• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.3
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• pp.520-525
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• 2019

Mines are an important infrastructure for securing resources, but safety problems can arise in the course of operation. Recently, the mining process is very complicated due to the large scale and mechanization. Therefore, it is necessary to construct accurate geospatial information on mine for systematic and safe mine operation. The geospatial information construction using the existing total station has a disadvantage that a lot of work time is required because the target must be collimated and measured. In this study, the data of the mines were acquired with the total station and the 3D laser scanner, and the mine spatial information was constructed by using the shape based registration method. By using the static scanner data of some area applying the reference point surveying result of the total station, it was possible to construct the accurate result on the wide area acquired by the mobile scanner effectively. Also, the accuracy of the constructed geospatial information was evaluated and the deviation of mean 0.083m was shown. Point cloud products constructed through the research can contribute to the efficiency improvement of mine management by enabling quantitative analysis such as visualization of mine shape, distance, area and slope, and automation of drawing creation for cross section shape.

• Journal of Food Hygiene and Safety
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• v.34 no.1
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• pp.52-57
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• 2019

Method development and validation of decursin for the standardization of Angelica gigas Nakai as a functional ingredient and health food were accomplished. The quantitative determination method of decursin as a marker compound of aerial parts of Angelica gigas Nakai extract (AAGE) was optimized by HPLC analysis using a C18 column ($3{\times}150mm$, $3{\mu}m$) with 0.1% TFA in water and acetonitrile as the mobile phase at a flow rate of 0.5 mL/min and detection wavelength of 330 nm. The HPLC/PDA method was applied successfully to quantification of the marker compound in AAGE after validation of the method with linearity, accuracy, and precision. The method showed high linearity in the calibration curve at a coefficient of correlation ($R^2$) of 0.9994 and the limit of detection and limit of quantitation were $0.011{\mu}g/mL$ and $0.033{\mu}g/mL$, respectively. Relative standard deviation (RSD) values of data from intra- and inter-day precision were less than 1.10% and 1.13%, respectively. Recovery of decursin at 0.5, 1, 5 and $10{\mu}g/mL$ were 92.38 ~ 104.11%. These results suggest that the developed HPLC method is very useful for the determination of marker compound in AAGE to develop a health functional material.

• Korean Journal of Pharmacognosy
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• v.49 no.4
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• pp.312-321
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• 2018

Recently, consumer demand for functional cosmetics containing natural ingredients has been greatly expanded. To develop the natural cosmetic materials, we selected 3 plants, Chrysanthemum zawadskii Herbich (CZ), Perilla frutescens (L.) Britton var. acuta Kudo (PF), and Rosa multiflora Thunberg (RM) which showed high total flavonoid contents (TFC), total polyphenol contents (TPC), and strong DPPH radical scavenging effect. We determined astragalin, chlorogenic acid, and rosmarinic acid as a marker compound for quantitative analysis of the content of each material and standardization of the quality standards and manufacturing standards through LC/MS analysis. HPLC-DAD was used to simultaneously analyze these marker components of three natural product complexes (Mix) and to validate the analytical method through experiments such as linearity, accuracy and precision. The detection wavelengths were set at 210, 265, and 330 nm. The detected 3 compounds from extract of CZ, PF, RM showed significant linearity ($R^2${\geq_-}$0.9947). The limit of detection (LOD) of chlorogenic acid, astragalin and rosmarinic acid were $8.29{\mu}g/ml$, $2.28{\mu}g/ml$, and $27.00{\mu}g/ml$, respectively. The limit of quantification (LOQ) of chlorogenic acid, astragalin and rosmarinic acid were $25.11{\mu}g/ml$, $6.92{\mu}g/ml$, and $81.83{\mu}g/ml$, respectively. The contents of the three indicators of Mix were 19.82-24.71 mg/g of chlorogenic acid, 43.80-46.02 mg/g of astragalin, and 46.33-48.57 mg/g of rosmarinic acid.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.37 no.1
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• pp.19-28
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• 2019

Images captured by drone have the advantage of quickly constructing spatial information in small areas and are applied to fields that require quick decision making. If an image registration technique that can automatically register the drone image on the ortho-image with the ground coordinate system is applied, it can be used for various analyses. In this study, a methodology for geo-referencing of a single image and sequential images using drones was proposed even if they differ in spatio-temporal resolution using linear features and distinct points. Through the method using linear features, projective transformation parameters for the initial geo-referencing between images were determined, and then finally the geo-referencing of the image was performed through the template matching for distinct points that can be extracted from the images. Experimental results showed that the accuracy of the geo-referencing was high in an area where relief displacement of the terrain was not large. On the other hand, there were some errors in the quantitative aspect of the area where the change of the terrain was large. However, it was considered that the results of geo-referencing of the sequential images could be fully utilized for the qualitative analysis.

• Korean Journal of Medicinal Crop Science
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• v.27 no.4
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• pp.247-258
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• 2019

Background: Astragali radix (A) and Lithospermi radix (L) have long been used as traditional medicines due to their known anti-inflammatory effects. This study aimed at evaluating, their optimal mixing ratio and their functional compounds by investigating the inhibitory effects of mixed extracts of A and L and their active compounds on matrix metalloproteinases (MMPs). Methods and Results: A and L extracts were obtained by extraction at $80^{\circ}C$ using 50% and 70% fermented alcohol, respectively, and then mixed at a ratio of 5 : 5, 6 : 4, 7 : 3 and 8 : 2 (w/w). The activities of MMP-1, MMP-3, and MMP-13 were evaluated in interleukin-1beta ($IL-1{\beta}$)-induced SW1353 cells. The extract mixtures showed synergistic inhibitory effects on MMP-3 and MMP-13, higher than the effects of the individual A and L extracts. The 7 : 3 mixture (ALM16) showed the most effective MMPs inhibitory activity, while among the active ingredients, calycosin-7-O-${\beta}$-D-glucoside and lithospermic acid exhibited excellent MMPs inhibitory activity. Additionally, an HPLC method was established for simultaneous quantification of the effective components of the extract mixtures, and validated by measuring the linearity, precision and accuracy of the limit of detection (LOD) and limit of quantification (LOQ). Conclusions: ALM16 showed the most effective MMPs inhibitory activity. Calycosin-O-${\beta}$-D-glucoside, calycosin and lithospermic acid were identified as useful candidates, as they were the major functional compounds in the MMP inhibitory activity. Summarily, ALM16 might be a highly effective in osteoarthritis management, owing to its because it exhibits a protective effect on cartilage via excellent inhibition of MMPs.

• Journal of Food Hygiene and Safety
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• v.34 no.3
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• pp.263-268
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• 2019

Methanol is a toxic alcohol used in various products such as antifreeze, detergent, disinfectant and industrial solvent. In the human body, methanol is oxidized to formaldehyde and formic acid, which can lead to metabolic acidosis, optic nerve impairment, and death. In this study, the methanol levels in detergents (n=191) and rinse aids (n=13) were analyzed by gas chromatography-headspace-mass spectrometry (GC-HS-MS). Limit of detection was 1.09 mg/kg, accuracy and precision were 91.1-97.9% and <10%, and it was suitable for quantitative analysis. This analysis method was simple and fast with a higher recovery rate than the conventional MFDS (Ministry of Food and Drug Safety) method of diluting the sample in water and putting it in a headspace vial.

• Journal of the Korean Society of Radiology
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• v.13 no.5
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• pp.765-771
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• 2019

Noise in skull X-ray imaging is inevitable, which reduces imaging quality and diagnostic accuracy and increases errors due to the nature of digital imaging devices. Increasing the dose can attenuate noise, but that could lead to big problems with higher exposure dose received by patients. Thus, noise reduction algorithms are actively being studied at low doses to solve dose problems and reduce noise at the same time. Wiener filter and median filter have been widely used, with the disadvantages of poor noise reduction efficiency and loss of much information about imaging boundary. The purpose of this study is to apply total variation (TV) algorithm to skull X-ray imaging that can compensate for the problems of previous noise reduction efficiency to assess quantitatively and compare them. For this study, skull X-ray imaging is obtained using various kVp and mAs using the skull phantom using the X-ray device of Siemens. In addition, contrast to noise ratio (CNR) and coefficient of variation (COV) are compared and measured when noisy image, median filter, Wiener filter and TV algorithm were applied to each phantom imaging. Experiments showed that when TV algorithms were applied, CNR and COV characteristics were excellent under all conditions. In conclusion, we've been able to see if we can use TV algorithm to improve image quality and CNR could be seen to increase due to the decrease in noise as the amount of increased mAs. On the other hand, COV decreased as the amount of increased mAs, and when kVp increased, noise was reduced and the transmittance was increased, so COV was reduced.

• Journal of the Korea Convergence Society
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• v.12 no.3
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• pp.187-196
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• 2021

The paper deals with comparative study for characteristics of approximation of design space according to various approximate models and sensitivity analysis using orthogonal array experiments in structure design of active type DSF which was developed for float-over installation of offshore plant. This study aims to propose the orthogonal array experiments based design methodology which is able to efficiently explore an optimum design case and to generate the accurate approximate model. Thickness sizes of main structure member were applied to the design factors, and output responses were considered structure weight and strength performances. Quantitative effects on the output responses for each design factor were evaluated using the orthogonal array experiment. Best design case was also identified to improve the structure design with weight minimization. From the orthogonal array experiment results, various approximate models such as response surface model, Kriging model, Chebyshev orthogonal polynomial model, and radial basis function based neural network model were generated. The experiment results from orthogonal array method were validated by the approximate modeling results. It was found that the radial basis function based neural network model among the approximate models was able to approximate the design space of the active type DSF with the highest accuracy.

• Journal of the Korean Society of Radiology
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• v.15 no.3
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• pp.307-312
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• 2021

In nuclear medicine, radioactive isotope tracers are administered to the human body to obtain and evaluate disease morphological information and biological function information. Dose calibrator is a device used to measure the radioactivity of a single nuclide in medical institutions. Administration of the correct dose to the human body acts as an important factor in diagnosis and treatment, and measurement through a dose calibrator before administration is the most important factor. Dose calibrator performs daily quality control after installation in each medical institution. Quality control is a means of guaranteeing quality control after installation, and is essential for improving the quality of treatment and promoting patient safety. Therefore, accurate and standardized performance evaluation methods should be established. In this study, 3D printing was used for quantitative evaluation of quality control by increasing the accuracy and standardization of quality control. When the 3D printer was installed and reproducibility was tested, the error range of the expected value and reading value decreased by 0.302% in the F-18 nuclide and 0.09% in the ^99mTc-pertechnate nuclide than when the 3D printer was installed. The error rate for other nuclides was also found to have a low error rate for reproducibility tests when 3D printing was installed.

• Journal of Food Hygiene and Safety
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• v.36 no.4
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• pp.281-288
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• 2021

This study was conducted to analyze and compare the concentrations of heavy metals in 430 different products of 20 types of herbal medicines available in the domestic market in Korea by Graphite Furnace-Atomic Absorption Spectrometry (GF-AAS) and automated mercury analyzer. The accuracy for lead (Pb), arsenic (As), cadmium (Cd), and mercury (Hg) was in the range 92.67-102.56%, and the precision was 0.21-6.00 relative standard deviation (RSD%), which was in compliance with the Codex acceptable range. Furthermore, the Food Analysis Performance Assessment Scheme (FAPAS) quality control (QC) material showed a recovery range of 96.7-102.0% and 0.33-4.93 RSD%. The average contents (㎍/kg) of Pb, As, Cd, and Hg in herbal medicines were 254.9 (not detected (N.D.)-2,515.2), 171.0 (N.D.-2,465.2), 99.2 (N.D.-797.1), and 6.0 (N.D.-83.6), respectively. Based on the quantitative analysis results, the heavy metal contents of 20 types of herbal medicines distributed in Korea are within the acceptable range according to the standards issued by the Ministry of Food and Drug Safety (MFDS). By using the manufacturer of herbal products as the standard for QC, the Pb, As, Cd, and Hg contents were investigated in the packaging process just before distribution to determine the actual conditions of residual heavy metals in herbal medicines. Thus, these result may contribute to monitoring the QC of herbal medicines distributed in Korea and could provide basic data for supplying safe herbal medicines to the public.