• Biomolecules & Therapeutics
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• v.30 no.5
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• pp.409-417
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• 2022

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, and accumulating evidence indicates that mitochondrial dysfunction is associated with progressive deterioration in PD patients. Previous studies have shown that sinapic acid has a neuroprotective effect, but its mechanisms of action remain unclear. The neuroprotective effect of sinapic acid was assayed in a PD mouse model generated by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as in SH-SY5Y cells. Target protein expression was detected by western blotting. Sinapic acid treatment attenuated the behavioral defects and loss of dopaminergic neurons in the PD models. Sinapic acid also improved mitochondrial function in the PD models. MPTP treatment increased the abundance of mitochondrial fission proteins such as dynamin-related protein 1 (Drp1) and phospho-Drp1 Ser616. In addition, MPTP decreased the expression of the REV-ERB α protein. These changes were attenuated by sinapic acid treatment. We used the pharmacological REV-ERB α inhibitor SR8278 to confirmation of protective effect of sinapic acid. Treatment of SR8278 with sinapic acid reversed the protein expression of phospho-Drp1 Ser616 and REV-ERB α on MPTP-treated mice. Our findings demonstrated that sinapic acid protects against MPTP-induced PD and these effects might be related to the inhibiting abnormal mitochondrial fission through REV-ERB α.

• Journal of Korean Society of Forest Science
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• v.110 no.2
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• pp.210-216
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• 2021

Musculoskeletal disorders affect workers' safety in most industries, and forest operations are classified as a musculoskeletal burden according to the Occupational Safety and Health Act in South Korea. In particular, felling and delimbing operations are mainly conducted by manpower, and then, it is necessary to evaluate ergonomic risk assessment for safety of felling and delimbing workers. Three ergonomic risk assessment methods, such as Ovako Working posture Analysis System (OWAS), Rapid Upper Limb Assessment (RULA), and Rapid Entire Body Assessment (REBA), are available for assessing exposure to risk factors associated with timber harvesting operations. Here, three ergonomic risk assessment methods were applied to examine ergonomic risk assessments in chainsaw felling and delimbing operations. Additionally, exposure to risk factors in each method was analyzed to propose an optimal working posture in felling and delimbing operations. The risk levels of these operations were evaluated to be highest in the RULA method, followed by the OWAS and REBA methods, and most of the exposed working postures were examined with a low-risk level of two and three without requiring any immediate working posture changes. However, two significant working postures, including the bending posture of the waist and leg in felling operation and standing posture on the fallen trees in delimbing operation, were assessed as the high-risk level and needed immediate working posture changes. Low-risk work levels were examined in the squatting posture for felling operation and the straightened posture of the waist and leg for delimbing operation. Moreover, the slope in felling operation and the tree height in delimbing operation significantly affected risk level assessment of working posture. Therefore, our study supports that felling and delimbing workers must operate with low-risk working postures for safety.