• Journal of Radiation Protection and Research
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• v.21 no.3
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• pp.201-215
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• 1996

Radiation and radioactive materials serve man in many beneficial ways. Diagnostic X-ray, radiation therapy, and other nuclear medicine uses of radioactivity save thousands of lives each year. Industrial application of radiation, such as radiography, make many manufactured products more reliable and less expensive. Nuclear power plants are producing more electrical power each year and reducing our dependence on imported oil. However, radiation can and dose produce harmful effects particularly as the reault of a radiation accident in which a victim receives as the result of a radiation accident in which a victim receives a large dose. Fortunately such accidents are very rare and recently we need more electric power produced by nuclear power plants. Considering increase of use of radiation or radioactive materials, we have to establish the radiological emergency response system prepared for radiation accidents.

• International Journal of Contents
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• v.14 no.4
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• pp.65-69
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• 2018

The objective of this study was to conduct a radiation shielding analysis for the facility equipped with radiation generator. The analysis was carried out in two aspects. First, from the aspect of the effect caused by primary and leakage radiation. Second, effect of scattered radiation was evaluated by applying a simple calculation method based on a scattering rate concept since effect of scattered radiation is significantly important at maze entrance of the radiation facility. The calculated results obtained using the simple method were compared to the results calculated using Geant4 code and the measured values. The results calculated by the suggested method indicate that slight error exists in a radiation shielding analysis done at the maze entrance comparing to other two results, while the results evaluated at the outside of the maze entrance door are relatively consistent with other values.

• Journal of the Korean Society of Radiology
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• v.14 no.6
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• pp.755-762
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• 2020

This study is desinged to examine the effects of Taheebo(Tabebuia avellanedae) extract on the prostate of male rats as a natural radiation protection agent. Taheebo extract is well known to inhibit cell growth for the cell lines of breast and prostate cancer. In this study, the X-ray 7 Gy was irradiated in the prostate of male rat to identify radiation protection effects by Taheebo Extracts, 1, 7, and 21 Days later, hematological changes, external toxicity assessments(LDH), antioxidant enzyme(SOD) activity changes and tissue change were observed. IR+TH group showed greater lymphocyte levels than the irradiation group, which is believed to affect the hematopoietic immune system's resilience. As a results of the external toxicity assessment, Taheebo extract's toxicity is maximum 18.128±5.16%, minimum 13.6945±4.43%. Taheebo is considered to be of little toxicity. The composition of prostate cell nuclei and cytoplasm in Control and TH group was honogeneous, whereas the cell nucleus cohesion in the prostate in irradiation group and inflammatory reactions in cytoplasm were shown. IR+TH group showed less inflammatory reactions of cytoplasm in the prostate than in the radiation irradiation group, but showed a cohesive phenomenon of cell nuclei. It is judged that Taheebo extract has radiation protection against prostate cells.

• Journal of the Korean Society of Radiology
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• v.15 no.3
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• pp.313-320
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• 2021

This study evaluates the radiation protection effects of Schizonepeta tenuifolia water extract on white rat by gender. Schizonepeta tenuifolia contains polyphenol and flavonoid, which are typical substances that remove free radical. Thus, to determine the effectiveness of radiation protection, the Schizonepeta tenuifolia water extract was administered to Sparaqu-Dawely (SD) rat males and females for two weeks, followed by hematological analysis, analysis of changes in the length of the small intestine villi length, and SOD activity evaluation. The male rat in ST+IR group showed a slightly greater recovery of platelets than the IR group. The ST+IR group also showed a higher platelet recovery capability than the IR group. lymphocyte showed that male and female rat ST+IR groups have higher resilience than IR groups likewise platelet. After irradiation, the villi length of the male rat and female rat decreased less in ST+IR group than in the IR group, indicating that the villi length of all genders was less damaged. This result confirmed that the Schizonepeta tenuifolia water extract had a radiation protection effect.

• Journal of Radiation Protection and Research
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• v.6 no.1
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• pp.45-52
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• 1981

The March 1979 accident at Three Mile Island provided physicians specializing in radiation medicine an opportunity to observe the field under conditions never seen before. Since no, injuries occurred at the site or within the community, medical personnel were immediately involved in efforts to allay fear, provide accurate information, and replace labortory resources rendered ineffective by the release in the reactor building. Valuable insights concerning medical emergency planning are derived from the accident; suggestions are made for handling any future mishaps.

• Journal of radiological science and technology
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• v.40 no.1
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• pp.135-142
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• 2017

Selenium (Se), which is natural materials existing was known as an important component of selenoprotein, one of the important proteins responsible for the redox pump of a living body. Selenium was orally administered to Rat and irradiated with 10 Gy of radiation. Then, the thyroid gland was used as a target organ for 1 day, 7 days and 21 days to investigate the radiation protection effect of selenium (Se) through changes of blood components, thyroid hormones (T3, T4), antioxidant enzyme (GPx) activity and thyroid tissue changes. As a result, there was a significant protective effect of hematopoietic immune system(hemoglobin concentration, neutrophil, platelet)(p<0.05). The activity of Glutathione Peroxidase (GPx), the antioxidant enzyme, and the activity of the target organ, thyroid hormone (T3, T4), also showed significant activity changes (p<0.05). In the observation of tissue changes, it was confirmed that there was a protective effect of thyroid cell damage which caused the cell necrosis by radiation treatment. Therefore, it is considered that selenium(Se) can be utilized as a radiation defense agent by inducing immunogenic activity effect of a living body.

• BMB Reports
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• v.47 no.10
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• pp.575-580
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• 2014

In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). A dose dependent relationship between arsenite and reduced cell growth is demonstrated, as well as induced ${\gamma}H2AX$ foci formation in both U87MG-neo and U87MG-E6 cells at low concentrations of arsenite. Senescence was induced by arsenite with senescence-associated ${\beta}$-galactosidase staining. Dimethyl- and trimethyl-lysine 9 of histone H3 (H3DMK9 and H3TMK9) foci formation was accompanied by p21 accumulation only in U87MG-neo but not in U87MG-E6 cells. This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway. p21 and p53 siRNA consistently decreased H3TMK9 foci formation in U87M G-neo but not in U87MG-E6 cells after arsenite treatment. Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage.

• Journal of Radiation Protection and Research
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• v.30 no.3
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• pp.131-148
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• 2005

In a nuclear emergency, protective actions for the public should be taken in time. It is internationally proposed that generic intervention levels (GILs) and generic action levels, determined based on cost-benefit analyses, be used as the decision criteria for protective actions. Operational intervention levels (OILs) are directly or easily measurable quantities corresponding to these generic levels. To assess the necessity of protective actions in a nuclear emergency, it is important that the environmental monitoring data required for applying and revising OILs should be promptly produced. It is discussed what and how to do for this task in the course of the emergency response. For an emergency environmental monitoring to be performed effectively, a thorough preparedness has to be made including maintenance of the organization and equipments, establishment of various procedure manuals, development of a supporting computer system and periodical training and exercises. It is pointed out that Korean legal provisions concerning GILs and OILs need to be amended or newly established.

• 대한핵의학회:학술대회논문집
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• 2003.05a
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• pp.19-21
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• 2003

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.10a
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• pp.305-306
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• 2017