• BMB Reports
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• v.52 no.2
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• pp.133-138
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• 2019

Upon viral infection, the 2', 5'-oligoadenylate synthetase (OAS)-ribonuclease L (RNaseL) system works to cleave viral RNA, thereby blocking viral replication. However, it is unclear whether OAS proteins have a role in regulating gene expression. Here, we show that OAS1 and OAS3 act as negative regulators of the expression of chemokines and interferon-responsive genes in human macrophages. Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein-9 nuclease (Cas9) technology was used to engineer human myeloid cell lines in which the OAS1 or OAS3 gene was deleted. Neither OAS1 nor OAS3 was exclusively responsible for the degradation of rRNA in macrophages stimulated with poly(I:C), a synthetic surrogate for viral double-stranded (ds)RNA. An mRNA sequencing analysis revealed that genes related to type I interferon signaling and chemokine activity were increased in $OAS1^{-/-}$ and $OAS3^{-/-}$ macrophages treated with intracellular poly(I:C). Indeed, retinoic-acid-inducible gene (RIG)-I- and interferon-induced helicase C domain-containing protein (IFIH1 or MDA5)-mediated induction of chemokines and interferon-stimulated genes was regulated by OAS3, but Toll-like receptor 3 (TLR3)- and TLR4-mediated induction of those genes was modulated by OAS1 in macrophages. However, stimulation of these cells with type I interferons had no effect on OAS1- or OAS3-mediated chemokine secretion. These data suggest that OAS1 and OAS3 negatively regulate the expression of chemokines and interferon-responsive genes in human macrophages.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.790-795
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• 2001

Since the characteristics of combustion and pollutant in Diesel engines were mainly affected by the characteristics of in-cylinder gas flow and fuel spray, an understanding of those was essential to the design of the D.I. Diesel engines. The improvement of volumetric efficiency of air charging into combustion chamber is a primary requirement to obtain better mean effective pressure of an engine. Since the air resistances in intake and exhaust flow passages, valve lift and valve shape influence greatly to the volumetric efficiency, it is very important to investigate the flow characteristics of intake and exhaust port which develops air motion in the combustion chamber. This paper presents the results of an experimental investigation of steady flow through the various kinds of commercial cylinder head ports, and the development procedures of HHI's H21/32 prototype cylinder head ports.

• Journal of Power System Engineering
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• v.5 no.3
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• pp.38-47
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• 2001

One stage axial type turbine is designed by mean-line analysis, streamline curvature method and blade design method using shape parameters. Tip and hub diameter of the turbine are 300mm and 206.4mm, respectively. The rotating speed is 1800RPM, and the output power is 1.4kW. The flow coefficient is 1.68 and the reaction factor at mean-line is 0.373. The number of stator and rotor of the turbine are 31 and 41, respectively. Mach number of stator exit flow near hub is 0.164. A test rig is developed for performance test to validate a developed design method. The experimental result shows that the maximum efficiency is obtained on the design point.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.67.2-67.2
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• 2013

Part of mid-J CO emission detected by the Herschel/PACS observations of embedded young stellar objects (YSOs) has been attributed to the UV-heated outflow walls. We have applied our newly developed self-consistent models of Photon Dominated Region (PDR) and Non-LTE line Radiative transfer In general Grid (RIG) to the Herschel FIR CO observations. If the black body radiation of T = 15,000 K is used, the observed mid-J CO line fluxes can be produced in inner dense regions (n ${\geq}$ 106 cm-3) with -4.5 ${\leq}$ log Gdust/n ${\leq}$ -2.5, where gas temperatures are larger than 300 K and CO abundances are ${\geq}$ 10-5, along the UV-heated outflow walls. The contribution of the UV heated outflow cavity wall in Class I seems to be larger than that in Class 0.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1997.04a
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• pp.253-259
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• 1997

A software for design of turbine bearings has been developed based on both the theoretical analysis and experimental investigation. Static and dynamic performance, i.e. load capacity, frictional loss, temperature distribution, stiffness and damping coefficients, stability etc., can be obtained by using this software taking into account the effects of three dimensional variation of lubricant viscosity, turbulence and inlet pressure. A performance test rig was developed by self-design and technology, which was used to verify static and dynamic characteristics and to investigate the proper boundary conditions for theoretical analysis. Consequently HANJUNG has developed the self-design technology for design of turbine bearings for power plants.

• Tribology and Lubricants
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• v.24 no.2
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• pp.82-89
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• 2008

The purpose of this study is to develop the proto type sensor installed inside an oil filter in order to detect oil deterioration level. The sensor is made up with two concentric cylinders with constant gap in between and a filter element inside the central area. The size will be designed as similar as real oil filters. The sensor will be tested on a test rig, which is circulating engine oil, with the same size of an oil filter adapting housing as real engines'. It will be measured the capacitance of a sample engine oil, then be able to be gotten the dielectric constant. The changes in the dielectric constant could be correlated with the engine oil deterioration level if the sensor development would be completed. In this paper, it will be shown the test results carrying out under variable temperature conditions at atmosphere pressure.

• Transactions on Electrical and Electronic Materials
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• v.2 no.2
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• pp.1-4
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• 2001

Urgency of using plasma-energy technologies in power industry, is outlined, increasing of economical efficiency, decreasing of energy consumption and decreasing of environmental pollution, are shown, scientific and technical bases for plasma-energy technologies of fuel utilisation, are designed, results of theoretical, experimental and rig investigations of processes of plasma ignition, gasification, thermochemical preparation for burning and combined processing of coals, are presented, results of realisation of plasma technologies of residual-oil-free (mazout) pulverised-coal boiler kindling, lighting of torch and stabilisation of luid slagging in furnaces with removal of fluid slag, are described.

• Journal of KSNVE
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• v.10 no.6
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• pp.1029-1034
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• 2000

A new electro-rheological squeeze film damper (ER-SFD) has been sealed with slotted piston rings which have electrodes at the inside of the constant gap. The slotted ER-SFD can prevent the problem of electric discharge which might be occurred in the previous configuration of an ER-SFD. The current paper presents the extraction of linearized dynamic coefficients within small orbit where these coefficients are controlled by the application of electric strength. Test rig has been modified to isolate the damper section for dynamic coefficient extraction. The results show that rotordynamic coefficients, damping and inertia terms, increase with increasing supply voltages, while stiffness coefficients decrease with increasing supply voltages. notating speed of rigid shaft does not affect these coefficients.

• IMMUNE NETWORK
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• v.13 no.1
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• pp.1-9
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• 2013

Autophagy is a fundamental cellular process in eukaryotic cells for maintaining homeostasis by degrading cellular proteins and organelles. Recently, the roles of autophagy have been expanded to immune systems, which in turn modulate innate immune responses. More specifically, autophagy acts as a direct effector for protection against pathogens, as well as a modulator of pathogen recognition and downstream signaling in innate immune responses. In addition, autophagy controls autoimmunity and inflammatory disorders by negative regulation of immune signaling. In this review, we focus on recent advances in the role of autophagy in innate immune systems.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.11 no.6
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• pp.871-879
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• 1999

Present study explains some experimental results on the aerodynamic noise of the cross-flow fan usually installed in the indoor unit of the room air-conditioners and provides a simple reduction method of radiating sound to decrease the total noise level. The spectrums of the noise of the cross-flow fan were analyzed by the spectral decomposition method to characterize the generated sound. The unsteady fluctuating flow field was also measured using the I-type hot-wire probe. Comparing the spectral characteristics of the sound and the flow velocity, a useful noise reduction method was proposed which bounds the region with a fence where the flow fluctuations were noticeably changed in the same fashion as the source spectral distribution functions vary. To validate the proposed method for reducing noise generated by the cross-flow fan, the sound pressure levels of the cross-flow fan system were compared of the experimental rig with and without the bounding fence for various flow rates.