• Title/Summary/Keyword: Quinolinones

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Synthesis of 3-Aryl-3-hydroxypyrrolidin-2-ones and 2-Benzyl-9b-hydroxy-3,3a,5,9b-tetrahydro-2H-pyrrolo[3,4-c]quinoline-1,4-dione Derivatives from the Baylis-Hillman Adducts of Isatins

  • Kim, Seung Chan;Lee, Ka Young;Gowrisankar, Saravanan;Kim, Jae Nyoung
    • Bulletin of the Korean Chemical Society
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    • v.27 no.8
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    • pp.1133-1139
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    • 2006

  • We prepared 3-aryl-3-hydroxypyrrolidin-2-one and tricyclic 2-benzyl-9b-hydroxy-3,3a,5,9b-tetrahydro-2H-pyrrolo[3,4-c]quinoline-1,4-dione derivatives starting from the Baylis-Hillman adducts of isatin derivatives.

  • https://doi.org/10.5012/bkcs.2006.27.8.1133 인용 PDF KSCI

Synthesis of Quinolinones for Novel Flavonoid Derivatives

  • Park, Myung-Sook;Park, Hae-Sun;Yoon, Myung-Sun;Kim, Nan-Young;Lee, Jae-In
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.241.2-241.2
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    • 2003

  • We report the synthesis of key intermediates for the development novel flavonoid derivatives with potential antiinflammatory activity and propose a mechanism of the one-pot reaction. The various amines (1) for this work were commercially available. Secondary amines (2) were formed by nucleophilic attraction using ethyl benzoylacetate. The C-N bond formation proceeded at refluxing in toluene with catalytic amount of p-toluenesulfonic acid and a removal of water was important in this reaction. (omitted)

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