• 한국건설관리학회논문집
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• 제12권2호
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• pp.101-110
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• 2011

사회기반시설물 중 교량은 다른 시설물보다 열악한 환경에 노출되며, 파손 등이 발생할 경우 훨씬 심각한 결과를 야기할 수 있으므로 일정 수준 이상의 안전에 관한 성능을 반드시 유지하여야 한다. 하지만 향후 교량의 유지관리를 위한 예산 및 인적자원은 더욱 한정되어 갈 것이다. 자산관리기법은 이러한 한정된 자원으로 효율적인 교량의 유지관리를 위한 중요한 대안이 될 수 있다. 자산관리기법을 적용하기 위해서는 교량이 제공하는 서비스의 수준(Level of Service; LOS)을 평가하기 위한 방법이 결정되어야 하며, LOS는 성능척도(Performance Measures; PM)를 통해 정량적으로 결정될 수 있다. 본 논문은 교량 자산관리를 위한 PM을 개발하였으며, PM을 활용한 LOS 평가 방법을 정립하였다. 이러한 LOS 평가 결과를 활용하여 자산관리 대상, 항목 등을 결정할 수 있으며, 효율적이고 합리적인 교량의 자산관리관련 의사결정을 도울 수 있을 것으로 판단된다.

• The Korean Journal of Physiology and Pharmacology
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• 제24권5호
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• pp.385-394
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• 2020

Eupatilin is known to possess anti-apoptotic, anti-oxidative, and anti-inflammatory properties. We report here that eupatilin has a protective effect on the ethanol-induced injury in rats. Sprague-Dawley rats were divided into 6 groups: control, vehicle, silymarin, eupatilin 10 mg/kg, eupatilin 30 mg/kg, and eupatilin 100 mg/kg. Plasma levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed to determine the extent of liver damage. Total cholesterol (TC) and triglycerides (TG) were analyzed to determine the level of liver steatosis. Malondialdehyde level, superoxide dismutase (SOD) activity, and glutathione (GSH) level were analyzed to determine the extent of oxidative stress. Tumor necrosis factor (TNF)-α and interleukin (IL)-1β were quantified to verify the degree of inflammation. Based on our findings, chronic alcohol treatment significantly changed the serum indexes and liver indicators of the model rats, which were significantly improved by eupatilin treatment. Rats in the eupatilin-treatment group showed reduced levels of AST, ALT, TG, TC, TNF-α, and IL-1β, increased SOD activity and GSH levels, and improved overall physiology compared to the alcoholic liver disease model rats. H&E staining also verified the eupatilin-mediated improvement in liver injury. In conclusion, eupatilin inhibits alcohol-induced liver injury via its antioxidant and anti-inflammatory effects.

• Toxicological Research
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• 제28권4호
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• pp.241-248
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• 2012

Exposure of cells to ultraviolet B (UVB) radiation can induce production of free radicals and reactive oxygen species (ROS), which damage cellular components. In addition, these agents can stimulate the expression of matrix metalloproteinase (MMP) and decrease collagen synthesis in human skin cells. In this study, we examined the anti-photoaging effects of extracts of Tetraselmis suecica (W-TS). W-TS showed the strongest scavenging activity against 2,2-difenyl-1-picrylhydrazyl (DPPH) and peroxyl radicals, followed by superoxide anions from the xanthine/xanthine oxidase system. We observed that the levels of both intracellular ROS and lipid peroxidation significantly increased in UVB-irradiated human skin fibroblast cells. Furthermore, the activities of enzymatic antioxidants (e.g., superoxide dismutase) and the levels of non-enzymatic antioxidants (e.g., glutathione) significantly decreased in cells. However, W-TS pretreatment, at the maximum tested concentration, significantly decreased intracellular ROS and malondialdehyde (MDA) levels, and increased superoxide dismutase and glutathione levels in the cells. At this same concentration, W-TS did not show cytotoxicity. Type 1 procollagen and MMP-1 released were quantified using RT-PCR techniques. The results showed that W-TS protected type 1 procollagen against UVB-induced depletion in fibroblast cells in a dose-dependent manner via inhibition of UVB-induced MMP-1. Taken together, the results of the study suggest that W-TS effectively inhibits UVB-induced photoaging in skin fibroblasts by its strong anti-oxidant ability.

• 농업생명과학연구
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• 제46권4호
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• pp.31-39
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• 2012

본 연구에서는 유전자, 종, 생태계, 문화로 구분한 4종류의 분류 기준에 따라 14 종류의 평가 지표를 선정하였고 이중 가치 평가가 가능한 11개 인자를 대상으로 화폐적 평가를 수행하였다. 산림생물다양성을 저해하는 부의 경제효과 인자인 산림훼손, 산불, 병충해, 산림전용과 국가의 전통지식 권리를 보상해주어야 하는 나고야의정서가 발효된다는 가정에서 비용을 산출한 결과, 2,545억 원으로 평가되었다. 산림생물 다양성에 의한 양의 경제효과에는 바이오산업, 자생종, 임산물 생산, 보호구역, 산촌 소득적인 측면에서 이루어졌으며 그 가치는 연간 6조 7,200억 원으로 평가되었다. 산림생물다양성으로 인한 경제적 순편익은 연간 6조 4,655억 원으로 나타났다.

• 한국BIM학회 논문집
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• 제9권1호
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• pp.11-21
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• 2019

Recently, there is an increase in fire incidents in building structures. Due to this, the importance of fire-damaged buildings' safety diagnosis and evaluation after fire is growing. However, the existing fire-damaged safety diagnosis and evaluation methods are personnel-oriented, so the diagnostic results are intervened by investigators' subjectivity and unquantified. Thus, improper repair and reinforcement can result in secondary damage accidents and economic losses. In order to overcome these limitations, this study proposes using 3D laser scanning technology. The case analysis of fire-damaged building structures was conducted to verify the effectiveness of accuracy and manpowering by comparing the existing method and the proposed method. The proposed method using 3D laser scanning technology to obtain point cloud data of fire-damaged field. The point cloud data and BIM model is combined to inspect the fire-damaged area and depth. From inspection, quantified repair and reinforcement quantity take-off can be acquired. Also, the proposed method saves half of the manpowering within same time period compared to the existing method. Therefore, it seems that using 3D laser scanning technology in fire-damaged safety diagnosis and evaluation will improve in accuracy and saving time and manpowering.

• Annals of Clinical Neurophysiology
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• 제21권1호
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• pp.36-43
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• 2019

Background: Diabetic peripheral polyneuropathy (DPN) is associated with a variety of symptoms. Nerve conduction studies (NCSs) are considered to be the gold standard of nerve damage assessments, but these studies are often dissociated from the subjective symptoms observed in DPN patients. Thus, the aim of the present study was to investigate the correlations between NCS parameters and neuropathic symptoms quantified using the Michigan Neuropathy Screening Instrument (MNSI). Methods: Patients with type 2 diabetes mellitus (T2DM) with or without symptoms of neuropathy were retrospectively enrolled. Demographic data, clinical laboratory data, MNSI score, and NCS results were collected for analysis; DPN was diagnosed based on the MNSI score (${\geq}3.0$) and abnormal NCS results. Pearson's correlation coefficients were used to evaluate the relationships between MNSI score and NCS variables. Results: The final analyses included 198 patients (115 men and 83 women) with a mean age of $62.6{\pm}12.7$ years and a mean duration of diabetes of $12.7{\pm}8.4$ years. The mean MNSI score was 2.8 (range, 0.0-9.0), and 69 patients (34.8%) were diagnosed with DPN. The MNSI score was positively correlated with the median motor nerve latency and negatively correlated with the median motor, ulnar sensory, peroneal, tibial, and sural nerve conduction velocities (NCVs). When the patients were categorized into quartiles according to MNSI score, peroneal nerve conduction velocity was significantly lower in the second MNSI quartile than in the first MNSI quartile (p = 0.001). A multivariate analysis revealed that the peroneal NCV was independently associated with MNSI score after adjusting for age, sex, and glycosylated hemoglobin A1c (HbA1c) levels. Conclusions: The present results indicate that a decrease in peroneal NCV was responsible for early sensory deficits in T2DM patients.

• 한국지반환경공학회 논문집
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• 제12권2호
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• pp.5-14
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• 2011

국내의 터널현장에서 흔히 봉착하는 난제는 주변에 존재하는 각종 구조물과 가옥의 피해에 대한 민원의 해결 문제이다. 현재 암반터널을 굴착하는데 있어서 가장 효과적인 방법은 강력한 폭력을 지닌 화약을 사용하는 것인데, 이때 발생하는 발파진동이 민원의 주원인이라 할 수 있다. 본 연구에서는 라인드릴링과 프리스플리팅의 진동저감 효과를 수치해석을 실시하여 비교 분석 하였다. 그리고 수치해석방법에 의한 결과의 유사성을 검증하고 진동저감 효과를 정량화하였다. 또한, 외곽공 제어발파에 적용하는 일반 화약과 폭속이 다른 이종화약류를 조합하여 폭속별 진동저감 효과와 추가로 터널 발파진동을 저감할 수 있는 외곽공 제어발파 공법으로서 적용 타당성을 검토하였다.

• Structural Engineering and Mechanics
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• 제77권2호
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• pp.197-215
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• 2021

Under a severe environment of multiple hazards such as earthquakes and winds, the life-cycle performance of engineering structures may inevitably be deteriorated due to the fatigue effect caused by long-term exposure to wind loads, which would further increase the structural vulnerability to earthquakes. This paper presents a framework for evaluating the lifetime structural seismic performance under the effect of wind-induced fatigue considering different sources of uncertainties. The seismic behavior of a high-rise steel-concrete composite frame with buckling-restrained braces (FBRB) during its service life is systematically investigated using the proposed approach. Recorded field data for the wind hazard of Fuzhou, Fujian Province of China from Jan. 1, 1980 to Mar. 31, 2019 is collected, based on which the distribution of wind velocity is constructed by the Gumbel model after comparisons. The OpenSees platform is employed to establish the numerical model of the FBRB and conduct subsequent numerical computations. Allowed for the uncertainties caused by the wind generation and structural modeling, the final annual fatigue damage takes the average of 50 groups of simulations. The lifetime structural performance assessments, including static pushover analyses, nonlinear dynamic time history analyses and fragility analyses, are conducted on the time-dependent finite element (FE) models which are modified in lines with the material deterioration models. The results indicate that the structural performance tends to degrade over time under the effect of fatigue, while the influencing degree of fatigue varies with the duration time of fatigue process and seismic intensity. The impact of wind-induced fatigue on structural responses and fragilities are explicitly quantified and discussed in details.

• 한국안전학회지
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• 제36권2호
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• pp.94-100
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• 2021

In general, the industrial complex is a place where factories of various industries are concentrated. It is only as efficient as it is designed. However, the risks vary as there are various industries. These features are also associated with various types of disasters. The dangers of natural disasters such as a typhoon, flood, and earthquake, as well as fire and explosions, are also latent. Many of these risks can make stable production and business activities difficult, resulting in massive direct and indirect damage. In particular, decades after its establishment, the vulnerabilities increase even more as aging and small businesses are considered. In this sense, it is significant to assess the vulnerability of the industrial complex. Thus analysing fire and explosion hazards as stage 1 of the vulnerability evaluation for the major potential disasters for the industrial complex. First, fire vulnerabilities were analyzed quantitatively. It is displayed in blocks for each company. The assessment block status and the fire vulnerability rating status were conducted by applying the five-step criteria. Level A is the highest potential risk step and E is the lowest step. Level A was 11.8% in 20 blocks, level B was 22.5% in 38 blocks, level C was 25.4% in 43 blocks, level D was 26.0% in 44 blocks, and level E was 14.2% in 24 blocks. Levels A and B with high fire vulnerabilities were analyzed at 34.3%. Secondly, the vulnerability for an explosion was quantitatively analyzed. Explosive vulnerabilities were analyzed at 4.7% for level A with 8 blocks, 3.0% for level B with 5, 1.8% for level C with 3, 4.7% for level D with 8, and 85.8% for level E with 145. Levels A and B, which are highly vulnerable to explosions, were 7.7 %. Thirdly, the overall vulnerability can be assessed by adding disaster vulnerabilities to make future assessments. Moreover, it can also assist in efficient safety and disaster management by visually mapping quantified data. This will also be used for the integrated control center of the N-Industrial Complex, which is currently being installed.

• 한국전산구조공학회논문집
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• 제35권3호
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• pp.149-158
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• 2022

교량은 사용년한이 증가함에 따라 노후화로 인해 역학적인 성질과 구조적인 성능이 저하되고, 이로 인해서 강진 시에 내진성능이 저하된다. 교각과 교량받침에 대한 노후화를 몇 가지 단계로 정량화하여 해석모델에 반영하였고, 노후화된 교각과 교량받침에 대하여 부재-수준의 지진취약도를 평가하였다. 교량 시스템의 파괴 메카니즘을 직렬시스템으로 가정하여, 부재-수준의 지진취약도 해석 결과로부터 시스템-수준의 지진취약도를 평가하는 방법을 제안하였다. 노후도에 취약한 부재인 교각과 교량받침에 대하여 5가지 정량적인 노후도(0, 5, 10, 25, 40%)를 가정하여 부재-수준의 지진취약도를 평가하였고, 이 결과로부터 시스템-수준의 지진취약도 평가를 수행하였다. 시스템-수준의 지진취약도는 교량받침 보다는 교각이 지배적인 영향을 줌을 알 수 있었다. 이는 보다 취약한 구조부재의 지진취약도가 전체 교량시스템의 지진취약도에 지배적인 영향을 주는 것을 의미한다.