• Title/Summary/Keyword: RPS

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Human RPS4X/Y Genes and Pseudogene Family: Chromosomal Localization and Phylogenetic Analysis

  • Lee, Ji-Won;Yi, Joo-Mi;Shin, Kyung-Mi;Kim, Heui-Soo
    • Journal of Life Science
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    • v.11 no.2
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    • pp.81-82
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    • 2001
  • The human ribosomal protein 54 genes, RPS4X and RPS4Y are located on the X and Y chromosomes. They have been postulated as candidate for Turner syndrome which was characterized by gonadal dysgenesis, short stature, and various external and internal anomalies. Using the BLAST search program, we identified sixteen RPS4 pseudogenes from the human genome and analyzed them phylogenetically. The RPS4-C12-1, C12-2, and C12-3 pseudogenes from chromosome 12 have been evolved independently during hominid evolution. The RPS4X gene from X chromosome it closely related to the RPS4-C12-2 from chromosome 12 and RPS4-C5 from chromosome 5, whereas the RPS4Y gene is very closely related to RPS4-C16 from chromosome 16. The exact mapping of the RPS4 pseudogene family was peformed, indicating that the RPS4 pseudogene family was mapped on human chromosomes 1, 2, 5, 6, 8, 10, 11, 12, 13, 16, 18, 19 and 20. Taken together, the precise chromosomal localization and phylegenetic relationship of the RPS4 pseudo-genes could be of great use in further study for understanding the Turner syndrome.

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Prognostic Value of Phosphorylated mTOR/RPS6KB1 in Non-small Cell Lung Cancer

  • Zhang, Yong;Ni, Huan-Juan;Cheng, De-Yun
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.6
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    • pp.3725-3728
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    • 2013
  • Background: The mammalian target of rapamycin (mTOR) /RPS6KB1 activation has recently been implicated in tumour development, but its role in lung cancer remains unclear. The aim of this study was to explore the role of mTOR/RPS6KB1 signaling pathway in non-small-cell lung cancer (NSCLC). Methods: Immunohistochemistry was performed to assess the expression of phosphorylated mammalian target of rapamycin (p-mTOR) and its downstream ribosomal phosphorylated RPS6KB1 (p-RPS6KB1) in NSCLC patients. We also analyzed p-mTOR/p-RPS6KB1 protein expression in 45 fresh NSCLC tissues using Western blotting. Results: The expression level of p-mTOR and p-RPS6KB1 was significantly higher in NSCLC tumor specimens than that in adjacent noncancerous normal lung tissues (P<0.01). p-mTOR expression correlated with p-RPS6KB1. Furthermore, high expression level of p-mTOR or p-RPS6KB1 in NSCLC was associated with a shorter overall survival (both P<0.01). Multivariate analysis indicated high level of p-mTOR expression was an independent prognostic factor (HR=2.642, 95%CI 1.157-4.904, p=0.002). Conclusions: p-mTOR and p-RPS6KB1 could be useful prognostic markers for NSCLC.

A Study on the Successful Introduction of Renewable Portfolio Standards Using Linear Programming Models (선형계획법을 이용한 RPS 제도의 효과적 도입 방안)

  • Lee, Hyeong-Seok;Yang, Seung-Ryong
    • Environmental and Resource Economics Review
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    • v.19 no.1
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    • pp.159-198
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    • 2010
  • The Korean government is planning to introduce the Renewable Portfolio Standard (RPS) system to replace the currently used Feed-in-Tariff (FIT) system which is a subsidy-based mechanism to foster the renewable energy industry. The RPS system is a market-oriented system in which the power companies are obliged to use renewable energy sources to produce electricity by a certain ratio of their production level. They can either produce for themselves or simply purchase the REC (renewable energy certificate) in the market to implement. The objective of this article is to compare the RPS system with the current FIT system in terms of the implementing cost to achieve the policy goal to expand the share of renewable energy m the total power generation. The analysis is conducted using Linear Programming models. The results of this study imply several policy suggestions to successfully introduce the RPS system.

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Ribosomal Protein S4 Genes in Macaca fuscata: Sequence, Evolution, and Phylogeny

  • Kim, Heui-Soo
    • Journal of Life Science
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    • v.11 no.1
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    • pp.34-38
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    • 2001
  • The cDNA encoding ribosomal protein S4(RPS 4) from an ovary cDNA library of the Japanese monkey (Macaca fuscata) was cloned and sequenced. The RPS4X gene from monkey X chromosome encodes a deduced protein of 263 amino acids and share 99.1% cDNA sequence similarity and 100% amino acid sequence identify with the human RPS4X. Rate of synonymous substitution was higher in RPS4Y than in RPS4X in comparison to the monkey and human. The ratio of synonymous and nonsynonymous substitutions per site indicated that directional selection has nor occurred in RPS4 genes. Phylogenetic analysis using the neighbor-joining method revealed that X and Y-linked RPS4 genes have evolved independently.

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Conditions to Introduce the Renewable Portfolio Standards in Korea ($\cdot$재생에너지 의무비율할당제(Renewable Portfolio Standards) 국내도입시 고려사항에 관한 연구)

  • Chang, Han-Soo;Choi, Ki-Ryun;Kim, Su-Duk
    • Journal of Energy Engineering
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    • v.14 no.2 s.42
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    • pp.82-97
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    • 2005
  • RPS (Renewable Portfolio Standards) is a policy tool to disseminate renewable energies through market mechanism. RPS promotes renewable power generation by obligating electricity market participants to deliver the required amount of electricity from renewable energies. To promote and encourage renewable energies, Korean government is considering to introduce RPS to domestic market in the near future. The purpose of this paper is to analyze the definition and market mechanism of RPS and to review key considerations in its design. In conclusion, we recommend some prerequisite in its introduction to Korea.

Fiber-Optic Pressure Sensor Using a Rugate-Structured Porous Silicon Diaphragm Coated with PMMA (PMMA가 코팅된 주름 구조를 갖는 다공성규소 격판을 이용한 광섬유 압력센서)

  • Lee, Ki-Won;Cho, So-Yeon
    • Journal of Sensor Science and Technology
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    • v.22 no.3
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    • pp.227-232
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    • 2013
  • In this research, fiber-optic pressure sensors were fabricated with rugate-structured porous silicon (RPS) diaphragms coated with PMMA (Polymethyl-Methacrylate). The reflectance spectrum of the PMMA/RPS diaphragm was almost the same as that of uncoated RPS diaphragm. However the mechanical strength of the PMMA/RPS diaphragm increased more than that of the uncoated diaphragm. As a result, the fiber-optic sensor fabricated with PMMA/RPS diaphragm could successfully detect more high pressure difference without diaphragm damage than the highest detectable pressure difference of the sensor with normal RPS diaphragm. The response data of the fiber-optic sensor recorded as a function of pressure difference were fitted by theoretical curves. During this process, elastic moduli of the used PMMA/RPS diaphragms were obtained numerically. The dynamic response properties of the fiber-optic sensor were also investigated under continuous variation of the pressure difference conditions.

Estimation of RPS Method Using 3-Dimensional Numerical Analysis (3차원 수치해석을 이용한 RPS 공법의 적용성 평가)

  • Roh, Jeong-Min;Shin, Eun-Chul
    • Journal of the Korean Society for Railway
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    • v.9 no.2 s.33
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    • pp.174-179
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    • 2006
  • Recently, the crossing tunnel has been constructed frequently to connect the separated area by highway and railroad. The construction of crossing tunnel must be progressed while maintaining the existing traffic of the highway as well as railroad. There are many cross funnelling methods such as NTR, TRCM, Messer Shield, Front Jacking, and Pipe Roof Method. The advantages of adopting RPS(Roof Panel Shield) method in crossing tunnel construction with comparing other existing cross funnelling methods are needed a little volume of concrete and easy to change the direction of cutting shoe during the construction of pipe roof, The 3-dimensional numerical analysis of RPS to consider the arching effect was performed for the application in the crossing tunnel under railroad. The earth pressure distribution and settlement were predicted when the RPS method was applied during the excavation for crossing railroad tunnel construction.

RPS(Rapidly Problem Solving)-TRIZ to Applied 6SC(6 Step Creativity) and Q(Quick)-TRIZ (6SC와 Q-TRIZ를 응용한 RPS-TRIZ)

  • Leem, Sa-Hwan;Huh, Yong-Jeong
    • Proceedings of the KAIS Fall Conference
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    • 2011.05b
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    • pp.635-637
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    • 2011
  • In this paper, to solve the problem of contradiction is proposed new RPS-TRIZ. RPS-TRIZ is evolved from TRIZ technique which 6SC of existing and tries to adopt the strong point of the Q-TRIZ techniques. RPS-TRIZ can be used to improve problems in the field more quickly and easily.

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Usefulness of RPS4Y Gene on Sex Determination in Human Teeth (사람치아에서 성별감정시 RPS4Y 유전자의 유용성)

  • Yoon, Wang-Ro;Ahn, Jong-Mo;Yoon, Chang-Lyuk
    • Journal of Oral Medicine and Pain
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    • v.33 no.1
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    • pp.59-66
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    • 2008
  • Ribosomal Protein S4Y(RPS4Y) gene is the human sex-linked gene on the Y chromosome. There are a number of reports on the sex determination using RPS4Y gene analysis for prevention and diagnosis in sex-linked disease. Thus RPS4Y gene is a reliable genetic marker for sex determination in forensic medicine. In general, the sex determination of an unidentified body can be achieved based on anatomical characteristics, but sometimes sex determination was considered to be difficult such as pre-adolescent bodies or decomposed, mutilated bodies. In this case, Sex determination using PCR method in human teeth produces good results. Because human teeth have a great structural durability, the DNA well preserved in the teeth. So author isolated nuclear DNA from the 20 human teeth(10 males, 10 females), performed to detect RPS4Y gene by PCR method. Samples were divided four group(10 pulp and 10 dentinal tissue in male, 10 pulp and 10 dentinal tissue in female). It was found that detection of RPS4Y gene for sex determination was possible in all the male pulp tissues and 6 out of 10 male dentinal tissues. But there was not detected in female pulp and dentinal tissues. In the view of this results demonstrates the possibility that detection of RPS4Y gene with other sex chromosome genes from the human teeth is useful to sex determination in forensic medicine.