• Fashion & Textile Research Journal
• /
• 제2권4호
• /
• pp.346-352
• /
• 2000

The purposes of this study are finding out thermophysiological properties throughout wearing experiment with standard cooling vest as well as providing data in order to design and apply more comfortable cooling vest. To do this study, we produced cooling vest newly. 1. Rectal temperature was ascended approximately from $37.2^{\circ}C$ to $38.05^{\circ}C$ in lab, but wearing cooling vest, the temperature was descended 0.2 while wearing developed product compare with existing product. Mean skin temperature which was showed distribution from $32.8{\sim}36.5^{\circ}C$, it was descended $1.0{\sim}1.1^{\circ}C$, while wearing cooling vest and comparing with existing product, wearing developed product was lower $0.5^{\circ}C$. 2. While wearing developed cooling vest, it was found that they had lower tendency than standard cooling vest. Specifically in case of temperature within clothing (chest) $0.2{\sim}2.0^{\circ}C$ in case of humidity within clothing 2~8%RH. Facts from above we confirmed that clothing microclimate had been improved and space was happened between body and garment in order to control. 3. In subjective sensation, standard cooling vest made negative response during experiment period from participants, but new cooling vest was nearing to comfortable area. It was con finned from above conclusions that wearing developed product is more effective in terms of comfort and reduction of heat stress in situation of working in hot environment.

• Development and Reproduction
• /
• 제4권2호
• /
• pp.243-250
• /
• 2000

To find the mechanism underlying the ADP-induced increase in the outward current in ovulated mouse oocytes, we examined changes in voltage-dependent currents using the whole cell voltage clamp technique and the internal perfusion technique. Eggs were collected from the oviduct of superovulated mice with PMSG and hCG. Membrane potential was held at -60 mV (or -80 mV in the case of recording $Ca^{2＋}$ currents) and step depolarizations or hyperpolarizations were applied for 300 ms. By step depolarizations, outward currents comprising steady-state and time-dependent components were elicited. They were generated in response to the positive potential more than 20 mV with severe outward rectification and were blocked by external TEA, a specific $K^{＋}$ channel blocker, suggesting that they be carried via $K^{＋}$ channels. Internally-perused 5 mM ADP gradually increased outward $K^{＋}$ currents (IK) 1 min after perfusion of ADP and reached slowly to maximum (150~170％) 5 min later over the positive potential range, implying that ADP might not be acted directly to the $K^{＋}$ channels. IK were decreased by 5 mM ATP without affecting the steady-state component of outward current. In contrast to the effect of ADP and ATP on IK, both effect of ATP and ADP on inward $Ca^{2＋}$ currents (ICa) could not be detected due to the continuous decrease in current amplitudes with time-lapse ("run-down" phenomena). To check if there is a G protein-involved regulation in the ionic current of mouse oocytes, 1 mM GTP was applied to the cytoplasmic side, and the outward current and inward currents were recorded. ICa was promptly increased in the presence of GTP whereas IK was not changed. from these results, it is concluded that the ATP-dependent regulation is likely linked in the ADP-induced increase in the outward $K^{＋}$ current, and G protein-involved cellular signalling might affect ion channels carrying $Ca^{2＋}$ and $K^{＋}$ in mouse oocytes.

• Development and Reproduction
• /
• 제4권1호
• /
• pp.61-66
• /
• 2000

This study was investigated to analyze the inactivating point mutation and expression level of follicle-stimulating hormone(FSH) receptor mRNA. In first experiment, we analyzed the point mutation. Peripheral blood was collected from each patient. To screen individuals for the C566T mutation, PCR was performed for exon 7 of the FSH receptor gene in 10 patients. No inactivating point mutation of FSH receptor gene was identified in women with premature ovarian failure. To analyze the expression level of FSH receptor, mRNA expressions were examined by RT-PCR method using specific primers for the FSH receptor. The amount of FSH receptor mRNA expressed in POF patients was lower than that in the control group. But it was not significantly different. These finding suggests that lower expression of FSH receptor in premature ovarian failure patients might be the cause of the low response to the gonadotropin during the hyperstimulation in IVF-ET cycles.

• Development and Reproduction
• /
• 제4권1호
• /
• pp.29-35
• /
• 2000

A phosphatidylinositol 3-kinase (PI3K) is a upstream component of insulin signaling by which protein synthesis can be stimulated in many systems. To elucidate involvement of PI3K and its downstream mammalian target of rapamycin (mTOR) in the insulin signaling in pleimplantation mouse embryos, 8-cell embryos were cultured to blastocysts in the presence or absence of insulin and／or inhibitor drugs. The number of blastomeres per blastocyst, protein synthesis, and protein phosphorylation were examined. There was significant difference in embryonic development to blastocyst stage and hatching was potentiated by the insulin supplementation. The increase in the mean celt numbers per blastocyst was apparent in the insulin culture. Wortmannin, a PI3K inhibitor and rapamycin, an inhibitor of mTOR abolished the stimulatory effect of insulin on morphological development mitosis and protein synthesis. In autoradiography, phosphoproteins pp22 and pp30 which undergo phosphorylation in response to insulin were identified. Taken together, it can be suggested that PI3K and mTOR engaged in insulin signaling in the mouse embryo 8-cell onward and mediate embryotropic offset of insulin.

• Archives of design research
• /
• 제13권4호
• /
• pp.145-154
• /
• 2000

Higher educational results might come from the rational method of curriculum operation. Therefore, every subject in the major course should be planned to response the specialty of students and the efficient method of education are still more needed in technical college, in which students have to get the specialty on the short period of education. Because each subject in the major course works as the close cause and result of educational goal to form the specialty of students, the achievement of educational results in each subject is an important studying part of the educators in technical college. This study is a case of the approaching method for the improvement of learning effect by the connection of subjects 'Space Design' and 'Computer Aided Design' in the Dept. of Industrial design. It is considered to achieve two subjects' educational goals by leading up the students' learning concentration from the comprehension and experience about the co-relationship of the two subjects. And it shows the results of this approaching method such as students could get the design technology of the two subjects, and they could have self-confidence to the managing of the design process and planning of the design works as well.

• Korean Journal of Acupuncture
• /
• 제24권2호
• /
• pp.99-112
• /
• 2007

Objectives : It was to translate three neck and spinal pain disability questionnaires - the Neck Disability Index (NDI), the Neck Pain and Disability Scale (NPDS), and the Functional Rating Index (FRI) - into Korean language, and evaluate the psychometric properties of Korean versions of questionnaires to achieve a good cross-cultural adaptation. Methods : Forty (23 males, 17 females) subjects aged from 15 to 64 years old, participated to examine test-retest reliability. One hundred and eighty (76 males, 104 females) subjects with a primary diagnosis of non-specific neck pain and 81 healthy volunteers were undertaken to examine internal consistemcy, discriminative validity and longitudinal construct validity. Versions of each questionnaire in idiomatic modern Korean were developed using a procedure proposed by Beaton et al. (2000). To assess reliability, the Intraclass Correlation Coefficient (ICC $_{(2,1)}$) was calculated. Internal consistency was evaluated by Cronbach's alpha. Discriminative validity was examined with independent-group t-tests. Responsiveness was tested by calculating the effect size and standardized response mean for each questionnaire and using Pearson' s r and the area under the receiver operating characteristic curve analysis. Results : Test-retest reliability ofthe translated versions of the three disability questionnaires was excellent (ICC $_{(2,1)$ = 0.86-0.90). High internal consistency was found in the three disability questionnaires (Cronbach's alpha ranged from ${\alpha}=0.88$ for the FRI to ${\alpha}=0.96$ for the NPDS and 0.82 for the Short Form McGill Pain Questionnaire(SFMPQ)). the VAS subscale of the SFMPQ was found to be the most responsive of the subscales (ES=1.44, SRM=1.37). The VAS was also the most responsive pain and disability index in internal responsiveness analysis, although disability indices showed marginally better responsiveness when compared with external standards. No floor or ceiling effects were observed. Conclusions : It is concluded that the questionnaires were successfully translated and exhibit acceptable measurement properties, and may suggest that they are suitable for use in clinical and research application.

• Toxicological Research
• /
• 제21권1호
• /
• pp.45-49
• /
• 2005

The purpose of this study is to evaluate the free radical scavenging ability and xanthine oxidase inhibitory activity of a complex herbal bath consisted of Artemisiae argyi folium, Angelicae sinensis radix, Ligustici wallichii radix and Angelicae tuhuo radix, and its potential irritation response were also tested for safety use in the rabbits. For antioxidative activity, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the complex herbal bath were examined at five different concentrations (0, 250, 500, 1000 and 2000 ㎍/ml). The concentration of the complex herbal bath required for scavenging DPPH free radical by 50% was 897.2 ㎍/ml. In the inhibition of xanthine oxidase (XO) activity, the concentration of the complex herbal bath required for 50% of inhibition was 221.4 ㎍/ml. In the skin irritation study in rabbit, all animals survived for the duration of the study and the examined skin exhibited no edema, erythema, and eschar formation. In the ocular irritation study in rabbit, after application of the sample to eyes, all of the eyes were normal. In summary, the complex herbal bath has potent antioxidant effects against the DPPH radical and XO and was considered to be a non-irritation bath for safety use.

• Tunnel and Underground Space
• /
• 제10권1호
• /
• pp.25-32
• /
• 2000

This paper presents two new extensions to the DDA method. The extensions consist of sequential loading or unloading and rock reinforcement by rockbolts, shotcrete or concrete lining. Examples of application of the DDA method with the new extensions are presented. Simulations of the underground excavation of the Unju Tunnel of Kyungbu High Speed Railway Project in Korea were carried out to evaluate the influence of excavation sequence and reinforcement on the tunnel stability. The results of the present study indicate that improper selection of excavation sequence could have a destabilizing effect on the tunnel stability. On the other hand, reinforcement by rockbolts and shotcrete can stabilize the tunnel. It is found that, in general, the DDA program with the three new extensions can now be used as d practical tool in the design of underground structures. In particular, phases of construction (excavation, reinforcement) can now be simulated more realistically.

• Tunnel and Underground Space
• /
• 제10권2호
• /
• pp.173-179
• /
• 2000

The influence of the plastic flow rules on the elasto-plastic behaviour of a discrete joint element was investigated by performing the numerical direct shear tests under both constant normal displacement and normal displacement conditions. The finite interface elements obeying Plesha’s joint constitutive law was used to allow the relative motion of the rock blocks on the joint surface. Realistic results were obtained in the tests adopting the non-associated flow rule, while the associated flow rule overestimated the joint dilation. To overcome the computational drawbacks coming from the non-symmetric element stiffness matrix in the conventional non-associated plasticity, the symmetric formulation of the tangential stiffness matrix for a non-associated joint element was proposed. The symmetric elasto-plastic matrix it derived by assuming an imaginary equivalent joint with associated flow rule which shows the same plastic response as that of original Joint with non-associated flow rule. The validity of the formulation was confirmed through the numerical direct shear tests under constant normal stress condition.

• Tunnel and Underground Space
• /
• 제10권2호
• /
• pp.237-248
• /
• 2000

Based on the preliminary results from the therm analysis, which is currently carrying, three-dimensional computer simulations using a finite element code, ABAQUS Ver. 5.8, were designed to determine the mechanically stable cavern and deposition hole spacing. Linear elastic modeling for the cases with different cavern and deposition hole spacing were carried out under three different in situ stress conditions. From the simulations, the response of the rock to the stress redistribution after the excavation of the openings could be investigated. Also the optimum cavern and deposition hole spacing could be estimated based on the factor of safety. When the in situ stress determined from the actual stress measurements in Korea were used, the case with cavern spacing of 40m and deposition hole spacing of 3m was in very stable condition, because the factor of safety was calculated as 3.42., When the in situ stress conditions for Sweden and Canada were used, the previous case, they seem to be in stable condition, since the factors of safety are still higher than 1.0. From these results, it was concluded that the rock will not fail even after the stress redistribution.