• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.18
• /
• pp.8247-8252
• /
• 2016

Background: The ubiquitin-proteasome system (UPS) degrades a variety of proteins which attach to specific signals. The ubiquitination pathway facilitates degradation of damaged proteins and regulates growth and stress responses. This pathway is altered in various cancers, including acute lymphoblastic leukemia, head and neck squamous cell carcinoma and breast cancer. Recently it has been reported that expression of newly characterized human genes, UBE2Q1 and UBE2Q2, putative members of ubiquitin-conjugating enzyme family (E2), has been also changed in colorectal cancer. Epigenetics is one of the fastest-growing areas of science and nowadays has become a central issue in biological studies of diseases. According to the lack of information about the role of epigenetic changes on gene expression profiling of UBE2Q1 and UBE2Q2, and the presence of CpG islands in the promoter of these two human genes, we decided to evaluate the promoter methylation status of these genes as a first step. Materials and Methods: The promoter methylation status of UBE2Q1 and UBE2Q2 was studied by methylation-specific PCR (MSP) in tumor samples of 60 colorectal cancer patients compared to adjacent normal tissues and 20 non-malignant controls. The frequency of the methylation for each gene was analyzed by chi-square method. Results: MSP results revealed that UBE2Q2 gene promoter were more unmethylated, while a higher level of methylated allele was observed for UBE2Q1 in tumor tissues compared to the adjacent normal tissues and the non malignant controls. Conclusions: UBE2Q1 and UBE2Q2 genes show different methylation profiles in CRC cases.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.12 no.11
• /
• pp.5135-5142
• /
• 2011

A flexible mechanism is proposed in this paper to improve the dynamic response performance of a traffic flow control system in an urban area. The roads, vehicles, and traffic control systems are all modeled as intelligent systems, wherein a wireless communication network is used as the medium of communication between the vehicles and the roads. The necessary sensor networks are installed in the roads and on the roadside upon which reinforcement learning is adopted as the core algorithm for this mechanism. A traffic policy can be planned online according to the updated situations on the roads, based on all the information from the vehicles and the roads. This improves the flexibility of traffic flow and offers a much more efficient use of the roads over a traditional traffic control system. The optimum intersection signals can be learned automatically online. An intersection control system is studied as an example of the mechanism using Q-learning based algorithm, and simulation results showed that the proposed mechanism can improve the traffic efficiency and the waiting time at the signal light by more than 30% in various conditions compare to the traditional signaling system.

• Proceedings of the KIEE Conference
• /
• 1994.07b
• /
• pp.1612-1614
• /
• 1994

Modulators Installed in PLS(Pohang Light Source) Linac are composed of a DC high voltage section, a charging section and a discharging section. PFN is charged by a resonant charging mechanism, and discharged by a switching device through the primary of the pulse transformer connected to a load. Charged PFN voltage must be well regulated to obtain stable output pulse voltage at the load. For this purpose, DCHV is controlled by a SCR controller with feedback signal, and PFN voltage is regulated by a De-Q'ing circuit. The full power operation test shows the pulse voltage regulation within ${\pm}0.13%$ with SCR feedback control alone, and within ${\pm}0.08%$ together with De-Q'ing. This paper describes the design concept and operational characteristics of the De-Q'ing circuit.

• KIPS Transactions on Software and Data Engineering
• /
• v.4 no.12
• /
• pp.577-584
• /
• 2015

In general, Q&A system retrieves passages by matching terms of a question in order to find an answer to the question. However it is difficult for Q&A system to find a correct answer because too many passages are retrieved and matching using terms is not enough to rank them according to their relevancy to a question. To alleviate this problem, we introduce a topic for a sentence, and adopt it for ranking in Q&A system. We define a set of person-related topic class and a clue expression which can indicate a topic of a sentence. A topic classification system proposed in this paper can determine a target topic for an input sentence by using clue expressions, which are manually collected from a corpus. We explain an architecture of the topic classification system and evaluate the performance of the components of this system.

• Journal of information and communication convergence engineering
• /
• v.8 no.3
• /
• pp.307-311
• /
• 2010

EPCglobal Class-1 Gen-2 protocol has been proposed for UHF-band RFID systems. In Gen-2 standard, Q-algorithm was proposed to select a frame size for the next query round without estimating the number of tags. Therefore, the Q-algorithm has advantage that the reader's algorithm is simpler than other algorithms. However, it is impossible to allocate the optimized frame size. Also, the original Q-algorithm did not define an optimized parameter C for adjusting the frame size. In this paper, we propose an adaptive Q-algorithm with the different parameter $C_c$ and $C_i$ in accordance with the status of reply slot. Simulation results show that the proposed adaptive Q-algorithm outperforms the original Gen-2 Q-algorithm.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.33 no.7A
• /
• pp.751-756
• /
• 2008

In this paper, we propose a modified I/Q diversity scheme receiver of UHF RFID reader system. The modified I/Q diversity receiver is more robust than the conventional homodyne receiver in the wireless noisy, fading channel and phase noise environments by making use of additional axes. In particular, it is shown that the closer the phase difference ${\theta}(t)$ between the reader and the tag to ${\pi}/4$, the larger performance improvement we can get. The performance of the proposed receiver is verified by equations and is demonstrated by the computer simulation for various difference ${\theta}(t)$ cases.

• Proceedings of the KIEE Conference
• /
• 1992.07a
• /
• pp.305-307
• /
• 1992

This paper presents a technique, which identifies both process noise covariance and sensor noise covariance by using innovation correlation test. A correlation test, which checks whether the square root Kalman filter is workingly optimal or not, is given. The system is stochastic autoregressive moving-average model with auxiliary white noise Input. The linear quadratic Gaussian control is used for minimizing stochastic cost function. This paper indentifies Q, R, and estimates parametric matrics $A(q^{-1}),B(q^{-1}),C(q^{-1})$ by means of extended recursive least squares and model reference control. And The proposed technique has been validated in simulation results on the fourth order system.

• The Korean Journal of Nuclear Medicine Technology
• /
• v.21 no.2
• /
• pp.31-36
• /
• 2017

Purpose Recently, the performance of PET/CT scanner has been improved and various techniques have been developed to increase the image quality such as Sensitivity and Resolution. The purpose of this study is to evaluate the usefulness of Q.Clear (a fully convergent iterative reconstruction) technique of GE Discovery IQ equipment to enhance the image quality. Materials and Methods All scans were acquired by Discovery IQ (GE Healthcare, MI, USA). In NEMA IEC Body Phantom test, Background to Hot-sphere (10 mm, 13 mm, 17 mm, 22 mm) ratio was 1:4 and scan time was 3 minutes. The images were reconstructed by VPHDs (VUE Point High-Definition + SharpIR) and Q.Clear to evaluate each Contrast. We injected 18F-FDG 187 M㏃ to PET/SPECT Performance Phantom. And then it was scanned for 4 minutes to evaluate Resolution and Uniformity. T-test statistical analysis was performed on SUVmax of small lesions less than 2 cm in 100 clinical patients regardless of disease type. Results In the NEMA IEC Body Phantom, the Contrast was $63.6{\pm}5.7%$ (VPHDs) and $75{\pm}4.8%$ (Q.Clear). In the PET/SPECT Performance Phantom, the Resolution was 9.2 mm (VPHDs) and 7.3 mm (Q.Clear). Uniformity of Q.Clear was 10.8% better than VPHDs. T-test statistic of the clinical patients showed a significant difference of p value of 0.021. Conclusion Both the phantom test and the clinical results showed that the quality of the image was improved in Q.Clear was applied. The SUVmax was highly measured in Q.Clear and the lesions were clearly distinguished visually. Therefore Q.Clear can be useful in various aspects such as dose-reduction, patients evaluation and image analysis.

• Journal of Korean Society for Quality Management
• /
• v.44 no.1
• /
• pp.77-94
• /
• 2016

Purpose: This paper reviews Type 1 Gage study, Gage R&R study, and procedure of ISO 22514-7 for assessing a measurement system, and discusses some relationships between the measurement capability indices. Methods: The gage capability index $C_g$ of Type 1 Gage study, precision-to-tolerance ratio PTR of Gage R&R study, and measurement performance ratio $Q_{MS}$ and $Q_{MP}$ of ISO 22514-7 are considered in this paper. Results: This paper derives the relationships between $C_g$ and $Q_{MS}$, PTR and $Q_{MP}$, and $Q_{MS}$ and $Q_{MP}$, respectively, and discusses the acceptance conditions for each procedures. Conclusion: The measurement capability analysis is the first step for the quality improvement of the manufacturing processes. Therefore the result of this study provides a helpful guidelines for assessing the measurement system, enabling proper evaluation of manufacturing processes.

• Journal of Korea Water Resources Association
• /
• v.49 no.12
• /
• pp.1015-1025
• /
• 2016

In general, manholes installed as urban drainage facilities are a variety forms such as straight path manholes, 90 degree bend manhole, three-way combining manhole, and four-way combining manhole. In particular, the surcharged flow at a four-way manholes installed in the downstream of urban sewer system is the main cause of the urban inundation caused by the energy loss. Therefore, it is necessary to analyze the flow characteristics and estimate the head loss coefficients at surcharged four-way combining manholes. The hydraulic experimental apparatus which can change the manhole shapes (square, circle) and flow ratios were installed to estimate the head loss coefficients. In the experiments, two inflows ($Q_m$, $Q_{lat}$) were varied from 0 to $4.8{\ell}/sec$ and 24 combinations were tested in total. The flow ratios $Q_{lat}/Q_{out}$ were varied from 0 to 1 for a total flow $Q_{out}$ ($Q_{out}=Q_m+2Q_{lat}$) of 2, 3, 4, and $4.8{\ell}/sec$, respectively. The variation of head losses were strongly influenced by the lateral inflow because the head loss coefficient increases as the flow ratios $Q_{lat}/Q_{out}$ increases. It was estimated head loss coefficients of the circular manhole is slightly lower than those of the square manhole. However, there was no significant difference of head loss as discharges change. The range of head loss coefficients at four-way combining manhole according to the change of the lateral inflow ratio was estimated to be 0.4 to 0.8. Also, the relation equations between the head loss coefficients (K) and the lateral inflow ratios ($Q_{lat}/Q_{out}$) were suggested in this paper.