• Title/Summary/Keyword: Quantitative-Risk-Analysis

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Calcium hydroxide intracanal medication effects on pain and flare-up: a systematic review and meta-analysis

  • Ibrahim, Ahmed Mohamed;Zakhary, Siza Yacoub;Amin, Suzan Abdul Wanees
    • Restorative Dentistry and Endodontics
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    • v.45 no.3
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    • pp.26.1-26.18
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    • 2020
  • Objectives: This study aimed to systematically review the pain and flare-up effects of calcium hydroxide (CH) as intracanal medication (ICM) in non-vital mature teeth. Materials and Methods: Electronic-databases searching for published and grey literature and manual searching were conducted. Only randomized clinical trials (RCTs) were included comparing CH to other ICMs in non-vital mature teeth. The risk of bias was assessed using the RoB 2.0 Cochrane tool. The main outcomes were pain and flare-up. Qualitative and quantitative analysis, wherever applicable, was performed. The certainty of evidence (CoE) was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: Sixteen articles were included in 6 comparisons at different time points for different outcomes. CH reduced pain risk than no ICM within the 1-14-days interval (p < 0.05) and than triple-antibiotic paste within the first day (p < 0.05) and was similar to corticosteroid/antibiotics combination (p > 0.05). Chlorhexidine (CHX) or CH/CHX, however, reduced pain levels than CH alone (p < 0.05). CH showed higher flare-up risk than CHX (p < 0.05). CoE, however, ranged from very low to moderate. Conclusion: Most comparisons for different outcomes are based on very few studies, mostly low-powered, with an overall low CoE. Thus, the available evidence is considered insufficient to either support or refute CH effectiveness or to recommend one ICM over another. Therefore, further well-designed, larger RCTs are required.

A Study on Business Process Based Asset Evaluation Model and Methodology for Efficient Security Management over Telecommunication Networks (정보통신망의 효율적 보안관리를 위한 비즈니스 프로세스 기반의 자산평가모델 및 방법론에 관한 연구)

  • Woo, Byoung-Ku;Lee, Gang-Soo;Chung, Tai-Myoung
    • The KIPS Transactions:PartC
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    • v.10C no.4
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    • pp.423-432
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    • 2003
  • It is essential suity management and standardized asset analysis for telecommunication networks, however existing risk analysis methods and tools are not enough to give shape of the method to evaluate value and asset. they only support asset classification schemes. Moreover, since the existing asset classification schemes are to evaluate comprehensive general risk, they are not appropriate for being applied telecommunication networks and they can´t offer any solutions to an evaluator´s subjectivity problem. In this paper, to solve these problems, we introduce the standardized definition of asset evaluation model new asset classification scheme, two-dimensional asset process classification scheme to consider business process and asset, various evaluation standards for quantitative value and qualitative evaluation. To settle an valuator´s subjectivity problem, we proposed $\beta$-distribution Delphi method.

A Systematic Review on Voice Characteristics and Risk Factors of Voice Disorder of Korea Teachers (우리나라 교사의 음성 특성과 음성장애 위험 요인에 관한 체계적 문헌고찰)

  • Cha, Seulki;Byeon, Haewon
    • Journal of the Korea Convergence Society
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    • v.9 no.8
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    • pp.149-154
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    • 2018
  • As the range of professional voice users are expanding, interest towards voice increases as well. Especially as teachers compose the occupational group, exposed to high risk of voice disorder, it is necessary to identify the cause of speech problems and speech disorders. The purpose of this study is to analyze the voice characteristics of teachers and to investigate the causes of voice disorders. From 2000 to 2018, 414 studies were found under a combinated set search words of 'profession', 'Teacher', 'Professional Voice User', 'Voice', 'Voice disorders', 'Risk' and out of them, 8 studies were selected as final focus analysis subjects. The qualitative evaluation was carried out by modifying the Quality: checklist for assessing the Risk of bias. The study confirmed that voice misuse frequently occurred to teachers when they used their voice and this feature was affected by the environment. These results suggest that environment improvement of teachers' speech abuse and consistent voice education are necessary.

A Study on the Applicability of FMEA and it's Results for Hand Grenade in Government Quality Assurance Planning (군수품 정부품보활동계획에 FMEA 분석결과의 적용방안 및 적용결과의 고찰)

  • Lee, YoungWoo;Kwon, InKyu
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.2
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    • pp.252-258
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    • 2016
  • Risk identification based on the government quality assurance activity for military goods is being conducted to determine the risks to be reflected in a government quality assurance plan. On the other hand, current risk evaluation method focuses mainly on the functional requirements of the product specifications, which is a lack of reflection and identification of risks considering the process and the method is determined from a personal opinion, for example experience and know-how, which results in a lack of objectivity. Therefore, a standard of judgment according to quantitative data, which includes the present process control data using the FMEA method is required to improve the objectivity and dependability. This paper proposes useful suggestions for a government quality planning method to apply the results of FMEA to hand grenades.

Calculation of an Indicator for Early Death Using Atomic Bomb Survivors' Data

  • Sasaki, Michiya;Fujimichi, Yuki;Yoshida, Kazuo;Iwasaki, Toshiyasu
    • Journal of Radiation Protection and Research
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    • v.47 no.1
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    • pp.22-29
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    • 2022
  • Background: A comprehensive, traceable, and easy-to-understand radiation risk indicator is desired for radiological protection. The early-onset hypothesis could be used for this purpose. Materials and Methods: An indicator for early death (IED) was developed and calculated using the epidemiological dataset from the 14th Report of the Life Span Study (LSS) of Hiroshima and Nagasaki. By clarifying the calculation process, IED for all-cause mortality was estimated. In addition, the characteristics of IED for solid cancer mortality and cardiovascular mortality as well as those of men and women, and their dependence on age at exposure were investigated for detailed analysis. Results and Discussion: The IED for all-cause mortality was estimated to be approximately 4 years for an acute radiation exposure of 1 Gy regardless of the fitting dose range. The cumulative death rate for all solid cancers also indicated the early-death tendency (approximately 7-10 years at 1 Gy). Although, there is a slight difference in the characteristics of the risk obtained from the LSS study and this study, it is considered that the IED in a unit of years can also be used to show the overall picture of risk due to radiation exposure. Conclusion: We developed and calculated the indicator for early death, IED, for the cumulative mortality rate of all causes of death, all solid cancers, and circulatory diseases. The quantitative values of IED were estimated to be 4 years for all causes of death, 7-10 years for all solid cancers. IED has an advantage for intuitively understanding the meaning of radiation risk since it can be obtained by a simple and traceable method.

Online Network Analysis of the Impact of Local Market-based Communities on Regional Revitalization (시골장터 기반 로컬 커뮤니티가 지역활성화에 미치는 영향에 대한 온라인 네트워크 분석)

  • Park, Jeong Sun;Park, Sang Hyeok;Oh, Seung Hee
    • The Journal of Information Systems
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    • v.33 no.1
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    • pp.45-68
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    • 2024
  • Purpose This paper examines the role of local market-based communities in driving regional revitalization, using detailed analysis of online networks. We aim to dissect a local community's communication network, highlighting members with high engagement levels and exploring their characteristics. Our goal is to identify the conditions that allow local community networks to grow independently and to demonstrate how the activation of these networks contributes to regional revitalization. Design/methodology/approach We employ a mixed-methods approach, combining social network analysis with statistical techniques to investigate the structure of online communication networks. Specifically, we use ANOVA to determine the statistical significance of our findings, ensuring their reliability. To complement our quantitative data, we include qualitative insights from interviews, adding depth and context to our analysis. Findings Our results show that individuals with high centrality in the online network are crucial for maintaining active local communities. We find that leveraging local resources to create a supportive and adaptable environment is essential for the communities' sustainability and expansion. Importantly, our research draws a direct connection between the vitality of local community networks and the broader process of regional revitalization. We argue that energizing local communities is an effective way to address the risk of regional decline. By integrating quantitative analysis with qualitative feedback, this study contributes to the understanding of local market-based communities as key drivers of regional development. It emphasizes the importance of building vibrant, resourceful community networks to revitalize areas experiencing socio-economic challenges.

A Cross-check based Vulnerability Analysis Method using Static and Dynamic Analysis (정적 및 동적 분석을 이용한 크로스 체크기반 취약점 분석 기법)

  • Song, Jun-Ho;Kim, Kwang-Jik;Ko, Yong-Sun;Park, Jae-Pyo
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.12
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    • pp.863-871
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    • 2018
  • Existing vulnerability analysis tools are prone to missed detections, incorrect detections, and over-detection, which reduces accuracy. In this paper, cross-checking based on a vulnerability detection method using static and dynamic analysis is proposed, which develops and manages safe applications and can resolve and analyze these problems. Risks due to vulnerabilities are computed, and an intelligent vulnerability detection technique is used to improve accuracy and evaluate risks under the final version of the application. This helps the development and execution of safe applications. Through incorporation of tools that use static analysis and dynamic analysis techniques, our proposed technique overcomes weak points at each stage, and improves the accuracy of vulnerability detection. Existing vulnerability risk-evaluation systems only evaluate self-risks, whereas our proposed vulnerability risk-evaluation system reflects the vulnerability of self-risk and the detection accuracy in a complex fashion to evaluate relative. Our proposed technique compares and analyzes existing analysis tools, such as lists for detections and detection accuracy based on the top 10 items of SANS at CWE. Quantitative evaluation systems for existing vulnerability risks and the proposed application's vulnerability risks are compared and analyzed. We developed a prototype analysis tool using our technique to test the application's vulnerability detection ability, and to show that our proposed technique is superior to existing ones.

A Study on the Safety Improvement of Buried Pipeline Using Scoring Model (Scoring Model을 이용한 매설배관 안전성 개선에 관한 연구)

  • Son, Myoung-Duck;Kim, Sung-Keun
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.37 no.1
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    • pp.175-185
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    • 2017
  • As the gas is manufactured, handled and used more often due to the continuous increase of gas, the related facility gets expanded and more complex causing small and big accident which causes economic loss including damage for humans and materials. The gas pipeline, the most common gas facility, has the biggest risk of accidents. Especially in the urban area and densely populated areas, the accident due to the high pressure pipeline may cause even more serious damages. To prevent the accident caused by the buried pipeline, it is required for the relevant authorities to evaluate the damage and risk of the whole pipeline system effectively. A risk is usually defined as a possibility or probability of an undesired event happening, and there is always a risk even when the probability of failure is set low once the pipeline is installed or under operation. It is reported that the accident caused by the failure of the pipeline rarely happens, however, it is important to minimize the rate of accidents by analyzing the reason of failure as it could cause a huge damage of humans and property. Therefore, the paper rated the risk of pipelines with quantitative numbers using the qualitative risk analysis method of the Scoring Model. It is assumed that the result could be effectively used for practical maintenance and management of pipelines securing the safety of the pipes.

Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens

  • Fukushima, Shoji;Gi, Min;Fujioka, Masaki;Kakehashi, Anna;Wanibuchi, Hideki;Matsumoto, Michiharu
    • Toxicological Research
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    • v.34 no.4
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    • pp.291-296
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    • 2018
  • Chemical carcinogenesis is a multistep process. Genotoxic carcinogens, which are DNA-reactive, induce DNA adduct formation and genetic alterations in target cells, thereby generating mutated cells (initiation). Subsequently, preneoplastic lesions appear through clonal proliferation of the mutated cells and transform into tumors (promotion and progression). Many factors may influence these processes in a dose-dependent manner. Therefore, quantitative analysis plays an important role in studies on the carcinogenic threshold of genotoxic carcinogens. Herein, we present data on the relationship between key carcinogenic events and their deriving point of departure (PoD). Their PoDs were also compared to those of the carcinogenesis pathway. In an experiment, the liver of rats exposed to 2-amino-3,8-dimethylimidazo-(4,5-f)quinoxaline (MeIQx) was examined to determine the formation of MeIQx-DNA adducts, generation of mutations at LacI transgene, and induction of preneoplastic glutathione S-transferase placental form (GST-P)-positive foci and tumors (benign and malignant). The PoDs of the above key events in the carcinogenicity of MeIQx were increased as the carcinogenesis advanced; however, these PoDs were lower than those of tumor induction. Thus, the order of key events during tumor induction in the liver was as follows: formation of DNA adducts ${\ll}$ Mutations ${\ll}$ GST-positive foci (preneoplasia) ${\ll}$ Tumor (adenoma and carcinoma). We also obtained similar data on the genotoxic and carcinogenic PoDs of other hepatocarcinogens, such as 2-amino-3,8-dimethylimidazo(4,5-f)quinoline. These results contribute to elucidating the existence of a genotoxic and carcinogenic threshold.

A Study on Facility Criteria of Small Petrol Stations based on Quantitative Risk Assessment (정량적 위험성 평가에 기반한 간이 주유취급소 시설기준에 대한 연구)

  • Park, Wooin;Ku, Jae-Hyun;Song, Yong-Sun
    • Journal of the Korean Institute of Gas
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    • v.18 no.3
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    • pp.44-52
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    • 2014
  • Small petrol stations have great potential for a wide distribution in metropolitan area in which the land value possesses primary installation cost of the facility. The objective of the present study is to propose appropriate facility regulations of small petrol stations in Korea that can be popularly installed in the future in terms of securing safety in addition to serviceability. The hazard analysis and damage prediction from the possible fire and explosion accidents were performed using a software, PHAST v.6.5. As essential components of the facility regulations proposed in this study, the regulations about the refueling lot, maximum capacity of underground tank, location of fixed refueling facilities, height of firewall for small petrol stations were subsequently compared with those for regular-sized petrol stations.