• Structural Engineering and Mechanics
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• 제28권5호
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• pp.525-548
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• 2008

This article deals the theory for solving an inverse problem of plate structures using the frequency-domain information instead of classical time-domain delays or free vibration eigenmodes or eigenvalues. A reduced set of output parameters characterizing the defect is used as a regularization technique to drastically overcome noise problems that appear in imaging techniques. A deconvolution scheme from an undamaged specimen overrides uncertainties about the input signal and other coherent noises. This approach provides the advantage that it is not necessary to visually identify the portion of the signal that contains the information about the defect. The theoretical model for Quantitative nondestructive evaluation, the relationship between the real and ideal models, the finite element method (FEM) for the forward problem, and inverse procedure for detecting the defects are developed. The theoretical formulation is experimentally verified using dynamic responses of a steel plate under impact loading at several points. The signal synthesized by FEM, the residual, and its components are analyzed for different choices of time window. The noise effects are taken into account in the inversion strategy by designing a filter for the cost functional to be minimized. The technique is focused toward a exible and rapid inspection of large areas, by recovering the position of the defect by means of a single accelerometer, overriding experimental calibration, and using a reduced number of impact events.

• 한국자동차공학회논문집
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• 제8권3호
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• pp.37-45
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• 2000

The technique of laser sheet beam has been applied to optically accessible diesel engine for the quantitative measurement of soot. The results provide the information for us for reduction of soot in diesel engine. We used both LIS nad LII techniques simultaneously in this study. LIS and LII images show the quantitative distribution of the soot concentration in an optically accessible diesel engine. In this study, several results were obtained by the simultaneous measurement of LIS and LII technique. The diameter and number density of soot in combustion chamber of the test engine were obtained from ATDC 20$^{\circ}$ to 110$^{\circ}$ . The increase rate of soot diameter was about 40$^{\circ}$ between ATDC 20$^{\circ}$and 110$^{\circ}$. And the number density of soot decreased significantly between ATDC 20$^{\circ}$and 40$^{\circ}$.

• 대한기계학회논문집A
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• 제29권10호
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• pp.1392-1398
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• 2005

API 581 guideline provides a methodology for calculating the risks of equipments in refinery or petrochemical plant. However, especially in part of the consequence of failure, there is a major limitation of its application to the petrochemical plant directly since only a representative material is considered in calculating the risk while the equipment is composed of numerous materials. The objectives of this paper are to propose an enhanced risk-based inspection (RBI) technique to resolve shortcomings inclusive of the above issue and to assess the risks of typical petrochemical equipments. In this respect, a program incorporating material database was developed to fully incorporate the characteristics of different materials. The proposed RBI program consists of qualitative, semi-quantitative and quantitative risk evaluation modules in which toxic materials as well as representative materials were selected automatically for comparison to those in the current guideline. It has been applied to assess the risks of equipments in ethylene facilities of petrochemical plants. Thereby, more realistic evaluation results were obtained and applicability of the proposed RBI program was proven.

• Tribology and Lubricants
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• 제21권5호
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• pp.236-240
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• 2005

In order to prepare for the suitable surfaces of implants or medical devices, quantitative evaluation of adhesion between cells and biomaterials is essential. To better understand adhesion formation between cells and biomaterials, we used the cytodetachment technique which measures the adhesive force of a single cell through changing the, culture time and detachment speed. The results showed that the adhesive force could be affected by the culture time of cells on the surface of materials and the detachment speed. Moreover, there was a large discrepancy among the adhesion strength measured by similar techniques conducted on the different cells and substrates. It can be 'concluded that the variation of the force measurement technique can seriously alter the level of the force required to detach a cell on the surface of materials.

• Molecular & Cellular Toxicology
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• 제4권2호
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• pp.170-176
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• 2008

The quantitative structure-activity relationship (QSAR) of a set of 35 flavonoid compounds presenting antioxidant activity was established by means of Genetic Algorithm-Multiple Linear Regression (GA-MLR) technique. Four-parametric models for two sets of data, the 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity $(R^2=0.788,\;Q^2_{cv}=0.699\;and\;Q^2_{ext}=0.577)$ and scavenging activity of reactive oxgen species (ROS) induced by $H_2O_2 (R^=0.829,\;Q^2_{cv}=0.754\;and\;Q^2_{ext}=0.573)$ were obtained with low external predictive ability on a mass basis, respectively. Each model gave some different mechanistic aspects of the flavonoid compounds tested in terms of the radical scavenging activity. Topological charge, H-bonding complex and deprotonation processes were likely to be involved in the radical scavenging activity.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1080-1084
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• 2007

Recently, as demands of new railway and the relocation of existing line, a number of tunnel structures have been constructed. Tunnel structures contribute to minimize the cost and time of transport, but in case of railway fire accident bring serious damages of human life caused by narrowness of shelter, smoke and high temperature, difficulty in rescue. For that reason, at the beginning of plan of tunnel, the optimum design of safety facility in tunnel for minimizing the risks and satisfying the safety standard is needed. In this study, QRA(Quantitative Risk Analysis) technique is applied to design of railway tunnel for assuring the safety function and estimating the risk of safety. The case study is carried out to verify the QRA technique for railway tunnels in Iksan-Sili.

• 약학회지
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• 제41권5호
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• pp.539-546
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• 1997

Capillary electrophoresis (CE) is perceived as an attractive tool for the analysis of pharmaceuticals and biological materials because of their high separation efficiency, easy separation and low running cost. New concept of micellar electrokinetic capillary chromatography (MECC) expanded the application of CE to the separation of neutral molecules. Validation of CE as an analytical technique for quality control of pharmaceuticals should be confirmed by quantitative analysis and the peak confirmation. In this study, the quantitative analyses of various types of neutral, acidic and basic components (acetaminophen, caffeine, ascorbic acid, riboflavin, thiamine, chlorpheniramine, phenylpropanolamine, dl-methylephedrine and dextromethorphan) in complex cold medicines have been accomplished using CE. Combined methods of MECC using SDS and capillary zone electrophoresis lowering the pH of running buffer were adopted to determine the ingredients in capsule type or liquid formula complex medicines without particular sample pretreatment. The results indicate that CE is a promising technique for quality control analysis of pharmaceuticals as a validation method.

• 대한안전경영과학회지
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• 제8권2호
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• pp.51-59
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• 2006

So far, there is no technique of quantitative evaluation on danger related to industrial accidents. Therefore, as an endeavor for obtaining technique of quantitative evaluation, this study presents feature analysis of industrial accidents in manufacturing field using QUEST algorithm. In order to analyze feature of industrial accidents, a retrospective analysis was performed in 10,536 subjects (10,313 injured people, 223 deaths). The sample for this work chosen from data related to manufacturing businesses during three years $(2002\sim2004)$ in Korea. The analysis results were very informative since those enable us to know the most important variables such as occurrence type, company size, and occurrence time which can affect injured people. Also, it is found that classification using QUEST algorithm which was performed in this study is very reliable.

• 대한인간공학회지
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• 제17권2호
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• pp.11-23
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• 1998

Dynamic motion difference between normal subjects and low-back pain (LBP) patients has been investigated in terms of kinematic variables such as range of motion, velocity and acceleration of the back and hip. Ten healthy subjects and ten LBP patients were recruited in this study. Electro-goniometer such as Lumbar Motion Monitor and Hip Monitor have been used for quantitative measurement of the trunk motion during repetitive flexion and extension for ten seconds. Results indicated that the velocity and acceleration of the back and hip were important parameters to quantitatively identify LBP patients. The consistency of cyclic trunk motion and the relationship between the back and hip were measured in terms of Variance Ratio and Phase Angle in order to accurately assess the motion characteristics of LBP patients. In particular, the hip motion has been proven to be a very important factor in describing the kinematics of damaged lower back. The functional evaluation technique suggested in this study will be a tool to assist physicians for an accurate diagnosis and timely rehabilitation along with current image diagnosis techniques.

• Annals of Clinical Neurophysiology
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• 제9권2호
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• pp.43-50
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• 2007

Analysis of intraepidermal nerve fibers using skin biopsy is a recently developed technique, providing diagnostic information on small fiber neuropathies. The specimens are obtained by 3 mm punch biopsy, which is safe and minimally invasive. Immunohistochemical staining by Protein gene product (PGP) 9.5 demonstrate not only intraepidermal nerve fibers but dermal structures, such as sweat gland and erector papillae. Up to now, many studies agree that intraepidermal nerve fiber density is dramatically reduced in various sensory neuropathies. The utility of density measure was confirmed with high sensitivity in the diagnosis of sensory neuropathy, comparable to sural nerve biopsy or quantitative sensory testing. Besides quantitative methods, morphological changes like axonal swelling and fragmentation can be used as predegenerative markers. This article reviews the technique of skin biopsy and clinical and experimental usefulness of skin biopsy in diagnosing and monitoring peripheral neuropathies.