• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.2
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• pp.235-240
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• 2000

Inhibitory effects of cockle extracts on carcinogen-induced cytotoxicity in C3H/10T1/2 cells were studied. Soup (62$\mu\textrm{g}$/mL), solubility (28$\mu\textrm{g}$/mL) and liposolubility (9 $\mu\textrm{g}$/mL) of the cockle inhibited 3-methyl-cholanthrene(MCA)-induced cytotoxicity in C3H/10T1/2 cells by 53 and 94%, respectively. These results suggest that the extracts cockle might have anticarcinogen-induced cytotoxicity of C3H/10T1/2 cells. The effects of cockle extracts on the immune response related to its antitumor activity in vitro and in vivo were investigated. The cockle extracts showed a direct cytotoxic effect on sarcoma-180 cells, tumor cells in vitro. Soup (0.49 mg/mL), solubility (0.11 mg/mL) and liposolubiliy (0.05 mg/mL) of the cockle markedly decreased the total numbers of sarcoma-180 cells, but not their viability. The phagocytic acitivity of peritoneal macrophage of mice was significantly augmented by these extracts of the cockle compared with that of control in vivo. These extracts also raised the phagocuytic index, indicating that the number of phagocytize dmicrobes per macrophage increased. Thus, cockle extracts might show a antitumor activity by enhancing the phagocytic cell activities.

• Animal cells and systems
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• v.4 no.4
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• pp.341-345
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• 2000

It has been very difficult to develop and evaluate efficient fish vaccines because fish immune cells have not been properly characterized. In this study, we investigated the cell-mediated immunological properties of B- and T-like cells in Nile tilapia (Oreochromis nilotica). Surface immunoglobulin negative ($slg^{-}$) cell population proliferated in response to mammalian T-cell mitogens PHA and Con A, while surface immunoglobulin positive ($slg^{+}$) cells responded to the B-cell mitogen LPS. The slg$^{[-10]}$ cells from hemocyanin (HC)-immunized Tilapia, compared to the non-immunized control, reacted more to PHA than to Con A. Unexpectedly, antigen (Ag)-specific response was observed in both $slg^{-}$ and $slg^{-}$cells. Regardless of HC immunization, whole leukocytes from 8 head kidney of fish showed natural killer (NK)cell activity. Especially, NK cell activity was much higher in slg$^{[-10]}$ cells than in slg$^{+}$cells, indicating the possibility that fish NK cells were not at least associated with slg$^{+}$ cell population and not activated by Ag. Further understanding of functional fish immune cells will help to evaluate and develop effective vaccines for fishes and to monitor the course of therapy In infected fishes.hes.

• Corrosion Science and Technology
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• v.20 no.3
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• pp.129-142
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• 2021

Effects of corrosion inhibitors (i.e., sodium nitrite, sodium hexametaphosphate, trimethylamine (TEA), sugar, and urea) on the corrosion resistance of carbon steel in CaCl₂ solution were investigated. The test solution was designed with response surface methodology of design of experiments (DOE) in the range of 0 ~ 50 ppm for NaNO₂, 0 ~ 200 ppm for (NaPO₃)₆, 0 ~ 2000 ppm for TEA, 0 ~ 3000 ppm for sugar, 0 ~ 200 ppm for urea with 3 wt% CaCl₂. The corrosion potential and the corrosion rate were measured with potentiodynamic polarization tests and analyzed statistically to find main effects of inhibitor concentrations and interactions between them. As a result, hexametaphosphate was the most effective compound in reducing the corrosion rate. Sugar also reduced the corrosion rate significantly possibly because it covered the surface effectively with a high molecular weight. The inhibiting action of sugar was found to be enhanced by adding trimethylamine into the solution. Nevertheless, trimethylamine did not appear to be effective in inhibiting corrosion by itself. However, urea and sodium nitrite showed almost no inhibition on corrosion resistance of steel.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2000.11b
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• pp.162-169
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• 2000

This study was carried out to develop a continuously variable-speed transmission(CVT) for agricultural tractor. A full-toroidal CVT mechanism with four discs and six rollers was selected as a device for changing speed ratio continuously. In the step of system layout design, the sizes of roller cylinders and end-load cylinder, which were critical factors for controlling the variator, were designed. Also the control pressure range was designed to limit the contact pressure of variator. In order to make the maximum speed of vehicle as 30km/h, the planetary gear and the six pairs of gears were designed. Also the hydraulic clutch, silent chain, hydraulic manifold and electronic controller were designed. After the design, a prototype with CVT controller was developed and tested. The speed of vehicle was changed continuously to the speed set by driver and the settling time was about 0.52 second at the step-response test (reduction ratio of variator 2.0 to 1.0), which was acceptable as a response time for working with tractor.

• Structural Engineering and Mechanics
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• v.81 no.2
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• pp.147-161
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• 2022

The Brace-Type Shear Fuse (BSF) device is a newly proposed steel damper with excellent cumulative ductility and stable energy dissipation. In consideration of the current situation where there are not many alternatives for transversal seismic devices used in long-span three-tower self-anchored bridges (TSSBs), this paper implements improved BSFs into the world's longest TSSB, named Jinan Fenghuang Yellow River Bridge. The new details of the BSF are developed for the TSSB, and the force-displacement hysteretic curves of the BSFs are obtained using finite element (FE) simulations. A three-dimensional refined finite element model for the research TSSB was established in SAP2000, and the effects of BSFs on dynamic characteristics and seismic response of the TSSB under different site conditions were investigated by the numerical simulation method. The results show that remarkable controlling effects of BSFs on seismic response of TSSBs under different site conditions were obtained. Compared with the case without BSFs, the TSSB installed with BSFs has mitigation ratios of the tower top displacement, lateral girder displacement, tower bending moment and tower shear force exceeding 95%, 78%, 330% and 346%, respectively. Meanwhile, BSFs have a sufficient restoring force mechanism with a minor post-earthquake residual displacement. The proposed BSFs exhibit good application prospects in long-span TSSBs.

• Architectural research
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• v.26 no.3
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• pp.83-92
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• 2024

The profound impact of earthquakes on human lives and the built environment emphasizes the substantial human and economic losses result-ing from structural collapses. Many researchers in this field highlight the longstanding societal challenge posed by earthquakes and under-score the imperative to minimize such losses. Over the decades, researchers have dedicated efforts to seismic design, focusing on improv-ing structural performance to mitigate earthquake-induced damages. This has led to the development of various structural analysis methods. In this research, a specific RC frame structure (401 Bldg.) at Kyungpook National University that is designed for educational purposes, serves as a representative case. This research employs SAP 2000 for simulation, aiming to assess the structural performance under seismic condi-tions, focusing on evaluating the structural behavior under different column orientations. This research utilizes RSA (Response Spectrum Analysis) to comprehensively examine parameters of displacement, base shear force, base moment, joint radians, and story drift. Referring to the results from RSA, this research also assesses the structural performance using LTHA (Linear Time History Analysis) by conducting synthetic frequency domain and synthetic time domain analyses based on the seismic wave from the Kobe 1995 earthquake (Abeno). Based on the findings from the discussions, this research is expected to be a valuable reference for structural design within seismic resistance and the seismic reinforcement of existing RC frame structures.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.4
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• pp.423-432
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• 2019

Along with an increase in marine activities every year, the frequency of marine accidents is on the rise. Accordingly, various research activities and policies for marine safety are being implemented. Despite these efforts, the number of accidents are increasing every year, bringing their effectiveness into question. Preliminary studies relying on annual statistical reports provide precautionary measures for items that stand out significantly, through the comparison of statistical provision items. Since the 2000s, large-scale marine accidents have repeatedly occurred, and case studies have examined the "accident response." Likewise, annual statistics or accident cases are used as core data in policy formulation for domestic maritime safety. However, they are just a summary of post-accident results. In this study, limitations of current marine research and policy are evaluated through a literature review of case studies and analyses of marine accidents. In addition, the ontology of the marine accident information classification system will be revised to improve the current limited usage of the information through an attribute analysis of boating accident status reports and text mining. These aspects consist of the reporter, the report method, the rescue organization, corrective measures, vulnerability of response, payloads, cause of oil spill, damage pattern, and the result of an accident response. These can be used consistently in the future as classified standard terms to collect and utilize information more efficiently. Moreover, the research proposes a data collection and quality assurance method for the practical use of ontology. A clear understanding of the problems presently faced in marine safety will allow "suf icient quality information" to be leveraged for the purpose of conducting various researches and realizing effective policies.

• Asia Marketing Journal
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• v.8 no.1
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• pp.1-17
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• 2006

A couple of previous studies have warned against the use of homogeneous choice models in assessing the effect of reference price since unaccounted for response heterogeneity may result in spurious reference price effects(Chang, Siddarth and Weinberg 1999; Bell and Lattin 2000). According to Meyer and Kahn(1991), not accounting for consideration set heterogeneity may also bias the effect parameters in the choice model. Therefore, failure to account for these two sources of bias, in fact, have cast doubt on the empirical support for reference price effects in general. In view of aforementioned potential sources of bias, the author investigates the robustness of loss aversion effect in the reference-dependent model after accounting for heterogeneity in response as well as consideration set. The proposed model defines individual household's consideration set based on the posterior distribution of preference obtained from the Empirical Bayes approach. In addition, the same posterior distribution is used to form household-specific reference prices. Response heterogeneity correction is carried out via the Latent Class approach. The proposed model outperforms the Reference-Dependent model that includes the reference price measure most often employed in the previous studies. This implies that as a way of simplifying decision task, consumers restrict their consideration set to a subset of available brands not only in making a brand choice but also in forming reference prices.

• Journal of Sasang Constitutional Medicine
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• v.15 no.2
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• pp.64-74
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• 2003

Objectives : To evaluate the properness and effectiveness of the question categories concerning 'total physiognomy', used in Iksan Wonkwang Oriental Medicine. Methods: We statistically analyzed data from those 1335 patients focussing on 'relative discrimination ability' to sasang constructions and 'response ratio'. Patients included in this research are only those who had been well treated in Iksan Wonkwang Oriental Medicine during the Period of three years from 2000 to 2002. The data are obtained through the electronic chart developed by Kim Jong-Yeol, and analyzed using the statistical Package SPSS. Results: The first category for discriminating Taeum type, 'heavy and looking steady', has more discriminating power and effectiveness among women than men, and especially in wemen with an age of 21 or more. The second category for discriminating Soeum type, 'delicate and modest', is more discriminating and effective among men than women, and mostly among men with ages 21-40. The third category for Soyang type, 'fast and brave', is almost equally discriminating and effective to both women and men, especially among women with ages 40 or less and among men with ages 21 or more. Finally, the forth category for discriminating Taeyang type, 'progressive', is neither discriminating nor effective among most the women than men in all age groups. Conclusions: The definition of 'relative discriminating power of constitution' and 'response ratio' are well evaluating the properness and effectiveness of the question categories regarding 'total physiognomy'. The first category is most discriminating and effective among women with ages 20 or less, and the second among 21-40 year old men, the third among women with ages 40 or less and among men with ages 21 or over. The forth category is neither discriminating nor effective.

• Journal of the Korean Chemical Society
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• v.44 no.2
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• pp.115-119
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• 2000

A PVC membrane electrode based on upper-rim calix[4] crown as ionophore was prepared using dioctyl sebacate (DOS) as a plasticizer. The potential response of this membrane electrode to alkali, alka-line earth and transitionmetal metal cations were examined. This membrane electrode exhibited a Nernstian response to $10^{-6}{\sim}10^{-2}M\;Pb(NO_3)_2$ with a slope ot 27.0 mV/decade. Its response time ($t_{90}$) was 10s and it could be used for at least 2 months. Also, the potential was maintained constantly in the rage of ph $2.0{\sim}12$.