• Journal of Biomedical Engineering Research
• /
• v.28 no.4
• /
• pp.503-511
• /
• 2007

Heart rate variability(HRV) is the clinical consequence of various influences of the autonomic nervous system(ANS) on heart beat. HRV can estimate the potential physiologic rhythm from the interval between consecutive beats(RR interval or HRV data), but cardiovascular system governed by ANS is in relation to respiration and autonomic regulation. It is known as RSA representing respiration-related HR rhythmic oscillation. Because the mechanism linking the variability of HR to respiration is complex, it has so far been unknown well. In this paper, we tried to evaluate 5-min RR interval segments under control of respiration in order to find out a proper respiration rate that can estimate the ANS function. 10 healthy volunteers were included to evaluate 5-min HRV data under 4 different respiration-controlled environments; 0.03Hz, 0.1Hz, 0.2Hz, and 0.4Hz respiration. HRV data were analyzed both in the frequency and the time domain, with cross-correlation coefficient(cross-coeff.) for HRV and respiration signal. The results showed maximum cross-coeff. of 0.84 at 0.1 Hz and minimum that of 0.16 at 0.4Hz respiration. Cross-coeff was decreased at a faster rate from 0.1Hz respiration. All mean SDNN, RMSSD, and pNN50 of time domain measures were 108.7ms, 71.85ms, and 28.47%, respectively, and LF, HF, and TP of frequency domain measures were $12,722ms^2,\;658.8ms^2$, and $7,836.64ms^2$ at 0.1Hz respiration, respectively. In conclusion, 0.1Hz respiration was observed to be very meaningful from time domain and frequency domain analysis in relation to respiration and autonomic regulation of the heart.

• The Journal of the Society of Korean Medicine Diagnostics
• /
• v.19 no.2
• /
• pp.75-90
• /
• 2015

Objectives The purposes of this study was to develope a Qi gong exercise that suits characteristics of post mastectomy women, and to evaluate the effect of Qi gong exercise on immune response, blood circulation index, pulse wave parameter and heart rate variability. Methods This study was applied to total 35 post mastectomy women, including 17 for experiment group and 18 for control group. The Qi gong exercise was composed of total 24 times of 90 minutes per each time, twice a week, and 12 weeks and it was conducted by the oriental medicine professor who was an expert of Qi gong exercise. Results 1. Two group comparison revealed that the experimental group had significantly improved immune response(p<.021), HR(beats/min)(p<.001), ESV(ml/beat)(p=.038), ESI($ml/beat/m^2$)(p=.040), ECO (L/min)(p=.019), ECI($L/min/m^2$)(p=.023), ECRI($dyne^*sec/cm$)(p=.015), Left Kwan($div^3$)(p=.021), Right Kwan($div^3$)(p=.038), Mean HRV(cycle/min)(p<.001), SDNN(ms)(p=.043), RMSSD(ms)(p=.040), and TP(log $ms^2$)(p=.039). 2. Two group comparison revealed that the experimental group had significantly decreased ECR ($dyne^*sec^*cm^{-5}$) (p=.034), Left RAI(p=.044), Right RAI(p=.042), and pNN50(%)(p=.038). Conclusions These results from Qi gong exercise program can be used as basic data for development of health promotion program for Post Mastectomy Women.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.24 no.3
• /
• pp.109-115
• /
• 2011

Objectives: To characterize autonomic dysfunction in patients with Cold hypersensitivity, their heart rate variability(HRV) were measured and analyzed with cold hypersensitivity patients, compared with those of normal population. Methods: We studied 56 patients visiting Gangnam Kyung-hee korean hospital from 1st January 2010 to 31th December 2010. Heart rate variability were obtained from 28 female patients who suffer from cold hypersensitivity and 28 healthy female controls in resting state. We studied the difference of Heart rate variability between two groups by Independent T-test using SPSS for windows(version 17.0). Results: Standard deviation of NN interval(SDNN), total power(TP), Very low frequency(VLF) in patients with cold hypersensitivity were significantly different with those of controls. While no significant differences were observed in square root of mean squared differences of successive NN intervals (RMSSD), low frequency (LF) and high frequency(HF). Conclusions: The decreased values of heart rate variability(HRV) study means that they may have some kinds of imbalance in autonomic nervous system in cold hypersensitivity patients. heart rate variabiliry(HRV) study might be a tool of diagnosis and predictors in cold hypersensitivity patients.

• The Journal of Pediatrics of Korean Medicine
• /
• v.25 no.3
• /
• pp.77-84
• /
• 2011

Objectives: This study was performed to investigate the effect of hot spring therapy on children weight, body composition and heart rate variability. Methods: The study was carried out from 30 children who visited the spa from August 1, 2011 to August 31, 2011. We measured the change of weight, body composition, and heart rate variability after hot spring therapy for an hour per day. Results: The subject was consisted of 13 boys and 17 girls. This study revealed that their weight got lost from a hot spring therapy, which was statistically significant. Their body mass index(BMI) was decreased in from a hot spring therapy, which was not statistically significant. Total body water, muscle, protein, and mineral were decreased from a hot spring therapy, which was statistically significant. We measured HRV(heart rate variability) before and after the hot spring therapy. The mean HRT was increased, which was statistically insignificant. SDNN(standard deviation of the NN interval) and RMSSD(square root of the mean of the sum of the square of differences) were not different before and after the hot spring therapy. ln TP was decreased insignificantly. ln VLF was not affected before and after hot spring therapy. ln LF and ln HF was decreased, LF norm was increased, and HF norm was decreased, which were not statistically significant. Also, LF/HF ratio was increased insignificantly. Conclusions: From these results, we concluded that the weight, total body water, muscle, protein, and mineral got lost from the hot spring therapy. However, the HRV was not affected from the hot spring therapy.

• Journal of Oriental Neuropsychiatry
• /
• v.17 no.2
• /
• pp.179-185
• /
• 2006

Objective : This research was designed to study the characteristics of heart rate variability in postpartum women compared with normal women. Method : HRV data of postpartum women were gathered from 255 women who was hospitalized for oriental postpartum treatments(Age : 25-35). HRV data of comparison group were gathered from 327 women who visited hospital to check up their health(Age : 25-35). The SPSS 12.0 for windows was used to analyze the date and the independent samples t-test was used to verify the result. Result : 1. Mean-RR and SDNN of postpartum women group significantly decreased compared with that of normal women group. But, Heart Rate of postpartum women group significantly increased compared with that of normal women group. 2. HRV-Index, RMSSD and SDSD of postpartum women group significantly decreased compared with that of normal women group. pNN50 of postpartum women group significantly increased compared with that of normal women group. 3. Ln(TP), Ln(VLF), Ln(LF) and Ln(HF) of postpartum women group significantly increased compared with that of normal women group. 4. There were no significant differences in Normal LF, Normal HF and LF/DF Ratio between postpartum women group and normal women group. Conclusion : The result suggest that the function of heart of postpartum women group significantly decreased compared with that of normal women group. Futhermore although the ANS maintained the balance in the range of normality, the sympathetic nervous system frequently revitalized which caused increasing the heart of pulsation.

• The Journal of Internal Korean Medicine
• /
• v.29 no.3
• /
• pp.778-786
• /
• 2008

Objectives : This study was to investigate the short time effect of caffeine on heart rate variability(HRV) and the effect of Neiguan(PC6) acupuncture stimulation on HRV. Methods : 27 healthy adult volunteers were randomly allocated to two groups: Neiguan group (N=13) or placebo group (N=14). The study was carried out under a randomized double-blinded placebo-controlled trial method. Each group orally received the same tablets with 200 mg caffeine. After 1 hour, acupuncture was applied to the Neiguan(PC6) points for the Neiguan group, and for the placebo group was applied to a non-acupuncture point. Both groups were estimated with HRV 3 times, before and after caffeine ingestion, 20 minutes after acupuncture stimulation. Results : After taking caffeine, pulse rate, mean-HRV, and pNN50(the proportion derived by dividing NN50 by the total number of NN intervals) decreased, SDNN(standard deviation of all normal-to-normal (NN) intervals), RMSSD (the root square of successive differences), TP log, HF(high frequency), and HRV index was increased. There were significant changes to the autonomic nervous system after taking caffeine. There were no significant differences between the two groups after acupuncture at Neiguan. Conclusion : Caffeine could induce general activation of the autonomic nervous system. Neiguan acupuncture stimulation may not have significant influence on the autonomic nervous system.

• Anxiety and mood
• /
• v.16 no.2
• /
• pp.83-90
• /
• 2020

Objective : Heart rate variability (HRV) is known to reflect autonomic nervous system activity. Individuals with posttraumatic stress disorder (PTSD) are reported to have lower HRVs. We attempted to find HRV indices with head up tilt position that reflect the symptoms well in order to evaluate PTSD symptoms. Methods : Sixty-seven patients with PTSD and 72 patients without PTSD were assessed using the PTSD Checklist for DSM-5 (PCL-5), the Beck Depression Inventory, the Beck Anxiety Inventory and the Pittsburgh Sleep Quality Index. HRV was measured in the head-up tilt position. We collected data regarding heart rate (HR), standard deviation of the NN intervals (SDNN), the square root of the mean squared differences of successive NN intervals (RMSSD), log low-frequency (LNLF) and log high-frequency (LNHF). Results : The value of LNHF was different according to presence or absence of PTSD after head-up tilt position. In the findings of the association between PTSD symptoms and HRV indices as based on head-up tilt, LNHF had a significant correlation with the total score of PCL-5. Conclusion : The reduction of the high-frequency component of HRVs in the PTSD group might reflect more PTSD symptoms.

• Journal of Korean Medicine Rehabilitation
• /
• v.19 no.2
• /
• pp.241-250
• /
• 2009

Objectives : To study autonomic nervous system dysfunction of Low Back Pain(LBP) patients, using spectral analysis of Heart Rate Variability(HRV). Methods : HRV of 190 patients was measured and seperated into two groups, those with LBP(n=95) and healthy controls(n=95). HRV was measured by SA-6000(Medicore, Korea) for 5 minutes after 5 minutes' resting. Results : 1. Mean heart rate(MHRT) of the experimental group was slightly higher than that of the control group, but did not show significant difference(P=0.428). The square root of the mean squared differences of successive normal-to-normal intervals(RMSSD), logarithmic very low frequency power(Ln VLF) and low frequency power/high frequency power ratio(LH/HF ratio) were not significantly low between experimental group and control group(P=0.16, 0.130, 0.537). 2. The standard deviation of all the normal-to-normal intervals(SDNN), logarithmic total power(Ln TP), logarithmic low frequency power(Ln LF) and logarithmic high frequency power(Ln HF) were significantly low between experimental group and control group(P=0.03, 0.005, 0.001, 0.007). 3. Ln LF of acute group was significantly low compared with those of chronic group(P= 0.039). Conclusions : This study suggests the activity and imbalance of autonomic nervous system in LBP is low. Also sympathetic nervous system of acute LBP is lower than that of chronic LBP. Further study of HRV related to LBP is needed in the clinical medicine.

• Journal of Biomedical Engineering Research
• /
• v.35 no.4
• /
• pp.75-80
• /
• 2014

This paper proposed a method that can automatically classify sleep apnea by using features extracted from pulse rate variability(PRV) signals induced from piezo snoring sensor for patients with obstructive sleep apnea(OSA). We have extracted eight features(NN, SDNN, RMSSD, NN10, NN50, LF, HF and LF/HF ratio) based on time and frequency analyses of PRV. Sleep apnea was classified by a linear discriminant analysis(LDA). A performance was evaluated using snore recordings from 13 patients with OSA (ages: $54.5{\pm}10.5$ years, body mass index: $26.3{\pm}2.5kg/m^2$, apnea-hypopnea index: $19.2{\pm}6.0/h$). The sensitivity and specificity were $78.9{\pm}0.9%$ and $78.9{\pm}0.9%$ for training set and $77.7{\pm}10.9%$ and $79.0{\pm}2.8%$ for test set, respectively. Our study demonstrated the feasibility of implementing a piezo snoring sensor based on a portable device as a simple and cost-effective solution for contributing to the OSA screening.

• Journal of Korean Medicine Rehabilitation
• /
• v.15 no.2
• /
• pp.17-30
• /
• 2005

Objectives : This study was designed to evaluate the changes of autonomic nervous system by heart rate variability(HRV) test on the musculoskeletal pain patients treated with acupuncture on the Back-su points and the unfixed points, and untreated healthy adults. Methods : This clinical study have been carried out with 64 cases of musculoskeletal pain patients and 26 healthy adults. 35 patients were treated with acupunctureon on the Back-su points(Group I) and 26 patients were treated on the Unfixed points(GroupII), and two groups were tested by HRV at pre and post acupuncture treatment. 26 healthy adults(GroupIII) were tested twice by HRV without any stimulation. Results : In Group I, VAS was decresased $5.83{\pm}1.62$ to $5.17{\pm}1.89$ significantly(p<0.05) after acupuncture treatment, and LF/HF ratio was decreased significantly(p<0.05) as compared with healthy control Group. In GroupII, SDNN & RMSSD were increased singnificantly(p<0.05) as compared with other Groups. in Group I & II, MHRT was decreased significantly(p<0.05) as compared with healthy control Group. Conclusions : These results suggest that acupuncture treatment on the Back-su points was able to reduce the pain, suppress the sympathetic activities and enhance the parasympathetic activities in musculoskeletal patients.