• Journal of Information Technology Application
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• 제3권4호
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• pp.63-92
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• 2001

This paper makes an attempt to look at the process of automatically generating an application software system based on the Entity-Relationship (E-R) model. Basically, the process consists of five steps as follows: First, the designer develops an E-R model of an real-world system. Second, the software generator automatically generates a stereo-type application system. Third, the generator produces database schema and link information between application programs. Fourth, the designer designs the user interface including menu, screen design and so on. Finally, the generator completes the process integrating all the elements of an application system. Five basic program generation rules, three extended rules and a database generation rule have been suggested. By following each rule with the generator, the designer can build an application with an extremely efficient manner compared with traditional approaches. A case study has been included in order to show the applicability of the automated software generation process suggested in this paper. It has been demonstrated from the case study that the idea of applying an automated generator in systems development based upon the E-R model worked well.

• Atmosphere
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• 제16권4호
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• pp.379-385
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• 2006

Meteorological Research Institute (METRI) participates the R&E (Research and Education) program of Korea Science and Engineering Foundation,"Variability of ocean status around Ulleung basin and Dok-do by using ARGO data" as a part of "Carricula development for gifted students" program. From this program, we support students to have an opportunity for handling scientific data with advanced technology and inspire their scientific interests. In this article, we introduce the training processes of this program and the results of data analysis by the students themselves.

• Korean Journal of Applied Biomechanics
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• 제24권3호
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• pp.217-227
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• 2014

The purpose of this study was to investigate the relationship between distance and factors of javelin in korean male's javelin throwing. To accomplish this purpose, the analyzed trail selected total 29 trails (subjects 9) recorded more than 65 m in the 93rd National Sports Festival. The Kwon3D 3.1 version was used to obtain the three dimensional coordinates about the top, grip, end of javelin. And the kinematic data such as projection factors and direction angle of javelin calculated using Matlab2009a program. The statical analysis on the records (n=29) were used to Pearson's product moment correlation coefficient. There was a statistically positive relationship between the records and horizontal velocity (r=.866, ${\rho}$<.01), height (r=.541, ${\rho}$ <.001), height rate (r=.373, ${\rho}$ <.05) and horizontal displacement of javelin (r=.749, ${\rho}$ <.01), but the medial/lateral velocity showed a negative relationship to r=-.663 (${\rho}$ <.01). The attack and yaw angle showed not a significant relationship between the records, but the medial-lateral tilt (E1:r =-.557 [p<.01)] E2:r=-.629 [${\rho}$<.01], E3:r=-.528 [${\rho}$ <.01]) and attitude angle (E2:r=-.629 [[${\rho}$<.01], E3:r=-.619 [${\rho}$ <.01]) of javelin showed a negative relationship between the records, as well as the projection angle of javelin (r=-.419, ${\rho}$ <.05) showed a negative relationship between the records.

• Computers and Concrete
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• 제11권6호
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• pp.493-513
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• 2013

Direct displacement-based design (DDBD) represents an innovative philosophy for seismic design of structures. When structural considerations are more critical, DDBD design should be carried on the basis of limiting material strains since structural damage is always strain related. In this case, the outcome of DDBD is strongly influenced by the displacement demand of the structural element for the target limit strains. Experimental studies have shown that anchorage slip may contribute significantly to the total displacement capacity of R/C column elements. However, in the previous studies, anchorage slip effect is either ignored or lumped into flexural deformations by applying the equivalent strain penetration length. In the light of the above, an attempt is made in this paper to include explicitly anchorage slip effect in DDBD of R/C column elements. For this purpose, a new computer program named RCCOLA-DBD is developed for the DDBD of single R/C elements for limiting material strains. By applying this program, more than 300 parametric designs are conducted to investigate the influence of anchorage slip effect as well as of numerous other parameters on the seismic design of R/C members according to this methodology.

• Bulletin of the Korean Chemical Society
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• 제30권12호
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• pp.2999-3005
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• 2009

Among the more than 120 different types of human papillomavirus (HPV), types 16 and 18 have been known to be high risk agents that cause cervical cancer. We examined, in an immuno-chromatographic analysis, the potential of using the early gene product, E7 protein, as a diagnostic marker of cervical cancer caused by HPV. We developed monoclonal antibodies specific to HPV-16 and 18 E7 proteins that were produced from bacterial cells using gene recombinant technology. For each E7 protein, the optimal antibody pair was selected using the immuno-chromatographic sandwichtype binding system based on the lateral flow through membrane pores. Under these conditions, this rapid testing assay had a detection capability as low as 2 ng/mL of E7 protein. Furthermore, since viral analysis required the host cell to be lysed using chemicals such as detergents, it was possible that the E7 protein was structurally damaged during this process, which would result in a decrease in detection sensitivity. Therefore, we examined the detrimental effects caused by different detergents on the E7 protein using HeLa cells as the host. In these experiments, we found that the damage caused by the detergent, nonylphenylpolyethylene glycol (NP-40), was minimal relative to Triton X-100 commonly used for the cell lysis. Temperature also affected the stability of the E7 protein, and we found that the E7 protein was stabilized at 4$^{\circ}C$ for about 2 h, which was 4 times longer than at room temperature. Finally, a HPV-infected cervical cancer cell line, which was used as a real sample model, was treated using the optimized conditions and the presence of E7 proteins were analyzed by immuno-chromatography. The results of this experiment demonstrated that this rapid test could specifically detect HPV-infected samples.

• Plant Journal
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• 제13권4호
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• pp.38-40
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• 2017

This study is for stabilization of the water balance of the closed cooling water system. The pipe network analysis program is used for the water balance review, and the resistance factor correction is performed through the field measurement with the ultrasonic flowmeter to improve the reliability of the pipe network software. Based on this, it is aimed to derive optimal driving method through various case simulations.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
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• pp.307-310
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• 2007

We describe effects of ionic and neutral additives on phase and structural behavior of the lyotropic chromonic liquid crystals used in preparation of optical elements such as polarizers and compensators.

• Animal cells and systems
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• 제9권3호
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• pp.139-144
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• 2005

The attractant (orange light) or repellent (white light) signal is transmitted from SRI (Sensory Rhodopsin I) via protein-protein interaction with its transducer Htrl (Halobacterial Transducer for Sensory Rhodopsin I) which in turn controls a cytoplasmic phospho-transfer pathway that modulates flagella motor switching in Halobacterium salinarum. Some mutations in both SRI and Htrl showed an unusual mutant phenotype called inverted signaling, in which the cell produces a repellent response to normally attractant light. Twelve mutations at the Glutamate 56 (E56) position in the second transmembrane helix of Htrl were introduced by site-specific random mutagenesis. Almost all E56 mutants showed orange-light inverted responses in pH and temperature-dependent manners except E56D and E56Y. Except for these two mutants, all mutants accelerated the $S_{373}$ decay compared to wild-type at $18^{\circ}C$. This supported that there is an interaction between SRI and the second transmembrane of Htrl. Also a structural model of Htrl based on the Tar crystal structure and the secondary structure prediction program proposed the E56 residue to be in the middle of the proton channel. The most important observation is that the E56 mutant provides the evidence that this residue is very sensitive for signal relay, which can be explained by the open and closed conformations of the channel (A and R conformations) in SRI, as was postulated by the unified conformational shuttling model for transport and signaling.

• Journal of Life Science
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• 제15권3호
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• pp.323-331
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• 2005

The objective of the present study was to investigate the effect of $\beta-lapachone$, a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America, on the cell growth of human hepatoma (HepG2) and bladder (T24) carcinoma cells. Exposure of cancer cells to $\beta-lapachone$ resulted in growth inhibition, morphological changes and apoptosis in a concentration-dependent manner, which could be proved by MTT assay and flow cytometry analysis. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analyses revealed that $\beta-lapachone$ did not affect the levels of tumor suppressor p53 and cyclin-dependent kinase (Cdk) inhibitor p21 (WAFl/CIPl) expression. However, the transcriptional factor Sp-l and proliferating cell nuclear antigen (PCNA) protein levels were significantly down-regulated by $\beta-lapachone$ in both cell lines. Moreover, $\beta-lapachone$ treatment caused a dose-dependent inhibition of the expression of telomere regulatory gene products such as human telomere reverse transcriptase (hTERT) and telomerase-associated protein-l (TEP-l). Taken together, these findings suggest that $\beta-lapachone$-induced inhibition of human hepatoma and bladder carcinoma cell proliferation is associated with the induction of apoptotic cell death via modulation of several major growth regulatory gene products, and provide important new insights into the additional mechanisms of the anti-cancer activity of $\beta-lapachone$.

• Kyungpook Mathematical Journal
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• 제48권4호
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• pp.545-551
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• 2008

Necessary and sufficient conditions for a radical class of rings to satisfy the polynomial equation $\rho$(R[x]) = ($\rho$(R))[x] have been investigated. The interrelationsh of polynomial equation, Amitsur property and polynomial extensibility is given. It has been shown that complete analogy of R.E. Propes result for radicals of matrix rings is not possible for polynomial rings.