• The Journal of Internal Korean Medicine
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• v.28 no.3
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• pp.662-669
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• 2007

Objectives : The aim of the present study is to derive further studies evaluating the effectiveness of oriental medical treatment on colon cancer patients. We present a case of a patient diagnosed with colon cancer with colon cancer with liver metastasis who has survived more than 8 years. Methods : We followed all of treatments and examination. We prescribed the patient to take HangAm-dan(HAD) three times a day for 5 years and 1 month from January, 2000 to February, 2005. Abdominal computed tomography(CT) was performed to evaluate the therapeutic efficacy and measuring concentration of carcinoembryonic antigen(CEA) in blood serum was also performed to monitor therapeutic response. Results : The patient was diagnosed with liver metastasis in September of 1999 but has survived for over 8 years since. Abdomen CT show no interval change. Conclusions : This case may give us a possibility that oriental medical treatment offers potential benefits for patients with colon cancer.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1997.04a
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• pp.283-289
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• 1997

A 500Wh class high-speed Flywheel Energy Storage System (FESS) driven by a built-in BLDC motor/generator has been designed, which runs from 30000 to 60000rpm nominally. Due to the motor/generator inside, the flywheel rotor made of composites supported by PM/EM hybrid bearing system has a shape of bell or pendulum and thus requires accurate rotordynamic analyses and prediction of its dynamic behavior to secure the operating reliability. Rotordaynamic analyses of the flywheel rotor-bearing system revealed that the bell shaped rotor has two conical rigid-body modes in the system operating range and the first conical mode, of which nodal point lies in the radial EM bearing position, can adversely affect the dynamic response of the rotor at the corresponding critical speed. To eliminate the possibility of wild behavior of the rotor, two guide bearings are adopted at the upper end of the rotor and motor/generator. It was also revealed that the EM bearing stiffness of 0.5~1.0E+6 N/m and damping of 2000 Ns/m are favorable for smooth operation of the system around the 2nd critical speed.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.19 no.12
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• pp.1306-1314
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• 2009

By rising the interests of the railroad, It has been required the research about railroad structure. And since 2000, the study about railway bridges caused by steel box railway bridges has been only 0.2 %. So I was hard to find out about steel box railway bridges. In this study, I evaluate and analyze 4 types(KTX, Saemaeul, Mugunghwa, Freight) of dynamic caused by train loading, natural frequency and damping ratio, verticality deflection and verticality acceleration, end slope deflection, impact factor for dynamic characteristics analysis. natural frequency was measured 2.45 Hz~3.34 Hz and damping ratio revealed for 1.26~2.84 %. Maximum verticality deflection(4.86 mm) was sufficiently satisfied the design criteria(30.1 mm), but in the case of verticality acceleration's respond, design criteria BRDM(bridge design manual) & CTRL presentation derive rail limit value 0.35 g be more than value 6 time recorded, maximum was measured 0.49 g in 3 kinds of train(KTX, Saemaeul, Mugunghwa), except for Freight. Survey impact factor of Experiment bridge was 0.20 which is measured when the KTX(15:04) was driving. impact factor is enough contended with design criteria 0.29 which is presented in domestic railway design criteria and thoroughly guarantee the dynamic stability.

• Science of Emotion and Sensibility
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• v.3 no.2
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• pp.103-112
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• 2000

본 연구는 Graphic simulator에서 자동차 속도 변화에 따른 운전자의 감성변화를 주관적 평가와 자율신경계의 반응을 통해 알아보고자 한다. 속도 변화는 정차(0km/h), 40km/h, 100km/h, 160km/h로 제시하였고, 건강한 10명의 피험자를 대상으로 심박변화율, 피부저항, 피부온도, 맥파 등의 생리신호를 측정하였다. 본 연구 목적에 적절한 속도 관련 어휘를 추출하여 각 속도에서의 주관적 감성 변화를 평가하였다. 또한, 각 속도 실험 전 후에 Simulator Sickness를 측정하여 Simulator Sickness가 실험 결과에 미치는 영향을 분석하였다. 속도가 증가함에 따라 긴장도와 쾌도가 증가한다는 주관적 평가 결과를 얻었다. 실험 전에 비해 실험 후의 Simulator Sickness 값은 증가하였지만 실험 전, 후의 통계적 차이는 관찰할 수 없었다. 속도 증가에 따라, 평균 R-R간격, 피부온도의 진폭은 감소하였고, 피부저항은 증가하였고, 맥파의 평균 진폭은 감소하였다. 그러므로 본 연구를 통해 Simulator Sickness의 큰 영향 없이 Graphic Simulator에서 속도의 증가에 따라 교감신경계가 활성화됨을 관찰할 수 있었고, 이는 실제 동적 환경에서 속도 변화에 따른 자율신경계의 반응 및 주관적 평가 결과와 일치하는 것이다. 향후 복합 감각 자극이 가능한 시뮬레이터가 구축이 될 것이고, 이를 통해 보다 현실감 있는 동적 환경 제시와 감성 측정이 가능할 것이다.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.381-381
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• 2000

Lectin binding assay was conducted on 3 A. tamarense isolates (AT-A, AT-2 and AT-6). Fatty acid composition of all 3 isolates was analyzed, and total carotenoid content and $\beta$-carotene were also determined. AT-A and AT-2 treated with different lectins in this study showed the positive response, whereas potentially toxic AT-6 did not bind DBA lectin, regardless of different growth phase, but conjugated ConA, PNA, RCA, SBA, UEA and WGA. It is possible that DBA is a desirable method for rapid and easy discrimination of highly toxic A. tamarense. AT-A, AT-2 and AT-6 comprised saturated fatty acids (49.0-61.9%), monounsaturated fatty acids (8.0-20.5%) and polyunsaturated fatty acids (23.2-30.5%). In particular, 22:6 (n-3) polyunsaturated fatty acid in AT-6 had a high abundance, compared with AT-A and AT-2. However, carotenoid content and $\beta$-carotene were not contributed to discriminate each isolate. Due to variability in biochemical composition at different isolates, possibly DBA and 22:6 (n-3) polyunsaturate fatty acid provide a good information for discrimination of AT-6.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.446-446
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• 2000

Specific polyclonal and/or monoclonal antibodies (MAbs) to immunoglobulins (Igs) and their subunits have proved to be valuable tools in immunological research and in immunological assays. In this study, we developed and characterized MAbs against flounder serum Igs. To obtain the pure flounder serum Igs, mouse IgG (mIgG) was immunized to flounder. Flounder Igs were purified by using mIgG-agarose affinity column chromatography. The structure of purified flounder Ig was observed, on denatured SDS-PAGE, to be composed of two heavy chains (77 and 72 kd) and two light chains (28 and 26 kd). MAbs were produced by fusion of myeloma cells (SP2/0) with Balb/c mouse spleen cells previously primed with the flounder Igs. Finally, three hybridoma clones, FIM 511, FIM 519 and FIM 562 were established to recognize both 2 heavy chains, 26 kd of light chain and 28 kd of light chain, respectively. On the other hand, the flounder immune sera collected on the weekly basis were tested on ELISA and immunoblot analysis whether boosting effect is present in flounder humoral immune system. As a result, the secondary immune response in flounder was ascertained on ELISA, but not on immunoblot analysis. Further, we observed an alteration of serum protein levels following immunization. Our MAbs and basic information on flounder humoral immune system obtained in this study will be helpful to control and monitor the efficiency of fish vaccines and therapeutic process of flounder diseases.

• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.5
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• pp.169-175
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• 2013

CRDi technology of diesel engine was developed from in the early 2000s due to a need to increase fuel efficiency and environment care. Especially, high-pressure fuel injection system in CRDi system which has a fuel injection unit including an injector, a fuel pump and common-rail, etc. becomes possible to make the exhaust gas clean as well as power improvement. In this study, comparison of dynamic characteristics of servo-hydraulic piezo-driven injector with 3-way and bypass-circuit type was analyzed by using the AMESim code. As results of this study, it found the bypass-circuit inside servo-hydraulic piezo injector can cause a faster injection response than that of the 3-way type. Also it was shown that bypass-circuit type had better control capability due to hydraulic bypass system.

• Science of Emotion and Sensibility
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• v.3 no.1
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• pp.7-16
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• 2000

본 연구에서는 화상 시뮬레이터 상에서 저속 (40km/h) 주행과 고속 (160km/h) 주행으로 지루감 및 긴장감을 유발시킨 후, 100%의 Jasmine abs와 Lavender oil france (KIMEX Co. Ltd)의 향 자극이 지루함 및 긴장감의 증감에 미치는 영향을 알아보고자 한다. 건강과 피험자 10명을 대상으로 심전도, 피부온도, 맥파의 자율신경계 반응을 측정하였다. 또한 각 실험 전후에 Simulator Sickness를 측정하여 Simulator Sickness가 실험 결과에 미치는 영향을 분석하였다. 지루한 저속 주행 시 향자극이 없을 때에 비해 각 향을 제시하였을 때 각성 효과가 발생하여 교감 신경계가 활성화됨을 자율신경계 반응으로 관찰할 수 있었다. 그러나 두 가지 향에 따라 큰 차이는 발생하지 않았다. 본 연구로부터 일정하고 느린 주행으로 유발되는 신체의 이완 현상 또는 졸리움 현상이 향 자극에 의해 감소되는 경향을 자율 신경계의 반응을 통해 관찰할 수 있었다. 고속 주행 시에는 향을 제시하지 않았을 때보다 두 가지 향을 제시하였을 때 긴장감이 모두 이완되는 경향을 나타내었다. 따라서 고속 주행으로 유발되는 신체의 긴장감이 향 자극으로 인해 감소된다는 사실을 자율신경계의 반응을 통해 관찰할 수 있었다. 그러므로 본 연구로부터 지루한 저속 주행으로 유발된 신체의 이완감과 고속 주행으로 유발된 신체의 긴장감은 각 향 자극에 의해 이완감의 감소와 긴장감의 감소를 유발하였다는 사실을 관찰할 수 있었고, 두 향의 차이는 관찰할 수 없었다.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.5
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• pp.340-344
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• 2000

Microbial oxidation of D-sorbitol to L-sorbose by Acetobacter suboxydans is of commercial importance since it is the only biochemical process in vitamin C synthesis. The main bottleneck in the batch oxidation of sorbitol to sorbose is that the process is severely inhibited by sorbitol. Suitable fed-batch fermentation designs can eliminate the inherent substrate inhibition and improve sorbose productivity. Fed-batch sorbose fermentations were conducted by using two nutrient feeding strategies. For fed-batch fermentation with pulse feeding, highly concentrated sorbitor (600g/L) along with other nutrients were fed intermittently in four pulses of 0.5 liter in response to the increased DO signal. The fed-batch fermentation was over in 24h with a sorbose productivity of 13.40g/L/h and a final sorbose concentration of 320.48g/L. On the other hand, in fed-batch fermentation with multiple feeds, two pulse feeds of 0.5 liter nutrient medium containing 600g/L sorbitol was followed by the addition of 1.5 liter nutrient medium containing 600g/L sorbitol at a constant feed rate of 0.36L/h till the full working capacity of the reactor. The fermentation was completed in 24h with an enhanced sorbose productivity of 15.09g/L/h and a sorbose concentration of 332.60g/L. The sorbose concentration and productivity obtained by multiple feeding of nutrients was found to be higher than that obtained by pulse feeding and was therefore a better strategy for fed-batch sorbose fermentation.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.13 no.8
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• pp.704-710
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• 2000

Metal electrode materials for plasma display panel should have low electrical resistivity in order to maintain stable gas discharge and have fast response time. They should also hae good film uniformity adhesion and thermal stability. In this study Cr/Cu/Cr metal electrode structure is formed by DC magnetron sputtering. Cr and Cu films were deposited on ITO coated glasses with various DC power density and main pressures as the major parameters. After metal electrodes were formed a heat treatment was followed at 55$0^{\circ}C$ for 20 min in a vacuum furnace. The intrinsic stress of the sputtered Cr film passed a tensile stress maximum decreased and then became compressive with further increasing DC power density. Also with increasing the main pressure stress turned from compression to tension. After heat the treatment the electrical resistivity of the sputtered Cu film of 2${\mu}{\textrm}{m}$ in thickness prepared at 1 motor with the applied power density of 3.70 W/cm$^2$was 2.68 $\mu$$\Omega$.cm With increasing the main pressure the DC magnetron sputtered Cu film became more open structure. The heat treatment decreased the surface roughness of the sputtered Cr/Cu/Cr metal electrodes.