• Journal of Korea Technology Innovation Society
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• v.10 no.4
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• pp.789-807
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• 2007

Technology Readiness Levels were initially proposed by NASA in 1995. TRL's definition and range were modified within adopted feilds such as hardware and software products. Many national R&D programs have similar evaluation conditions. However, they are influenced by the experts' ability. Relatively, they have shown the little reliance and the low performance of the developed prototype and technology. The purpose of this study is to apply the TRL to the materials and components development program. We defined TRLs for the program and devided them in three technology fields. Proposals, which were submitted for the program in 2007, were assessed with our TRL definitions for the study on the applicability. As a result, we could understand the characteristic TRLs of the technical proposals to the materials and components development program. This shows that the objective tools such as TRLs are required as the R&D program management factors. For the sake, it is the important factor that the detail directives to assess TRL should be developed according to the branches of industrial technology fields.

• Journal of the Korea Institute of Military Science and Technology
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• v.9 no.2 s.25
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• pp.60-69
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• 2006

The PMB(performance measurement baseline) is the total time-phased budget plan against which program performance is measured. Additionally it is the schedule for expenditure of the resources allocated to accomplish program scope and schedule objectives, and is formed by the budget assigned. In this paper, we suggest an improvement of the R & D(research and development) program for defense acquisition by using the PMB and an application of the IBR(integrated baseline review) to review the PMB for project manager of the defense agency.

• The Korean Journal of Nuclear Medicine
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• v.38 no.4
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• pp.294-299
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• 2004

Purpose: Both human NIS and mutant $D_2R$ transgenes are proposed as reporting system in transplanted cell tracking. Using hepatoma cell lines, we constructed a dual reporter system containing human sodium-iodide symporter (hNIS) and dopamine 2 receptor ($D_2R$) and compared its characteristics. Materials and Methods: The recombinant plasmid ($pIRES-hNIS/D_2R$) was constructed with IRES (internal ribosome entry site) under control of the CMV promoter $pIRES-hNIS/D_2R$ was transfected to human hepatoma SK-Hep1 cell line with lipofectamine. HEP-ND ($SK-Hep1-hNIS/D_2R$) cells stably expressing hNIS and $D_2R$ was established by selection with G418 for two weeks. RT-PCR was performed to investigate the expression of both hNIS and $D_2R$ genes. The expressions of hNIS and $D_2R$ were measured by $^{125}I$ uptake assays and receptor binding assays. Specific binding of $D_2R$ to $[^3H]spiperone$ was verified by Scatchard plot with (+) butaclamol as a specific inhibitor. $K_d\;and\;B_{max}$ values were estimated. The correlation between hNIS and $D_2R$ expression was compared by using each clone. Results: Similar quantities of hNIS and $D_2R$ genes were expressed on HEP-ND as RT-PCR assays. HEP-ND cells showed 30 to 40 fold higher radioiodine uptakes than those of parental SK-Hep1 cells. $^{125}I$ uptake in HEP-ND cells was completely inhibited by $KClO_4$, a NIS inhibitor Specific binding to HEP-ND cells was saturable and the $K_d\;and\;B_{max}$ values for HEP-ND cells were 2.92 nM, 745.25 fmol/mg protein and 2.91nM, 1323 fmole/mg protein in two clones, respectively. The radioiodine uptake by hNIS activity and $D_2R$ binding was highly correlated. Conclusion: We developed a dual positron and gamma imaging reporter system of hNIS and $D_2R$ in a stably transfected cell line. We expect that $D_2R$ and hNIS genes can complement mutually as a nuclear reporting system or that $D_2R$ can be used as reporter gene when hNIS gene were used as a treatment gene.

• The Journal of Information Systems
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• v.12 no.1
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• pp.159-175
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• 2003

During the early stage of radioactive disposal programs, important issues related with quality assurance of data sets, methodologies, R&D procedures are recognized as important ones. This paper focused on the development of web-based workflow standards for the QA procedures of the radioactive waste disposal programs. The flow of process was analyzed based on workflow concepts proposed by the Workflow Management Coalition (WfMC). QA system is based on the principles of T2R3. T2R3 Workflow was used to standardize and restructure the business and/or work process in the industry or organization. The WfMC has identified five functional interfaces to a workflow service as part of its standardization program. They are composed of process definition interface, worklist handler, application program interface, interface between workflows, and system management. The task flow and QA program were defined based on the workflow ideas. QA procedures for the R&D results of radiation disoposal were analyzed following the reference model of workflow. In addition, six program run list were created and implemented. The creation, revision, and approval of the test data were designed to be inplemented on the web environment. Through this system, R&D procedures such as planning, research, documentation, internal review and future independent peer review processes could be well organized and stored more systematically on the database and knowledge base. This will encourage the usage and data sharing between interested parties through it's clear and transparent workflow standards.

• Journal of Digital Contents Society
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• v.13 no.3
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• pp.317-324
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• 2012

Recently, coordination task of similarity between national R&D programs is emphasized on view from the R&D investment efficiency. But the previous similarity search method like text-based similarity search which using keyword of R&D projects has reached the limit due to deviation of document's quality. For the solve the limitations of text-based similarity search using the keyword extraction, in this study, utilization of R&D project's technical classification will be discussed as a new similarity search method when analyzed of similarity between national R&D programs. To this end, extracts the Science and Technology Standard Classification of R & D projects which are collected when national R&D Survey & analysis, and creates peculiar vector model of each R&D programs. Verify a reliability of this study by calculate the cosine-based and Euclidean distance-based similarity and compare with calculated the text-based similarity.

• Nutrition Research and Practice
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• v.13 no.6
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• pp.498-508
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• 2019

BACKGROUND/OBJECTIVES: Lower circulating 25-hydroxyvitamin D [25(OH)D] levels are associated with a higher risk of hypertension (HTN); however, it remains unclear whether the relationship is causal. We aimed to evaluate the causal effects of circulating 25(OH)D levels on the prevalence of HTN in the Korean population using the Mendelian randomization (MR) approach. SUBJECTS/METHODS: Epidemiological data, serum 25(OH)D data, and genomic DNA biospecimens were obtained from 2,591 participants, a subset of the study population in the Korea National Health and Nutrition Survey 2011-2012. Five 25(OH)D-related single nucleotide polymorphisms (SNPs; DHCR7 rs12785878, CYP2R1 rs10741657, CYP2R1 rs12794714, CYP24A1 rs6013897, and GC rs2282679), identified a priori from genome-wide association studies, were used as instrument variables (IVs) for serum 25(OH)D levels. In the MR analysis, we performed IV analyses using the two-stage least squares method. RESULTS: In the observational analysis, circulating 25(OH)D levels were found to be inversely associated with the HTN prevalence in ordinary least squares models (odds ratio: 0.97, 95% confidence interval: 0.96, 0.99) after adjusting for the potential confounders. There were differences in the circulating 25(OH)D levels across genotypes of individual SNPs. In the MR analysis, using individual SNPs as IVs, 25(OH)D levels were not associated with the HTN prevalence. CONCLUSIONS: We found no association between genetically determined circulating 25(OH)D levels and HTN in Korean adults. Our results are listed owing to the relatively small sample size and possible weak instrument bias; therefore, further studies are needed to confirm these results.

• Journal of the Korea Safety Management & Science
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• v.16 no.1
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• pp.207-211
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• 2014

SME is a major company to keep employment in Korea and highly depends on large company as vendor. R&D is critical to keep its position under the global competition. Government makes a policy to support SME R&D investement. We reviewed SMBA(Small and Medium Business Administration) policy for SME R&D and try to find alternatives. One of the alternatives is to increase a budget for large and SME co-development program.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.11a
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• pp.134-136
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• 2014

차세대 에너지 관리시스템에서 계통 해석 프로그램은 집중원격감시 시스템으로부터 취득된 데이터를 이용해 토폴로지, 상태추정, 조류계산, 상정사고, 고장해석 등의 해석 정보를 계통 운영자에게 전달한다. 지속적으로 증가하는 전력수요에 신속하게 대처하기 위해서 계통 해석 프로그램은 대규모 계통의 계획과 운영을 빠르고 정확하게 분석하여 대책을 수립할 수 있어야 한다. 본 논문에서는 계통 해석 프로그램들 중 특히 많은 시간이 소요되는 상정사고 해석 프로그램의 특성을 분석하고 성능 개선 방안을 제안한다.

• Proceedings of the Korea Information Processing Society Conference
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• 2011.11a
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• pp.209-212
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• 2011

국가의 미래지향적 정책을 위해서는 무엇보다도 이를 선도해나아갈 핵심인재의 확보가 매우 중요하다. 이러한 핵심인재 확보를 위해 각 부처에서는 지역 R&D 인력양성과 관련된 사업이 진행 중에 있다. 지역 R&D 인력양성사업의 전담기관은 시기와 목적에 따라 변경될 수 있으며, 변경될 때마다 사업목적과 수단이 부합하는지를 점검하기 위하여 사업성과를 객관적으로 분석 및 평가하고 그 결과를 새로운 사업계획 설계에 반영할 필요성이 제기되어 왔다. 그러나, 지역 R&D 인력양성사업은 전담기관 및 사업의 성격에 따라 성과분석 모형을 다르게 적용해 왔으며, 객관적 성과 분석 프레임워크가 부재하다. 따라서, 본 논문에서는 인력양성사업의 특성을 파악하여 객관적으로 분석 및 평가에 활용할 수 있는 성과 분석 모형을 설계하고자 한다.

• Journal of Technology Innovation
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• v.31 no.2
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• pp.83-110
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• 2023

This study deals with the process by which 'Social problem-solving R&D model' is established in Korean society through the evolution of the government's R&D program. We will examine the process by which a 'Social problem-solving R&D model', which was not present in companies, science and technology communities, and civil society, is formed through government R&D programs. To this end, we present a conceptual framework to analyze the process of co-evolution of 'Social problem solving R&D model', the organizational community that supports and implements it, and the institutions that supports the new model. In the synthesis, policy measures to enhance 'Social problem-solving R&D model' are dealt with.