• The Korean Journal of Physiology and Pharmacology
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• v.12 no.6
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• pp.307-314
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• 2008

Retinal prostheses are being developed to restore vision for the blind with retinal diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Among the many issues for prosthesis development, stimulation encoding strategy is one of the most essential electrophysiological issues. The more we understand the retinal circuitry how it encodes and processes visual information, the greater it could help decide stimulation encoding strategy for retinal prosthesis. Therefore, we examined how retinal ganglion cells (RGCs) in in-vitro retinal preparation act together to encode a visual scene with multielectrode array (MEA). Simultaneous recording of many RGCs with MEA showed that nearby neurons often fired synchronously, with spike delays mostly within 1 ms range. This synchronized firing - narrow correlation - was blocked by gap junction blocker, heptanol, but not by glutamatergic synapse blocker, kynurenic acid. By tracking down all the RGC pairs which showed narrow correlation, we could harvest 40 functional connectivity maps of RGCs which showed the cell cluster firing together. We suggest that finding functional connectivity map would be useful in stimulation encoding strategy for the retinal prosthesis since stimulating the cluster of RGCs would be more efficient than separately stimulating each individual RGC.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.12
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• pp.1730-1736
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• 2015

This paper presents a 16-channel transimpedance amplifier (TIA) array implemented in a standard $0.18-{\mu}m$ CMOS technology for the applications of panoramic scan LADAR (PSL) systems. Since this array is the front-end circuits of the PSL systems to recover three dimensional image for unmanned vehicles, low-noise and high-gain characteristics are necessary. Thus, we propose a voltage-mode inverter TIA (I-TIA) array in this paper, of which measured results demonstrate that each channel of the array achieves $82-dB{\Omega}$ transimpedance gain, 565-MHz bandwidth for 0.5-pF photodiode capacitance, 6.7-pA/sqrt(Hz) noise current spectral density, and 33.8-mW power dissipation from a single 1.8-V supply. The measured eye-diagrams of the array confirm wide and clear eye-openings up to 1.3-Gb/s operations. Also, the optical pulse measurements estimate that the proposed 16-channel TIA array chip can detect signals within 20 meters away from the laser source. The whole chip occupies the area of $5.0{\times}1.1mm^2$ including I/O pads. For comparison, a current-mode 16-channel TIA array is also realized in the same $0.18-{\mu}m$ CMOS technology, which exploits regulated-cascode (RGC) input configuration. Measurements reveal that the I-TIA array achieves superior performance in optical pulse measurements.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.10 s.352
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• pp.1-9
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• 2006

In this paper, a couple of 10Gb/s transimpedance amplifiers are realized in a 0.18um standard CMOS technology for optical communication applications. First, the voltage-mode inverter TIA(I-TIA) exploits inverter input configuration to achieve larger effective gm, thus reducing the input impedance and increasing the bandwidth. I-TIA demonstrates $56dB{\Omega}$ transimpedance gain, 14GHz bandwidth for 0.25pF photodiode capacitance, and -16.5dBm optical sensitivity for 0.5A/W responsivity, 9dB extinction ration and $10^{-12}$ BER. However, both its inherent parasitic capacitance and the package parasitics deteriorate the bandwidth significantly, thus mandating very judicious circuit design. Meanwhile, the current-mode RGC TIA incorporates the regulated cascade input configuration, and thus isolates the large input parasitic capacitance from the bandwidth determination more effectively than the voltage-mode TIA. Also, the parasitic components give much less impact on its bandwidth. RGC TIA provides $60dB{\Omega}$ transimpedance gain, 10GHz bandwidth for 0.25pF photodiode capacitance, and -15.7dBm optical sensitivity for 0.5A/W responsivity, 9dB extinction ration and $10^{-12}$ BER. Main drawback is the power dissipation which is 4.5 times larger than the I-TIA.

• Proceedings of the IEEK Conference
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• 2003.07b
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• pp.947-950
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• 2003

본 논문에서는 고속 적외선 무선 데이터통신(IrDA) 에 사용되는 트랜스임피던스 증폭기(Transimpedance Amplifier)를 설계하였다. 트랜스임피던스 증폭기는 잡음을 최소화하기 위해 PMOS 차동 구조로 설계하였으며 입력과 출력의 피드백을 통해 주위의 빛에 의해 발생되는 photocurrent 에 의한 DC 옵셋을 제거하였다 또한 공통 게이트(CG)와 Regulated Cascode Circuit (RGC)을 추가하여 대역폭(Bandwidth)을 향상시켰다. 설계한 회로는 0.25 um CMOS 공정을 이용하였으며 트랜스임피던스 이득은 200 MHz의 대역폭에서 10 KΩ (80 dBΩ )이다. 전체 전력 소비는 18 mW이다.

• BMB Reports
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• v.50 no.2
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• pp.60-70
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• 2017

Glaucoma is characterized by a slow and progressive degeneration of the optic nerve, including retinal ganglion cell (RGC) axons in the optic nerve head (ONH), leading to visual impairment. Despite its high prevalence, the biological basis of glaucoma pathogenesis still is not yet fully understood, and the factors contributing to its progression are currently not well characterized. Intraocular pressure (IOP) is the only modifiable risk factor, and reduction of IOP is the standard treatment for glaucoma. However, lowering IOP itself is not always effective for preserving visual function in patients with primary open-angle glaucoma. The second messenger cyclic adenosine 3',5'-monophosphate (cAMP) regulates numerous biological processes in the central nervous system including the retina and the optic nerve. Although recent studies revealed that cAMP generated by adenylyl cyclases (ACs) is important in regulating aqueous humor dynamics in ocular tissues, such as the ciliary body and trabecular meshwork, as well as cell death and growth in the retina and optic nerve, the functional role and significance of cAMP in glaucoma remain to be elucidated. In this review, we will discuss the functional role of cAMP in aqueous humor dynamics and IOP regulation, and review the current medications, which are related to the cAMP signaling pathway, for glaucoma treatment. Also, we will further focus on cAMP signaling in RGC growth and regeneration by soluble AC as well as ONH astrocytes by transmembrane ACs to understand its potential role in the pathogenesis of glaucoma neurodegeneration.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.11C
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• pp.1044-1051
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• 2006

System level diagnosis algorithms use the properties of t-diagnosable system where the maximum number of the faults does not exceed 1. The existing diagnosis algorithms have limit when dealing with large fault sets in large multiprocessor systems. Somani and Peleg proposed t/k-diagnosable system to diagnose more faults than t by allowing upper bounded few number of units to be diagnosed incorrectly. In this paper, we propose adaptive hypercube diagnosis algorithm using t/k-diagnosable system. When the number of faults exceeds t, we allow k faults to be diagnosed incorrectly. Simulation shows that the performance of the proposed algorithm is better than Feng's HADA algorithm. We propose new algorithm to reduce test rounds by analyzing the syndrome of RGC-ring obtained in the first step of HADA/IHADA method. The proposed algorithm also gives similar performance compared to HYP-DIAG algorithm.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.4 s.346
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• pp.16-22
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• 2006

Gigabit transimpedance amplifiers are realihzed in submicron CMOS technologies for Gigabit Ethernet applications. The regulated cascode technique is exploited to enhance the bandwidth and noise performance simultaneously so that it can isolate the large input parasitic capacitance including photodiode capacitance from the determination of the bandwidth. The 1.25Gb/s TIA implemented in a 0.6um CMOS technology shows the measured results of 58dBohm transimpedance gain, 950MHz bandwidth for a 0.5pF photodiode capacitance, 6.3pA/sqrt(Hz) average noise current spectral density, and 85mW power dissipation from a single 5V supply. In addition, a 10Gb/s TIA is realized in a 0.18um CMOS incorporating the RGC input and the inductive peaking techniques. It provides 59.4dBohm transimpedance gain, 8GHz bandwidth for a 0.25pF photodiode capacitance, 20pA/sqrt(Hz) noise current spectral density, and 14mW power consumption for a single 1.8V supply.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.83-88
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• 1984

It is now well established that the rodenticide Vacor (N-3-pyridyl-mehtyl-N'-p-nitropheny-lurea) causes a hyperglycemia in human and rats. It is also reported that there are some components (DPG-3) in ginseng radix which cause hypoglycemic effect on alloxan diabetic mice. In the present study, attempts were made to demonstrate in Vacor-poisoned rats the hypo-glycemic activity of red ginseng component(RGC), which was extracted by Kimura's DPG-3 extraction procedure and found to be effective for lowering a hyperglycemia in alloxan-diabetic rats. Vacor in a dose of $LD_{50}$ (10mg/kg) produced a glucose intolerance with a paradoxical moderate increase in blood immunoreactive insulin and derangement in glucose metabolism of epididymal adipocytes in rats. Although RGC (20mg/kg, i.p.) did not exert any significant influence on a hyperglycemia induced by large lethal doses (25mg/kg) of Vacor ingestion, it improved the LDso Vacor-induced glucose intolerance and caused a further increase in blood insulin levels in Vacor-poisoned rats. The administration of RGC (20mg/kg, i.p.) normalized Vacor-induced depression of glucose metabolism and lipogenesis in the epididymal adipocytes with an improvement of reduced responses to insulin of adipocytes from Vacor-poisoned rats. These results suggest that some red ginsneng components contained in RGC fraction normalize the depressed peripheral glucose unitlization and insulin response and eventually lead to an improvement of abnormal glucose tolerance developed in rats poisoned with small doses of Vacor.

• Journal of The Korean Astronomical Society
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• v.29 no.2
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• pp.181-194
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• 1996

We present a study of the metallicity of the old open cluster NGC 1245 , based on the Washington CCD photometry obtained using the 0.6 m telescope at the Sobaeksan Observatory, Korea. NGC 1245 has been known to be a unique cluster among the known open clusters in the sense that the previous metallicity estimates for this cluster are much larger $(by\;\sigma)$ than the value expected from the radial metallicity gradient of the old open clusters in Our galaxy. We have estimated the metallicity of the cluster red giants using the four color-color diagrams, obtaining a value for the mean metallicity of $[Fe/H] = -0.04\pm0.05$ dex. The total error including the error of the metallicity calibration, 0.15 dex, is 0.16 dex. The metallicity estimate of NGC 1245 we have obtained in this study is smaller than previous estimates, and is consistent with the radial metallicity gradient of the old open clusters, showing that the mean metallicity of NGC 1245 is not abnormally high. The reddening, distance, and age of the cluster have also been derived using the isochrones based on the convective overshooting models: the reddening $E(B-V) = 0.28\pm0.03$; the distance $d = 2.5\pm0.2 kpc$ (the corresponding galactocentric distance is RGC = 10.7 kpc, and the distance from the galactic plane is z = -0.4 kpc); and the age $t = 1.1\pm0.1 Gyrs$.

• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.29.4-30
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• 2009

Extra-tidal feature of the globular clusters such as tidal tails and halos can be a crucial evidence of the merging scenario of the Galaxy formation in the dynamical point of view. To search for such an extra-tidal feature of globular clusters located in the Galactic bulge(RGC<3kpc), we obtained wide-field near-infrared JHKs images of 6 metal-poor ([Fe/H]<-1.0) clusters and 3 metal-rich ([Fe/H]>-1.0) clusters. Observations were carried out using IRSF 1.4m telescope and SIRIUS near-infrared camera, during 2006~2007. The obtained images have a total maximum field-of-view of ~ $21'\times 21'$. To select clusters' member stars and minimize the field star contaminations, we applied CMD masking algorithm. Smoothed surface density contour maps with selected stars for each cluster show overdensity features around the tidal radius and beyond. Also, radial surface density profiles within the tidal radius of the clusters show an overdensity feature as a change of slope of the radial profile. The results add further observational constraints of the formation of the Galactic bulge.