• 품질경영학회지
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• 제49권3호
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• pp.245-254
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• 2021

Purpose: In order to accurately reach an underwater projectile to a target point, reliable INS and accurate arrangement of INS between master and slave INS is paramount. Unlike terrestrial and aerial environments, underwater projectile will operates in a restricted environment where location information cannot be received or sent through satellites. In this report, we review the factors affecting the transfer alignment of master and slave INS, as well as how to improve the positional error between INS through improved transfer alignment algorithms. Methods: In this work, we propose an improvement algorithm and verify it through simulation and driving test. The simulation confirmed the difference in the transfer alignment azimuth by fitting the MINS and SINS indoors, displacement in posture, and the process of transfer alignment between MINS and SINS through a driving test to confirm algorithm can improve the arrangement. Results: According to this study, reason for the error in the transfer alignment between MINS/SINS is the factors of the system where movements such as roll, pitch, yaw are not inter locked in real time due to the delay in transmit/receive system. And confirm that the improved algorithm has a desirable effect on accuracy. Conclusion: Through this work, it is possible to identify ways to improve the accuracy of underwater projectiles to reach their target points under various underwater environments and launch condition.

• 융합정보논문지
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• 제11권10호
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• pp.270-276
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• 2021

본 연구는 홈케어 헤어트리트먼트 특성 및 사용 빈도에 따라 퍼머넌트 웨이브 시술시 모발에 미치는 영향을 알아보고자 수행하였다. 시중에 유통되는 헤어트리트먼트를 양이온계면활성제, 실리콘 오일로 구분하였다. 사용빈도에 따라 제품별 5회, 10회, 20회 다르게 헤어트리트먼트를 처리한 후 헤어 퍼머넌트 웨이브를 시술하였다. 실험 방법으로 모발의 굵기, 인장강도, SEM을 이용한 모표피 관찰, EDS를 이용한 모발 구성 원소 분석을 하였다. 실험 결과 천연유래성분이 주성분이며 양이온계면활성 및 실리콘 오일이 미첨가된 제품군이 모발 보호 효과가 높게 측정되었다. 이에 천연유래성분을 이용한 제품군이 더욱 연구 개발되어야 하며 자극적 화학 성분이 첨가된 제품은 사용 방법 및 빈도에 대한 연구가 진행 되어야 할 것으로 사료된다.

• The Korean Journal of Pain
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• 제32권3호
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• pp.215-222
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• 2019

Background: Several nerve blocks can reduce the incidence of postherpetic neuralgia (PHN) as well as relieve acute zoster-related pain, but the long-term outcome of PHN has not been clearly determined. This study investigated the efficacy of selective nerve root block (SNRB) for herpes zoster (HZ) on the long-term outcome of PHN. Methods: We prospectively conducted an interview of patients who had undergone an SNRB for HZ from January 2006 to December 2016 to evaluate their long-term PHN status. The relationship between the time from HZ onset to the first SNRB and the long-term outcome of PHN was investigated. Results: The data of 67 patients were collected. The patients were allocated to acute ($SNRB{\leq}14days$, n = 16) or subacute (SNRB > 14 days, n = 51) groups. The proportions of cured patients were 62.5% and 25.5% in the acute and subacute groups (P = 0.007), respectively. In logistic regression, an SNRB >14 days was the significant predictor of PHN (adjusted odd ratio, 3.89; 95% confidence interval, 1.02-14.93; P = 0.047). Kaplan-Meier analysis revealed that time from the SNRB to the cure of PHN was significantly shorter in the acute group ($2.4{\pm}0.7yr$) than in the subacute group ($5.0{\pm}0.4yr$; P = 0.003). Conclusions: An early SNRB during the acute stage of HZ (within 14 days) appears to decrease the incidence and shorten the duration of PHN, with a median of 5.0 years of follow-up.

• 대한한의학회지
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• 제40권2호
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• pp.51-62
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• 2019

Objectives: This study was designed to evaluate the macrophages polarization of traditional Korean medicine on cardiac pain about Geum-Gwe-Yo-Ryak's two prescriptions including Kwaruhaebaekbanha-tang (KHB) and Kwaruhaebaekpaekju-tang (KHP). Materials and methods: Flow cytometry analysis was used to measure the changes in the ratio of M1 type and M2 type macrophages. Protein expression of nuclear factor-like 2 (Nrf2), heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) were measured by Western Blot, and ABCA1 and SR-B1 were detected by real time PCR (RT-PCR). Intracellular lipid accumulation was measured by Oil Red O staining (ORO staining). Results: KHB and KHP increase anti-oxidative activity related protein levels including Nrf2 and HO-1. Furthermore, KHB and KHP inhibit lipid accumulation on intracellular levels through induction of ATP binding receptor cassette subfamily A member 1 (ABCA1) and scavenging receptor class B member 1 (SR-B1), respectively. Finally, KHB and KHP also blocked pro-inflammatory mediators including tumor necrosis factor-alpha ($TNF{\alpha}$) and interleukin-6 (IL-6), iNOS and COX-2 expression. Conclusion: This study suggests that KHB and KHP potently regulate the M1/M2 macrophage polarization.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2015년도 학술발표회
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• pp.604-604
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• 2015

급속한 도시화와 산업화로 보수 및 유수기능이 감소하였고, 세계적인 기후변화로 국지성호우가 빈번히 발생하여 기존 우수관망시스템의 문제점이 야기되고 있다. 최근 발생하는 도시유역의 홍수 피해는 대부분이 내수에 의한 침수 피해로 이러한 피해를 감소시키기 위해서는 도시하천에 적합한 강우-유출모형을 이용하여 침수 위험 유역을 정확히 예측하여 사전 보강 및 예 경보를 수행하는 것이 중요하다. 따라서 본 연구에서는 최근들어 잦은 침수피해가 발생한 도림천 유역을 대상으로 강우-유출모형인 XP-SWMM을 이용하여 민감도 및 미래 유출 특성변화 분석을 수행하였다. 첫 번째로, 지형자료 및 관거 자료, 2014년에 완공된 저류지 및 펌프시설 자료를 모두 적용하여 유역의 특성을 최대한 반영한 모형을 설계하고 실측유량과 모형유량을 비교하여 최적화된 모형임을 확인하였다. 두 번째로, 최적화된 모형의 매개변수를 기준으로 인자별 민감도 분석을 수행하여 현재 도림천의 유출특성을 살펴보았다. 마지막으로 미래 경향을 예측할 수 있는 인자인 강우량과 불투수율의 경향성을 반영하여 도림천 유역의 미래 유출특성(첨두유출량, 침수심, 침수면적, 홍수위)의 변화를 검토하였다. 민감도 분석결과 강우량을 20% 감소시켰음에도 최대 침수심과 침수면적이 3.772m, 침수면적이 $5.027km^2$로 여전한 내수침수가 발생하고 있어 도림천 유역이 치수로 부터 취약한 지역임을 확인하였다. 비정상성 빈도해석으로 강우를 산정하고 log형 회귀식으로 불투수율을 산정하여 도림천 유역의 미래 유출특성을 모의한 결과 2020년과 2030년의 최대침수심이 각각 4.9352m, 4.9954m로 현재의 최대 침수심(4.8093m)보다 평균 0.156m 증가하였다. 마지막으로 현재와 미래의 홍수위와 여유고를 이용하여 제방안전성 평가를 수행한 결과, 현재에도 전체구간이 안전구간으로 이루어져 있지 않으며 2030년으로 갈수록 안정단면은 평균 8.5% 감소하고 위험단면은 평균 17% 증가함을 확인하였다. 향후 본 연구의 결과를 이용하여 추후 침수피해 저감을 위한 대응방안 및 효과적인 대피소, 대피경로 수립 등에 활용 가능할 것으로 판단된다.

• 한방안이비인후피부과학회지
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• 제34권1호
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• pp.44-55
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• 2021

Objectives : The aim of this article is to compare the effect of the korean medicine alone with korean-western combination treatment to herpes zoster. Methods : Domestic databases(OASIS, NDSL, RISS, KISS, KTKP, KMBASE, DBPIA, KoreaMed, National Assembly Library) were used to search case study papers related to herpes zoster and korean medicine treatment. We searched them using the term 'Herpes zoster' or 'Ramsey Hunt' combinated with 'Acupuntcure', 'Herbal medicine' or 'Korean medicine'. Results : A total of 36 studies were selected and analyzed. 25 studies treated with korean medicine and 11 studies treated with korean-western combination treatment which include any western medication. Of these 36 papers, there were a total of 24 cases in which a VAS test was undertaken. According to 36 published papers, no statistically significant difference in the periods of treatment with korean medicine alone from those of korean-western combination treatment was found. Also, no statistical difference in the VAS changes per period with korean medicine alone from those with korean-western combination treatment was found. Conclusions : According to the results, These findings suggest that korean medicine treatment can be effective for the herpes zoster the same as korean-western combination treatment.

• Journal of Ginseng Research
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• 제45권2호
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• pp.254-263
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• 2021

Background: A chronic social defeat stress (CSDS) model has been proposed as relevant to stress-induced behavioral change in humans. In this study, we examined the effect of Korean Red Ginseng (KRG) on CSDS-induced mood disorders and protein expression in an animal model. Methods: To evaluate the effect of KRG on social defeat stress, test mice were exposed in the resident aggressor's home cage compartment for 14 days beginning 1 h after KRG treatment (10, 20, and 40 mg/kg, per oral (p.o.)). After the exposure, behavioral tests to measure anxiety, social interaction, and depression-like behavior were performed. To investigate the underlying mechanism, N-methyl-D-aspartate receptor expression levels in CSDS-induced mice were evaluated using Western blot analysis. Results: CSDS induced anxiety-like behaviors by decreasing central activity in the open-field test and open-arm approach in the elevated plus maze test and led to social avoidance behavior in the social interaction test. CSDS mice showed upregulated NR1, NR2A, and NR2B expression in the hippocampus. KRG 20 and 40 mg/kg ameliorated anxiety-like activities and KRG 20 mg/kg alleviated social avoidance by decreasing time in the corner zone. KRG treatment recovered CSDS-induced NR1, NR2A, and NR2B protein levels in the hippocampus. Conclusion: These results indicate that KRG has a therapeutic effect on CSDS-induced mood disorder by alleviating N-methyl-D-aspartate receptor overexpression in the hippocampus.

• International Journal of Oral Biology
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• 제46권2호
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• pp.85-93
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• 2021

Asarum sieboldii Miq. (Aristolochiaceae) is a perennial herbaceous plant and has been used as traditional medicine for treating diseases, cold, fever, phlegm, allergies, chronic gastritis, and acute toothaches. Also, it has various biological activities, such as antiallergic, antiinflammatory, antinociceptive, and antifungal. However, the anticancer effect of A. sieboldii have been rarely reported, except anticancer effect on lung cancer cell (A549) of water extracts of A. sieboldii. This study investigated the anticancer activity of methanol extracts of A. sieboldii (MeAS) and the underlying mechanism in human FaDu hypopharyngeal squamous carcinoma cells. MeAS inhibited FaDu cells grown dose-dependently without affecting normal cells (L929), as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and live and dead assay. In addition, concentration of MeAS without cytotoxicity (0.05 and 0.1 mg/mL) inhibited migration and colony formation. Moreover, MeAS treatment significantly induced apoptosis through the proteolytic cleavage of caspase-3, -7, -9, poly (ADP-ribose) polymerase, and downregulation of Bcl-2 and upregulation of Bax in FaDu cells, as determined by fluorescence-activated cell sorting analysis, 4'6-diamidino-2-phenylindole stain, and western blotting. Altogether, these results suggest that MeAS exhibits strong anticancer effects by suppressing the growth of oral cancer cells and the migration and colony formation via caspase- and mitochondrial-dependent apoptotic pathways in human FaDu hypopharyngeal squamous carcinoma cells. Therefore, MeAS can serve as a natural chemotherapeutic for human oral cancer.

• Journal of Applied Biological Chemistry
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• 제63권4호
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• pp.393-399
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• 2020

방풍(Saposhnikoviae Radix, SR) 과 식방풍(Peucedani Japonici Radix, PR)은 각각 다른 기원식물을 가지며 속과 종이 다르지만 한국, 중국, 및 일본에서 대표적인 전통 한약재로 오랫동안 혼용되어 사용되었다. 본 연구에서는 방풍과 식방풍의 판별 마커를 확인하기 위하여 UPLC-QTOF/MS를 이용한 대사체 프로파일링 및 다변량 통계분석을 진행하였다. 그 결과, 5-O-methylvisammioside와 peucedanol을 각각 방풍과 식방풍의 지표성분으로 선정하였으며, UPLC를 이용하여 분석법을 검증하였다. 제안된 방풍 및 식방풍의 지표성분에 대한 분석법 검증은 방풍과 식방풍의 분류와 품질 평가 및 성분 검증을 위한 효과적인 방법이 될 것으로 기대된다.

• Journal of Ecology and Environment
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• 제45권4호
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• pp.237-254
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• 2021

Background: Some of the introduced alien species introduced settle, multiply, and spread to become invasive alien species (IAS) that threaten biodiversity. To prevent this, Korea and other countries legally designate and manage alien species that pose a risk to the environment. Moreover, 2160 alien species have been introduced in South Korea, of which 1826 animals and 334 plants are designated. The inflow of IAS can have negative effects such as ecosystem disturbance, habitat destruction, economic damage, and health damage to humans. To prevent damage caused by the inflow of IAS in advance, species that could potentially pose a risk to the environment if introduced in South Korea were designated as alert alien species (AAS). Results: The designation criteria were in accordance with the "Act on the Conservation and Use of Biological Diversity" and the "Regulations on the Ecological Risk Assessment of AAS and IAS" by the National Institute of Ecology. The analysis result of risk and damage cases indicated that mammals affect predation, competition, human economic activity, virus infection, and parasite infection. Birds have been demonstrated to affect predation, competition, human economic activity, and health. It was indicated that plants intrude on the ecosystem by competing with native species with their high-population density and capacity to multiply and cause allergic inducement. Interestingly, 300 species, including 25 mammals, 7 birds, 84 fishes, 28 amphibians, 22 reptiles, 1 insect, 32 spiders, 1 mollusk, 1 arthropod, and 99 plants, are included in the list of AAS. Conclusions: AAS designation plays a role in preventing the reduction of biodiversity by IAS in South Korea and preserving native species. Moreover, it is determined to provide considerable economic benefits by preventing socio-economic losses and ecological damage.