• Journal of Microbiology and Biotechnology
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• v.26 no.2
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• pp.233-240
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• 2016

FK506, a widely used immunosuppressant, is a 23-membered polyketide macrolide that is produced by several Streptomyces species. FK506 high-yielding strain Streptomyces sp. RM7011 was developed from the discovered Streptomyces sp. KCCM 11116P by random mutagenesis in our previous study. The results of transcript expression analysis showed that the transcription levels of tcsA, B, C, and D were increased in Streptomyces sp. RM7011 by 2.1-, 3.1-, 3.3-, and 4.1-fold, respectively, compared with Streptomyces sp. KCCM 11116P. The overexpression of tcsABCD g enes in Streptomyces sp. RM7011 gave rise to approximately 2.5-fold (238.1 μg/ml) increase in the level of FK506 production compared with that of Streptomyces sp. RM7011. When vinyl pentanoate was added into the culture broth of Streptomyces sp. RM7011, the level of FK506 production was approximately 2.2-fold (207.7 μg/ml) higher than that of the unsupplemented fermentation. Furthermore, supplementing the culture broth of Streptomyces sp. RM7011 expressing tcsABCD genes with vinyl pentanoate resulted in an additional 1.7-fold improvement in the FK506 titer (498.1 μg/ml) compared with that observed under non-supplemented condition. Overall, the level of FK506 production was increased approximately 5.2-fold by engineering the supply of allylmalonyl-CoA in the high-yielding strain Streptomyces sp. RM7011, using a combination of overexpressing tcsABCD genes and adding vinyl pentanoate, as compared with Streptomyces sp. RM7011 (95.3 μg/ml). Moreover, among the three precursors analyzed, pentanoate was the most effective precursor, supporting the highest titer of FK506 in the FK506 high-yielding strain Streptomyces sp. RM7011.

• Medical Lasers
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• v.10 no.4
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• pp.220-228
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• 2021

Background and Objectives In designing a resistance exercise program, intensity, rest, and exercise volume are important. Many studies have been conducted to find the most suitable resistance exercise program incorporating the above, and in particular, many prior studies have been conducted on intensity. This study attempted to determine the effective volume of exercise by analyzing the number of repetitions performed at intensities of 65% one-repetition maximum (1RM) and 75% 1RM during the bench press exercise, and the electromyography (EMG) response of the agonist muscle. Materials and Methods Eight males in their 20s were selected as study subjects and they performed five sets of bench presses at two levels of intensity (65% 1RM, 75% 1RM). The following results were obtained by measuring the number of repetitions and the EMG response according to the exercise intensity and sets during the workout. Results First, the number of repetitions showed a sharp drop from the first set to the third set at 65% 1RM intensity and showed no change in the fourth and fifth sets. At 75% 1RM intensity, the intensity of hypertrophy showed a gradual decrease from the first set to the fifth set. Second, at 75% 1RM exercise intensity, the pectoralis major, anterior deltoid and triceps brachii showed high muscle activity, and the activity of the anterior deltoid continued to increase from the first set to the fourth set at 65% 1RM intensity, and from the first set to the fifth set at 75% 1RM. Conclusion It was found that during the bench press exercise, three minutes of rest at 75% 1RM intensity, five sets of five sets, one minute rest at 65% 1RM intensity, and three sets of the exercise were effective.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.83.1-83.1
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• 2010

In the last meeting of KAS, we reported the first statistical study of Faraday rotation measure (RM) in the large-scale structure of the universe using the data of cosmological structure formation simulations. With a turbulence dynamo model for the intergalactic magnetic field (IGMF), we predicted that the root mean square of RM through filaments is \sim 1 rad/m^2. Future radio observatories such as the Square Kilometer Array (SKA) could detect this signal level. However, it is known that the typical foreground galactic RM is a few tens and less than ten rad/m^2 in the low and high galactic latitudes, respectively. So the RM in the large-scale structure could be detected only after the foreground galactic RM is removed. In this talk, we show how we remove the foreground galactic RM and what we obtain from the masked data, by using some noise models and masking techniques. Our results can be used to simulate future RM observations by SKA, and eventually to constrain the origin and evolution of the IGMF in the large-scale structure.

• Proceedings of the KIEE Conference
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• 2015.07a
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• pp.894-895
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• 2015

This paper deals with the characteristic analysis & optimum design of Permanent Magnet Assisted Synchronous Reluctance Motor(PMASynRM) for Premium Efficiency Performance. The focus of this paper is characteristic analysis of d and q-axis inductances and torque according to magnetizing quantity of interior permanent magnet for PMASynRM. The d and q-axis current component ratios, load angles of a PMASynRM are investigated quantitatively on the basis of the proposed analysis method and the experimental test. Comparisons are given with output characteristic curves of PMASynRM and those according to the rated wattage in PMASynRM, respectively. And optimum design of PMASynRM is performed by Response Surface Methodology(RSM).

• The Journal of Asian Finance, Economics and Business
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• v.9 no.10
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• pp.105-113
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• 2022

The purpose of this paper is to analyze the relationship between the ratio of non-controlling shareholder interests (minority equity ratio, MER) and the measurement error in real activities manipulation (RM) proxy for Japanese firms. Many Japanese firms have practiced stakeholder-oriented corporate governance systems. Previous studies suggest that the higher the MER, the more Japanese businesses tend to employ management techniques for the group's sales growth while also reallocating resources inside the group to reduce principal-principal conflicts. Such differences in management strategies by firms could lead to measurement error in the RM proxy. The analysis uses 16,450 firm-years listed on the Tokyo Stock Exchange. The results of our analysis show that there is a positive relationship between MER and the RM proxy, and high persistence of RM proxies, suggesting that the RM proxies may contain measurement error. We also find that MER is correlated with variables associated with management strategy and that controlling for these variables can reduce the measurement error of RM proxy in firms with large MER. This study extends previous research on measurement error in RM proxy by relating them to ownership structure and corporate governance. This paper would contribute to researchers examining issues related to RM.

• Journal of Energy Engineering
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• v.20 no.2
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• pp.163-169
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• 2011

This research is to decide the possibility of using RM50(reformulated methanol fuel) without any modification of engine by the method of numerical analysis. Comparing the heat release rate, the difference among each fuel was decreased according to the increase of the engine speed, and the maximum heat release rate was higher in the order of RM50 and gasoline fuel. Also, this order corresponds to the order of burning speed. RM50 had the higher turbulent burning speed, and the curve of turbulent intensity was showed similar tendency to the curve of turbulent burning speed. RM50 had relatively high burning speed, short quenching length, high temperature in cylinder, so that it might increase NO emission, but owing to chemical reaction dynamics, it was decreased NO emission. Therefore, in order to predict the possibility of using RM50, it is needed to consider not only the temperature in cylinder by low heating value, but also combustion characteristics including burning speed.

• Korean Journal of Community Nutrition
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• v.22 no.4
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• pp.279-288
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• 2017

Objectives: Recommended Menu (RM) prepared according to the Target Pattern expected to meet the dietary reference intake (DRI) of nutrients. Nutritional adequacy of RM in 'DRI for Koreans 2015' were analyzed to verify whether such expectation was fulfilled. Methods: Dishes in RM are categorized by 5 food groups, and number and types of dishes for main meal and between-meals were analyzed. The energy and 12 nutrients (protein, dietary fiber, Ca, P, Fe, Na, K, vitamin A, thiamin, riboflavin, niacin and vitamin C) contents in 10 RMs were calculated using the food composition table (CD) in 'DRI for Koreans'. Energy, energy contribution ratio, and nutrient contents in 10 RMs for 18 age groups were evaluated based on the 'DRI for Koreans 2015'. Results: Number of dishes per meal were 4.83, and representative table setting consisted of cooked rice + soup (or stew) +3 side dishes. Energy contents of RM were 75~109% of estimated energy requirement (EER). None of the RM met the DRI of all 12 nutrients examined. Calcium was the most insufficient nutrient. Only 1-2 years' RM met the DRI, all the other RMs did not meet the calcium DRI. Dietary fiber and potassium contents were also insufficient in most RM. In adult male's RM, only 1 nutrient, i.e. calcium did not meet the DRI, but in female adult's RM, 5~6 nutrients did not meet the DRI. Energy contribution ratio of carbohydrate, protein, and fat in RM were 59.0~70.4%, 15.7~17.5%, 12.1~23.5%, respectively. And 4 RMs out of 10 exceeded the upper limit of acceptable macro-nutrient distribution range (AMDR) of carbohydrate and 3 RMs out of 10 RM were below the lower limit of fat AMDR. Contribution ratio of nutrients were ${\geq}40%$ by food groups were as follows: grain group in energy and carbohydrate; meat fish egg legume group in fat, protein, and niacin; vegetables group in dietary fiber, vitamin A, and vitamin C; milk dairy products group in calcium. Conclusions: RM prepared according to the Target Pattern did not meet nutritional adequacy as expected. Especially calcium, potassium, and dietary fiber contents are needed to be increased in many RMs. Further, energy content in RM needs to be adjusted for fat sugar food group assigned in Target Pattern and condiment.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.4
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• pp.30-37
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• 2011

Recently, SynRM has been focused by many researchers and there has been a lot of works for the industrial application of SynRM. In spite of several merits of SynRM, the information of exact rotor position is also required to perform the precise torque control, which causes the increment of cost and demerits SynRM to use in industrial application. Therefore, we studied sensorless control algorithm for the torque control of SynRM to overcome the demerits. Specially we proposed simple algorithm to estimate rotor position using trigonometric function, verified with computer simulation and experiment.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.716_717
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• 2009

This paper deals with the characteristic analysis & optimum design of Permanent Magnet Assisted Synchronous Reluctance Motor(PMASynRM) for Premium Efficiency Performance. The focus of this paper is characteristic analysis of d and q-axis inductances and torque according to magnetizing quantity of interior permanent magnet for PMASynRM. The d and q-axis current component ratios, load angles of a PMASynRM are investigated quantitatively on the basis of the proposed analysis method and the experimental test. Comparisons are given with output characteristic curves of normal SynRM and those according to the load in PMASynRM, respectively. And optimum design of PMASynRM is performed by Response Surface Methodology(RSM).

• The Transactions of the Korean Institute of Electrical Engineers B
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• v.53 no.10
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• pp.585-596
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• 2004

In this paper, finite element analysis for a PMASynRM is presented and the characteristic analysis of inductance and torque is performed under the effect of saturation. The focus of this paper is characteristic analysis of d and q-axis inductances and torque according to magnetizing quantity of interior permanent magnet for PMASynRM. The d and q-axis current component ratios, load angles of a PMASynRM are investigated quantitatively on the basis of the proposed analysis method and the experimental test. Comparisons are given with output characteristic curves of normal SynRM and those according to the load in PMASynRM, respectively And it is confirmed that the proposed model results in high output power performance.