• Tunnel and Underground Space
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• v.27 no.2
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• pp.89-99
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• 2017

For a successful performance of Carbon Capture Sequestration (CCS) projects, appropriate injection conditions should be designed to be optimized for site specific geological conditions. In this study, we built a simple 2-dimensional analysis model, based on the geology of Jang-gi basin which is one of the potential sites of domestic CCS projects. We evaluated the impact of initial stress conditions and injection rate through coupled TOUGH-FLAC simulator. From the preliminary analysis, we constructed risk scenarios with the higher potential of shear slip and performed scenario analysis. Our analysis showed that normal stress regime produced the highest potential of shear slip and stepwise increasing injection rate scenario resulted in much larger pore pressure build up and consequent higher potential of the shear slip, which was evaluated using a mobilized friction coefficient.

• Journal of Acupuncture Research
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• v.23 no.2
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• pp.125-137
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• 2006

Objectives : The effect of water extract of the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong), a traditional immuno-suppressive and immuno-activating Korean oriental medicine, on collagen-induced arthritis (CIA) mice model was studied. Identification of common Nokyong capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. Methods : Nokyong has shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of DAE on collagen-induced arthritis in mice. Results : In three independent experiments mice given DAE in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice given no DAE in water (84% to 100%). The arthritis index also was significantly lower in DAE-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2 (Cox-2), $Interferon-{\gamma}\;(INF-{\gamma})$, and tumor necrosis factor ${\alpha}\;(TNF-{\alpha})$ in arthritic joints of DAE-fed mice. The neutral endopeptidase (NEP) activity was approximately 6-fold higher in arthritic joints of non-DAE-fed mice in comparison to nonarthritic joints of nonimmunized mice whereas it was only 2-fold higher in the arthritic joints of DAE-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in the arthritic joints of DAE-fed mice. Conclusion : Taken together our studies suggest that DAE may be useful in the prevention of onset and severity of arthritis.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.213-220
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• 2011

In the current construction industry where various stakeholders take part, BIM Data exchange using standard format can provide a more efficient working environment for related staffs during the life-cycle of the building. Currently, the formats used to exchange the data from 3D-CAD application to structure energy analysis at the design stages are IFC, the international standard format provided by IAI, and gbXML, developed by Autodesk. However, because of insufficient data compatibility, the BIM data produced in the 3D-CAD application cannot be directly used in the energy analysis, thus there needs to be additional data entry. The reasons for this are as follows: First, an IFC file cannot contain all the data required for energy simulation. Second, architects sometimes write material names on the drawings that are not matching to those in the standard material library used in energy analysis tools. DOE-2.2 and Energy Plus are the most popular energy analysis engines. And both engines have their own material libraries. However, our investigation revealed that the two libraries are not compatible. First, the types and unit of properties were different. Second, material names used in the library and the codes of the materials were different. Furthermore, there is no material library in Korean language. Thus, by comparing the basic library of DOE-2, the most commonly used energy analysis engine worldwide, and EnergyPlus regarding construction materials; this study will analyze the material data required for energy analysis and propose a way to effectively enter these using semantic web's ontology. This study is meaningful as it enhances the objective credibility of the analysis result when analyzing the energy, and as a conceptual study on the usage of ontology in the construction industry.

• Therapeutic Science for Rehabilitation
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• v.10 no.3
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• pp.83-96
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• 2021

Objective : This study aimed to determine Korea-type family function factors that affect individual growth and social activities, and examine check the appropriate contents and domestic culture components based on the McMaster model, a family function evaluation tool, through the Delphi technique. Methods : The Delphi technique was applied to 12 expert panels in fields related to family function. The period lasted 9 weeks, from May to June 2020. The Delphi survey was conducted twice. In the first survey, the domestic culture and appropriate contents of the McMaster model were selected and localized, and expert' opinions about the components were collected using closed and open-ended questions. In the second survey, the fitness and importance of the components were investigated. Results : As a result of the first Delphi investigation, 18 items were deleted from the 53 items presented. After adding 11 items and excluding any overlapping items, a total of 40 items were selected. Subsequently, sentences that were difficult to understand were revised to familiar vocabulary. A second survey was constructed, with an example sentence. In the second Delphi investigation, 33 items were selected. The average content validity ratio for the final selected component was 0.76, and the stability was 0.28. Conclusion : Family function and the factors influencing domestic family function identified though this study can be used to conduct family function evaluations and interventions in clinical sites or relevant research studies.

• Journal of Korean Society of Rural Planning
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• v.19 no.2
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• pp.193-202
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• 2013

This study aims at suggesting some measures to establish rural community development information system through ISP. A future model for rural community development information system was established by applying such 3-step ISP methodology as environment analysis, current status(AS-IS) analysis, future(To-Be) directions. As a result, with the vision of realizing comprehensive information service for rural development projects, rural development information system has established such goals as the assistance of project decision making through preparing rural development project data management system and acquiring evaluation efficiency, the preparation of spatial information utilization system, the utilization of objective GIS-based information through the increase of data management efficiency, the community activation and participatory rural development through rural spatial information portal service. In order to attain the goals, four strategical subject matters were derived. They are: 1) one-stop service subject matter for data management including pilot DB building for rural development projects, 2) rural information GIS service strengthening subject matter including DB building for rural development, O&M measures, 3) step-by-step DB building subject matter including the sharing of integrated information system for rural development, and 4) core value increase subject matter of spatial information data including the building of active service delivery system.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.111.2-111.2
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• 2012

We observed an Ellerman bomb(EB) and its associated surge using the Fast Imaging Solar Spectrograph(FISS) and the broadband TiO filter of the 1.6 meter New Solar Telescope at Big Bear Solar Observatory. As is well-known, the EB appears as a feature that is very bright at the far wings of the H alpha line. The lambdameter method applied to these wings indicates that the EB is blue-shifted up to 6km/s in velocity. In the photospheric level below the EB, we see rapidly growing "granule-like" feature. The transverse velocity of the dark lane at the edge of the "granule" increased with time as reached a peak of 6km/s, at the time of the EB's occurrence. The surge was seen in absorption and varied rapidly both in the H alpha and the Ca II 8542 line. It originated from the Ellerman bomb, and was impulsively accelerated to 20km/s toward us(blueshift). Then the velocity of the surge gradually changed from blueshift of 20km/s to redshift of 40km/s. By adopting the cloud model, we estimated the temperature of the surge material at about 27000K and the non-thermal velocity at about 10km/s. Our results shed light on the conventional idea that an EB results from the magnetic reconnection of an emerging flux tube and pre-existing field line.

• Biomolecules & Therapeutics
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• v.27 no.4
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• pp.363-372
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• 2019

Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4'-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine (OHDA)-induced neurotoxicity are not well understood. In the current study, 7,8,4'-THIF significantly inhibited neuronal cell death and lactate dehydrogenase (LDH) release induced by 6-OHDA in SH-SY5Y cells, which were used as an in vitro model of Parkinson's disease (PD). Moreover, pretreatment with 7,8,4'-THIF significantly increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) and decreased malondialdehyde (MDA) activity in 6-OHDA-induced SH-SY5Y cells. In addition, 7,8,4'-THIF significantly recovered 6-OHDA-induced cleaved caspase-3, cleaved caspase-9, cleaved poly-ADP-ribose polymerase (PARP), increased Bax, and decreased Bcl-2 levels. Additionally, 7,8,4'-THIF significantly restored the expression levels of phosphorylated c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase 1/2 (ERK 1/2), phosphatidylinositol 3-kinases (PI3K)/Akt, and glycogen synthase kinase-3 beta ($GSK-3{\beta}$) in 6-OHDA-induced SH-SY5Y cells. Further, 7,8,4'-THIF significantly increased the reduced tyrosine hydroxylase (TH) level induced by 6-OHDA in SH-SY5Y cells. Collectively, these results suggest that 7,8,4'-THIF protects against 6-OHDA-induced neuronal cell death in cellular PD models. Also, these effects are mediated partly by inhibiting activation of the MAPK and PI3K/Akt/$GSK-3{\beta}$ pathways.

• Korean Journal of Construction Engineering and Management
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• v.12 no.5
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• pp.137-145
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• 2011

BIM Data exchange using standard format can provide a user friendly and practical way of integrating the BIM tools in the life cycle of a building on the currently construction industry which is participated various stakeholder. It used IFC format to exchange the BIM data from Design software to energy analysis software. However, since we can not use the material name data in the library of an energy analysis directly, it is necessary to input the material property data for building energy analysis. In this paper, to matching the material named of name of DOE-2 default library, rhe extracted material names from BIM file are inferred by the ontology With this we can make the reliable input data of the engine by development a standard data and also increase the efficient of building energy analysis process. The methodology can enable to provide a direction of BIM-based information management system as a conceptual study of using ontology in the construction industry.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.5
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• pp.1-9
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• 2012

Memristor which is known as fourth basic circuit element has been developed recently but its electrical characteristics are not still fully understood. Memristor has the incremental and decremental feature of the resistance depending upon the connected polarities. Also, its operational behavior become diverse depending on its connection topologies. In this work, electrical characteristics of diverse types of serial and parallel connections are investigated using the HP $TiO_2$ model. The characteristics are analyzed with pinched hystersis loops on the V-I plane when sine input signal is applied. The results of the work would be utilized usefully for analyzing the characteristics of memristor element and applications to logic circuit and neuron cells.

• Journal of Animal Reproduction and Biotechnology
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• v.37 no.2
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• pp.136-143
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• 2022

Recent progress has been made to establish intestinal organoids for an in vitro model as a potential alternative to an in vivo system in animals. We previously reported a reliable method for the isolation of intestinal crypts from the small intestine and robust three-dimensional (3D) expansion of intestinal organoids (basal-out) in adult bovines. The present study aimed to establish next-generation intestinal organoids for practical applications in disease modeling-based host-pathogen interactions and feed efficiency measurements. In this study, we developed a rapid and convenient method for the efficient generation of intestinal organoids through the modulation of the Wnt signaling pathway and continuous apical-out intestinal organoids. Remarkably, the intestinal epithelium only takes 3-4 days to undergo CHIR (1 µM) treatment as a Wnt activator, which is much shorter than that required for spontaneous differentiation (7 days). Subsequently, we successfully established an apical-out bovine intestinal organoid culture system through suspension culture without Matrigel matrix, indicating an apical-out membrane on the surface. Collectively, these results demonstrate the efficient generation and next-generation of bovine intestinal organoids and will facilitate their potential use for various purposes, such as disease modeling, in the field of animal biotechnology.