• Journal of Computing Science and Engineering
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• v.3 no.2
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• pp.109-126
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• 2009

Taxonomies are widely used to classify information, and multiple (possibly competing) taxonomies often exist for the same domain. Given a set of correspondences between two taxonomies, it is often necessary to "merge" the taxonomies, thereby creating a unied taxonomy (e.g., that can then be used by data integration and discovery applications). We present an algorithm for merging taxonomies that have been related using articulations given as RCC-5 constraints. Two taxa Nand M can be related using (disjunctions of) the ve base relations in RCC-5: M; N ${\subseteq}$M; N ${\supseteq}$; N ${\oplus}$M (partial overlap of Nand M); and N ! M (disjointness: N ${\cap}$M = ${\varnothing}$). RCC-5 is increasingly being adopted by scientists to specify mappings between large biological taxonomies. We discuss the properties of the proposed merge algorithm and evaluate our approach using real-world taxonomies.

• Oncology Letters
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• v.18 no.6
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• pp.5731-5738
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• 2019

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Novel biomarkers of ccRCC may provide crucial information on tumor features and prognosis. The present study aimed to determine whether the expression of γ-aminobutyric acid (GABA) A receptor subunit θ (GABRQ) could serve as a novel prognostic marker of ccRCC. GABA is the main inhibitory neurotransmitter in the brain that activates the receptor GABAA, which is comprised of three subunit isoforms: GABRA3, GABRB3 and GABRQ. A recent study reported that GABRQ is involved in the initiation and progression of hepatocellular carcinoma; however, the role of GABRQ in ccRCC remains unknown. In the present study, clinical and transcriptomic data were obtained from cohorts of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). Differential GABRQ expression levels among early (TI and II), late (TIII and IV), nonmetastatic (M0) and metastatic (M1, primary tumor) stages of ccRCC samples were then identified. Furthermore, the use of GABRQ as a prognostic gene was analyzed using Uno's C-index based on the time-dependent area under the curve (AUC), the AUC of the receiver operating characteristic curve at 5 years, the Kaplan-Meier survival curve and multivariate analysis. The survival curve analysis revealed that low GABRQ mRNA expression was significantly associated with a poor prognosis of ccRCC (P<0.001 and P=0.0012 for TCGA and ICGC data, respectively). In addition, analyses of the C-index and AUC values further supported this discriminatory power. Furthermore, the prognostic value of GABRQ mRNA expression was confirmed by multivariate Cox regression analysis. Taken together, these results suggested that GABRQ mRNA expression may be considered as a novel prognostic biomarker of ccRCC.

• Journal of the Korean Society of Safety
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• v.27 no.6
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• pp.14-19
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• 2012

The Helium cooled ceramic reflector(HCCR) test blanket module(TBM) has been designed and developed to participate the ITER(International Thermonuclear Experimental Reactor) test blanket program in Korea. The TBM was one of the main objectives for developing ITER for proving the tritium self-sufficiency and the heat transfers to produce the electricity with the breeding blanket concept. Among the TBM components, the first wall(FW) was the most important component in safety since it was directly faced a high level of a heat and fast neutrons from the plasma side and could protect the others components inside TBM. In this paper, the FW has been designed through the thermo-mechanical analysis considering ITER operation conditions. With the developed simple models, the stress limit analysis based on RCC-MR code which is the nuclear power plant design codes in France was evaluated for the allowable design criteria. The results showed that the designed FW model satisfied $1.5S_m$ or $3S_m$ of the allowable stress($S_m$) in RCC-MR code at the maximum stress region in the FW.

• International Journal of Highway Engineering
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• v.19 no.6
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• pp.37-46
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• 2017

PURPOSES : A composite pavement utilizes both an asphalt surface and a concrete base. Typically, a concrete base layer provides structural capacity, while an asphalt surface layer provides smoothness and riding quality. This pavement type can be used in conjunction with rollercompacted concrete (RCC) pavement as a base layer due to its fast construction, economic efficiency, and structural performance. However, the service life and functionality of composite pavement may be reduced due to interfacial bond failure. Therefore, adequate interfacial bonding between the asphalt surface and the concrete base is essential to achieving monolithic behavior. The purpose of this study is to investigate the bond characteristics at the interface between asphalt (HMA; hot-mixed asphalt) and the RCC base. METHODS : This study was performed to determine the optimal type and application rate of tack coat material for RCC-base composite pavement. In addition, the core size effect, temperature condition, and bonding failure shape were analyzed to investigate the bonding characteristics at the interface between the RCC base and HMA surface. To evaluate the bond strength, a pull-off test was performed using different diameters of specimens such as 50 mm and 100 mm. Tack coat materials such as RSC-4 and BD-Coat were applied in amounts of 0.3, 0.5, 0.7, 0.9, and $1.1l/m^2$ to determine the optimal application rate. In order to evaluate the bond strength characteristics with temperature changes, a pull-off test was carried out at -15, 0, 20, and $40^{\circ}C$. In addition, the bond failure shapes were analyzed using an image analysis program after the pull-off tests were completed. RESULTS : The test results indicated that the optimal application rate of RSC-4 and BD-Coat were $0.8l/m^2$, $0.9l/m^2$, respectively. The core size effect was determined to be negligible because the bond strengths were similar in specimens with diameters of 50 mm and 100 mm. The bond strengths of RSC-4 and BD-Coat were found to decrease significantly when the temperature increased. As a result of the bonding failure shape in low-temperature conditions such as -15, 0, and $20^{\circ}C$, it was found that most of the debonding occurred at the interface between the tack coat and RCC surface. On the other hand, the interface between the HMA and tack coat was weaker than that between the tack coat and RCC at a high temperature of $40^{\circ}C$. CONCLUSIONS : This study suggested an optimal application rate of tack coat materials to apply to RCC-base composite pavement. The bond strengths at high temperatures were significantly lower than the required bond (tensile) strength of 0.4 MPa. It was known that the temperature was a critical factor affecting the bond strength at the interface of the RCC-base composite pavement.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4239-4243
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• 2014

Background: This study investigated the influence of curcumin on HOX transcript antisense RNA (HOTAIR)-mediated migration of cultured renal cell carcinoma (RCC) cells. Materials and Methods: Five RCC cell lines (769-P, 769-P-vector, 769-P-HOTAIR, 786-0, and Kert-3 ) were maintained in vitro. The expression of HOTAIR mRNA was determined by quantitative real-time PCR and cell migration was measured by transwell migration assay. The effects of different concentrations of curcumin (0 to $80{\mu}mol/L$) on cell proliferation was determined by the CCK-8 assay and influence of non-toxic levels (0 to $10{\mu}M$) on the migration of RCC cells was also determined. Results: Comparison of the 5 cell lines indicated a correlation between HOTAIR mRNA expression and cell migration. In particular, the migration of 769-P-HOTAIR cells was significantly higher than that of 769-P-vector cells. Curcumin at $2.5-10{\mu}M$ had no evident toxicity against RCC cells, but inhibited cell migration in a concentration-dependent manner. Conclusions: HOTAIR expression is correlated with the migration of RCC cells, and HOTAIR may be involved in the curcumin-induced inhibition of RCC metastasis.

• Advances in concrete construction
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• v.2 no.2
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• pp.125-144
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• 2014

The development in roller compacted concrete (RCC) is replacing the conventionally vibrated concrete (CVC) for faster construction of dam during last three-four decades. Notwithstanding, there have been relatively less works reported on the utilization of RCC in dam constructions, especially the dams having considerable height. Further, the Ghatgar dam was the only dam in the tropical country like India constructed using the technology of RCC until two years back. However, with the completion of 102.4 m high Middle Vaitarana Dam (MVD), owned by Muncipal Corporation of Greater Mumbai (MCGM), India, has become the first largest roller compacted concrete dam. The paper traces step by step aspects of the mix design of RCC in respect of the afore-mentioned project besides the construction aspects; and also, demonstrates as to how 12.15 lacs cubic meter of roller compacted concrete was placed within the record duration of 15.2 months, thus, rendering the MVD as the ninth fastest RCC dam in the world. The paper also discusses the various mix proportioning, quality control, constructional features and instrumentation with respect to the high RCC dam such as Middle Vaitarana.

• Structural Monitoring and Maintenance
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• v.2 no.2
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• pp.95-113
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• 2015

The knowledge of the behavior of any roller compacted concrete (RCC) dam and its foundation is gained by studying the service action of the dam and its foundation using measurements of an external and internal nature. The information by which a continuing assurance of structural safety of the RCC dam can be gauged is of primary importance. Similarly, the fact that the information on structural and thermal behavior and the properties of concrete that may be used to give added criteria for use in the design of future RCC dams is of secondary importance. Wide spread attention is now being given to the installation of more expensive instrumentation for studying the behavior of concrete dams and reservoirs and forecasting of any adverse trends. In view of this, the paper traces installation and need of the comprehensive instrumentation scheme implemented to monitor the structural and thermal behavior of 102.4 m high RCC dam constructed near Mumbai in India. An attempt is made in the present paper to emphasize the need to undertake an instrumentation program and evaluate their performance during construction and post construction stage of RCC structures. Few typical results, regarding the thermal and structural behavior of the dam, obtained through instrumentation installed at the dam site are presented and compared with the design considerations. The fair agreement is seen in the response observed through instrumentation with that governing the design criteria.

• International Journal of Concrete Structures and Materials
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• v.3 no.1
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• pp.57-61
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• 2009

The present work deals with the prediction, through models and experimental evaluation, of the bending strength of roller compacted concrete (RCC) for pavement applications. This concrete was manufactured using low cement proportioning (150 to $250\;kg/m^3$). The characterization of hardened RCC was carried out by experimental measurements of bending strengths. The predictions of these characteristics were achieved using empirical models. Comparison, of the values found in experiments with those empirically obtained, was made in order to choose and to propose the adapted and the most reliable models of prediction. The study showed that the bending strengths of the RCC mixture, experimentally found, can be also identified by models.

• Molecules and Cells
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• v.38 no.7
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• pp.624-629
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• 2015

Since the emergence of proteomics methods, many proteins specific for renal cell carcinoma (RCC) have been identified. Despite their usefulness for the specific diagnosis of RCC, such proteins do not provide spatial information on the diseased tissue. Therefore, the identification of cancer-specific proteins that include information on their specific location is needed. Recently, matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) based imaging mass spectrometry (IMS) has emerged as a new tool for the analysis of spatial distribution as well as identification of either proteins or small molecules in tissues. In this report, surgical tissue sections of papillary RCC were analyzed using MALDI-IMS. Statistical analysis revealed several discriminative cancer-specific m/z-species between normal and diseased tissues. Among these m/z-species, two particular proteins, S100A11 and ferritin light chain, which are specific for papillary RCC cancer regions, were successfully identified using LC-MS/MS following protein extraction from independent RCC samples. The expressions of S100A11 and ferritin light chain were further validated by immunohistochemistry of human tissues and tissue microarrays (TMAs) of RCC. In conclusion, MALDI-IMS followed by LC-MS/MS analysis in human tissue identified that S100A11 and ferritin light chain are differentially expressed proteins in papillary RCC cancer regions.

• Korean Journal of Clinical Pharmacy
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• v.34 no.3
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• pp.184-193
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• 2024

Background: Sunitinib, commonly used for metastatic renal cell carcinoma (mRCC), often induces hypothyroidism, affecting 27 to 85% of patients. There are clues suggesting an association between sunitinib-induced hypothyroidism and improved survival outcomes. This study aims to identify the predictive factors of sunitinib-induced hypothyroidism and evaluate whether the occurrence of overt or subclinical hypothyroidism predicts tumor outcome in patients with mRCC. Methods: Patients administered to sunitinib for mRCC was included in this retrospective study. Log-rank test and Cox proportional hazards model were conducted to identify predictive factors of hypothyroidism and prognostic factors of progression-free survival (PFS) and overall survival (OS). Results: A total of 156 patients with mRCC treated with sunitinib were included. Predictive factors of sunitinib-induced hypothyroidism were female (odds ratio (OR), 2.77), sunitinib-induced hypertension (OR, 2.99) and dose reduction of sunitinib due to intolerance (OR, 3.57). Sunitinib-induced overt hypothyroidism was a significant prognostic factor in predicting PFS and OS (hazard ratio, 0.38 and 0.23, respectively). Thyroid hormone replacement did not have an influence on PFS and OS. Conclusions: Female patients, patients who experienced sunitinib-induced hypertension and sunitinib dose reduction are at higher risk of hypothyroidism and need close monitoring. Overt hypothyroidism is a strong prognostic factor of sunitinib treatment outcome in mRCC patients and thyroid hormone replacement does not have a negative effect on tumor outcome.