• Advances in concrete construction
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• v.3 no.4
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• pp.317-331
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• 2015

This paper presents the effect of different micro-silica (MS) contents of 5, 10 and 15 wt.% as partial replacement of cement on mechanical and durability properties of high volume fly ash - recycled aggregate concretes (HVFA-RAC) containing 50% class F fly ash (FA) and 35% recycled coarse aggregate (RCA) as partial replacement of cement and natural coarse aggregate (NCA), respectively. The measured mechanical and durability properties are compressive strength, indirect tensile strength, elastic modulus, drying shrinkage, water sorptivity and chloride permeability. The effects of different curing ages of 7, 28, 56 and 91 days on above properties are also considered in this study. The results show that the addition of MS up to 10% improved the early age (7 days) strength properties of HVFA-RAC, however, at later ages (e.g. 28-91 days) the above mechanical properties are improved for all MS contents. The 5% MS exhibited the best performance among all MS contents for all mechanical properties of HVFA-RAC. In the case of measured durability properties, mix results are obtained, where 10% and 5% MS exhibited the lowest sorptivity and drying shrinkage, respectively at all ages. However, in the case of chloride ion permeability a decreasing trend is observed with increase in MS contents and curing ages. Strong correlations of indirect tensile strength and modulus of elasticity with square root of compressive strength are also observed in HVFA-RAC. Nevertheless, it is established in this study that MS contributes to the sustainability of HVFA-RAC significantly by improving the mechanical and durability properties of concrete containing 50%less cement and 35% less natural coarse aggregates.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.165.2-165.2
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• 2003

Phosphatidylinositol 3-kinase (PI3K) and Rac play important roles that regulate cellular functions including cell survival and migration. In the present study, we investigated the functional roles of PI3K and Rac1 pathways in H-ras-induced invasive phenotype and motility of MCF10A cells. Akt, a downstream molecule of PI3K, was effectively activated not only by H-ras but also by N-ras, suggesting that the activation of PI3K pathway is not sufficient to induce metastatic potential of MCF10A cells. (omitted)

• Proceedings of the IEEK Conference
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• 2000.11a
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• pp.189-192
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• 2000

This paper proposes a fuzzy-based random access controller with a superimposed frame structure (F$^2$RAC) fur voice/data-integrated wireless networks. F$^2$RAC adopts mini-slot technique for reducing contention cost, and these mini-slots of which number may dynamically vary from one frame to the next as a function of the traffic load are further partitioned into two regions for access requests coming from voice and data traffic with their respective QoS requirements. And F$^2$RAC is designed to properly determine the access regions and permission probabilities for enhancing the data packet delay while ensuring the voice packet dropping probability constraint. It mainly consists of the estimator with Pseudo-Bayesian algorithm and fuzzy logic controller with Sugeno-type of fuzzy rules. Simulation results prove that F$^2$RAC can guarantee QoS requirement of voice and provide the highest throughput efficiency and the smallest data packet delay amongst the different alternatives including PRMA［1］, IPRMA［2］, and SIR［3］.

• International Journal of Concrete Structures and Materials
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• v.10 no.1
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• pp.61-73
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• 2016

In predicating the probability distribution of chloride diffusion coefficient of recycled aggregate concrete ($D_{RAC}$), the morphological characteristics of three phases, i.e., the old attached mortar, the natural aggregate and the new mortar, should all be taken into account. The present paper attempts to develop a probability density evolution method (PDEM) to achieve this. After verifying the derived PDEM results with experimental results, the effects of old attached mortar to the $D_{RAC}$ are examined in a quantitative manner. It is found that (1) the variation of the attached mortar content is much sensitive to $D_{RAC}$; (2) given the probability distribution of the content and chloride diffusion coefficient of old mortar, the probability distribution of DRAC can be analysed based on the PDEM; and (3) the critical chloride diffusion coefficient at a certain assurance rate can be obtained by the PDEM. The analysis results of this investigation will be valuable to the durability design for RAC.

• Steel and Composite Structures
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• v.45 no.3
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• pp.369-388
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• 2022

Composite effect between steel and recycled aggregate concrete (RAC) in steel reinforced-RAC (SRRAC) structures can effectively improve RAC's adverse mechanical properties due to the natural defects of recycled coarse aggregate (RCA). However, the performance of SRRAC after thermal exposure will have a great impact on the safety of the structure. In this paper, firstly, the mechanical properties of SRRAC structures after high temperatures exposure were tested, including 24 SRRAC columns and 32 SRRAC beams. Then, the change rules of beams and columns performance with the maximum temperature and replacement percentage were compared. Finally, the formulas to evaluate the residual bearing capacity of SRRAC beams and columns after exposure to high temperatures were established. The experimental results show that the maximum exposure temperature can be judged by the apparent phenomenon and mass loss ratio of RAC. After high temperatures exposure, the mechanical properties of SRRAC beams and columns change significantly, where the degradation of bearing capacity and stiffness is the most obvious. Moreover, it is found that the degradation degree of compression member is more serious than that of flexural member. The formulas of residual bearing capacity established by introducing influence coefficient of material strength agree well with the experimental results.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6305-6309
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• 2013

Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells. Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2. Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells. GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLC cells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Further experiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and down-regulate the expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promote invasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genes may be involved in the underlying processes.

• Experimental and Molecular Medicine
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• v.51 no.2
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• pp.9.1-9.10
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• 2019

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. The proportion of ${\alpha}-SMA^+/PCNA^+$ cells was increased in the kidney cortex of db/db mice compared with control mice. Treatment with LPA concomitantly increased the proliferation of mouse mesangial cells (SV40 MES13) and the expression of cyclin D1 and CDK4. On the other hand, the expression of $p27^{Kip1}$ was decreased. The expression of $Kr{\ddot{u}}ppel$-like factor 5 (KLF5) was upregulated in the kidney cortex of db/db mice and LPA-treated SV40 MES13 cells. RNAi-mediated silencing of KLF5 reversed these effects and inhibited the proliferation of LPA-treated cells. Mitogen-activated protein kinases (MAPKs) were activated, and the expression of early growth response 1 (Egr1) was subsequently increased in LPA-treated SV40 MES13 cells and the kidney cortex of db/db mice. Moreover, LPA significantly increased the activity of the Ras-related C3 botulinum toxin substrate (Rac1) GTPase in SV40 MES13 cells, and the dominant-negative form of Rac1 partially inhibited the phosphorylation of p38 and upregulation of Egr1 and KLF5 induced by LPA. LPA-induced hyperproliferation was attenuated by the inhibition of Rac1 activity. Based on these results, the Rac1/MAPK/KLF5 signaling pathway was one of the mechanisms by which LPA induced mesangial cell proliferation in DN models.

• Macromolecular Research
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• v.12 no.3
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• pp.316-321
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• 2004

We have performed copolymerizations of ethylene with 1-hexene using various ansa-metallocene compounds in the presence of the non-coordinative [CPh$_3$][B(C$\_$6/F$\_$5/)$_4$ion pair as a cocatalyst. The metallocenes chosen for this study are isospecific metallocene diamide compounds, rac-(EBI)Zr(NMe$_2$)$_2$ [1, EBI = ethylene-l ,2-bis(1-indenyl)], rac-(EBI)Hf(NMe$_2$)$_2$ (2), rac-(EBI)Zr(NC$_4$H$\_$8/)$_2$ (3), and rac-(CH$_3$)$_3$Si(1-C$\_$5/H$_2$-2-CH$_3$-4-$\^$t/C$_4$H$\_$9/)2 Zr(NMe$_2$)$_2$ (4), and syndiospecific metallocene dimethyl compounds, ethylidene(cyclopentadienyl)(9-fluorenyl) ZrMe$_2$ [5, Et(Flu)(Cp )ZrMe$_2$] and isopropylidence (cyclopentadienyl)(9-fluorenyl)ZrMe$_2$ [6, iPr(Flu)(Cp)ZrMe$_2$]. The copolymerization rate decreased in the order 4 ＞1-3＞2 ＞5＞6. The reactivity of I -hexene decreased in the order 2 ＞6＞1- 3-5＞ 4. We characterized the microstructure of the resulting poly(ethylene-co-l-hexene) by $\^$l3/C NMR spectroscopy and investigated various other properties of the copolymers in detail.

• Steel and Composite Structures
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• v.9 no.1
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• pp.19-38
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• 2009

The present paper provides test data to evaluate the seismic performance of recycled aggregate concrete (RAC) filled steel square hollow section (SHS) beam-columns. Fifteen specimens, including 12 RAC filled steel tubular (RACFST) columns and 3 reference conventional concrete filled steel tubular (CFST) columns, were tested under reversed cyclic flexural loading while subjected to constant axially compressive load. The test parameters include: (1) axial load level (n), from 0.05 to 0.47; and (2) recycled coarse aggregate replacement ratio (r), from 0 to 50%. It was found that, generally, the seismic performance of RACFST columns was similar to that of the reference conventional CFST columns, and RACFST columns exhibited high levels of bearing capacity and ductility. Comparisons are made with predicted RACFST beam-column bearing capacities and flexural stiffness using current design codes. A theoretical model for conventional CFST beam-columns is employed in this paper for square RACFST beam-columns. The predicted load versus deformation hysteretic curves are found to exhibit satisfactory agreement with test results.

• Journal of Korean Medical classics
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• v.11 no.1
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• pp.396-413
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• 1998

The HyeolRacRon(血絡論) of the YoungChu(靈樞) is one of the section associate with the study of bloodletting(depletion of blood) by acupunture. The bloodletting therapy, one of the treatment of Oriental Medicine, has been advanced in civilization. By studying of this section, I could find some conculution as follows: 1. It is the superficial venules(血絡) that has been included blood stasis which has been interrupted by pathogenic factor(邪氣), and still could not enter into the meridian's line. 2. When bloodletting therapy, we should carefully study of patient's health condition, because doctor's missed acupuncure leads to very serious side effects. 3. External shape of HyeolRac(血絡) is like acu-niddle or muscle, so its thickness and location were not fixed position, its color is redish, and its quality is hard. 4. It is reason of heating that fixation of acu-niddle and muscle fiber.