• Korean Journal of Microbiology
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• v.43 no.4
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• pp.237-242
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• 2007

One of the chief characteristics of the retrovirus life cycle is the appearance of provirus caused by integration of viral genome into the host cell genome, and its delivery stably to the next generation as a part of host germ line. This stable form is called endogenous retrovirus (ERV) and expressed by exogenous or endogenous factors. HERVs and MuERVs are present in humans and mice correspondingly, and their expressions frequently cause diseases. Several diseases such as cancer, autoimmunity and neurological disorders are related with HERVs. Therefore, various strategies should be established for the development of effective therapies for the suffering patients.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.668-673
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• 2010

The purpose of this research was the comparative study of 3 kinds of black soybean on murine immune cells. The 3 kinds of black soybean are Glycine max Merr. with inner color-yellow (GY), Glycine max Merr. with inner color-greenish (GG) and Rhynchosia volubilis Lour. (RV). All of the black soybean increased the viability of murine thymocytes in vitro. The combined treatment of GY or GG and mitogen did not affect the viability of splenic T- and B-lymphocytes compared with mitogen-treated group, but the combined treatment of RV and mitogen increased their action compared with mitogen-treated group. Also, the 3 kinds of black soybean were given p.o. once a day for 7 days, respectively. RV increased the population of thymic-$CD8^+$, splenic-$CD8^+$ and $B220^+$ cells in vivo. Furthermore, GY and GG did not affect the phagocytic activity and the production of nitric oxide in peritoneal macrophages in vitro, but RV enhanced their action. These results suggest that immunopotentiative action of Rhynchosia volubilis Lour. is more potent than their of Glycine max Merr.

• Mycobiology
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• v.34 no.1
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• pp.14-21
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• 2006

Crude protein (CP) content of mechanically ground rice straw into small particles by an electric grinder and reducing value (RV) and soluble protein (SP) in the culture filtrate were lower than that of the chopped straw into $5{\sim}6\;cm$ lengths when both ground and chopped straws were fermented with Aspergillus ochraceus, A. terreus or Trichoderma koningii, at steady conditions. The reduction rate of RV, SP and CP was 22.2, 2.4, 7.3%; 9.1, 4.9, 8.5% or 0.0, 0.0, 3.6% for the three fungi, respectively. Chemical pretreatment of straw by soaking in $NH_{4}OH$ for a day caused significant increase in CP of the fermented straw than the other alkali and acidic pretreatments. Gamma irradiation pretreatment of dry and wet straw with water, specially at higher doses, 100, 200 or 500 kGy, caused significant increase in RV and SP as CP in the fermented straw by any of these fungi. Chemical-physical combination pretreatment of rice straw reduced the applied dose of gamma irradiation required for increasing fermentable ability of fungi from 500 kGy to 10 kGy with approximately the same results. Significant increases in RV and SP of fermented straw generally occurred as the dose of gamma irradiation for pretreated straw, which combined with $NH_{4}OH$, gradually rose. Whereas, the increase percentage in CP of fermented straw that was pretreated by $NH_{4}OH-10\;kGy$ was 12.4%, 15.4% or 8.6% for A. ochraceus, A. terreus or T. koningii, respectively.

• Journal of The Korean Astronomical Society
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• v.41 no.3
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• pp.59-64
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• 2008

To detect exoplanets and study pulsation of K giant stars, we have observed precise RV (radial velocity) of about 55 early K giant (K0 - K4) stars brighter than V = 5 magnitude since 2003 by using BOES, a high resolution Echelle spectrograph attached to the 1.8 m telescope at BOAO (Bohyunsan Optical Astronomy Observatory). We detected periodic RV variation of KO III star $\beta$ Gem (HD 62509) with a period $P\;=\;596.6\;{\pm}\;2.3$ days and a semi-amplitude $K\;=\;44.8\;{\pm}\;0.7\;ms^{-1}$. If we adopt 1.7 $M_{\odot}$ for the mass of $\beta$ Gem, this yields the minimum mass of the companion m sin i = 2.64 $M_{Jupiter}$. Our results agree well with Hatzes et al. (2006) and Reffert et al. (2006), and confirm their discovery of a planetary object around $\beta$ Gem. We also confirmed about 192 minutes short period stellar oscillation found by Hatzes and Zechmeister (2007). This is the first report of exoplanet detection using BOES and demonstrates that the RV observation using BOES is accurate and stable enough to detect exoplanets around bright K giant stars.

• Journal of ILASS-Korea
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• v.23 no.2
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• pp.66-73
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• 2018

Volatile organic compounds (VOCs) are well known as ozone precursors from photochemical reactions and contribute to the formation of photochemical smog which pose health hazards. Also, some of these compounds directly affect the human health due to their toxicity such as benzene. In this study, NMVOCs composition in exhaust gas from recreational vehicle (RV) and (MPV) were characterized using a chassis dynamometer. The results for NMVOCs have reported that alkanes emission was higher than alkenes, aromatics and cycloalkanes due to reactive of diesel oxidation catalysts. The NMVOCs composition according to carbon number was highly distributed between C3 and C6~C8. During the engine cold start condition, NMVOCs emission was higher compared to the engine hot start condition due to the increased catalytic activity. The NMVOCs emission with DPF increased compared to that without DPF. The results of this study will be provide to calculate VOCs emissions from mobile source.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.7
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• pp.1199-1205
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• 2010

The recent power system is required to a large size of facilities and high power technology according to increasing power demand. However, it could lead to spoiling the beauty of city and environment problem. The miniaturized facilities with large capacity such as GIS have been required in recent power system. The GIS(Gas Insulated Substation) using the SF6 insulation gas enables to miniaturize facilities with large capacity with high insulation performance. However, the substation installed GIS has required to new design model which is different from the conventional substation. The TRV(Transient Recovery Voltage) analysis on simple circuit may applied by differential equation. However, in case of relatively complicated system, EMTP(Electro Magnetic Transients Program) mainly has been used to design and simulate for transient analysis. This paper mainly design the 22.9 kV GIS system and analyze the transient recovery voltage of main circuit breaker using EMTP/RV. It also enables to easily design the other substation installed GIS with same maker and voltage level because the proposed GIS model consists of separated modules such as busbar, circuit breaker, bushing, CT, PT etc. Eventually, it contributes to comfortably compare the interrupting performance of circuit breaker and system TRV corresponding to the substation system configuration.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.28.2-28.2
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• 2011

To search for and study the nature of the long-periodic variations of massive stars, we have been carrying out a precise radial velocity (RV) survey for supergiants. Here, we present high-resolution RV measurements of ${\alpha}$ Per which lies near the Cepheid instability strip from November 2005 to February 2011 using the fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) at Bohyunsan Optical Astronomy Observatory (BOAO). The orbital solution yields a period of 129 days, a 2K amplitude of 80 m/s, and an eccentricity of 0.1. Assuming a possible stellar mass of 7.3 $M{\bigodot}$, we estimate the minimum mass for the planetary companion to be 7.5 MJup with the orbital semi-major axis of 0.97 AU. We do not find the correlation between RV variations and chromospheric activity indicator (Ca II H & K region). The Hipparcos photometry and bisector velocity span (BVS) do not show any obvious correlations with RV variations. These analyses suggest that ${\alpha}$ Per is a pulsating supergiant that hosts an exoplanet. If the 129 days variations of ${\alpha}$ Per do not come from an exoplanet but Cepheid-like pulsations, the theoretical boundary of the Cepheid instability strip may need to be extended to the bluer side.

• Korean Circulation Journal
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• v.48 no.12
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• pp.1135-1144
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• 2018

Background and Objectives: Mitochondria play a key role in the pathophysiology of heart failure and mitochondrial permeability transition pore (MPTP) play a critical role in cell death and a critical target for cardioprotection. The aim of this study was to evaluate the protective effects of cyclosporine A (CsA), one of MPTP blockers, and morphological changes of mitochondria and MPTP related proteins in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). Methods: Eight weeks old Sprague-Dawley rats were randomized to control, MCT (60 mg/kg) and MCT plus CsA (10 mg/kg/day) treatment groups. Four weeks later, right ventricular hypertrophy (RVH) and morphological changes of right ventricle (RV) were done. Western blot and reverse transcription polymerase chain reaction (RT-PCR) for MPTP related protein were performed. Results: In electron microscopy, CsA treatment prevented MCT-induced mitochondrial disruption of RV. RVH was significantly increased in MCT group compared to that of the controls but RVH was more increased with CsA treatment. Thickened medial wall thickness of pulmonary arteriole in PAH was not changed after CsA treatment. In western blot, caspase-3 was significantly increased in MCT group, and was attenuated in CsA treatment. There were no significant differences in voltage-dependent anion channel, adenine nucleotide translocator 1 and cyclophilin D expression in western blot and RT-PCR between the 3 groups. Conclusions: CsA reduces MCT induced RV mitochondrial damage. Although, MPTP blocking does not reverse pulmonary pathology, it may reduce RV dysfunction in PAH. The results suggest that it could serve as an adjunctive therapy to PAH treatment.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.723-730
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• 2019

Acquiring instrumentation signals generated from nuclear power plants (NPPs) is essential to maintain nuclear reactor integrity or to mitigate an abnormal state under normal operating conditions or severe accident circumstances. However, various safety-critical instrumentation signals from NPPs cannot be accurately measured on account of instrument degradation or failure under severe accident circumstances. Reactor vessel (RV) water level, which is an accident monitoring variable directly related to reactor cooling and prevention of core exposure, was predicted by applying a few signals to deep neural networks (DNNs) during severe accidents in NPPs. Signal data were obtained by simulating the postulated loss-of-coolant accidents at hot- and cold-legs, and steam generator tube rupture using modular accident analysis program code as actual NPP accidents rarely happen. To optimize the DNN model for RV water level prediction, a genetic algorithm was used to select the numbers of hidden layers and nodes. The proposed DNN model had a small root mean square error for RV water level prediction, and performed better than the cascaded fuzzy neural network model of the previous study. Consequently, the DNN model is considered to perform well enough to provide supporting information on the RV water level to operators.

• Clinical and Experimental Pediatrics
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• v.57 no.11
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• pp.484-488
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• 2014

Purpose: Chronic upper airway obstruction causes hypoxemic pulmonary vasoconstriction, which may lead to right ventricle (RV) dysfunction. Adenotonsillar hypertrophy (ATH) is the most common cause of upper airway obstruction in children. Therefore, we aimed to evaluate RV function in children with ATH. Methods: Twenty-one children (male/female, 15/6; mean age, $92.3{\pm}39.0$ months; age range, 4-15 years) with ATH and 21 healthy age- and gender-matched controls were included in this study. Tricuspid annular plane systolic excursion and RV myocardial performance index were measured by transthoracic echocardiography. Further, the plasma level of N-terminal of probrain natriuretic peptide (NT-proBNP), an indicator of RV function, was determined. Results: The snoring-tiredness during daytime-observed apnea-high blood pressure (STOP) questionnaire was completed by the patients' parents, and loud snoring was noted in the ATH group. The plasma NT-proBNP level was significantly higher in the ATH group than that in the controls ($66.44{\pm}37.63pg/mL$ vs. $27.85{\pm}8.89pg/mL$, P=0.001). The echocardiographic parameters were not significantly different between the groups. Conclusion: We were unable to confirm the significance of echocardiographic evidence of RV dysfunction in the management of children with ATH. However, the plasma NT-proBNP level was significantly higher in the ATH group than that in the control, suggesting that chronic airway obstruction in children may carry a risk for cardiac dysfunction. Therefore, more patients should be examined using transthoracic echocardiography. In addition, pediatricians and otolaryngologists should consider cardiologic aspects during the management of children with severe ATH.