• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.1
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• pp.133-141
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• 2020

Korea Infrastructure Safety and Technology Corporation (KISTEC) specifies that the safety inspection and precise safety diagnosis of concrete structures shall be conducted in accordance with the 'Special Law on Safety Management of Infrastructure'. The detailed safety inspection and precise safety diagnosis guidelines presented by KISTEC, however, gives only the grade of members and structures, and thus it is impossible to quantify remaining service life (RSL) of the structures and to quantitatively reflect the effect of differential settlements on the RSL. Therefore, this study aims to develop a RSL evaluation model considering the differential settlements. To this end, a simple equation was proposed based on the correlations between differential settlements and angular distortion, by which the angular distortion of structures was then reflected in nominal strengths of structural members. In addition, the effects of the differential settlements on the RSL of structures were analyzed in detail by using the safety diagnosis results of actual concrete structure.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.63-63
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• 2003

$\alpha$$_1$-Antityrpsin is a member of the serine protease inhibitor (SERPIN) family that shares a common tertiary structure. The reactive site loop (RSL) of serpins is exposed at one end of the molecule for protease binding. Upon cleavage by a target protease, the RSL is inserted into the major $\beta$-sheet A, which is a necessary process for formation of a tight inhibitory complex. Various biochemical and structural studies suggest that the rate of the RSL insertion upon binding a target protease is critical for inhibitory activity, and it is thought that helix F region (thFs3A and helix F) located in front of $\beta$-sheet A, should be lifted for the loop insertion during complex formation.

• Journal of the Institute of Convergence Signal Processing
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• v.12 no.1
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• pp.62-66
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• 2011

This paper proposes a parallel architecture of random signal-based learning (PRSL), merged with simulated annealing (SA), to optimize the fuzzy logic controller (FLC). Random signal-based learning (RSL) finds the local optima very well, whereas it can not finds the global optimum in a very complex search space because of its serial nature. To overcome these difficulties, PRSL, which consists of serial RSL as a population, is considered. Moreover, SA is added to RSL to help the exploration. The validity of the proposed algorithm is conformed by applying it to the optimization of a FLC for the inverted pendulum.

• Journal of the Korea Society of Computer and Information
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• v.11 no.1 s.39
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• pp.71-85
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• 2006

The environment of computational grid is composed of the LAN/WAN each of which has different efficiency and heterogeneous network conditions, and where various programs are running. In this environment, the role of the resource selection broker is very important because the work of each node is performed by considering heterogeneous network environment and the computing power of each node according to the characteristics of a program. In this paper, a new resource selection broker is presented that decides the number of work processes to be allocated at each node by considering network state information and the performance of each node according to the characteristics of a program in the environment of computational grid. The proposed resource selection broker has three steps as follows. First, the performance ratio of each node is computed using latency-bandwidth-cpu mixture information reflecting the characteristics of a program, and the number of work processes that will be performed at each node are decided by this ratio. Second, RSL file is automatically made based on the number of work processes decided at the previous step. Finally, each node creates work processes by using that RSL file and performs the work which has been allocated to itself. As experimental results, the proposed method reflecting characteristics of a program, compared with the existing (uniformity) and latency-bandwidth method is improved $278%\sim316%,\;524%\sim595%,\;924%\sim954%$ in the point of work amount, work process number, and node number respectively.

• Safety and Health at Work
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• v.10 no.2
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• pp.237-244
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• 2019

Background: Street vendors spend relatively more time near roadways and are vulnerable to air pollution related health disorders. However, there is limited information on the quality of the air they breathe. The objectives of this present study were to calculate the mass concentration of atmospheric particulate matter (PM) in eight size fractions ($PM_{0.4-0.7}$, $PM_{0.7-1.1}$, $PM_{1.1-2.1}$, $PM_{2.1-3.3}$, $PM_{3.3-4.7}$, $PM_{4.7-5.8}$, $PM_{5.8-9.0}$, and $PM_{9.0--0{\mu}m}$) at commercial (CML) and residential site (RSL) in Dehradun city from November 2015 to May 2016. To estimate the corresponding respiratory deposition dose (RDDs) in alveolar (AL), tracheobronchial (TB), and head airway (HD) region on street vendors working at CML and RSL. To find the association of atmospheric PM with RDDs and the incidence of respiratory related disorders among street vendors. Methods: Andersen cascade impactor was employed for calculating the PM mass concentration. Questionnaire based health survey among street vendors were carried out through personal interview. Results: A significant difference (p < 0.05; t-test) between the mean $PM_{0.4-10{\mu}m}$ mass concentration at CML and RSL was observed with ($mean{\pm}SD$) $84.05{\pm}14.5$ and $77.23{\pm}11.7{\mu}g\;m^{-3}$, respectively. RDDs in AL, TB and HD region at CML was observed to be 9.9, 7.8, and 7.3% higher than at RSL, respectively. Health survey revealed 1.62, 0.96, 0.04, and 0.57 times higher incidence of cold, cough, breathlessness, and chest pain, respectively with street vendors at CML compared to RSL. Conclusion: The site characteristics plays a major role in the respiratory health status of street vendors at Dehradun.

• Proceedings of the Korean Biophysical Society Conference
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• 2002.06b
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• pp.31-31
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• 2002

$\alpha$$_1$-Antitrypsin is a member of the serine protease inhibitor (serpin) family that share a common tertiary structure. The reactive site loop (RSL) of serpins is exposed at one end of the molecule for protease binding. Upon cleavage by a target protease, the RSL is inserted into the major $\beta$-sheet A, which is a necessary process for formation of a tight inhibitory complex.(omitted)

• Natural Product Sciences
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• v.16 no.3
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• pp.192-197
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• 2010

The seeds of Raphanus sativus L. (RSL) and Phaseolus calcaratus Roxburgh (PHCR), the root of Scutellaria baicalensis (SB), and the flower of Lonicera japonica (LJ) have been traditionally used as herbal medicines for anti-inflammation. Unlike the SB and LJ, little information is available for the scientific bases that show the anti-inflammatory mechanisms of RSL and PHCR. In this study, we prepared boiled water extracts from the medicines and determined their potentials in inhibiting nitric oxide (NO) production, cyclooxygenase-2 (COX-2) expression, and tumor necrosis factor (TNF)-$\alpha$ and interleukin (IL)-6 secretion in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The effects of the medicines on serum IgE levels in ovalbumin (OVA)-administrated mice were also studied. The medicines inhibited production of TNF-$\alpha$ and IL-6, and COX-2 expression in LPSstimulated macrophages. Especially, PHCR water extract showed more potent inhibition on TNF-$\alpha$ production than SB and LJ extracts, but RSL extract did not exert these effects. Similar to the cases of SB and LJ, PHCR extract prevented the phosphorylation of $I{\kappa}B{\alpha}$ and c-Jun, and the activation of NF-${\kappa}B$-DNA binding. Further, oral supplementation of PHCR extract attenuated significantly serum levels of total and OVA-specific IgE in OVAtreated animals. These results suggest a possibility that PHCR water extract can be used for the treatment of inflammatory and allergic diseases.

• Biomolecules & Therapeutics
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• v.30 no.2
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• pp.184-190
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• 2022

Targeting the cystine/glutamate exchange transporter, system x_c^-, is a promising anticancer strategy that induces ferroptosis, which is a distinct form of cell death mediated by iron-dependent lipid peroxidation. The concentration of ⳑ-cystine in culture medium is higher than the physiological level. This study was aimed to evaluate the effects of ⳑ-cystine concentration on the efficacy of ferroptosis inducers in hepatocellular carcinoma cells. This study showed that treatment with sulfasalazine or erastin, a system x_c^- inhibitor, decreased the viability of Huh6 and Huh7 cells in a dose-dependent manner, and the degree of growth inhibition was greater in medium containing a physiological ⳑ-cystine concentration of 83 µM than in commercial medium with a concentration of 200 µM ⳑ-cystine. However, RSL3, a glutathione peroxidase 4 inhibitor, decreased cell viability to a similar extent in media containing both ⳑ-cystine concentrations. Sulfasalazine and erastin significantly increased the percentages of propidium iodide-positive cells in media with 83 µM ⳑ-cystine, but not in media with 200 µM ⳑ-cystine. Sulfasalazine- or erastin-induced accumulation of lipid peroxidation as monitored by C11-BODIPY probe was higher in media with 83 µM ⳑ-cystine than in media with 200 µM ⳑ-cystine. In contrast, the changes in the percentages of propidium iodide-positive cells and lipid peroxidation by RSL3 were similar in both media. These results showed that sulfasalazine and erastin, but not RSL3, were efficacious under conditions of physiological ⳑ-cystine concentration, suggesting that medium conditions would be crucial for the design of a bioassay for system x_c^- inhibitors.

• The Journal of the Korea Contents Association
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• v.16 no.9
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• pp.66-77
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• 2016

This research defined causal relationships among the perception of retirement and senior life(PRSL), retirement preparation actions(RPA), and retirement satisfaction level(RSL) to know the expectation about retired life according to the differences of retirement related factors, PRSL, and RPA. For this, From November 2015 to February 2016, I researched from 20 to 69, 1,500 currently working adults in the country, mailing surveys with the letter introducing this research's purpose and procedure and having them send them back, or researcher's spreading and collecting the surveys, eliminating 83 cases of negligent answers, finally analyzing 1,417 surveys. The result shows age, monthly income, and residing at their own places made more positive PRSL, RPA, financial retirement preparation level(FRPL), and expectancy about satisfactory retirement life. When they had less children, PRSL and RSL were higher. When they had more children, RPA was more proactive, and FRPL was higher. When they had positive PRSL, RPA was more proactive, and expectancy about retired life was higher. This research is significant in defining differences of retirement related factors and causal relationships among PRSL, RPA, and RSL.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.402-417
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• 2023

Objective: Liver fibrosis is a highly conserved wound-healing response and the final common pathway of chronic inflammatory injury. This study aimed to evaluate the potential anti-fibrotic effect of the combination of Rhei Radix et Rhizoma water extract (RW) and silymarin in a thioacetamide (TAA)-induced liver fibrosis model. Methods: The liver fibrosis mouse model was established through the intraperitoneal injection of TAA (1 week 100 mg/kg, 2-3 weeks 200 mg/kg, 4-8 weeks 400 mg/kg) three times per week for eight weeks. Animal experiments were conducted in five groups; Normal, Control (TAA-induced liver fibrosis mice), Sily (silymarin 50 mg/kg), RSL (RW 50 mg/kg+silymarin 50 mg/kg), and RSH (RW 100 mg/kg+silymarin 50 mg/kg). Biochemical analyses were measured in serum, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA), and ammonia levels. Liver inflammatory cytokines and fibrous biomarkers were measured by Western blot analysis, and liver histopathology was evaluated through tissue staining. Results: A significant decrease in the liver function markers AST and ALT and a reduction in ammonia and total bilirubin were observed in the group treated with RSL and RSH. Measurement of reactive oxygen species and MDA revealed a significant decrease in the RSL and RSH administration group compared to the TAA induction group. The expression of extracellular matrix-related proteins, such as transforming growth factor β1, α-smooth muscle actin, and collagen type I alpha 1, was likewise significantly decreased. All drug-administered groups had increased matrix metalloproteinase-9 but a decreasing tissue inhibitor of matrix metalloproteinase-1. RSL and RSH exerted a significant upregulation of NADPH oxidase 2, p22^phox, and p47^phox, which are oxidative stress-related factors. Furthermore, pro-inflammatory proteins such as cyclooxygenase 2 and interleukin-1β were markedly suppressed through the inhibition of nuclear factor kappa B activation. Conclusions: The administration of RW and silymarin suppressed the NADPH oxidase factor protein level and showed a tendency to reduce inflammation-related enzymes. These results suggest that the combined administration of RW and silymarin improves acute liver injury induced by TAA.