• 한국산학기술학회논문지
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• 제18권11호
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• pp.7-15
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• 2017

본 연구에서는 콘크리트 적용 저품질 순환골재의 콘크리트 적용을 위하여 공학적 특성을 평가 하였다. 이를 위해서 저품질 순환골재의 세척유무에 따라서 골재 치환율을 30%, 60%, 100%로 콘크리트 제작하여 실험하였으며, 성능평가를 위하여 제작된 순환골재 사용 콘크리트의 압축강도, 흡수율, 표면전기저항, 초음파속도, 염소이온침투저항성 평가를 실시하였다. 세척한 저품질 순환골재의 경우 30% 치환시 천연골재와 유사한 결과를 모든 시험에서 나타내었다. 또한 60%를 치환한 콘크리트에서도 천연골재와 유사한 성능을 나타내는 것으로 확인되었다. 그러나 100%의 골재를 사용하는 것은 천연 골재 보다 다소 낮은 결과 값을 나타내었다. 반면 세척을 하지 않은 저품질 순환골재의 경우는 치환율에 관계없이 전체적으로 천연골재보다 좋지 않은 결과를 나타내었다. 특히 내구성 평가의 척도로 평가한 염소이온침투저항성 평가에서는 초기의 경우 매우 높음의 결과를 나타내었으며, 28일 재령에서도 보통 수준의 저항성을 나타내어 세척 순환골재와 약 2배 정도의 차이를 나타내었다. 따라서, 저품질 순환골재의 콘크리트 적용에 있어서 골재의 세척유무에 따라서 성능이 변화하는 것을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6305-6309
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• 2013

Background: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration. Here, we aimed to investigate the role of TIAM2 in non-small cell lung cancer (NSCLC) cells. Materials and Methods: A small interference RNA (siRNA) was introduced to silence the expression of TIAM2. Invasion and motility assays were then performed to assess the invasion and motility potential of NSCLC cells. GST-pull down assays were used to detect activation of Rac1. Results: TIAM2 was highly expressed in NSCLC cells. Knockdown of TIAM2 inhibited the invasion and motility, and suppressed activation of Rac1. Further experiments demonstrated that knockdown of TIAM2 could up-regulate the expression of E-cadherin, and down-regulate the expression of MMP-3, Twist and Snail. Conclusions: Our data suggest that TIAM2 can promote invasion and motility of NSCLC cells. Activation of Rac1 and regulation of some EMT/invasion-related genes may be involved in the underlying processes.

• 한국항공우주학회지
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• 제35권4호
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• pp.347-352
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• 2007

논문에서는 과학기술위성 2호용으로 개발된 탑재체데이터 수신시스템(Data Receiving Equipment, DRE)을 소개하고 개발된 준비행모델(Proto Flight Model, PFM)에서의 기능 및 성능 시험 결과를 제시 한다. 탑재체데이터 수신시스템은 X 대역 수신기, 데이터 합성장치(Data Combine Equipment, DCE)와 수신 저장 컴퓨터(Receiving and Archiving Computer, RAC)로 구성되어 있다. DCE는 I&Q 신호 합성기와 ECL 신호 분배기로 구성 된다. RAC은 데이터 수신 카드(Data Receiving Card, DRC)와 소프트웨어인 ST2RAS(STSAT-2 Receiving and Archiving Software, ST2RAS)로 구성된다. X 대역 수신기를 통해서 수신된 I, Q 데이터는 DCE를 통해서 I&Q 데이터로 합성된다. 합성된 데이터는 데이터 수신 카드를 통해서 수신 저장 컴퓨터의 RAID(Redundant Array of Inexpensive Disk)에 저장되고, 이 데이터는 ST2RAS의 전처리를 통해서 위성의 상태 정보와 탑재체 정보로 분리된다. 탑재체데이터 수신시스템에 대한 기능 시험과 열진공 시험을 통해서 10-6 의 BER(Bit Error Rate) 요구사항을 만족하는 결과를 확인하였다.

• Experimental and Molecular Medicine
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• 제51권2호
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• pp.9.1-9.10
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• 2019

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. The proportion of ${\alpha}-SMA^+/PCNA^+$ cells was increased in the kidney cortex of db/db mice compared with control mice. Treatment with LPA concomitantly increased the proliferation of mouse mesangial cells (SV40 MES13) and the expression of cyclin D1 and CDK4. On the other hand, the expression of $p27^{Kip1}$ was decreased. The expression of $Kr{\ddot{u}}ppel$-like factor 5 (KLF5) was upregulated in the kidney cortex of db/db mice and LPA-treated SV40 MES13 cells. RNAi-mediated silencing of KLF5 reversed these effects and inhibited the proliferation of LPA-treated cells. Mitogen-activated protein kinases (MAPKs) were activated, and the expression of early growth response 1 (Egr1) was subsequently increased in LPA-treated SV40 MES13 cells and the kidney cortex of db/db mice. Moreover, LPA significantly increased the activity of the Ras-related C3 botulinum toxin substrate (Rac1) GTPase in SV40 MES13 cells, and the dominant-negative form of Rac1 partially inhibited the phosphorylation of p38 and upregulation of Egr1 and KLF5 induced by LPA. LPA-induced hyperproliferation was attenuated by the inhibition of Rac1 activity. Based on these results, the Rac1/MAPK/KLF5 signaling pathway was one of the mechanisms by which LPA induced mesangial cell proliferation in DN models.

• Steel and Composite Structures
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• 제9권1호
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• pp.19-38
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• 2009

The present paper provides test data to evaluate the seismic performance of recycled aggregate concrete (RAC) filled steel square hollow section (SHS) beam-columns. Fifteen specimens, including 12 RAC filled steel tubular (RACFST) columns and 3 reference conventional concrete filled steel tubular (CFST) columns, were tested under reversed cyclic flexural loading while subjected to constant axially compressive load. The test parameters include: (1) axial load level (n), from 0.05 to 0.47; and (2) recycled coarse aggregate replacement ratio (r), from 0 to 50%. It was found that, generally, the seismic performance of RACFST columns was similar to that of the reference conventional CFST columns, and RACFST columns exhibited high levels of bearing capacity and ductility. Comparisons are made with predicted RACFST beam-column bearing capacities and flexural stiffness using current design codes. A theoretical model for conventional CFST beam-columns is employed in this paper for square RACFST beam-columns. The predicted load versus deformation hysteretic curves are found to exhibit satisfactory agreement with test results.

• 대한한의학원전학회지
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• 제11권1호
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• pp.396-413
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• 1998

The HyeolRacRon(血絡論) of the YoungChu(靈樞) is one of the section associate with the study of bloodletting(depletion of blood) by acupunture. The bloodletting therapy, one of the treatment of Oriental Medicine, has been advanced in civilization. By studying of this section, I could find some conculution as follows: 1. It is the superficial venules(血絡) that has been included blood stasis which has been interrupted by pathogenic factor(邪氣), and still could not enter into the meridian's line. 2. When bloodletting therapy, we should carefully study of patient's health condition, because doctor's missed acupuncure leads to very serious side effects. 3. External shape of HyeolRac(血絡) is like acu-niddle or muscle, so its thickness and location were not fixed position, its color is redish, and its quality is hard. 4. It is reason of heating that fixation of acu-niddle and muscle fiber.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 추계 학술논문 발표대회
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• pp.101-103
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• 2011

Various desired performances of concrete cannot be always obtained by current conventional mix proportion methods for recycled aggregate concrete (RAC). This paper suggests a new design method of mix proportion for RAC to reduce the number of trial mixes using genetic algorithm (GA) which has been an optimization technique to solve the multi-object problem. In mix design method by GA, several fitness functions for the required properties of concrete, i.e., slump, strength, price, and carbonation speed coefficient were considered based on conventional data or fitness function. As a result, various optimum mix proportions for RAC that meet required performances were obtained and the risk evaluation was also conducted for selected mixtures.

• Elastomers and Composites
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• 제54권4호
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• pp.286-293
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• 2019

In this study, flexible poly(ethylene-ter-1-hexene-ter-divinylbenzene) was prepared using four types of metallocene catalysts (rac-Et(Ind)₂ZrCl₂, rac-SiMe₂(Ind)₂ZrCl₂, rac-SiMe₂(2-Me-Ind)₂ZrCl₂, (C₅Me₅)TiCl₂[O-2,6-ⁱPr₂(C₆H₃)]) and two types of borate catalysts (trityl tetrakisborate and dimethylanilinium tetrakisborate). The yield, catalytic activity, molecular weight, structure, composition, and thermal properties of the terpolymers prepared using the various catalysts and cocatalyst systems were evaluated. Epoxidation of the terpolymers was successfully performed and this transformation was studied by ¹H NMR and FTIR.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.165.2-165.2
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• 2003

Phosphatidylinositol 3-kinase (PI3K) and Rac play important roles that regulate cellular functions including cell survival and migration. In the present study, we investigated the functional roles of PI3K and Rac1 pathways in H-ras-induced invasive phenotype and motility of MCF10A cells. Akt, a downstream molecule of PI3K, was effectively activated not only by H-ras but also by N-ras, suggesting that the activation of PI3K pathway is not sufficient to induce metastatic potential of MCF10A cells. (omitted)

• 폴리머
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• 제24권4호
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• pp.445-452
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• 2000

다양한 종류의 메탈로센 촉매와 공촉매인 개질-MAO (MMAO)을 이용한 에틸렌 (E)과 노르보르넨 (N)의 공중합에서 중합조건이 촉매 활성 및 공중합체의 구조와 성질 등에 미치는 영향을 조사하였다. 즉 $C_2$-대칭구조를 가지는 rac-Et(Ind)$_2$ZrC $l_2$, $M_2$Si(Ind)$_2$ZrC $l_2$, M $e_2$Si-(Cp)$_2$ZrC $l_2$ 및 $C_{s}$-대칭구조를 가지는 iPr(FluCp)ZrC $l_2$, 그리고 constrained geometry catalyst (CGC)와 이중다리 (di-bridged) 지르코노센 둥의 다양한 메탈로센 촉매를 사용하여 [N]/[E] 공급비에 따른 촉매 활성, 공중합체 (COC)의 열적 성질 및 N 함량을 조사하였다. rac-Et(Ind)$_2$ZrC $l_2$를 촉매로 사용한 경우에 공촉매의 몰비, 중합 온도 및 공촉매 종류 등의 중합조건을 조사한 결과 [Al]/[Zr]=3000, 4$0^{\circ}C$, MMAO 공촉매 등이 적합하였다. [N]/[E] 공급비가 증가됨에 따라 COC내의 N 함량이 증가하는 일반적인 경향을 보였으나, 촉매 활성은 사용된 메탈로센 촉매의 구조에 따라 달랐다. 즉 [N]/[E]가 증가할수록 $C_2$-대칭구조의 촉매 활성은 감소하였으나 $C_{s}$-대칭구조의 경우에는 증가하였다. 촉매활성과 N함량 등을 고려해 보면 rac-Et(Ind)$_2$ZrC $l_2$/MMAO계에서 비교적 높은 촉매 활성과 COC의 $T_{g}$제어가 용이한 결과를 얻을 수 있었다. 촉매종류에 따른 단량체의 반응성비를 Helen-Tudos 방법으로 구하였다.하였다.