• Journal of Microbiology and Biotechnology
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• 제29권11호
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• pp.1852-1859
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• 2019

Chikungunya virus (CHIKV) is a single-stranded positive-sense RNA virus, belonging to the genus Alphavirus of the Togaviridae family. It causes multiple symptoms, including headache, fever, severe joint and muscle pain, and arthralgia. Since CHIKV was first isolated in Tanzania in 1952, there have been multiple outbreaks of chikungunya fever. However, its pathogenesis and mechanisms of viral immune evasion have been poorly understood. In addition, the exact roles of individual CHIKV genes on the host innate immune response remain largely unknown. To investigate if CHIKV-encoded genes modulate the type I interferon (IFN) response, each and every CHIKV gene was screened for its effects on the induction of the IFN-β promoter. Here we report that CHIKV nsP2, E2 and E1 strongly suppressed activation of the IFN-β promoter induced by the MDA5/RIG-I receptor signaling pathway, suggesting that nsP2, E2, and E1 are the major antagonists against induction of IFN-β. Delineation of underlying mechanisms of CHIKV-mediated inhibition of the IFN-β pathway may help develop virus-specific therapeutics and vaccines.

• Journal of Mechanical Science and Technology
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• 제15권3호
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• pp.291-299
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• 2001

Recently, severe wear on the shutdown rod cladding of Ulchin Nuclear Power Plant #1, #2 were observed by the Eddy Current Test(E.C.T.). In particular, the wear at the sixth card location was up to 75%. The test results indicated that the Flow Induced Vibration(F.I.V.) might be the cause of the fretting wear resulting from the contact between Rod Cluster Control Assemblies(RCCAs) and their spacing cards(guide plates) arranged in the guide tube. From reviewing RCCAs fretting wear repots and analyzing the general characteristics of F.I.V. mechanism in the reactor, geometric layout and flow conditions around the control rod, it is concluded that the turbulence excitation is the most probable vibration mechanism of RCCA. To identify the governing mechanism of RCCA vibration, an experiment was performed for a representative rod position in which the most serious fretting wear experienced among the six rod positions. The experimental rig was designed and set up to satisfy the governing nondimensional numbers which are Reynolds number and mass damping parameter. The vibration amplitude measurement by the non-contact laser displacement sensor showed good agreements in the frequency and the maximum wearing(vibration) location with Ulchin E.C.T. results and Framatome report, respectively. The sudden increase in the vibration amplitude was sensed around the 6th guide plate with mass flow rate variation. Comparing the similitude rod behaviour with the idealized response of a cylinder in flow induced vibration, it was found that he dominant mechanism of vibration was transferred from turbulence excitation to periodic shedding at the mass flow ate 90ι/min. Also the critical velocity of the vibration in RCCAs was determined and the vibration can be prevented by reducing the bypass flow rate below the critical velocity.

• 한국추진공학회지
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• 제24권1호
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• pp.1-8
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• 2020

메탄/산소 이원추진제 소형로켓엔진의 성능평가를 위한 형상설계 및 시험평가시스템을 구축하였다. 인젝터는 추진제 미립화 성능이 우수하고, 연소불안정성이 적은 스월 동축형(swirl-coaxial) 방식을 채택하였다. 연소효율 비교를 위해 연소실의 종횡비는 1.5, 1.8, 2.1로 각각 설정하였다. 그리고 정밀추력측정장치의 측정 신뢰성을 높이기 위해 pre/post calibration을 실시하였다. 그 결과, 예비 지상연소시험에서 추력과 비추력은 89.2 N, 181.8 s로 78.4%의 효율을 가지고, 특성속도는 84.2%의 효율을 갖는 것이 확인되었다.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 2002년도 proceedings of the second asia international conference on tribology
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• pp.379-380
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• 2002

Steam generators (S/G) of pressurized water reactors are large heat exchangers that use the heat from the primary reactor coolant to make steam in the secondary side for driving turbine generators. Reciprocating sliding wear experiments have been performed to examine the wear properties of Incoloy 800 and Inconel 690 steam generator tubes in high temperature water. In present study, the test rig was designed to examine the reciprocating and rolling wear properties in high temperature (room temperature - $300^{\circ}C$) water. The test was performed at constant applied load and sliding distance to investigate the effect of test temperature on wear properties of steam generator tube materials. To investigate the wear mechanism of material, the worn surfaces were observed using scanning electron microscopy. At $290^{\circ}C$, wear rate of Inconel 690 was higher than that of Incoloy 800. It was assumed to be resulted from the oxide layer property difference due to the a\loy composition difference. Between 25 and $150^{\circ}C$ the wear loss increased with increasing temperature. Beyond $150^{\circ}C$, the wear loss decreased with increasing temperature. The wear loss change with temperature were due to the formation of wear protective oxide layer. From the worn surface observation, texture patterns and wear particle layers were found. As test temperature increased, the proportion of particle layer increased.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.635-640
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• 2004

The present paper provides the design specifications and working principle of flow controlling vortex valve which will be adopted in a Korean next generation reactor (APR1400). The vortex valve is installed inside the pressurized safety injection tank of APR1400, and it passively controls the water discharge flowrate from the tank. In the present study, the performance of the vortex valve have been evaluated throughout the repeated experiments in the full-scale test facility called VAPER(VAlve Performance Evaluation Rig). Based on the experimental results, it is confirmed that the currently developed vortex valve satisfies the major performance requirements of APR1400 plant design in view of the peak discharge flowrate, pressure loss coefficient, and total discharge duration time. To achieve the highest quality of the experimental results, a quality assurance program for vortex valve tests has been strictly applied.

• International Journal of Fluid Machinery and Systems
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• 제4권1호
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• pp.199-208
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• 2011

This work presents numerical results, using OpenFOAM, of the flow in the swirl flow generator test rig developed at Politehnica University of Timisoara, Romania. The work shows results computed by solving the unsteady Reynolds Averaged Navier Stokes equations. The unsteady method couples the rotating and stationary parts using a sliding grid interface based on a GGI formulation. Turbulence is modeled using the standard k-${\varepsilon}$ model, and block structured wall function ICEM-Hexa meshes are used. The numerical results are validated against experimental LDV results, and against design velocity profiles. The investigation shows that OpenFOAM gives results that are comparable to the experimental and design profiles. The unsteady pressure fluctuations at four different positions in the draft tube is recorded. A Fourier analysis of the numerical results is compared whit that of the experimental values. The amplitude and frequency predicted by the numerical simulation are comparable to those given by the experimental results, though slightly over estimated.

• 대한기계학회논문집B
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• 제32권8호
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• pp.597-603
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• 2008

The catalyzed diesel particulate filter (CDPF) is widely used for collecting soot from the exhaust gas of diesel engine. However, the CDPF need being regenerated after the soot accumulation. It is important to know characteristics of regeneration for CDPF with variation of exhaust gas temperature and composition. This study presents characteristics of regeneration according to variable exhaust gas composition. Furthermore, the experiment were performed variable gas temperature of CDPF inlet gas at each exhaust gas composition. Test-rig is used to control at each in let gas temperature and composition during regeneration of CDPF. Reaction intensity($I_c$) is used to compare with each result. Experimental results indicated that increased concentration of $NO_x$ and $O_2$ lead to regenerate more greatly. Also, higher temperature of exhaust gas leads to make CDPF cleaner.

• 오토저널
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• 제9권3호
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• pp.16-22
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• 1987

직접분사식 디젤기관의 성능과 배기가스 문제에 여향을 주는 실린더 내에서의 연소형태는 크게 연료분사계와 흡입공기 유동계 두 가지에 의해 결정된다. 즉 분사율, 부사시기, 분무형태와 같은 분사계의 특성과 공기선회, 스퀴시(squish), 난류와 같은 공기 유동 특성에 의하여 연소형태가 결 정된다. 이러한 복잡한 연소형테를 기관 특성에 맞게 조정한다는 것은 대단히 어려운 문제인데 이것은 연료화 공기의 혼합이 연소실형상과 흡기계의 형상에 큰 영향을 받으며 연료가 액체 상 태로 연소실내로 들어와 분무과정을 통하여 증발이 되어야만 연소가 가능하기 때문이다. 특히 흡입공기 유동계에 있어서 현재의 직접 분사식 대젤기관의 흡입구 형상은 흡입공기의 운동에너 지에 모멘트를 가하여 연소실내에서 공기의 선희(swirl)를 발생시켜 줌으로써 연료와 공기의 혼 합기를 형성시키는 Helical type이 많이 이용되고 있다. 그러나 기관 성능과 배기가스 특히 NOx는 상반관계를 이루기 때문에 연소실내로 들어오는 흡입공기의 선희강도(swirl ratio)를 너무 강하게만 한다고 하여 좋은 결과를 얻을 수는 없다. 따라서 설계하고자 하는 각 기관에 있어서 요구되는 성능과 배기가스 문제를 만족하는 흡입공기의 선희강도가 얻어질 수 있도록 흡입구 형상을 설계한다는 것은 많은 연구와 경험이 요구되고 있다. 본 자료에서는 직접분사식 디젤기 관에 있어서 흡입공기의 최적 선희강도에 대한 설정방법과 흡입구 형상 설계를 위한 설계 이론 및 정상류 Rig test상에서의 흡입공기 선희강도의 평가방법을 소개하고자 한다.

• 대순사상논총
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• 제20권
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• pp.193-222
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• 2009

There is no place in the scriptures of Daesoonjinrihoe(大巡眞理會) where Indian philosophy is directly discussed. The philosophies dealt with in Daesoon thought are mostly those of Christianity, Confucianism, Buddhism, and Taoism. Of course, the thoughts that are not widely known and those that are not considered to be worth comparing with the Daesoon thought must have been omitted. It seems that Indian philosophy and Daesoon thought have considerable similarity. First of all, the two philosophies are rooted in religion. True, there is no dearth of religious philosophies in the East, for instance, Confucianism and Taoism, and yet comparing Daesoon thought and Indian philosophy is significant because they both presuppose a theistic paradigm. At the core of the two perspectives, there is personal God, i.e., Isvara or Gucheon Sangje (九天上帝), upon whom human beings and the world absolutely depend as his creation. Unlike traditional Christian theology, the two philosophies are alike in being indifferent to proving the existence of the deity and focusing on his form and role. In this article, the author try to examine the meaning of the four tenets of Daesoonjinrihoe(Eumyanghapdeok 陰陽合德, Shininjohwa 神人調化, Haewonsangsaeng 解冤相生, Dotongjingyeong 道通眞境) from the perspective of Indian philosophy in general, Purusa-sukta of Rig-veda, theistic Upanisads, and Ramanuja's Visistadvaita(限定不二論) in particular. Before making up the main subject, the author inquires into the characteristics of Ultimate Reality in Daesoon thought and Indian philosophy.

• International Journal of Automotive Technology
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• 제6권1호
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• pp.1-8
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• 2005

Recently, the HSDI (High Speed Direct Injection) diesel engine has been spotlighted as a next generation engine because it has a good potential for high thermal efficiency and fuel economy. This study was carried out to investigate the in-cylinder flow characteristics generated in a HSDI diesel engine with a 4-valve type cylinder head. The four kinds of cylinder head were manufactured to elucidate the effect of intake port geometry on the in-cylinder flow characteristics. The steady flow characteristics such as coefficient of flow rate $(C_{f})$, swirl ratio (Rs), and mass flow rate (m,) were measured by the steady flow test rig and the unsteady flow velocity within a cylinder was measured by PIV. In addition, the in-cylinder flow patterns were visualized by the visualization experiment and these results were compared with simulation results calculated by the commercial CFD code. The steady flow test results indicated that the mass flow rate of the cylinder head with a short distance between the two intake ports is $13\%$ more than that of the other head. However, the non-dimensional swirl ratio is decreased by approximately $15\%$. As a result of in-cylinder flow characteristics obtained by PIV and CFD calculation, we found that the swirl center was eccentric from the cylinder center and the position of swirl center was changed with crank angle. As the piston moves to near the TDC, the swirl center corresponded to the cylinder center and the velocity distribution became uniform. In addition, the results of the calculation are in good agreement with the experimental results.