• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5073-5076
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• 2013

Objective: This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer. Methods: MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined. Results: MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P<0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P=0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P=0.014), tumor length (P=0.040) and expression (P=0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively. Conclusion: miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.

• Development and Reproduction
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• v.3 no.1
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• pp.69-74
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• 1999

Insulin-like growth factors (IGF-1 and IGF-2) play an important regulatory role in premplantation embryonic development. To study the role of IGF-1 during premplantation embryonic development in mouse, the presence of mRNA transcripts for IGF-1 and IGF-lR in the oocytes and preimplantation embryos was examined. In this study, the transcripts of IGF-1 was detected in oocytes using primers for IGF-1. The PCR products were identified by Msp I restriction enzyme digest. We revealed that the transcripts of IGF-1 and IGF-1R were presented in the oocytes and preimplantation embryos. The highest mRNA levels in GV stage oocytes were decreased at 4- or 8-cell stage and then reincreased upto blastocyst. The presence of IGF-1 and IGF-lR in GV-oocytes suggests that the transcripts in the early stage embryos were derived from maternal genome. Additionally, the presence of IGF-1 and IGF-lR in the oocytes and preimplantation embryos suggests that IGF-1 plays an autocrine role during preimplantation embryonic development through IGF-lR as a signalling pathway.

• Journal of The Korean Astronomical Society
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• v.49 no.5
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• pp.193-198
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• 2016

Early-type galaxies (ETGs) are supposed to follow the virial relation $M=k_e{\sigma}^2R_e/G$, with M being the mass, σ_* being the stellar velocity dispersion, R_e being the effective radius, G being Newton's constant, and k_e being the virial factor, a geometry factor of order unity. Applying this relation to (a) the ATLAS^3D sample of Cappellari et al. (2013) and (b) the sample of Saglia et al. (2016) gives ensemble-averaged factors 〈k_e〉 = 5.15 ± 0.09 and 〈k_e〉 = 4.01 ± 0.18, respectively, with the difference arising from different definitions of effective velocity dispersions. The two datasets reveal a statistically significant tilt of the empirical relation relative to the theoretical virial relation such that $M{\propto}({\sigma}^2_*R_e)^{0.92}$. This tilt disappears when replacing R_e with the semi-major axis of the projected half-light ellipse, a. All best-fit scaling relations show zero intrinsic scatter, implying that the mass plane of ETGs is fully determined by the virial relation. Whenever a comparison is possible, my results are consistent with, and confirm, the results by Cappellari et al. (2013). The difference between the relations using either a or R_e arises from a known lack of highly elliptical high-mass galaxies; this leads to a scaling (1 - ϵ ) ∝ M^0.12, with ϵ being the ellipticity and $R_e=a\sqrt[]{1-{\epsilon}}$. Accordingly, a, not R_e, is the correct proxy for the scale radius of ETGs. By geometry, this implies that early-type galaxies are axisymmetric and oblate in general, in agreement with published results from modeling based on kinematics and light distributions.

• Environmental and Resource Economics Review
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• v.25 no.1
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• pp.89-112
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• 2016

In this paper, as a determining factor of the Environment Kuznets Curve hypothesis, we analyzed the impact of technological innovation. In this paper, in order to empirically validate the role of technological innovation to an inverted U-shaped Environments Kuznets Curve hypothesis, we utilize the 2SLS considering relationship between R&D and the GDP per capita. Also, using the Panel VAR (Panel Vector Auto Regression) model to analyze with what time lag R&D per capita has impact on the emissions of greenhouse gases per capita. Empirical results show that R&D per capita(proxy of innovation) is a important factor to explain Environmental Kuznets Curve hypothesis, and that the external shock such as R&D per capita reduces greenhouse gas emissions per capita with about 3 time lag.

• Journal of Convergence for Information Technology
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• v.10 no.2
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• pp.9-14
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• 2020

This study studied on innovation and R&D performance measurement, and especially the dimensions of measuring performance. The Empirical study is based on the opinions of 169 experts from a R&D group with a career for SMBA's support. The results reveal that what the most optimal and appropriate measures of project-level success are will depend on the type of innovation involved and the development project type and the relatively low significance of financial measures for innovation projects in general. Additionally, measurability is not major significance factor for selecting measures, whereas the level of innovativeness were to be selected as important factor. The roles of the evaluators are affected. It is expected to help make government policy for R8D performance evaluation.

• Anxiety and mood
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• v.8 no.2
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• pp.127-132
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• 2012

Objective : This study aims to investigate the relationship between addictive mobile phone use and post-traumatic stress disorder (PTSD) symptoms in bullies who experienced school violence. Methods : The study subjects consisted of 97 adolescents in The Foundation for Preventing Youth Violence after school violence. The participants conducted self-report questionnaire for addictive mobile phone use and Impacted Event Scale-revised-Korean version (IES-R-K). Partial correlation and multiple logistic regressions were performed. Results : The scores related to addictive mobile phone use were correlated with total score (r=0.21, p=0.04), avoidance score (r=0.21, p=0.04) and intrusive score (r=0.26, p=0.01) related to PTSD symptoms on the IES-R-K. Intrusive score related to PTSD symptoms on the IES-R-K were significant risk factor for addictive mobile phone use (O.R=1.25, 95% CI=1.12-1.39). Conclusion : This data supports that PTSD intrusive symptoms could be predictable factor of addictive mobile phone use. An appropriate intervention about PTSD symptoms might play a useful role in preventing addictive mobile phone use in bullies of school violence.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.2B
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• pp.154-163
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• 2006

The importance of R & D investment has dramatically been increased as industrial paradigm rapidly changes to knowledge-based economy. In order to preserve recent economic growth and reinforce competitive advantage, government policy and regulatory framework needs to be reshaped in ways that minimize the distorted use of limited resources and maximize the efficiency of R & D investment. In this regards, this paper aims to investigate the influence of R & D investment in national economic growth and to compare the effectiveness of IT R & D investment with other industries, in respect to the time lag.

• Journal of Advanced Navigation Technology
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• v.17 no.6
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• pp.693-699
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• 2013

In this paper, ${\pi}/4$-DQPSK modem according to ITU-R M.1842-1 recommendation Annex1 is investigated and simulated. At first, standardization and technical trend of VHF maritime mobile communication are introduced. The ${\pi}/4$-DQPSK modem defined in the Annex1 should support 28.8Kbps bit transmission rate within 25KHz frequency bandwidth. We describe the system model and simulation process of ${\pi}/4$-DQPSK modem transmitter and receiver design with RRC(Root Raised Cosine) transmitter and receiver filter. Then we suggest various graphical simulation results(time domain signals, constellation, power spectral density according to roll-off factor, eye diagram), and show simulated BER performance of the modem. From the simulation results, it is shown that roll-off factor of RRC filter affects to BER performance according to SNR and the designed simulation model meets the spectrum mask requirement suggested in ITU-R M.1842-1 recommendation.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.187-187
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• 2001

Since hypoxia-inducible factor-lalpha (HIF-lalpha) and the arylhydrocarbon receptor (AhR) shared the AhR nuclear translocator (Arnt) for hypoxia- and AhR-mediated signaling, respectively, it was possible to establish the hypothesis that hypoxia could regulate Cyp1a1 expression.(omitted)

• Journal of The Korean Astronomical Society
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• v.13 no.1
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• pp.27-33
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• 1980

Surface density distributions for globular clusters were obtained from photoelectric surface photometry (using centered aperture photometry). These surface brightness profiles were then compared with the theoretical surface density distribution of King's model. From the comparison of the theoretical and observed surface density distributions, we determine he structural parameters of the clusters (the core radius $r_c$, the tidal cut off $r_t$, and the concentration factor C).