• Proceedings of the Korean Magnestics Society Conference
• /
• 2009.12a
• /
• pp.220-221
• /
• 2009

• Proceedings of the Korean Magnestics Society Conference
• /
• 2010.06a
• /
• pp.180-180
• /
• 2010

• The Zoological Society Korea : Newsletter
• /
• v.15 no.1
• /
• pp.12-19
• /
• 1998

• Bulletin of the Korean Chemical Society
• /
• v.33 no.2
• /
• pp.409-414
• /
• 2012

Xanthorrhizol is a bisabolane type of natural sesquiterpene, the major component of essential oils of Curcuma xanthorrhiza. 2-(3-Methoxy-4-methylphenyl)propan-1-ol and 2-(3-hydroxy-4-methyl phenyl)propan-1-ol could be essential building block for enantioselective synthesis of xanthorrhizol. Enantioselective (c = 53%, E = $80{\pm}3$) for R-(+)-2-(3-hydroxy-4-methylphenyl) propan-1-ol and (c = 58%, E = $27{\pm}1$) for R-(+)-2-(3-methoxy-4-methylphenyl) propan-1-ol resolution processes were developed via lipase-catalyzed reaction. We found lipase Aspergillus oryzae (AOL) and Porcine pancreas (PPL) are selective to transesterification and hydrolysis in organic and aqueous phase. Modified demethylated substrate is appropriate for enantioselective hydrolysis reaction without any additives. Enantiopure chiral alcohol was crystallized from ethyl acetate/n-hexane co-solvent system. Gram scale resolved chiral intermediate will facilitate the synthesis of the unnatural S-(+)-xanthorrhizol, the corresponding isomer of the natural one.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2012.11a
• /
• pp.73-74
• /
• 2012

The elastic modulus of recycled aggregate concrete (RAC) can be evaluated by using composite models with experiment. In this study, Hashin's composite model was adapted to evaluate elastic modulus considering physical properties of recycled coarse aggregate (RCA) that mortar is attached. Elastic modulus testes for cement paste, mortar and recycled coarse aggregate concrete were carried out considering W/C and recycled coarse aggregate content rate. As a result, the elastic modulus of RAC was evaluated comparing with both experiment results and the existing estimation formula. Those can be used for further studies as a preliminary data.

• BMB Reports
• /
• v.49 no.11
• /
• pp.623-628
• /
• 2016

GPR78 is an orphan G-protein coupled receptor (GPCR) that is predominantly expressed in human brain tissues. Currently, the function of GPR78 is unknown. This study revealed that GPR78 was expressed in lung cancer cells and functioned as a novel regulator of lung cancer cell migration and metastasis. We found that knockdown of GPR78 in lung cancer cells suppressed cell migration. Moreover, GPR78 modulated the formation of actin stress fibers in A549 cells, in a RhoA- and Rac1-dependent manner. At the molecular level, GPR78 regulated cell motility through the activation of $G{\alpha}q$-RhoA/Rac1 pathway. We further demonstrated that in vivo, the knockdown of GPR78 inhibited lung cancer cell metastasis. These findings suggest that GPR78 is a novel regulator for lung cancer metastasis and may serve as a potential drug target against metastatic human lung cancer.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2005.05a
• /
• pp.119-124
• /
• 2005

It is necessary for prediction of recycled aggregate concrete(RAC) strength at the early stage that facilitate concrete form removal and scheduling for construction. However, to predict RAC strength is difficult because of being influenced by complicated many factors. Therefore, this research suggest optimized estimation method that can reflect many factors. One way is Case-Based Reasoning(CBR) that solved new problems by adapting solutions to similar problems solved in the past, which are solved in the case library. Other way is Artificial Neural Networks(ANN) that solved new problems by training using a set of data, which is representative of problem domain. This study is to propose comparing accuracy of the estimating the compressive strength of recycled aggregate concrete using Case-Based Reasoning(CBR) and Artificial Neural Networks(ANN).

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1994.04a
• /
• pp.167-167
• /
• 1994

Thioglycerol과 Glycerol을 출발물질로 1번 탄소(C) 위치의 산소(O),또는 황(S)에 octadecyl기로 alkylation한 후, 2번 탄소(C)위치 산소(O)를 palmitoyl기로acetylation시켜 만든 thioether lipid 및 ether lipid유도체를 인산화시킨 rac-1-S-octa-decyl-2-O-palmitoyl-1-S-thioglycerol-3-phosphate (DL-PTBA-P)와 rac-1-O-octadecyl-2-O-palmitoylglycerol-3-phosphate (DL-PBA-P)등을 합성하였다. 이들 thioether lipid 및 ether lipid유도체는 그 자체로도 in vitro와 in vivo에서anti-neoplastic property를 가지고 있는데, 이들 중간체를 핵산 화합물로써 역시 강한 항암 작용에도 불구하고 독성등 부작용이 문제가 되고있는 Ara-C (일명 Cytarabine)의 인산화물인 ara-CMP morpholidate와 conjugation시켜 최종물질로서 ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara-CDP-DL-PTCA 및 ara-CDP-DL-PTBA등을 합성하였다. 이들 중 ara-CDP-DL-PTBA가 본 과제와 관련하여 항암제로서 최종 개발하고자하는 주요 물질인 Cytoros이다.

• Computers and Concrete
• /
• v.14 no.5
• /
• pp.547-561
• /
• 2014

Artificial neural networks (ANN) has been proven to be able to predict the compressive strength and elastic modulus of recycled aggregate concrete (RAC) made with recycled aggregates (RAs) from different sources. However, ANN is itself like a black box and the output from the model cannot generate an exact mathematical model that can be used for detailed analysis. So in this study, sensitivity analysis is conducted to further examine the influence of each selected factor on the output value of the models. This is not only conducive to the determination and selection of the more important factors affecting the results, but also can provide guidance for researchers in adjusting mix proportions appropriately when designing RAC based on the variation of these factors.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 1995.10a
• /
• pp.136-141
• /
• 1995

Room Air Conditioner(이하 RAC) 실내기는 열교환기, Cross Flow Fan(이하 CFF), 곡률, Stabilizer(이하 STB) 등 여러 설계인자가 소음, 풍량 및 압력 등에 상호 복합적으로 연성(Coupled)되어 있어 각 인자가 성능에 미치는 영향을 정량적으로 밝혀 내기가 쉽지 않다. 따라서 RAC 실내기의 고성능 및 저소음화를 실현하기 위해서는 실내기를 구성하는 각 인자간의 상호 관련성 및 각 인자가 소음.성능 등에 미치는 영향을 체계적으로 분석하는 것이 필수적이다. 본 연구에서는 설계인자중 소음 및 풍량에 민감한 영향을 주는 STB 위치 및 형상 등에 관하여 자세히 다루고자 한다. STB위치의 적절한 범위를 설정하기 위해 Laser Doppler Velicitimeter(이하 LDV)를 이용하여 곡률별 실내기 내부의 유속분포 및 속도 벡터를 측정하였고, CFF내부 Vortex의 정확한 위치를 찾아냈다. 또한 실내기 저소음화를 위한 소음원 규명 측면에서 실내기 내부의 난류도와 관련하여 속도 Fluctuation을 정의하고, 실험을 통해 구하였다.