• 한국식품과학회지
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• 제28권4호
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• pp.772-778
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• 1996

레토르트 처리시 일어나는 휘발성분 변화를 관찰하고자 닭고기 50%, 식염 1%, 닭고기 육수 49%로 구성된 모형식품을 설정하고, 가열살균에 따른 휘발성분변화를 GC (gas chromatography)로 조사하고, GC-MS (mass spectrometry)로 각 GC peak의 휘발성분을 분석하였다 살균 전, 후의 모형식품에서 NPT (Nitrogen purge and trap)방법으로 휘발성분을 포집한 후 이를 분석한 결과 총 53개 peak가 검출되었고 그 중 42개 peak를 동정하였다. 동정된 42개 peak는 aldehyde류 17종, hydrocarbon류 9종, alcohol류 8종, ketone류 7종 및 furan과 terpene이 각 1종씩이었다. 살균에 따른 휘발성분의 변화량을 비교하고, 동정된 휘발성분의 향기특성 등을 고려해 볼 때 레토르트취에 관여하는 화합물은 2-heptanone, 2-pentyl furan 및 ketone류인 것으로 추정 되었다.

• 한국운동역학회지
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• 제29권3호
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• pp.173-183
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• 2019

Objective: The aim of this study was to investigate the correlation coefficients between anthropometric parameters of the foot and kinetic variables during running. Method: This study was conducted on 21 healthy young adults (age: $24.8{\pm}2.1yes$, height: $177.2{\pm}5.8cm$, body mass: $73.3{\pm}7.3kg$, foot length: $256.5{\pm}12.3mm$) with normal foot type and heel strike running. To measure the anthropometric parameters, radiographs were taken on the frontal and sagittal planes, and determined the length and width of each segment and the navicular height. Barefoot running was performed at a preferred velocity ($3.0{\pm}0.2m/s$) and a fixed velocity (4.0 m/s) on treadmill (Bertec, USA) in order to measure the kinetic variables. The vertical impact peak force, the vertical active peak force, the braking peak force, the propulsion peak force, the vertical force at mid-stance (vertical ground reaction when the foot is fully landed in mid-stance or at the point where the weight was uniformly distributed on the foot) and the impact loading rate were calculated. Pearson's correlation coefficient was used to investigate the relationship between anthropometric variables and kinetical variables. The significance level was set to ${\alpha}=.05$. Results: At the preferred velocity running, the runner with longer forefoot had lower active force (r=-.448, p=.041) than the runner with short forefoot. At the fixed velocity, as the navicular height increases, the vertical force at full landing moment increases (r= .671, p= .001) and as the rearfoot length increases, the impact loading rate decreases (r=- .469, p= .032). Conclusion: There was a statistically significant difference in the length of fore-foot and rearfoot, and navicular height. Therefore it was conclude that anthropometric properties need to be considered in the foot study. It was expected that the relationship between anthropometric parameters and kinetical variables of foot during running can be used as scientific criteria and data in various fields including performance, injury and equipment development.

• 대한임상독성학회지
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• 제7권2호
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• pp.156-163
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• 2009

Purpose: Doxylamine succinate (DS) is frequently used to treat insomnia and it may induce rhabdomyolysis in the overdose cases. The purpose of this study is to evaluate the factors that can predict the serum creatine kinase (CK) level normalization time for patients with rhabdomyolysis due to DS ingestion. Methods: This study was conducted on 71 patients who were admitted with rhabdomyolysis after DS ingestion during the period from January 2000 to July 2009. Rhabdomyolysis was defined as a serum CK level over 1,000 U/L. The collected data included the general characteristics, the anticholinergic symptoms, the ingested dose, the peak serum CK level, the time interval (TI) from the event to the peak CK level and the TI from the event to a CK level below 1,000 U/L. We evaluated the correlation between the patients' variables and the TI from the event to the peak CK level time and the time for a CK level below 1,000 U/L. Results: The mean ingested dose per body weight (BW) was $30.86{\pm}18.63\;mg/kg$ and the mean TI from the event to treatment was $4.04{\pm}3.67$ hours. The TI from the event to the peak CK level was longer for the patients with a larger ingestion dose per BW (r=0.587, p<0.05). The CK normalization time was longer for the patients with a larger ingested dose per BW (r=0.446, p<0.05) and a higher peak CK level (r=0.634, p<0.05). Conclusion: The ingested dose per BW was correlated with the TI from the event to the peak CK level, and the ingested dose per BW and the peak CK level have significant correlations with the CK normalization time. These factors may be used to determine the discharge period of patients who had rhabdomyolysis following a OS overdose.

• 융합신호처리학회논문지
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• 제21권1호
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• pp.49-54
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• 2020

심혈관질환은 전 세계 주요 사망 원인으로 다양한 원인에 의해 발생한다. 심혈관질환의 가장 높은 위험인자는 고혈압으로 뚜렷한 증상이 없지만 방치할 경우 여러 합병증을 유발한다. 고혈압을 치료하기 위하여 약물치료와 규칙적 운동을 진행해야한다. 고혈압 환자의 경우 과도한 신체 활동 시 심장에 큰 무리가 발생해 심혈관질환으로 이어질 수 있다. 따라서 적정 강도로 운동을 진행할 수 있는 PTT 계측을 통한 운동 강도 모니터링 시스템이 요구된다. 본 연구에서는 심전도와 맥파 계측을 통해 PTT를 산출하여 운동 강도에 따른 PTT 변화 모니터링 시스템을 구현하였다. 구현된 시스템은 심전도의 R-peak와 맥파의 P-peak를 미분하여 peak간의 시간차를 이용하여 PTT를 산출한다. 운동 강도에 따른 PTT 변화 모니터링을 위하여 달리기 실험을 진행하였다. 실험결과 저강도는 0.313s, 중강도는 0.220s, 고강도는 0.188s의 PTT가 측정되었으며, 운동 강도가 증가함에 따라 PTT는 감소하는 것을 확인하였다.

• Nuclear Engineering and Technology
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• 제6권1호
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• pp.3-8
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• 1974

천연 녹주석의 방사선조사에 의한 효과를 없애기 위한 열처리방법을 연구하였다. Glow곡선분석에서 최적열처리시간과 온도는 145$0^{\circ}C$에서 1시간이었고, 녹주석을 다시 사용할 시에는 145$0^{\circ}C$에서 1시간동안 열처리를 다시 할 필요는 없고 55$0^{\circ}C$에서 1시간만 열처리를 하면 된다. 145$0^{\circ}C$에서 열처리된 녹주석시료를 $^{60}$Co감마선으로 100R 조사한 후 glow곡선을 그려보니 $65^{\circ}C$와 20$0^{\circ}C$에서 glow peaks를 발견하였다. $65^{\circ}C$ glow peak는 곧 없어졌으나 20$0^{\circ}C$ glow peak는 매우 안정하였다. 따라서 열형광방사선측정에는 20$0^{\circ}C$ glow peak를 이용하여 $^{60}$Co감마선을 측정할 수 있다.

• 한국임상약학회지
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• 제16권1호
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• pp.28-33
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• 2006

The stability of cefditoren in three kinds of oral liquid preparations at 4 and $25^{\circ}C$ was studied for 90 days. Two tablets of 100 mg cefditoren pivoxil were mixed with 200 mL of each oral liquid syrup, which is Pebron syrup (oxolamine citrate 10 mg/mL), $Mucopect^{(R)}$ syrup (ambroxol hydrochloride 3 mg/mL) or $Tyrenol^{(R)}$ suspension (acetaminophen encapsulated 32 mg/mL). Three samples of each formulation were refrigerated $(4^{\circ}C)$ and three were stored at room temperature $(25^{\circ}C)$. At predetermined time, samples were assayed by stability-indicating HPLC method. The chromatographic analysis after deliberate degradation showed no evidence of any breakdown product likely to interfere with the chromatographic peak of the parent substance. The relation between cefditoren pivoxil concentration and peak area was linear from 10 to $150{\mu}g/mL\;(r^2=0.9998)$. The analysis method was precise, with coefficients of variation no greater than 3.6%. Cefditoren was stable in $Mucopect^{(R)}$ syrup up to 4 weeks regardless of the temperature; in $Tyrenol^{(R)}$ suspension and Pebron syrup, it was stable for at least 28 and 45 days, and 7 and 45 days at 25 and $4^{\circ}C$, respectively. The percentages of initial cefditoren concentration remaining after 90 days were $51.5{\pm}1.8\;and\;80.9{\pm}5.6%,\;61.7{\pm}7.8\;and\;70.2{\pm}7.3%,\;and\;39.9{\pm}3.2\;and\;81.4{\pm}5.5%$ in $Mucopect^{(R)}$ syrup, $Tyrenol^{(R)}$ suspension and $Pebron^{(R)}$ syrup at 25 and $4^{\circ}C$, respectively. The pH variations of all test solutions were minimal, which was within 0.5. The results indicated that the stability of cefditoren was significantly affected by liquid solutions mixed with cefditoren, and storage tempertature.

• 한국식품과학회지
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• 제36권5호
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• pp.754-760
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• 2004

한국산 밀의 이화학적 특성과 sugar-snap cookie의 제조적성을 알아보고자 시판 밀가루 4종류와 국내산 밀 6품종을 본 연구에 공시하여 검토한 바 그 결과는 다음과 같다. 밀가루 종류 및 품종에 따라서 AWRC는 42.7-65.2%, Pelshenke 값은 17-43min, 침전가는 19.6-49.5mL이었고, RVA에 의한 initial pasting temp.는 $68.4-74.5^{\circ}C$이었으며, mixograph mixing time은 1.3-3.5min이었다. Sugar-snap cookie의 직경은 7.1-7.9cm, spread factor는 102-139%로서 시판 박력분과 우리밀이 가장 좋았다. Mixograph peak height와 단백질 함량 및 AWRC와는 $r=0.704^*$ 및 $r=0.648^*$의 정의상관이 있었다. Cookie의 직경은 밀가루의 단백질 함량과 $r=-0.891^{**}$, AWRC와는 $r=-0.736^{**}$, 침전가와는 $r=-0.734^*$의 고도의 부의 상관이 있었다. Cookie spread factor와 mixograph peak height와는 $r=-0.855^{**}$, 7-min height와는 $r=-0.810^{**}$의 고도의 부의 상관성이 있었으며, cookie top grain score와 단백질 함량은 $r=-0.899^{**}$, 침전가와는 $r=-0.742^{**}$의 부의 상관을 보여 cookie의 특성은 밀가루의 단백질 함량에 따라서 크게 영향을 받는 것을 알 수 있었다.

• 대한핵의학회지
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• 제28권1호
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• pp.52-61
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• 1994

Background : The demand for refinement in noninvasive and quantitative assessment of left ventricular (LV) function is increasing. Purpose : To assess normal values of left ventricular functional parameters during both systole and diastole by scintigraphic method using computerized triple-head gamma camera and to evaluate correlations between these parameters. Methods : ECG gated blood pool scan with $^{99m}Tc$-Human serum albumin was performed in 94 normal Korean subjects. Ejection fraction (EF), systolic parameters [peak emptying rate (PER), average emptying rate (AER), time to peak emptying rate (TPER)], and diastolic parameters [peak filling rate (PFR), average filling rate (AFR), time to peak filling rate (TPFR)] were obtained by analysis of LV time-activity curve, the correlation of these parameters to the age and sex, and the correlation between these parameters were evaluated. Results : 1) Mean value of ejection fraction in study subjects was $59.6{\pm}5.25%$ and showed no significant correlation to age (r=-0.08) and sex but showed most pronounced correlation to PFR (r=0.46, p<0.001), PER (r=0.41, p<0.001), AFR (r=0.34, p<0.001) and AER (r=0.28, p<0.01). 2) Mean values of systolic parameters were as follows: $PER=3.22{\pm}0.50$ end-diastolic volume/sec, $AER=2.22{\pm}0.45$ end-diastolic volume/sec, $TPER=103.5{\pm}29.30$ msec. They showed no significant correlation to age and sex. 3) Mean values of diastolic parameters were as follows: $PFR=2.71{\pm}0.51$ end-diastolic volume/sec, $AFR=1.83{\pm}0.44$ end-diastolic volume/sec, $TPFR=132.1{\pm}33.45$ msec. They showed strong correlation to age (r=0.70, -0.64, 0.37, p<0.001). Conclusions : Left ventricular functional parameters in normal Korean subjects were obtained reliably by computerized scintigraphic method and may be applied to the evaluation of cardiac function in diseased patients.

• Biomolecules & Therapeutics
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• 제15권3호
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• pp.187-191
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• 2007

This study was conducted to compare the bioavailability of two brands of atenolol (50 mg) tablets, which are a generic product of $Ditent^{\circledR}$ (Daewon Pharmaceutical Co., Ltd., Korea) and an innovator product $Tenormin^{\circledR}$ (Hyundai Pharm. Ind. Co., Ltd., Korea), in 20 healthy Korean male volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way cross-over design. The washout period between treatments was 1 week. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs. time curves, the following parameters were compared: area under the plasma concentration-time curve ($AUC_{0-24}$), peak plasma concentration ($C_{max}$), time to reach peak plasma concentration ($T_{max}$), and terminal first order elimination half-life ($t_{1/2}$). No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed $AUC_{0-24}$ and $C_{max}$ values of the two products. The 90% confidence interval for the ratio of the logarithmically transformed AUC and $C_{max}$ values of $Ditent^{\circledR}$ over those of $Tenormin^{\circledR}$ were calculated to be between 0.85 and 1.04, and 0.89 and 1.07, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ group was 3.1 hour, and that in Ditent$^{\circledR}$ group was 3.2 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean values were 5.2 hour in the both products. Based on these results, it was concluded that $Ditent^{\circledR}$ was comparable to $Tenormin^{\circledR}$ in both the rate and extent of absorption, indicating that $Ditent^{\circledR}$ was bioequivalent to the reference product, $Tenormin^{\circledR}$.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.247-249
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• 2008

Low Temperature a-Si:H TFT on stainless steel substrate has been developed for the flexible electrophoretic display. Stability of low temperature a-Si:H TFT is more important point than its initial device characteristics. Thus, we have studied device characteristics of low temperature a-Si:H TFT in terms of stability for driving electrophoretic display.