• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.524-530
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• 2013

In this study, we describe the most expected behavior of cells on the modified surface and the correlation between the modified substrates and the response of cells. The physicochemical characteristics of substrates played an essential role in the adhesion and proliferation of cells. Glass and polymer substrates were modified using air plasma oxidation, and the surfaces were coated with self-assembled monolayer molecules of silanes. The PDMS substrates embedded with parallel micropatterns were used for evaluation of the effect of topologically modified substrate on cellular behaviour. BALB/3T3 fibroblast cells were cultured on different surfaces with distinct wettability and topology, and the growth rates and morphological change of cells were analyzed. Finally, we found the optimum conditions for the adhesion and proliferation of cells on the modified surface. This study will provide insight into the cell-surface interaction and contribute to tissue engineering applications.

• 대한의용생체공학회:의공학회지
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• 제17권4호
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• pp.535-544
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• 1996

In this paper, we analyzed the coil-magnet type vibrating transducer for the implantable middle ear hearing aid which is appropriate for patient's hearing level, and an experimental transducer system is designed For the objective and quantitative analysis of the transducer, a theoretical equivalent model containing coil, magneto and inner ear is developed To perform effective evaluation of the transducer, a transforming ratio Tr is introduced and its range that is suitable for practical implantable middle ear hearing device is foun4 The result of applying physical parameters of ear system to the proposed analytical model shows that frequency response of the coil magrlet type vibrator is predominantly governed by resistive impedance of the coil rather than inertia effect of the magnet and the inner parameters. In addition, we realized an experimental middle ear hearing aid system to show the theoretical validity of designed system and this will provide the basis of the development for actually implantable system.

• 핵의학기술
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• 제21권2호
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• pp.55-64
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• 2017

최근 SPECT/CT의 보급과 함께 다양한 영상보정 방법들을 빠르고 정확하게 적용할 수 있게 되면서, 영상품질 향상과 더불어 정량적 정확성까지 기대할 수 있게 되었다. 그중 Collimator Detector Response (CDR) 회복(recovery)은 검출기면의 거리로부터 발생된 blurring 효과를 보상하여 분해능 회복을 목적으로 하는 보정방법이다. 본 연구에서는 SPECT/CT 영상에서 CDR recovery 가 적용되었을 때 검출거리 변화에 따른 정량적 변화를 알아보고자 하였다. 검출거리의 변화에 따른 획득 계수의 차이를 알아보고자 검출거리를 궤도방식(obit type)에 따라 Circular는 X, Y축 반경 30 cm, Non-Circular는 X, Y축 반경 21 cm, 10 cm, Non-Circular Auto(=Auto Body Contouring_ ABC, spacing limit 1 cm)로 설정하였고, 재구성 방법은 CDR recovery(CDRr)의 사용 유/무에 따른 계수 회복 차이를 알아보고자 OSEM (w/o CDRr)와 Astonish(3D-OSEM with CDRr)로 구분하여 적용하였다. 이 때 감쇠, 산란, 붕괴 보정은 모든 영상에 공통 적용하였다. 정량적 평가를 위해 교정인자(calibration factor_CF) 산출을 목적으로 교정영상(cylindrical phantom, $^{99m}TcO_4$ 123.3 MBq, 물 9293 ml)을 획득하였고, 팬텀 실험을 위하여 50 cc 주사기에 물 31 ml를 채우고 $^{99m}TcO_4$ 123.3 MBq를 설정하여 팬텀영상을 획득하였다. 팬텀 영상에서 주사기 전체 체적에 VOI(volume of interest)를 설정하여 각 조건별로 총 계수 값을 측정하였고, CF를 적용시켜 설정된 참값 대비 추정값의 오차를 구하여 보정에 따른 정량적 정확성을 확인하였다. 산출된 CF는 154.27 (Bq/ml/cps/ml)이며, 각 조건별 영상에서 참값 대비 추정값은 OSEM에서 Circular 86.5%, Non-Circular 90.1%, ABC 91.3% Astonish에서 Circular 93.6%, Non-Circular 93.6%, ABC 93.9%으로 분석되었다. OSEM은 검출거리가 가까울수록 정확성이 높아졌으며, Astonish의 경우에는 거리와 상관없이 거의 유사한 값을 나타내었다. 오차는 OSEM Circular(-13.5%)에서 가장 크고, Astonish ABC(-6.1%)에서 가장 적었다. SPECT/CT영상에서 CDR recovery 적용을 통한 거리보상이 이루어 졌을 때 검출거리가 먼 조건에서도 근접검출과 거의 동일한 정량적 정확성을 보였고, 검출거리의 변화에 영향을 받지 않고 정확한 보정이 가능한 것을 확인 할 수 있었다.

• 대한조선학회논문집
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• 제61권2호
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• pp.125-134
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• 2024

The Safe Operating Envelope (SOE) combined with Short-Take-Off and Vertical Landing (STOVL) performance is an essential consideration of a light aircraft carrier for design of hull shape with excellent seakeeping performance in terms of naval air operations as well as traditional naval ship missions such as Transit and Patrol (TAP), and Replenishment at Sea (RAS) and so on. A variety of procedures are systematically combined to determine SOE considering rather complicated missions associated with operation of aircraft onboard. The evaluation of take-off and landing safety missions onboard should consider wind effect on deck and severer seakeeping indices and standards compared with conventional naval ships. In order to support take-off and landing missions, various support activities of the crews are required. So, additional evaluation is needed for indicators such as MSI(Motion sickness Index) and MII(Motion Induced Interruptions), which are quantitative indicators of work ability that appear as a result of motion response. In this study, a standard procedure is developed including the seaworthiness performance indicators, standards, and evaluation procedures that should be considered during design of STOVL aircraft carrier. Analysis results are discussed in terns of air-wake on deck as well as seakeeping indices associated with design parameter changes in view of conceptual design of a light aircraft carrier.

• 한국축산식품학회지
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• 제44권4호
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• pp.873-884
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• 2024

Flunixin is a veterinary nonsteroidal anti-inflammatory agent whose residues have been investigated in their original form within tissues such as muscle and liver. However, flunixin remains in milk as a metabolite, and 5-hydroxy flunixin has been used as the primary marker for its surveillance. This study aimed to develop a quantitative method for detecting flunixin and 5-hydroxy flunixin in milk and to strengthen the monitoring system by applying to other livestock and fishery products. Two different methods were compared, and the target compounds were extracted from milk using an organic solvent, purified with C₁₈, concentrated, and reconstituted using a methanol-based solvent. Following filtering, the final sample was analyzed using liquid chromatography-tandem mass spectrometry. Method 1 is environmentally friendly due to the low use of reagents and is based on a multi-residue, multi-class analysis method approved by the Ministry of Food and Drug Safety. The accuracy and precision of both methods were 84.6%-115% and 0.7%-9.3%, respectively. Owing to the low matrix effect in milk and its convenience, Method 1 was evaluated for other matrices (beef, chicken, egg, flatfish, and shrimp) and its recovery and coefficient of variation are sufficient according to the Codex criteria (CAC/GL 71-2009). The limits of detection and quantification were 2-8 and 5-27 ㎍/kg for flunixin and 2-10 and 6-33 ㎍/kg for 5-hydroxy flunixin, respectively. This study can be used as a monitoring method for a positive list system that regulates veterinary drug residues for all livestock and fisheries products.

• 한국전자거래학회지
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• 제14권3호
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• pp.87-105
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• 2009

IT산업의 인적자원에 대한 중요성과 관심은 증가하고 있으나 IT인력관리에 대한 체계적인 접근이 부족한 실정이며 국내 IT산업은 전문인력의 부족 및 우수인력들의 잦은 이직현상 등 여러 가지 문제점을 노출하고 있다. 본 연구에서는 IT인력을 대상으로 개인특성과 조직특성이 경력만족, 경력전망 및 경력몰입에 미치는 영향을 연구하였다. IT 인력의 경력몰입을 실증적으로 연구하기 위해 국내 IT관련 업체에 종사하고 있는 개발자 및 전산실 직원들을 대상으로 설문조사를 실시하였다. 분석결과, 개인특성 중 자아존중감이 경력만족에 가장 큰 영향을 미치는 것으로 나타났으며 조직특성 중에서는 분배공정성 및 성장기회제공 등에 대한 지각 정도가 높을수록 경력전망에 유의미한 영향을 미치는 것으로 나타났다. 하지만 경력계획과 경력관리는 IT인력의 경력몰입에 미미한 영향을 미치는 것으로 나타나 IT인력관리의 시사점을 제시하였다. 본 연구는 향후 국내 IT인적자원의 체계적인 관리에 기여할 것으로 기대된다.

• 한국산업융합학회 논문집
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• 제7권4호
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• pp.331-340
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• 2004

This paper presents a feasibility study of a fresh air load reduction system by using an underground double floor space. The fresh air is introduced into the double slab space and passes through the opening bored into the footing beam. The air is cooled by the heat exchange with the inside surface of the double slab space in summer, and heated in winter. This system not only reduces sensible heat load of the fresh air by heat exchange with earth but also reduces latent heat load of the fresh air by ad/de-sorption of underground double slab concrete. In this paper, we used a model for evaluation of fresh air latent heat load reduction by hygroscopic of air to earth exchange system taking into account coupled heat and moisture transfer of underground double floor space. In conclusion it shows the validity of the proposed method for a design tool and the quantitative effect of the system.

• 한국해양공학회지
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• 제23권2호
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• pp.28-36
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• 2009

Many researches have been done to define the physical parameters for the wave generation and transformation over a coastal region. However, most of these have been limited to the application of particular conditions, as they are generally too empirical. To yield more reasonable wave estimation using a spectral wave model, it is important to understand how they work for the wave estimation. This study involved a comprehensive sensitivity test against the spectral resolution and the physical source/sink terms of the spectral wave model using SWAN and TOMAWAC, which have the same physical background with several different empirical/theoretical formulations. The tests were conducted for the East Anglian coast, UK, which is characterized by a complex bathymetry due to several shoals and offshore sandbanks. For the quantitative and qualitative evaluation of the models' performance with different input conditions, the wave elements and spectrums predicted at representative sites the East Anglia coast were compared/analyzed. The spectral resolution had no significant effect on the model results, but the lowest resolution on the frequency and direction induced underestimations of the wave height and period. The bottom friction and depth-induced breaking terms produced relatively high variations in the wave prediction, depending on which formulation was applied. The terms for the quadruplet and whitecapping had little effect on the wave estimation, whereas the triads tended to predict shorter and higher waves by energy transferring to higher frequencies.

• 한국태양에너지학회 논문집
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• 제24권4호
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• pp.45-53
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• 2004

In the summer, the irradiated solar heat gain through the roof has an effect on the thermal environment of the top floor units of apartment houses. This paper investigated the differences of the indoor air temperature and thermal comfort index between the top floor unit and the middle floor unit by measuring them at the sample houses. The purpose of this paper is to provide quantitative data about the irradiated solar heat gain during the summertime through the roof of an apartment house and these data to be the source to reevaluate the appropriate roof insulation efficiency. From this study, we obtained the brief results as follows. Indoor air temperature at the top floor unit is $1.2\sim2.2^{\circ}C$ higher than that of middle floor unit. The evaluation of the indoor thermal comfort index at each sample rooms reveals notable thermal differences between the two units. Top floor units need more cooling load during the summertime compared to middle floor units. Therefore, solutions to reduce solar Heat gain at top floor units to be considered.

• 대한한방종양학회지
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• 제7권1호
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• pp.1-18
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• 2001

Objective: This experimental study was carried out to evaluate the effects of Saussurea Radix and Plantaginis Herba on cellular viability, proliferation, apoptosis and expression of the cell cycle-related genes in cultured gastric cancer cells. Method :MTT assay for analysis of cellular toxicity and the effect on suppression of cellular viability, $[^{3}H]$ thymidine incorporation assay for evaluation of the effect on suppression of DNA replication, tryphan blue exclusion assay for measurement of induction of apoptosis and Quantitative RT-PCR for analysis of the effects on expression of cell cycle or apoptosis-related genes were performed. Results: Antitumor activity of Saussurea Radix associated with inhibition of cell cycle progression and promotion of apoptosis caused by transcriptional regulation of p53, p21/Wafl and the other related genes was observed.