• Journal of Periodontal and Implant Science
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• 제44권6호
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• pp.274-279
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• 2014

Purpose: To evaluate whether the levels of immunoglobulin G (IgG) antibody to Tanerella forsythia are associated with periodontal status. Methods: Patients with a diagnosis of chronic periodontitis were considered candidates for the study; thus 80 chronic periodontitis patients and 28 healthy persons (control group) were invited to participate in this investigation. The presence of T. forsythia was detected by polymerase chain reaction (PCR) analysis using primers designed to target the respective 16S rRNA gene sequences. Peripheral blood was collected from each subject to identify the IgG1 and IgG2 serum antibodies against T. forsythia. All microbiological and immunological laboratory processes were completed blindly, without awareness of the clinical status of the study patients or of the periodontal sites tested. Results: The bivariate analysis showed that lower mean levels of clinical attachment level (CAL) and probing depth were found in the presence of the IgG1 antibody titers against whole-cell T. forsythia; however, only the difference in CAL was statistically significant. In the presence of the IgG2 antibody titers against whole-cell T. forsythia, the periodontal parameters evaluated were higher but they did not show statistical differences, except for plaque. The unadjusted linear regression model showed that the IgG1 antibody against whole-cell T. forsythia in periodontitis patients was associated with a lower mean CAL (${\beta}=-0.654$; 95% confidence interval [CI], -1.27 to -0.28; P<0.05). This statistically significant association remained after adjusting for possible confounders (${\beta}=-0.655$; 95% CI, -1.28 to -0.29; P<0.05). On the other hand, smoking was a statistically significant risk factor in the model (${\beta}=0.704$; 95% CI, 0.24 to 1.38; P<0.05). Conclusions: Significantly lower mean levels of CAL were shown in the presence of the IgG1 antibody titers against whole-cell T. forsythia in periodontitis patients. Thus, the results of this study suggest that IgG1 antibody to T. forsythia may have been a protective factor from periodontitis in this sample.

• Safety and Health at Work
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• 제6권1호
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• pp.71-74
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• 2015

Obesity and fitness have been identified as key health concerns among USA firefighters yet little is known about the current habits related to exercise and diet. In particular, high-intensity training (HIT) has gained increasing popularity among this population but limited quantitative data are available about how often it is used and the relationship between HIT and other outcomes. Using survey methodology, the current study evaluated self-reported HIT and diet practice among 625 male firefighters. Almost one-third (32.3%) of participants reported engaging in HIT. Body composition, as measured by waist circumference and percentage body fat, was significantly related to HIT training, with HIT participants being approximately half as likely to be classified as obese using body fat [odds ratio (OR) = 0.52, 95% confidence interval (CI) = 0.34-0.78] or waist circumference (OR = 0.61, 95% CI = 0.37-0.98). Those who engaged in HIT were more than twice as likely as those who did not (OR = 2.24, 95% CI = 1.42-3.55) to meet fitness recommendations. Findings highlight directions for future prevention and intervention efforts.

• Safety and Health at Work
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• 제5권2호
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• pp.80-85
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• 2014

Background: Currently available questionnaires for evaluating the quality of worklife do not fully examine every factor related to worklife in all cultures. A tool in Thai is therefore needed for the direct evaluation of the quality of worklife. Our aim was to translate the Work-related Quality of Life Scale-2 (WRQLS-2) into Thai, to assess the validity and reliability of the Thai-translated version, and to examine the tool's accuracy vis-$\grave{a}$-vis nursing in Thailand. Methods: This was a descriptive correlation study. Forward and backward translations were performed to develop a Thai version of the WRQLS. Six nursing experts participated in assessing content validity and 374 registered nurses (RNs) participated in its testing. After a 2-week interval, 67 RNs were retested. Structural validity was examined using principal components analysis. The Cronbach's alpha values were calculated. The respective independent sample t test and intraclass correlation coefficient were used to analyze known-group validity and test-retest reliability. Multistate sampling was used to select 374 RNs from the In- and Outpatient Department of Srinagarind Hospital of the Khon Kaen University (Khon Kaen, Thailand). Results: The content validity index of the scale was 0.97. Principal components analysis resulted in a seven-factor model, which explains 59% of the total variance. The overall Cronbach's alpha value was 0.925, whereas the subscales ranged between 0.67 and 0.82. In the assessment results, the known-group validity was established for the difference between civil servants and university employees [F (7.982, 0.005) and t (3.351; p < 0.05)]. Civil servants apparently had a better quality worklife, compared to university employees. Good test-retest reliability was observed (r = 0.892, p < 0.05). Conclusion: The Thai version of a WRQLS appears to be well validated and practicable for determining the quality of the work-life among nurses in Thailand.

• Asian Journal of Atmospheric Environment
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• 제2권1호
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• pp.14-25
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• 2008

Benzene, toluene, ethyl benzene and m-, p-, and o-xylene, the most influential aromatic volatile organic compounds (VOCs), were measured in Bangkok, Thailand, one of the most rapidly developing urban areas in Southern East Asia. The purpose of this study is to characterize the ambient air quality with respect to above mentioned aromatic compounds. The data were monitored in ten sites which cover roadside area, residential area and background area. Canister technique was used to obtain air sample at 24 hour interval per a month during April-August in 2007. GC/MS with three stage preconcentrator was used to analyze these samples. The average concentrations of benzene, toluene, ethyl benzene m-, p-xylene and o-xylene are 5.8, 36.1, 4.1, 11.0 and $3.7{\mu}g/m^3$, respectively. They were observed to be distributed in a log-normal form. Moreover, o-xylene and m, p-xylene exhibited a very good correlation (r=0.976). The slope of the regression equation between them was 3.07 which consisted with a previous reported value. The average ratio of toluene to benzene was 6.4 in April, May June and August. This value was comparable to the ones measured in other Asian cities. Two types of statistical analyses, cluster and factor analyses, were applied to the data in this study. Well characterization was made to understand the air quality of Bangkok area.

• 한국수산과학회지
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• 제10권3호
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• pp.173-177
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• 1977

1976년 9월부터 10월 사이에 동해 북동해역 9개 관측점에서 투명도, 태양광선의 적색광(파장;$600\~620nm$)에 대한 수심별 수중조도와 태양고도 등을 조사하여 검토한 결과를 요약하면 다음과 같다. 1. 본 조사해역의 평균투명도는 $19.8m(15\~23m)$로 나타났다. 2. 태양광선의 적색광에 대한 해수의 흡수계수는 $0.142\~0.323$(평균 0.232)였다. 3. 적색광에 대한 해수의 흡수계수 m와 투명도 D와의 관계는 m=4.93/D로 나타났다. 4. 적색강의 수중투과율은 수성 5m층에서 표면광의 $15\~34.2\%$(평균 $23.11\%$), 수신 10m층에서는 $3.04\~12\%$(평균 $6.49\%$)였고, 수심 20m층에서는 $0.113\~1.27\%$(평균 $0.698\%$)로 나타났다.

• 대한전자공학회논문지TC
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• 제44권1호
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• pp.113-122
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• 2007

이동 통신망에서 시간 기반 및 이동 기반의 위치 갱신 방법을 결합한 혼합형 위치 갱신 방법을 제안한다. 제안된 방법에서는 이동단말이 셀 경계를 n번 이동한 후 T의 시간이 지난 후에 자신의 위치를 갱신한다. 또한 사용자의 이동특성을 다중 상태의 지수분포 셀 체류시간 모델로 정의하여, 제안된 혼합형 위치 갱신 방법을 적용한다. 제안된 혼합형 위치 갱신 방법 및 다중 상태의 지수 분포 셀 체류시간 모델에 대한 수식적인 분석을 수행하였으며, 이를 모의 실험 분석을 통하여 검증하였다. 수식적인 분석과 모의 실험 분석의 결과, 다중 상태의 이동성 모델의 경우 제안하는 혼합형 위치 갱신 방법이 시간 기반의 위치 갱신 방법이나 이동 기반의 위치 갱신 방법 보다 뛰어남을 보여주며, 따라서 시간에 따라 수시로 변하는 이동성을 갖는 사용자에게 혼합형 위치 갱신 방법이 효과적으로 적용될 수 있음을 알 수 있었다.

• 미생물학회지
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• 제33권1호
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• pp.7-14
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• 1997

성장인자가 포함되지 않은 무기염 액체배지(ISP-4)에서 Streptomyces coelicolor A3(2)의 포자가 발아할 때, 성장인자의 주기적인 요구성이(양 등,1993_ 단백질과 RNA 합성과 어떤 관계를 가지고 있는지를 규명하고자 하ㅣ였다. 발아는 10시간 정도 걸렸으며 이때 성장인자의 요구성이 2시간 주기로 반복되는 것을 재입증하였다. 포자의 크기는 시간에 따라 증가하였으나, 포자수는 표준 평판계수법에서 감소하였다. 포자 집단은 생리적으로 살아있거나, 휴면 중인 포자와 죽은 포자로 구분될 수 있었다. 이러한 발아과정에서 포자를 acridine orange(AO)와 iodonitrotetrazolium chloride(INT)로 염색하여 형광현미경으로 관찰하였을 때 RNA와 단백질도 일정한 주기를 갖고 합성되었으며, 이 주기성은 성장인자의 요구 주기와 거의 일치하였다. 이로써 발아 초기에 포자 집단은 성장인자 중에서 특히 단백질 합성과 관련된 물질인 아미노산이 주기적으로 요구되고 있음을 토론하였다.

• 대한치과마취과학회지
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• 제13권3호
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• pp.89-94
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• 2013

Background: Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50). Methods: Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra$^{(R)}$; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of $3{\mu}g/ml$. Results: The EC50 of remifentanil to prevent the propofol injection pain was $1.80{\pm}0.35ng/ml$ by Dixon's up and down method. Conclusions: The EC50 of remifentanil to blunt the pain responses to propofol injection was $1.80{\pm}0.35ng/ml$ for propofol TCI anesthesia.

• Journal of Periodontal and Implant Science
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• 제45권1호
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• pp.14-22
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• 2015

Purpose: The purpose of this study was to compare serum amyloid A (SAA) protein levels with high-sensitive C-reactive protein (hs-CRP) levels as markers of systemic inflammation in patients with chronic periodontitis. The association of serum titers of antibodies to periodontal microbiota and SAA/hs-CRP levels in periodontitis patients was also studied. Methods: A total of 110 individuals were included in this study. Patients were assessed for levels of hs-CRP and SAA. Nonfasting blood samples were collected from participants at the time of clinical examination. The diagnosis of adipose tissue disorders was made according to previously defined criteria. To determine SAA levels, a sandwich enzyme-linked immunosorbent assay was utilized. Paper points were transferred to a sterile tube to obtain a pool of samples for polymerase chain reaction processing and the identification of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia. The serum level of IgG1 and IgG2 antibodies to P. gingivalis, A. actinomycetemcomitans, and T. forsythia was also determined. Results: SAA and hs-CRP levels were higher in periodontitis patients than in controls (P<0.05). In bivariate analysis, high levels of hs-CRP (>3 mg/L) and SAA (>10 mg/L) were significantly associated with chronic periodontitis (P=0.004). The Spearman correlation analysis between acute-phase proteins showed that SAA positively correlated with hs-CRP (r=0.218, P=0.02). In the adjusted model, chronic periodontitis was associated with high levels of SAA (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.6-18.2; P=0.005) and elevated hs-CRP levels (OR, 6.1, 95% CI, 1.6-23.6; P=0.008). Increased levels of serum IgG2 antibodies to P. gingivalis were associated with high levels of SAA (OR, 3.6; 95% CI, 1.4-8.5; P=0.005) and high concentrations of hs-CRP (OR, 4.3; 95% CI, 1.9-9.8; P<0.001). Conclusions: SAA and hs-CRP concentrations in patients with chronic periodontitis are comparably elevated. High serum titers of antibodies to P. gingivalis and the presence of periodontal disease are independently related to high SAA and hs-CRP levels.

• Journal of Gastric Cancer
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• 제17권4호
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• pp.331-341
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• 2017

Purpose: This study aimed to evaluate the clinical significance of microscopic invasion to determine the adequate resection margin in early gastric cancer (EGC). Materials and Methods: A retrospective review was performed that included patients who underwent gastrectomy for clinical early gastric cancer (cEGC) at Seoul National University Hospital between January 2007 and December 2010. After subtracting the microscopic resection margin from the gross resection margin for each proximal or distal resection margin, microscopic invasion was represented by the larger value. Microscopic invasion and its risk factors were analyzed according to the clinicopathologic characteristics. Results: In total, 861 patients were enrolled in the study. Microscopic invasion of cEGC was $6.0{\pm}12.8mm$, and the proportion of patients with microscopic invasion ${\geq}0mm$ was 78.4%. In the risk group, tumor location, pT stage, and differentiation did not significantly discriminate the presence of microscopic invasion. The microscopic invasion of EGC-IIb was $13.9{\pm}16.8mm$, which was significantly greater than that of EGC-I. No linear correlation was observed between the overall tumor size and microscopic invasion (R=0.030). The independent risk factors for microscopic invasion ${\geq}20mm$ were EGC-IIb vs. EGC-I/IIa/IIc/III (odds ratio [OR], 3.103; 95% confidence interval [CI], 1.533-6.282; P=0.002) and male vs. female sex (OR, 1.655; 95% CI, 1.012-2.705; P=0.045). Conclusions: Male sex and EGC-IIb were independent risk factors for microscopic invasion ${\geq}20mm$. Examination of intraoperative frozen sections is highly recommended to avoid resection margin involvement, especially in cases of EGC-IIb.