• Journal of Acupuncture Research
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• v.23 no.2
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• pp.125-137
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• 2006

Objectives : The effect of water extract of the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong), a traditional immuno-suppressive and immuno-activating Korean oriental medicine, on collagen-induced arthritis (CIA) mice model was studied. Identification of common Nokyong capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. Methods : Nokyong has shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of DAE on collagen-induced arthritis in mice. Results : In three independent experiments mice given DAE in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice given no DAE in water (84% to 100%). The arthritis index also was significantly lower in DAE-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2 (Cox-2), $Interferon-{\gamma}\;(INF-{\gamma})$, and tumor necrosis factor ${\alpha}\;(TNF-{\alpha})$ in arthritic joints of DAE-fed mice. The neutral endopeptidase (NEP) activity was approximately 6-fold higher in arthritic joints of non-DAE-fed mice in comparison to nonarthritic joints of nonimmunized mice whereas it was only 2-fold higher in the arthritic joints of DAE-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in the arthritic joints of DAE-fed mice. Conclusion : Taken together our studies suggest that DAE may be useful in the prevention of onset and severity of arthritis.

• Composites Research
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• v.33 no.4
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• pp.205-212
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• 2020

In this study, HfC was coated on two types of carbon/carbon composites coated with SiC by vacuum plasma spraying(VPS). The experiment was performed using a plasma wind tunnel with heat flux of 5.06 MW/㎡ for 120 s heat flux before and after the coating. The mass ablation rate was calculated through the mass change before and after the test, and the length change was measured by using calipers and high speed camera. The oxidation/ablation behavior were observed by FE-SEM with EDS analysis of the specimens cross section. The plasma wind tunnel test results showed that the coated specimens had low weight loss and length change, and high oxidation/ablation resistance. However, two types of the specimens tested under the same conditions were different in the ablation behavior and ablation rate, and it was evaluated that the cylindrical type had higher oxidation/ablation resistance.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.10
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• pp.1041-1046
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• 2011

Micro shockwaves are induced in laser shock peening and their effect on metal samples is presented. Laser shock peening produces maximized internal compressive stress on metal surfaces. This research evaluated the effects of micro shockwaves from laser shock peening with a pulsed Nd:YAG laser on steel samples, through the analysis of the mechanical properties of the samples. In the experiments, a piezo material was applied to measure the micro shockwaves and the hardnesses and micro tensile strengths of the samples were evaluated.

• International Journal of Oral Biology
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• v.42 no.2
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• pp.47-54
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• 2017

Anthriscus sylvestris (L.) Hoffm. is a perennial herb found widely distributed in various regions of Korea, Europe, and New Zealand. The root of A. sylvestris have been extensively used in the treatment for antitussive, antipyretic, cough remedy in Oriental medicine, but the physiologically active function of the leaf of A. sylvestris is as yet unknown. In this study, we investigated the anti-cancer activity and the mechanism of cell death of water extracts of leaf of Anthriscus sylvestris (WELAS), on human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that WELAS treatment inhibited cell viability in a concentration- and time-dependent manner. In addition, the treatment of WELAS markedly induced apoptosis in FaDu cells, as determined by the viability assay, DAPI stain and FACS analysis. WELAS also increased the proteolytic cleavage of procaspase-3, -9 and PARP (poly(ADP-ribose) polymerase). In addition, exposure to WELAS decreased the expression of Bcl-2 (an anti-apoptotic factor), but increased the expression of Bax (a pro-apoptotic factor), suggesting that mitochondria-dependent apoptotic pathways are mediated in WELAS-induced apoptosis. Taken together, these results indicate that water extracts of leaf of A. sylvestris inhibits cell growth and induces apoptosis via the mitochondrial-dependent apoptotic pathway in FaDu human hypopharyngeal squamous carcinoma cells. Therefore, we propose that the water extracts of leaf of A. sylvestris is a novel chemotherapeutic drug, having growth inhibitory properties and induction of apoptosis in human oral cancer cells.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.49 no.5
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• pp.1-9
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• 2012

Memristor which is known as fourth basic circuit element has been developed recently but its electrical characteristics are not still fully understood. Memristor has the incremental and decremental feature of the resistance depending upon the connected polarities. Also, its operational behavior become diverse depending on its connection topologies. In this work, electrical characteristics of diverse types of serial and parallel connections are investigated using the HP $TiO_2$ model. The characteristics are analyzed with pinched hystersis loops on the V-I plane when sine input signal is applied. The results of the work would be utilized usefully for analyzing the characteristics of memristor element and applications to logic circuit and neuron cells.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.703-712
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• 2004

A variant of the magnetoplasma jet engine (magjet) is here proposed for airbreathing flight in the hypersonic regime. As shown in Figure 1, the engine consists of two distinct ducts: the high-speed duct, in which power is added electromagnetically to the incoming air by a momentum addition device, and the fuel cell duct in which the flow stagnation temperature is reduced by extracting energy through the use of a magnetoplas-madynamic (MPD) generator. The power generated is then used to accelerate the flow exiting the fuel cells with a fraction bypassed to the high-speed duct. The analysis is performed using a quasi one-dimensional model neglecting the Hall and ion slip effects, and fix-ing the fuel cell efficiency to 0.6. Results obtained show that the specific impulse of the magjet is at least equal to and up to 3 times the one of a turbojet, ram-jet, or scramjet in their respective flight Mach number range. Should the air stagnation temperature in the fuel cell compartment not exceed 5 times the incoming air static temperature, the maximal flight Mach number possible would vary between 6.5 and 15 for a magnitude of the ratio between the Joule heating and the work interaction in the MPD generator varied between 0.25 and 0.01, respectively. Increasing the mass flow rate ratio between the high speed and fuel cell ducts from 0.2 to 20 increases the engine efficiency by as much as 3 times in the lower supersonic range, while resulting in a less than 10% increase for a flight Mach number exceeding 8.

• Proceedings of the KAIS Fall Conference
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• 2006.11a
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• pp.220-224
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• 2006

The text to be included in the natural images has many important information in the natural image. Therefore, if we can extract the text in natural images, It can be applied to many important applications. In this paper, we propose a text region extraction method using pattern histogram of character-edge map. We extract the edges with the Canny edge detector and creates 16 kind of edge map from an extracted edges. And then we make a character-edge map of 8 kinds that have a character feature with a combination of an edge map. We extract text region using 8 kinds of character-edge map and 16 kind of edge map. Verification of text candidate region uses analysis of a character-edge map pattern histogram and structural feature of text region. The method to propose experimented with various kind of the natural images. The proposed approach extracted text region from a natural images to have been composed of a complex background, various letters, various text colors effectively.

• Journal of Navigation and Port Research
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• v.37 no.2
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• pp.221-229
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• 2013

To find the influence of incident angle of wave on the moment of 3 storied steel moment resisting frame which is placed on the concrete rectangular pontoon, the fluid dynamic analysis is carried out, varying the period of wave from 5 to 15 second by 2 seconds. As increasing incident angle of wave to longitudinal axis, the influence of RAO-rolling is increased. The moment of longitudinal frame is increased apparently by the wave pressure when the incident angle is $0^{\circ}$. And the moment of the frame due to the wave pressure is decreased as the incident angle is increased. But the moment of frame due to acceleration caused from pitching and rolling is increased. It is shown that the increased moment when incident angle is $90^{\circ}$ is much greater than that of incident angle $0^{\circ}$.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.533-533
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• 2007

The stress effect of SiGe p-type metal oxide semiconductors field effect transistors(MOSFETs) has been investigated to compare device properties using Si bulk and partially depleted silicon on insulator(PD SOI). The electrical properties in SiGe PD SOI presented enhancements in subthreshold slope and drain induced barrier lowering in comparison to SiGe bulk. The reliability of gate oxides on bulk Si and PD SOI has been evaluated using constant voltage stressing to investigate their breakdown (~ 8.5 V) characteristics. Gate leakage was monitored as a function of voltage stressing time to understand the breakdown phenomena for both structures. Stress induced leakage currents are obtained from I-V measurements at specified stress intervals. The 1/f noise was observed to follow the typical $1/f^{\gamma}$ (${\gamma}\;=\;1$) in SiGe bulk devices, but the abnormal behavior ${\gamma}\;=\;2$ in SiGe PD SOI. The difference of noise frequency exponent is mainly attributed to traps at silicon oxide interfaces. We will discuss stress induced instability in conjunction with the 1/f noise characteristics in detail.

• The Korean Journal of Food And Nutrition
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• v.30 no.4
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• pp.735-741
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• 2017

This study was conducted to investigate if the supplement formula may improve alcohol metabolism in healthy adult men. In a double-blinded, randomized, crossover study, subjects were administrated yeast extract mixtures (YEM, n=15), Hovenia dulcis mixtures (HDM, n=15), placebo (PLA, n=15), and control (CON, n=15) in an oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 week), subjects drank 450 mL, 20.1 percent alcohol after administered mixtures. Blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hours). Fifteen subjects completed the protocol and were included in the analysis. Plasma ethanol concentration was lower in YEM (10 percent) and the HDM (5 percent) groups. The area under the curves (AUC) and $C_{max}$ for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUC and $C_{max}$ for plasma acetaldehyde concentration were significantly decreased in the YEM (45 and 54 percent) and the HDM (35 and 53 percent) groups respectively, when compared with PLA (p<0.01). Together, these findings validate that YEM or HDM improved alcohol metabolism and hangover syndromes, leading to reduce alcohol concentration and acetaldehyde concentration without adverse effects.