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Analgesic effect of Daeganghwal-Tang on a rat model of CFA-induced arthritis (CFA에 의해 유도된 백서(白鼠)모델 관절염(關節炎)에서 대강활탕(大羌活湯)의 진통효과(鎭痛效果))

  • Seo, Yoon-Jung;Koo, Sung-Tae;Yang, Yoon-Jung;Kim, San;Yoo, In-Sik;Lim, Kyu-Sang
    • Korean Journal of Acupuncture
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    • v.21 no.4
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    • pp.83-99
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    • 2004
  • Objectives : Daeganghwal-Tang(DGHT) is one of the prescriptions used for the treatment of rheumatoid arthritis(RA) in oriental medicine. The present study aimed to examine the analgesic effect of DGHT on a rat model of CFA-induced arthritis, and the relations between DGHT-induced analgesia and endogenous nitric oxide(NO) and inducible NO synthase(iNOS)/neuronal NOS. Methods : CFA-induced arthritis model used to test the effect of DGHT was chronic pain model. After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 18 days. the reduced stepping force of the limb was presumably due to a painful knee. DGHT dissolved in water was orally administrated. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 4 hours. Results : DGHT produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 2 hours. DGHT produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner. Both NO production and nNOS/iNOS protein expression which is increased by arthritis were suppressed by DGHT administration. Conclusions : The data suggest 1) that DGHT produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and 2) that DGHT-induced analgesia modulate endogenous NO through the suppression of nNOS/iNOS protein expression.

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Analysis of Images of Scientists and Science Learning Drawn by Third Grade Students (초등학교 3학년의 과학자와 과학 학습에 대한 이미지 분석)

  • Ju, Eun-Jeong;Lee, Soo-Young;Kim, Jae-Geun;Lee, Jane Ji-Young
    • Journal of Korean Elementary Science Education
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    • v.28 no.1
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    • pp.35-45
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    • 2009
  • We analyzed $3^{rd}$ graders' images of scientists and science learning students. We chose $3^{rd}$ graders because this is the time when children first encounter formal science learning opportunities. Draw-A-Scientist-Test (DAST) and the revised Draw-A-Scientist-Test Checklist (DAST-C) were used to analyze students' images of scientists, whereas Drawing-A-Science-Learner- and a checklist were used to analyze students' images of science learning students. We found that $3^{rd}$ graders showed common features of scientists who wore laboratory coats but not wearing glasses, goggles or masks and smiling. While most boys drew a male scientist, about a half of girls drew female scientists. Old and weird looking images of scientists that were typically known in other literatures were not found in this study. Science learning students were not wearing lab coasts, glasses, goggles, nor masks. Most of those students were conducting chemistry related experiments, which seemed to be influenced by the $3^{rd}$ grade's science curriculum. We also found relationships among components of images of scientists and science learning students. Although $3^{rd}$ graders' images of scientists and science learning students showed common features, this typical image was not the same as the previous studies have reported. This implies that the images of scientists and science learning students have not yet fixed by $3^{rd}$ grade. Thus, this seems to be a critical time when children start developing images of scientists. Children's direct experiences in the science classroom along with environmental factors such as media exposures can influence their formation of images of scientists and science learning students.

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A Questionnaire Analysis about the Female Patients with Functional Gastrointestinal Disturbance and Effect of Oriental Medical Treatment (설문을 통한 여성 기능성 위장장애 환자의 경향과 한방치료 효과에 대한 연구)

  • Lee, Soo-Jung;Kim, Hyo-Jin;Han, Hyun-Young;Lee, Su-Young;Kim, Jong-Hwan;Kim, Won-Il
    • Journal of the Korean Institute of Oriental Medical Informatics
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    • v.15 no.2
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    • pp.101-113
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    • 2009
  • Objectives: Nowadays, the number of patients having the Functional Gastrointestinal Disturbance has been on the rise and this tendency is clear in the female group. This study is aimed to investigate their cause of disease, dietary lifestyle, digestion functions, general symptoms and any disadvantages in daily lives etc. Also, it would suggest any effective results from oriental medical treatments. Methods: The total number of 20 female patients, who have been participated in this study, have been treated at Oriental Internal Medicine, Dong-eui Hospital. We have performed the survey with 50 questionnaires. Results: Most patients were having dyspepsia and had been treated more than once before the survey. The major cause of their disease includes irregular eating habits(p<0.05) and stressful mental conditions. The patients had suffered much disadvantages in daily lives and different symptoms. Specially, pain in the below of stomach pit and early satiation were common.(p<0.05) However, the Discomfort index of patients has been decreased from 9.22 point to 2.85 point after oriental medical treatment. It means this treatment has meaningful effectiveness to the Functional Gastrointestinal Disturbance patients. Conclusion: We have investigated the features of female patients with Functional Gastrointestinal Disturbance and conclude that the Oriental Medical Treatment is effective to them.

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System Analysis for Receiving Performance Improvement of Mobile Station in PCS (개인휴대통신에서 이동국의 수신성능개선을 위한 시스템 분석)

  • Ju, Jae-Han;Park, Se-Seung;Park, Jong-An;Cheon, Jong-Hun
    • The Transactions of the Korea Information Processing Society
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    • v.6 no.1
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    • pp.159-166
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    • 1999
  • In this paper, we examined noise figure and the 3rd order intercept point in sensitivity single tone desensitization, and response attenuation by intermodulation spurious of receiver and also analyzed them through simulation based on J-STD-0.18, which is the minimum specification of PCS mobile station. The result of simulation was as follows ; In sensitivity specification, the total noise figure was 5.99dB and the 3rd order intercept point was -33.979dB. Ins ingle tone desensitization and intermodulation spurious response attenuation specification, the total noise figure was 6.375dB and the 3rd order intercept point was -26.99dBm. When there is an interference tone, the nosie figure and the 3rd order intercept point have been increasedly 0.367dB respectively, compared wit that of no interference tone. Because the amount of increase in the 3rd order intercept point was highly raised more than that of noise figure, mixer, closely related to interference tone should be specified in high 3rd order intercept point. At a frequency spacing of 1.25MHz and 2.05MHz from center frequency in IF SAW filter, attenuation should be more than 45dB.

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SAR Test-bed to Acquire Raw Data and Form Real-time Image (실시간 영상형성 및 원시데이터 획득용 SAR 테스트 베드)

  • Shin, Hyun-Ik;Kwon, Kyoung-Il;Yoon, Sang-Ho;Kim, Hyung-Suk;Hwang, Jeonghun;Ko, Young-Chang;You, Eung-Noh;Kim, Jin-Woo
    • Journal of the Korea Institute of Military Science and Technology
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    • v.20 no.2
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    • pp.181-186
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    • 2017
  • Synthetic aperture radar(SAR) has been widely used for reconnaissance. It provides high-resolution, day-and-night and weather-independent images for a multitude of applications. Because SAR coherently combines many viewing angles to effectively create a large aperture(narrow beam) radar, the test-bed should be capable of moving straightly SAR sensor for the integration angle to meet resolution. This paper describes the test-bed developed to test and evaluate the SAR performance. It forms high-quality images in real time and saves the raw data for the purpose of post processing on the ground.

Initial Stage of Atmospheric Corrosion of Carbon and Weathering Steels in Thailand Climate

  • Nii, K.;Bhamornsut, C.;Chotimongkol, L.;Vutivat, E.;Nakkhuntod, R.;Jeenkhajohn, P.;Suphonlai, S.
    • Corrosion Science and Technology
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    • v.2 no.4
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    • pp.183-188
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    • 2003
  • Corrosion of carbon and weathering steels were evaluated under 3 environmental exposures in Thailand (urban, rural and marine) for a year. The seasonal study was designed to determine different corrosion mechanisms by 6 months of dry season and 6 months of rainy season in a year. The sheltered exposure racks were used to determine the washing effect of min. At each site, climatic and pollutants analyses were carried out. The present study showed that the difference in corrosion rates of carbon and weathering steels was not so distinguished in both rural (AIT) and urban (TISTR) environments. The corrosion rate of weathering steel was somewhat lower than that of carbon steel and the decreasing tendency of corrosion rate with time was slightly higher for weathering steel than for carbon steel. In marine (Rayong) environment, the corrosion rate was higher and the effect of wet and dry seasons was observed. The corrosion rate in 6 dry months was higher for direct exposure than for sheltered exposure. However, in 6 rainy months. the corrosion rate of sheltered exposure was higher than that of direct exposure. In direct exposure for I year, that is, the first 6 dry months and the next 6 rainy months, the corrosion rate decreased with time. but in sheltered exposure, the corrosion rate did not decrease with time. instead, increased in the next 6 rainy months. This indicated that the protect ive layer formed in the first 6 dry months could be destroyed by high deposition of chloride to r sheltered exposure in the next 6 rainy months; whereas the rust layer for direct exposure could be kept sound due to washing effect in rainy season, even though the deposition rate of chloride was almost the same for direct and sheltered exposures. In marine environment, the weathering steel showed higher corrosion resistance than carbon steel but its corrosion rate was higher than those in other environments.

An evaluation of stream naturalness for Close-to-nature stream restoration in case of Hakui Stream (학의천을 중심으로 본 자연형 하천복원을 위한 하천자연도 평가)

  • Kim, Dong-Chan;Yoon, Young-Seok;Park, Ik-Su
    • Journal of the Korean Society of Industry Convergence
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    • v.6 no.4
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    • pp.315-324
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    • 2003
  • The purpose of this is to evaluate Hakui Stream Naturalness Index(S.N.I). and to find out stats, problems and opportunities of the Hakui stream by assessment standard. Assessment standard is mainly based on physical structure of stream environment. The purpose evaluating sectors and elements are physical form and structure restoration of stream. To find out assessment standard of stream naturalness index, conceptual frame of assessment standard has been established, for which four sections, for example, longitudinal section, lateral section, stream bottom structure and water environment, have been selected. Overall stream naturalness index of the Hakui stream has been distributed at 3rd to 4th grade, and its assessment index accounted for 3.2 to be 3rd grade, and its mode also did 3rd grade. Stream naturalness index of each section was as follows: Longitudinal section index accounted for 3.6 in average to be 4th grade, and later section index did 3.0 to be 3rd grade, and stream bottom structure index did 3.0 to be 3rd grade, and water environment index did 2.7 to be 3rd grade. Analysis of assessment outcome of stream naturalness index has checked status, Problems and opportunities of corresponding stream. Assessment of stream naturalness index of the study provides useful information for restoration of close-to-nature stream, and furthermore has its meaning in checking problems and opportunities of Hakui stream.

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The Effects of the Routine Mental Care with 10% Betadine on the Reduction of Catheter-Associated Urinary Tract Infection (베타딘을 사용한 외요도구 간호가 유치도뇨관 삽입환자의 요로감염에 미치는 영향)

  • 김필환;김영경
    • Journal of Korean Academy of Nursing
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    • v.29 no.3
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    • pp.614-624
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    • 1999
  • The purpose of this study is to determine the effectiveness of routine meatal care on the reduction of catheter-associated urinary tract infection (UTI). The study was carried out on 30 patients with foley catheters in an intensive care unit of a general hospital from September 30 to April 1, 1998. Participants were both male and female. Data were collected from each patients by urinary specimen obtained with aseptic collection technique at the 3rd and the 7th day of the experiment after giving daily mental care with 10% betadine for periods ranging from 1st to 7th day to the experimental group but not to the control group. The results are as follows : 1. The rate of urinary tract infection within the experimental group was 0.0%, at the 3rd day of the experiment and 20.0% at the 7th day, but that of the control group was 20.0% at the 3rd day and 7% at the 7th day. There was a significant difference in urinary tract infection rate between the two groups at the 3rd day but no significant difference at the 7th day. 2. In the control group, the rate of UTI was 0.7% for male and 13.3% for female at the 3rd day, and 6.7% for male and 40% for female at the 7th day. In the experimental group, the rate of UTI was 6.7% for male and 0.0% for female at the 3rd day and 13.3% for male and 20% for female at the 7th day of experiment. There was a no significant difference between male and female. 3. By comparing the rate of UTI to the length of time the urinary catheter was in place, the longer the catheter was in place the more significant was the rate of UTI. 4. Microorganisms isolated in the control group were bacteria for 7 cases and fungus for 3 cases but in the experimental group, only 2 cases of bacteria were isolated.

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RNA silencing-mediated resistance is related to biotic / abiotic stresses and cellular RdRp expression in transgenic tobacco plants

  • Wu, Xiao-Liang;Hou, Wen-Cui;Wang, Mei-Mei;Zhu, Xiao-Ping;Li, Fang;Zhang, Jie-Dao;Li, Xin-Zheng;Guo, Xing-Qi
    • BMB Reports
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    • v.41 no.5
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    • pp.376-381
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    • 2008
  • The discovery of RNA silencing inhibition by virus encoded suppressors or low temperature leads to concerns about the stability of transgenic resistance. RNA-dependent RNA polymerase (RdRp) has been previously characterized to be essential for transgene-mediated RNA silencing. Here we showed that low temperature led to the inhibition of RNA silencing, the loss of viral resistance and the reduced expression of host RdRp homolog (NtRdRP1) in transgenic T4 progeny with untranslatable potato virus Y coat protein (PVY-CP) gene. Moreover, RNA silencing and the associated resistance were differently inhibited by potato virus X (PVX) and tobacco mosaic virus (TMV) infections. The increased expression of NtRdRP1 in both PVX and TMV infected plants indicated its general role in response to viral pathogens. Collectively, we propose that biotic and abiotic stress factors affect RNA silencing-mediated resistance in transgenic tobacco plants and that their effects target different steps of RNA silencing.

Protective Effect of Rhizoma Dioscoreae on the Gastric Mucosal Lesions Induced by Alcohol in Rats (산약이 알콜로 유도된 흰쥐의 위 점막 손상 예방에 미치는 영향)

  • Jeong, Yong-Yeon;Lee, Young-Su
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.3
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    • pp.639-644
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    • 2009
  • The aim of this study was carried out to investigate the protective effect of Rhizoma Dioscoreae on the gastric mucosal lesions induced by alcohol in rats. Experimental groups were treated by oral infusion with Rhizoma Dioscoreae extract at the dose of 0.03465 g/ml(OA-RD1 group), 0.0693 g/ml(OA-RD2 group), and 0.1386 g/ml(OA-RD3 group), while D.W group was administrated with the distilled water and control group did not pretreated. Experimental groups pretreated for 14 days, and given orally 1 ml of 75% alcohol two times(30min interval). The animals were killed 1hr 30min after alcohol treatment, and measured rats body weight, absolute stomach weight, relative stomach weight, SOD activity, glutathione peroxidase(GPx) activity, observed gastric mucosal lesions. The body weight was unremarkable changed. In once as dose intake group's absolute stomach weight was increased and In once as dose intake group, twice as dose intake group's relative stomach weight was increased. SOD activity, glutathione peroxidase activity in twice as dose intake group is remarkably increased. Light microscopy Observations of congestion, hemorrhage, and erosion in gastric mucosal lesions were shown severely in control group than OA-RD1, OA-RD2, OA-RD3. These results suggest that the proposed gastroprotective effect may involve activation of antioxidant effect. And Twice as dose is especially effective.