid process). Used machine was 250KV, 24mA, orthovoltage x-ray machine. Histopathological changes of acute skin reaction at the level of total irradiation dose were analyzed and the possible mechanism of later chronic changes were investigated. Obtained results are as follows: 1. In 1,000 rad irradiated group, only mild epidermal edema is noted. 2. In 2,000 rad irradiated group, slightly decreased number and size of hair follicles and appendages, dermal edema and scanty infiltration of inflammatory cells are visible. 3. In 3,000 rad irradiated group, marked increased capillary congestion and prominant infiltration of inflammatory cells are observed. 4. In 4,000 rad irradiated group, vascular wall thickening with proliferation of endothelial cells are prominant. Dermal thinning and hyalinization are newly developed. 5. In 5,000 rad irradiated group, complete desquamation of epidermis is not seen, despite of acceleration of all above mentioned changes.