• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.65-71
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• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.

• The Journal of Engineering Geology
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• v.18 no.1
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• pp.17-26
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• 2008

In this study, the design method of slope reinforced by the earth retention systems were systematically developed, and the flow chart of design procedure fur each system were constructed to design the slope rationally. The proposed design method is composed of 5 steps such as field condition investigation step, slope design step, landslide occurrence prediction step, slope failure scale estimation step and reinforcement countermeasure selection step. The quantitative standard of slope failure scale was established based on the arrangement of various overseas standards which is estimating the slope failure, and the analysis of slope failure scale which is occurred in the country. The slope failure scale is classified into three categories the small scale of slope failure is less than $150m^3$ of slope failure volume, the middle scale of slope failure is from $150m^3$ to $900m^3$ and the large scale of slope failure is more than $900m^3$. The earth retention system could be selected by the proposed slope failure scale based on the slope failure volume. Meanwhile, the design methods of earth retention system such as piles, soil nails and anchors were developed. The optimal countermeasure for slope stability could be proposed using above design methods.

• The Journal of the Korea Contents Association
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• v.12 no.4
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• pp.216-224
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• 2012

Usually, bundled software is unwittingly packaged with a user's PC when purchased it. A reason of provides it is for manufacturers to increase the value of the product. However, almost users cannot recognize bundled SW. Paradoxically, sometimes the bundled SW may complain to the user. Eventually these symptoms negatively affect the product. As a result, the SW bundle could not reflect user needs. This study for installed bundled SW on users laptop and we would like to know the understanding and acceptance it of the user. Finally, how can we provides it more effectiveness and looking for ways to make was conducted. From a user perspective, these study four major countries (USA, Germany, China, South Korea) laptop users to perform a total 3,000 people were surveyed. A method of investigation was the quantitative evaluation survey and was conducted online survey approach. Through this study was an analysis to awareness of users by different ages, gender, and usage patterns. Bundle SW through the study of the laptop to the user, effectively providing a way to be confirmed. And right through bundle SW distribution is expected to increase the manufacturer's worth.

• Journal of Pharmaceutical Investigation
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• v.38 no.3
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• pp.191-197
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• 2008

The purpose of the present study was to examine the pharmacokinetics and lymphatic delivery of the oligopeptide, a model peptide of X antigen epitope peptides, after the intramuscular administration of the peptide-bearing liposomes in rats. $^{14}C$-labelled peptide was used as a tracer to analyze the peptide levels in plasma, bile, urine, tissue homogenates, and lymph nodes (superior cervical nodes, brachial nodes and superior mesenteric nodes). Model peptide rapidly disappeared from the plasma by 30 min (${\alpha}$ phase) after i.v. administration, which was followed by the late disappearance. The apparent plasma half-lives ($t_{1/2({\alpha}),app}$) of the peptide at the ${\alpha}$ phase when administered at a dose of 0.2-1.0 mg/kg were about 5 min. The maximum plasma concentration ($C_{max}$) was $1.52\;{\mu}g/mL$, after the i.m. administration of the peptide at a dose of 1.0 mg/kg. The bioavailability, which was calculated from the time zero to last quantitative time, of the i.m. administered peptide was over 60%. Of the various tissues tested, the peptide was mainly distributed in the kidney after the i.m. administration. The peptide levels in the kidney 3 hr after the i.m. administration were higher than those of maximum plasma concentration ($C_{max}$). The cumulative amounts of the peptide found in the urine 72 hr after the administration of 1.0 mg/kg were 2-folder higher than those in the bile, suggesting that the peptide is mostly excreted in the urine. Moreover, the concentrations of the peptide in the lymph nodes were as high as that of the plasma and the tissues. In conclusion, the peptide concentration in the lymph nodes was maintained by 24 hr after the i.m. administration of the peptide-bearing liposomes.

• The Journal of the Petrological Society of Korea
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• v.12 no.4
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• pp.196-206
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• 2003

The geochemical and mineralogical investigation on the rocks and repair material comprising of the Sungryemun (The 1st National Treasure) has been made. Rock of the Sungryemun is highly weathered coarse-grained calc-alkali granite. The rock consists mainly of quartz, perthite, plagioclase and biotite with small amounts of orthoclase, muscovite, chlorite and sericite, which are major weathering products from perthite. For obtaining informations about degree of weathering, mineral composition of the original rock calculated by CIPW norm and weathered rock composition determined by XRD quantitative analysis were plotted on a ternary diagram of quartz-potash feldspar-plagioclase. Original rock compositions are plotted on the central granite area. whereas weathered ones are plotted on the granite area close to quartz. The result means that quartz is more abundant in weathered rock, due to selective chemical weathering of potash feldspar and plagioclase over quartz. On the whole, surface of the rocks were black-coated, exfoliated and highly fractured due to the physical and chemical weathering and heavy load has made the cracks in the lower parts of the stone construction. Also, cement and nails, which was used as repair material, during the repair work in the early 1960's, has accelerated the weathering process. Furthermore, weathered conditions of repair materials are very severe. Therefore, it is very urgent to establish of the conservation plan for the Sungryemun.

• Journal of the Mineralogical Society of Korea
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• v.20 no.3
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• pp.203-212
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• 2007

Mineral compositions of 89 Yellow Sea surface sediments collected at the second cruise in 2001, were determined using the high resolution X-ray diffractometer and Siroquant v.3.0 program. Yellow Sea surface sediments are composed of major minerals (quartz 57.8%, plagioclase 16.0% and alkali feldspar 10.0%), clay minerals, and calcite. Illite (8.7%) is the most abundant clay mineral, chlorite (2.6%) is the second, and kaolinite (0.6%) is few. however smectite is not detected. Quartz content is very high around the margin of the Yellow Sea, however is very low along the northwest to southeast direction extending from southeast of Sandong Peninsula to southwest of Jeju Island. It has similar distribution pattern with that of coarse sediment (sand). The coarse sediment, is mainly consisted of quartz, may be much supplied from the eastern part and southwestern part of the Yellow Sea. Illite distribution pattern is opposite to that of quartz. It is similar to those of clay and mud particles, therefore it can be suggested that fine sediment may be largely supplied from the northwestern part of the Yellow Sea. It is necessary to continue this kind of investigation, because it is difficult to interpret the sediment provenance of the Yellow Sea only from the result of this study.

• Spatial Information Research
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• v.19 no.5
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• pp.1-11
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• 2011

This study mainly focused on the method of accurately extracting damage information in the im agery change detection process using the constructed high resolution aerial im agery. Bongwha-gun in Gyungsangbuk-do which had been severely damaged from a localized torrential downpour at the end of July, 2008 was selected as study area. This study utilized aerial im agery having photographing scale of 30cm gray image of pre-disaster and 40cm color image of post-disaster. In order to correct errors from the differences of the image resolution of pre-/post-disaster and time series, the prelim inary phase of image processing techniques such as normalizing, contrast enhancement and equalizing were applied to reduce errors. The extent of the damage was calculated using one to one comparison of the intensity of each pixel of pre-/post-disaster im aged. In this step, threshold values which facilitate to extract the extent that damage investigator wants were applied by setting difference values of the intensity of pixel of pre-/post-disaster. The accuracy of optimal image processing and the result of threshold values were verified using the error matrix. The results of the study enabled the early exaction of the extents of the damages using the aerial imagery with identical characteristics. It was also possible to apply to various damage items for imagery change detection in case of utilizing multi-band im agery. Furthermore, more quantitative estimation of the dam ages would be possible with the use of numerous GIS layers such as land cover and cadastral maps.

• Journal of the Korea Fashion and Costume Design Association
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• v.17 no.3
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• pp.85-98
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• 2015

Modern fashion shows the trend of various styles and the period focusing on only product functions is changed to the period focusing on consumer's sensibility. Consumers show different sensitivities and preference by individual at the stage cognizing and recognizing the stimulation of given image and the method of objective measurement based on the fashion sensible vocabularies is necessary to measure fashion sensibility. Therefore, this research is significant to examine differences of preference to classic fashion by generation and awareness for sensible vocabularies and suggest methodology of design sensible evaluation research through the quantitative evaluation objectifying subjective sensibility. For the method of research, precedent theses related to classic, concept and characteristics of classic in books and definition and characteristics by generation were examined, the best 3 domestic portal sites were selected and adjective vocabularies and images related to classic were collected from 2010 to 2014. Among the 206 adjectives collected, vocabularies whose average is more than 3.5 were drawn by 5-point Likert scale for fashion expert group. And, among the total 306 images collected, 21 representative images were selected by preliminary investigation of fashion expert group. For the classic images and vocabularies selected, frequency analysis, factor analysis and variance analysis were conducted by SPSS 19.0. The results of analysis are as follows. Preference to classic fashion image by generation was analyzed. As a result, both of two generations selected classic fashion as the most classic one. The images of the next orders were analyzed. As a result, Y generation selected basic classic fashion image which is casual with high activity as a classic one. Baby boom generation selected ancient classic fashion image, so there were differences in preference for classic by generation. As a factor analysis on classic adjective vocabularies, they could be divided into 5 factors such as basic form, attractive form, traditional form, vintage form and active form and they verified that credibility of all measuring variables for classic sensible vocabularies was achieved. Differences of classic sensible vocabularies by classic fashion image and generation were examined. As a result, generation and classic fashion image made a significant effect on five factors. Therefore, there were differences of the awareness on classic fashion images and sensible vocabularies among the generations and this thesis can be a fundamental material which objectifies subjective sensibility and suggests the methodology of new research.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.64-72
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• 2014

As the importance of interface became emphasized recently, function of icon as an element that helps operation and formative function as an aesthetic element are becoming emphasized. Specially, various research methodologies for measuring the understanding degree of users are being attempted in functional aspect, however, they are facing limitations as user evaluation method of quantitative investigation for statistical analysis became overly dependent on the consent from majority. To overcome such limitation, a methodology of measuring sensibility as aesthetic impression or individuality based on the system of emotion or system of understanding of users and designing icon based on the measurement is being attempted continuously. Therefore, this study suggested an evaluation method using reminding words and conducted an empirical study to apply results on the icon design by applying the evaluation method on icon design of printing products to measure the user sensibility and understanding level. Through this process, this study intended to research summaries on the design evaluation method which based on the evaluation of user sensibility and understanding level and to debate effective design methodologies through the process of applying these summaries on the project. The intention was to progress discussion from practical application perspectives apart from the textbook type discussion by applying a research methodology through concrete cases. This study objectified sensibility and understanding level of users in the icon design aspect, suggested a methodology that can be applied on the design, and it is expected to be used when progressing the icon and GUI design.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.6
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• pp.374-379
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• 2017

Hair loss affects interpersonal relationships and causes psychological stress. In this study, we investigated the antioxidant activity of Cynanchi Wilfordii Radix (CWR) and its effects on dermal papilla (DP) cells. Antioxidant efficacy was examined by ABTS assay. To confirm the effect on cell activity, MTS assay was performed and cell count was directly measured by hemocytometer. The mRNA expression of genes involved in hair formation and hair loss formation was confirmed by quantitative RT-PCR. CWR has a strong antioxidant activity. Cell viability of DP cells was increased to 118.5% by treatment of 0.5 mg/ml CWR for 24 hours, but the effect on the cell number was insignificant. These results suggest that CWR increases mitochondrial activity without promoting cell proliferation. Treatment of DP cells with 0.5 mg/ml CWR resulted in 48.5% reduction of mRNA expression of type 2 $5{\alpha}$-reductase, a major cause of male hair loss. In addition, mRNA expression of bone morphogenetic pretein (BMP), fibroblast growth factor (FGF)7, and FGF10, which are closely related to hair growth, was also decreased. Reactive oxygen species (ROS) acts as a cause of hair loss. The excellent antioxidant efficacy of CWR is thought to be able to effectively remove ROS. The dihydrotestosterone produced by type 2 $5{\alpha}$-reductase in DP cells is a potent inducer of male pattern hair loss. The inhibitory effect of type 2 $5{\alpha}$-reductase mRNA on DP cells induced by CWR may induce a positive therapeutic effect of male pattern hair loss.