• Bulletin of the Korean Chemical Society
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• v.27 no.2
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• pp.266-272
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• 2006

Three-dimensional quantitative structure-activity relationship (3D-QSAR) models were developed for 67 molecules of 2-amino-benzothiazole-6-anilide derivatives against lymphocyte-specific protein tyrosine kinase (P56 LCK). The molecular field analysis (MFA) and receptor surface analysis (RSA) were employed for QSAR studies and the predictive ability of the model was validated by 15 test set molecules. Structure-based investigations using molecular docking simulation were performed with the crystal structure of P56 LCK. Good correlation between predicted fitness scores versus observed activities was demonstrated. The results suggested that the nature of substitutions at the 2-amino and 6-anilide positions were crucial in enhancing the activity, thereby providing new guidelines for the design of novel P56 LCK inhibitors.

• Korean Journal of Veterinary Research
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• v.46 no.1
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• pp.47-55
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• 2006

To evaluate method for monitoring anesthetic depth with quantitative electroencephalography (q-EEG), we recorded processed EEG (raw EEG) and pain score till 100 minutes in beagle dogs anesthetized for 60 minutes with propofol (n = 5, PRO group), isoflurane (n = 5, ISO group) and propofol-ketaminefentanyl (n = 5, PFK group). Raw EEG was converted into 95% spectral edge frequency (SEF) by fast Fourier transformation (FFT) method. We investigated anesthetic depth by comparing relationship (Pearson's correlation) between q-EEG (95% SEF) and pain score. Pearson's correlation coefficients are +0.2372 (p = 0.0494, PRO group), +0.79506 (p < 0.001, ISO group) and +0.49903 (p = 0.0039, PFK group).

• Journal of the Ergonomics Society of Korea
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• v.17 no.2
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• pp.11-23
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• 1998

Dynamic motion difference between normal subjects and low-back pain (LBP) patients has been investigated in terms of kinematic variables such as range of motion, velocity and acceleration of the back and hip. Ten healthy subjects and ten LBP patients were recruited in this study. Electro-goniometer such as Lumbar Motion Monitor and Hip Monitor have been used for quantitative measurement of the trunk motion during repetitive flexion and extension for ten seconds. Results indicated that the velocity and acceleration of the back and hip were important parameters to quantitatively identify LBP patients. The consistency of cyclic trunk motion and the relationship between the back and hip were measured in terms of Variance Ratio and Phase Angle in order to accurately assess the motion characteristics of LBP patients. In particular, the hip motion has been proven to be a very important factor in describing the kinematics of damaged lower back. The functional evaluation technique suggested in this study will be a tool to assist physicians for an accurate diagnosis and timely rehabilitation along with current image diagnosis techniques.

• Bulletin of the Korean Chemical Society
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• v.31 no.10
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• pp.2823-2829
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• 2010

We investigated the solvent effects on the relative free energies of binding of $Na^+$ and $Li^+$ ions to 12-crown-4 and ${\Delta}log\;K_s$ (the difference of stability constant of binding) by a Monte Carlo simulation of statistical perturbation theory (SPT) in several solvents. Comparing the relative free energies of binding of $Na^+$ and $Li^+$ ions to 12-crown-4, in $CH_3OH$ of this study with experimental works, there is a good agreement among the studies. We have reported the quantitative free energy polarity (of solvent) relationships (QFPR) of the relationship between the relative free energies and solvent polarity studied on the solvent effects on the relative free energies of binding of $Na^+$ and $Li^+$ ions to 12-crown-4.

• KDI Journal of Economic Policy
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• v.42 no.1
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• pp.31-56
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• 2020

Does financial development contribute to economic growth? The literature finds that an expansion in financial resources is useful for economic growth if the degree of financial development is under a certain threshold; otherwise, the expansion is detrimental to growth. Almost every published study, however, considers country-panel data. Accordingly, the results are not directly applicable to the Korean economy. By examining Korean time-series data, this paper finds that there is an inverse U-shaped relationship between the per capita real GDP growth rate and private credit (as a percentage of nominal GDP)-a well-known measure of quantitative financial development, where the threshold is 171.5%. This paper also finds that private credit is positively associated with economic growth if the share of household credit out of private credit is less than 46.9%; otherwise, private credit is negatively associated with economic growth. As of 2016, the ratio of private credit to GDP and the ratio of household credit to private credit are both higher than the corresponding thresholds, which implies that policymakers should place more emphasis on qualitative financial development than on a quantitative expansion of financial resources.

• Bulletin of the Korean Chemical Society
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• v.17 no.2
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• pp.147-152
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• 1996

To see the quantitative relationship between the structures of the C-7 substituted quinolones and their antibacterial activities, theoretical parameters such as the molecular van der Waals volume, surface area and some electrostatic parameters based on the molecular electrostatic potential, which represent lipophilicity, and some quantum mechanical parameters are introduced as descriptors. The sixteen substituted quinolone derivatives and twenty bacteria are used for the study. It is found that the QSARs of C-7 substituted quinolones are obtained for eleven bacteria and our descriptors are more useful for Gram positive organisms than negative ones. It is also shown that molecular surface area (or molecular Waals volume) of the C-7 substituent and net charge of C-7 atom of the quinolones are the descriptors of utmost importance.

• Journal of Korean language education
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• v.23 no.1
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• pp.161-182
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• 2012

The purpose of this study is to examine level of individual foreign learners' quantitative knowledge of korean vocabulary through the Foreign Learners' Korean Vocabulary Knowledge Assessment and to propose a vocabulary education plan reflecting the result. This assessment was written in focus of semantic relation to identify category, integrated and analytical knowledge of Korean verbs acquired by foreign learners and as a result, the following educational implications were made. First, the learners' knowledge about the vocabulary combinational relationship was very limited. Second, learners are not interested in vocabulary's synonymous relation and antonymous relations. Lastly, there needs to be a concern about postpositional particle-use education. The results of these kinds of research, observes the learners vocabulary acquisition process to determine Korean textbook and present vocabulary level in appropriate in terms of learners' perspective, and provide an opportunity to check if current professors' method is adequate and valid.

• Bulletin of the Korean Chemical Society
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• v.14 no.4
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• pp.485-487
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• 1993

The critical behavior of the classical D-dimensional spin model (D${\ge}$2), which is intermediate model that link up the Ising (D = 1) and the spherical model (D = ${\infty}$), is studied for the case of constant coupling interaction independent of the spin-spin distance (Curie-Weiss model). Analytical results show that the critical behavior of the present model is in quantitative agreement with the prediction of the phenomenological mean-field theory independent of D. Critical temperature is calculated to be T$_c$=k/JD. This gives a quantitative explanation of the relationship between the spin degree of freedom and the critical temperature.

• Journal of Distribution Science
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• v.15 no.2
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• pp.91-100
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• 2017

Purpose - Domestic franchise market has been grown steadily, reaching 50 trillion won in sales and 3,360 franchise headquarters in 2014. A franchise system is an effective business system for the franchisees to lower the failure rate due to the fact that the inexperienced entrepreneurs are supported by their headquarters through the franchisee contract. However, there are also conflicts between franchiser and franchisee behind the quantitative growth of domestic franchise industry. Therefore, it is very important to structure the causes of conflicts and to examine the effect of factors on the relationship commitment and performances. Research design, data, and methodology - In this study, the author divides the composite incompatibility between the franchise and the franchisee into goal incongruity, domain dissensus, and perceptual differences, and examines each dimension to the relationship with commitment and performances. To verify the proposed research model and test hypotheses, the author selected 200 franchise responses in food and beverage industry. The data were analyzed using SPSS 18.0 and AMOS structural equation modeling program. Results - The empirical findings provide goal incongruity and perceptual differences have a negative effect on the affective commitment, but not the calculative commitment. In addition, affective commitment and calculative commitment are found to have a positive effect on re-contractual intention and extended brand shop running intention, respectively. Affective commitment have a stronger effect on re-contractual intention than calculative commitment. Conclusions - First of all, the fact that goal incongruity and perceptual differences negatively affect the affective commitment, but it does not affect the calculative commitment. It means the relationship commitment in distribution channel are multi-dimensional concept that may be attributed to emotional or affective dimensions but may exist in terms of necessity or power-dependence. Second, the level of relationship commitment such as affective and calculative commitment to franchise headquarters positively affects the re-contractual intention and franchiser's extend brand shop running intention suggest that franchiser should encourage and support existing franchisee's commitment. Third, the fact that affective commitment has a greater effect on relationship performance than calculative commitment means to induce franchisee's affective commitment and to prevent the inconsistency between goals and perceptual differences.

• Korean Journal of Human Ecology
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• v.22 no.4
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• pp.559-574
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• 2013

The purpose of this study was to develop the couple relationship improvement program for college students and to examine the effects of the program based on the family of origin and attachment. Does based on Bowen's theory of differentiation of self, adult attachment, group counseling for this and establishes program goals according to systematic group counseling program development model and composed program. In order to attain like this research objective, six male and female couples attending colleges were divided into the participating group and comparison group; the students were from H University in Daejeon, Korea, and they had the experience of participating in the comprehensive group program. The changes shown by the couples were studied, and the cases were analyzed by examining the minutes and reports, which supplemented the quantitative analysis of the effectiveness of the group counseling program. The analysis of the effectiveness of the program showed the following. The case showed that goals of the individuals and couples, enhancing the understanding of self and partners by understanding the self-differentiation and adult attachment while having a positive impact on understanding, acceptance, disclosure of self partner and couple relationship based on the social support of the cognitive emotion regulation strategies.