• 운동과학
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• 제28권1호
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• pp.82-90
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• 2019

PURPOSE: The purpose of this study was to examine the association of waist to height ratio (WHtR) and resting heart rate (RHR) with cardio-metabolic risk factors among Korean postmenopausal women. METHODS: A cross-sectional analysis was performed using the 2015 Korea National Health and Nutrition Examination Survey. The analysis included a total of 1,540 postmenopausal women. RESULTS: Individuals with higher WHtR (>0.56) showed significantly higher glucose, triglyceride, insulin, Homeostatic Model Assessment for Insulin resistance (HOMA-IR), total cholesterol, systolic and diastolic blood pressure compared with ones with lower WHtR (≤0.51). Similar findings were found in those with higher RHR (≥90 bpm) compared with ones with lower RHR (<60 bpm) for glucose and HOMA-IR. When determining the combined effects of WHtR and RHR on the prevalence of metabolic syndrome, individual with WHtR above 0.5 and RHR above 80 bpm showed 10.39 times higher prevalence of metabolic syndrome compared with those with WHtR below 0.5 and RHR below 70 bpm. We further performed multiple linear regression analysis to understand how WHtR and RHR contribute to fasting glucose, and found that both WHtR and RHR contribute to fasting glucose levels independent of age, education level, marital status and income level. CONCLUSIONS: The current study showed that the WHtR and RHR are associated with cardio-metabolic risk factor and prevalence of metabolic syndrome in Korean postmenopausal women.

• Archives of Pharmacal Research
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• 제20권5호
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• pp.389-395
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• 1997

We investigated the interaction between nitric oxide and the renin angiotensin system in regulating isolated pulmonary arterial tension and pulmonary arterial pressure (PAP) in renal hypertensive rats (RHR) made by complete ligation of left renal artery. Losartan induced a depressor response that was smaller in RHR than in normotensive rats (NR) (3.3 and 7.0 mmHg, respectively, at 3.0 mg/kg, p<0.05), and the response was significantly reduced by $N^{G}$-nitro-Larginine methyl ester (L-NAME). Angiotensin II elevated the PAP (7.6 and 10.8 mmHg at $0.1 {\mu}g/kg$; 20.3 and 23.6 mmHg at $1.0{\mu}g/kg$, respectively) and contracted the isolated pulmonary artery ($pD_2$: 8.79 and 8.71, respectively) from both NR and RHR with similar magnitude, and these effects were significantly enhanced by L-NAME in NR, but not in RHR. Acetylcholine lowered the PAP slightly less effectively in RHR than in NR (3.8 and 6.0 mmHg at 10 .mu.g/kg, respectively) and relaxed the pulmonary artery precontracted with norepinephrine in both rats with similar magnitude ($E_max$: 60.8 and 63.6%, respectively), and the effect being completely abolished after pretreatment.with L-NAME or removal of endothelial cells. These results suggest that nitric oxide interacts with renin angiotensin system to control the pulmonary vascular tension and pulmonary arterial circulation of RHR.R.

• Steel and Composite Structures
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• 제30권3호
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• pp.217-230
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• 2019

One of the most important design criteria in underground structure is to design lightweight protective layers to resist significant blast loads. Sandwich blast resistant panels are commonly used to protect underground structures. The front face of the sandwich panel is designed to resist the blast load and the core is designed to mitigate the blast energy from reaching the back panel. The design is to allow the sandwich panel to be repaired efficiently. Hence, the underground structure can be used under repeated blast loads. In this study, a novel sandwich panel, named RC panel - Helical springs- RC panel (RHR) sandwich panel, which consists of normal strength reinforced concrete (RC) panels at the front and the back and steel compression helical springs in the middle, is proposed. In this study, a detailed 3D nonlinear numerical analysis is proposed using the nonlinear finite element software, AUTODYN. The accuracy of the blast load and RHR Sandwich panel modelling are validated using available experimental results. The results show that the proposed finite element model can be used efficiently and effectively to simulate the nonlinear dynamic behaviour of the newly proposed RHR sandwich panels under different ranges of free air blast loads. Detailed parameter study is then conducted using the validated finite element model. The results show that the newly proposed RHR sandwich panel can be used as a reliable and effective lightweight protective layer for underground structures.

• Animal cells and systems
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• 제11권2호
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• pp.93-98
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• 2007

Gonadotropin-releasing hormone (GnRH), synthesized in the hypothalamus, plays a pivotal role in the regulation of vertebrate reproduction. Since molecular isoforms of GnRH and their receptors (GnRHR) have been isolated in a broad range of vertebrate species, GnRH and GnRHR provide an excellent model for understanding the molecular co-evolution of a peptide ligand-receptor pair. Vertebrate species possess multiple forms of GnRH, which have been created through evolutionary mechanisms such as gene/chromosome duplication, gene deletion and modification. Similar to GnRHs, GnRH receptors (GnRHR) have also been diversified evolutionarily. Comparative ligand-receptor interaction studies for non-mammalian and mammalian GnRHRs combined with mutational mapping studies of GnRHRs have aided the identification of domains or motifs responsible for ligand binding and receptor activation. Here we discuss the molecular basis of GnRH-GnRHR co-evolution, particularly the structure-function relationship regarding ligand selectivity and signal transduction of mammalian and non-mammalian GnRHRs.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2004년도 요약집 춘계학술발표대회
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• pp.450-450
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• 2004

• Asian-Australasian Journal of Animal Sciences
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• 제24권4호
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• pp.463-470
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• 2011

Gonadotropin-releasing hormone receptor (GnRHR) gene is expressed at the anterior pituitary gland and plays a key role in gonad development. This study aimed to investigate molecular genetic characteristics of the GnRHR gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of GnRHR gene on sex steroid level in Japanese flounder (Paralichthys olivaceus). We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the GnRHR gene in 75 individuals. We identified three SNPs in the GnRHR gene: P1 locus (C759A and C830T) in the coding region of exon2 which were both linked together and P2 locus (G984T) in the coding region of exon3, which added a new transcript factor (ADR1) and a new methylation site (CG). Only C830T of P1 leads to amino acid changes Thr266Ile. Statistical analysis showed that P1 was significantly associated with $17{\beta}$-estradiol ($E_2$) level (p<0.01) and gonadosomatic index (GSI) (p<0.05). Individuals with genotype BB of P1 had significantly higher serum $E_2$ levels (p<0.01) and GSI (p<0.05) than those of genotype AA or AB. Another SNP, P2, synonymous mutation, was significantly associated with GSI (p<0.05). Individuals with genotype AB of P2 had significantly higher GSI (p<0.05) than that of genotype AA. In addition, there was a significant association between one diplotype based on three SNPs and reproductive traits. The genetic effects for both serum $E_2$ level and GSI of diplotype D4 were super diplotypes (p<0.05). These results suggest that the SNPs in Japanese Flounder GnRHR are associated with $E_2$ level and GSI.

• 한국체육학회지인문사회과학편
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• 제57권2호
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• pp.509-518
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• 2018

본 연구는 국민건강 영양조사 자료를 활용하여 한국 성인의 안정시 심박수와 대장암 유병율의 관계를 살펴보고자 하였다. 데이터는 국민건강 영양조사 2005년부터 2014년 자료를 통합하여 만 19세 이상 성인 총 10,564명을 분석하였다. 분석 결과, 안정시 심박수가 가장 높은 그룹은 안정시 심박수가 가장 낮은 그룹에 비해 대장암 유병율이 2.27배 (95%CI: 1.34-3.85) ~ 3배 (95%CI: 1.30-6.92) 더 높은 것으로 나타났으며, 안정시 심박수가 10 회/분 (beat per minutes)씩 증가할수록 대장암 유병율은 1.27배 (95%CI; 1.03-1.58) 증가하는 것으로 나타났다. 또한 65세를 기준으로 연령과 성별을 층화하여 분석한 결과, 65세 이상에서 안정시 심박수가 가장 높은 그룹은 안정시 심박수가 가장 낮은 그룹에 비해 남자는 3.19배 (95%CI: 1.10-9.24) ~ 3.38배 (95%CI: 1.18-9.73), 여자는 2.90배 (95%CI: 1.13-7.42) ~ 5.59배 (95%CI: 1.20-25.99) 대장암 유병율이 증가하는 것을 확인하였다. 본 연구를 통해 대장암 유병율 예측 인자로써 안정시 심박수의 활용 가능성을 확인할 수 있었으며 특히, 65세 이상의 연령이 65세 미만 연령에 비해 안정시 심박수가 대장암 유병율과 밀접한 관련성이 있는 것을 확인하였다.

• Biomolecules & Therapeutics
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• 제1권2호
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• pp.220-225
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• 1993

Effect of BR-900317 on the angiotensin I-induced pressor response in pithed rats and the effects of its single oral administration on plasma angiotensin converting enzyme (ACE) activities in normotensive rats and on the cardiovascular system in hypertensive model rats (SHR, RHR), were compared with those of captopril. BR-900317 attenuated the angiotensin I-induced pressor effects in pithed rats. In a single oral dose administration study, BR-900317 inhibited the plasma ACE activities in a dose-dependent fashion. Duration of the action of BR-900317 was similar to that of captopril. BR-900317 produced antihypertensive effect in spontaneously hypertensive rats and dose-dependent antihypertensive effect in 2-kidney Goldblatt hypertensive rats without affecting heart rate. These results suggest that the main mechanism of the antihypertensive effect of BR-900317 is the suppression of angiotensin II production due to the inhibition of the ACE.

• Biomolecules & Therapeutics
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• 제12권1호
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• pp.19-24
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• 2004

The vascular relaxant effect of amlodipine adipate, a new salt of amlodipine, was evaluate in isolated rat aorta, and compared with that of amlodipine besylate. Furthermore, antihypertensive effects were measured in hypertensive rat models, such as spontaneously hypertensive rats (SHR) and rena1 hypertensive rats (RHR). Amlodipine adipate concentration-dependently inhibited $Ca^{2+}$-induced contraction of rat aorta with a very slow onset of action (reached its maximum at 3.5 h;$IC_{50}$: 3.76 nM), having a pattern and a potency similar to those of amlodipine besylate ($IC_{50}$: 4.01 nM). In SHR and RHR, orally administered amlodipine adipate produced a dosedependent and long-lasting (>10-24 h) antihypertensive effect ($ED_{20}$: 2.48 and 1.57 mg/kg, respectively), with a pattern and a potency similar to those of amlodipine besylate ($ED_{20}$: 2.50 and 1.99 mg/kg in SHR and RHR, respectively). These results suggest that amlodipine adipate is a potent and long-lasting antihypertensive agent and that its antihypertensive effect is not significantly different to that of amlodipine besylate.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1995년도 추계학술발표회논문집(2)
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• pp.525-530
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• 1995

최적 열수력 전산 코드인 CATHARE2 Vl.3u 코드를 이용하여 영광 3/4호기 midloop 운전중 잔열제거(RHR) 기능 상실사고를 해석하였다. 본 연구의 주된 목적은 사고시 계통에서 발생하는 열수력 현상의 이해 향상 및 증기발생기 열제거 능력 평가에 있다. 사고 복구 절차 관점에서 노심 비등, 노출 시점 및 계통압력 등이 중요한 인자이다. 본 계산 수행시 사용한 가정은 다음과 같다. 가) 초기 계통 수위는 고온관 중간에 위치하며 그 윗 부분은 질소 가스로 차 있다. 나) 3/4 인치 크기의 방출 밸브가 원자로 용기 상부 및 가압기 상부에 각각 설치되어 있으며, RHR 흡입구에 수위지시계가 설치되어 있다. 다) 증기발생기의 이차측은 U-튜브가 잠기도록 물로 차있다. 라) 두 증기발생기의 대기 방출 밸브(ADV)는 항상 열려 있어 사고시 이차측 압력을 대기압으로 유지하기에 충분하다. 사고는 원자로 정지 2일 후 발생하였다고 가정한다. 이와 같은 조건하에서 사고시 주된 계통 열제거 수단은 증기발생기 U-튜브내의 응축 작용이며 이는 전체 열제거량의 94%로 나타났다. 노심 비등 시점온 사고후∼300초 이후이며, 계통압력은 10,800초 이후에 최고 압력인 0.25MPa에 도달한 후 그 값을 계속 유지하고 있다. RHR 배관에 연결된 수위지 시계를 통해 10,200초 이후부터 냉각수가 방출되었다. 2개의 방출밸브 및 수위지시계를 통하여 방출된 유량에 근거하여 원자로 용기 냉각재 수위가 고온관 바닦까지 낮아지는 시점을 계산하면 사고 약 6.4 시간 이후가 된다.