• The KSFM Journal of Fluid Machinery
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• v.9 no.2 s.35
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• pp.39-43
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• 2006

The magnitude of the axial force acting on turbopump bearings has a great influence on the operational reliability and service life of a turbopump. In the turbopump under current investigation the cavity vanes are introduced to the pump shroud casing to control the axial thrust of the turbopump. To investigate the effect of the cavity vanes, 3D computational flow analyses for a propellant pump stage including an inducer, impeller, volute and secondary flow passages are performed with and without the vanes. The results show that the cavity vanes are very effective in reducing the magnitude of axial thrust without notable changes on the overall performance of the turbopump.

• 유체기계공업학회:학술대회논문집
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• 2005.12a
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• pp.354-358
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• 2005

The magnitude of the axial force acting on turbopump bearings has a great influence on the operational reliability and service life of a turbopump. In the turbopump under current investigation the cavity vanes are introduced to the pump shroud casing to control the axial thrust of the turbopump. To investigate the effect of the cavity vanes, 3D computational flow analyses for a propellant pump stage including an inducer, impeller, volute and secondary flow passages are performed with and without the vanes. The results show that the cavity vanes are very effective in reducing the magnitude of axial thrust without notable changes on the overall performance of the turbopump.

• Journal of Aerospace System Engineering
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• v.14 no.5
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• pp.100-106
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• 2020

Turbopumps for liquid rocket engines are exposed to various cavitation instabilities under their operating conditions. The instabilities affect the stability of the turbopumps. To make sure of the stability of the turbopump of KSLV-II, the present work examined the characteristics of the cavitation instabilities during the turbopump assembly test. In the test, the LOx pump was operated under super-synchronous rotating cavitation and attached to uneven cavitation. In the vibration analysis of the fuel pump, the characteristic frequency by the super-synchronous cavitation of the LOx pump was clearly shown.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.34 no.4
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• pp.70-75
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• 2006

The performance of a turbopump system composed of an inducer, an impeller, a volute and seals has been computationally analyzed. To save the computational time, only one flow passage of the inducer and impeller is considered for the computations. A steady mixing-plane method is used on the impeller/volute interface for simulating the unsteady interaction phenomena. The axial thrust is predicted from the turbopump calculation in its entirety, which is necessary for such estimation. Moreover, the effects of each component on the pump performance are investigated at a design condition through the analysis of flow structures. The predicted performance is in good agreement with experimental data in terms of head rise, efficiency and volute wall pressure distributions despite of highly complex flow structures being present. The computational results also show that the axial and radial thrusts are within the design limit although corresponding experimental measurements were not taken.

• Transactions of the Korean Society of Mechanical Engineers
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• v.12 no.3
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• pp.520-527
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• 1988

Liquid ejectors are widely used as marine pumps, inducer stage for the boiler feed water pump, boiler recirculating pump, cooling water recirculating pump in boiling water type nuclear reactor and a deep well pump, because of their high working confidence and simplicity. Furthermore, it requires only a modest net positive suction head for cavitation-free operation and it can be installed in remote location from mechanical power source. It is not easy to presume the friction losses, because it is complicately affected by area ratio, flowrate ratio, nozzle spacing, throat length, shape of liquid ejector and so on. Therefore, the optimization of liquid ejector design is still dependent, to a large extent, on the experimental results and empirical procedures. On the design of the liquid ejector, the area ratio and the nondimensional throat length are the most important design factors among the mentioned above. In this experiment, the effects of the area ratio and the nondimensional throat length to ejector efficiency are carried out systematically by the combination of 4 kinds of motive nozzle and 2 kinds of throat length. In this paper, the present experimental results are compared with the calculated ones by the previous computer aided design program based on one dimensional flow equation. And also, an empirical equation for the working limit of liquid ejector is reported.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.216-227
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• 2004

A new cavitating model by using bubble size distribution based on bubbles-mass has been proposed. Both liquid and vapor phases are treated with Eulerian framework as a mixture containing minute cavitating bubbles. In addition vapor phase consists of various sizes of vapor bubbles, which are distributed to classes based on their mass. The bubble number-density for each class was solved by considering the change of the bubble-mass due to phase change as well as generation of new bubbles due to heterogeneous nucleation. In this method, the bubble-mass is treated as an independent variable, and the other dependent variables are solved in spatial coordinates and bubble-mass coordinate. Firstly, we employed this method to calculate bubble nucleation and growth in stationary super-heated liquid nitrogen, and bubble collapse in stationary sub-cooled one. In the case of bubble growth in super-heated liquid, bubble number-density of the smallest class based on its mass is increased due to the nucleation. These new bubbles grow with time, and the bubbles shift to larger class. Therefore void fraction of each class is increased due to the growth in the whole class. On the other hand, in the case of bubble collapse in sub-cooled liquid, the existing bubbles are contracted, and then they shift to smaller class. It finally becomes extinct at the smallest one. Secondly, the present method is applied to a cavitating flow around NACA00l5 foil. Liquid nitrogen and liquid oxygen are employed as working fluids. Cavitation number, $\sigma$, is fixed at 0.15, inlet velocities are changed at 5, 10, 20 and 50m/s. Inlet temperatures are 90K in case of liquid nitrogen, and 90K and 1l0K in case of liquid oxygen. 110K of oxygen is corresponding to the 90K of nitrogen because of the same relative temperature to the critical one, $T_{r}$=$T/T_c^{+}$. Cavitating flow around the NACA0015 foils was properly analyzed by using bubble size distribution. Finally, the method is applied to a cavitating flow in an inducer of the LE-7A hydrogen turbo-pump. This inducer has 3 spiral foils. However, for simplicity, 2D calculation was carried out in an unrolled channel at 0.9R cross-section. The channel moves against the fluid at a peripheral velocity corresponding to the inducer revolutions. Total inlet pressure, $Pt_{in}$, is set at l00KPa, because cavitation is not generated at a design point, $Pt_{in}$=260KPa. The bubbles occur upstream of the foils and collapse between them. Cavitating flow in the inducer was successfully predicted by using the bubble size distribution.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.04a
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• pp.309-312
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• 2007

The cryogenic fluid is the propellant for the liquid rocket engine. The design of space launcher vehicle is guided by minimum size and weight criteria, so the turbo pump solicits high impeller speed. Such high speed results in a zone of pressure drop below vapor pressure causing caivtation around inducer blades. The cryogenic fluid has different characters from isothermal fluid like water. The cryogenic fluid has very sensible thermodynamic properties and the phase change undergoes evaporative cooling. So, the developed code has to be modified cavitation modeling and it is added the energy equation for temperature sensitivity.

• Journal of Digestive Cancer Research
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• v.6 no.1
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• pp.6-10
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• 2018

The importance of signal transducer and activator of transcription 3 (STAT3) signaling in gastric carcinogenesis was firmly evaluated in the previous studies. Fully activated STAT3 induces various target genes involving tumor invasion and epithelial-mesenchymal transition (EMT), and mediates interaction between cancer cells and microenvironmental immune cells. Thus, suppression of STAT3 activity is an important issue for inhibition of gastric carcinogenesis and invasion. Unfortunately, data from clinical studies of direct inhibitor targeting STAT3 have been disappointing. SH2-containing protein tyrosine phosphatase 1 (SHP-1) effectively dephosphorylates and inhibits STAT3 activity, which has not been extensively studied gastric cancer research field. However, by summarizing recent data, it is evident that protein and gene expression of SHP-1 are minimal in gastric cancer cells, and induction of SHP-1 effectively downregulates phosphorylated STAT3 and inhibits cellular invasion in gastric cancer cells. Several SHP-1 inducers have been investigated in the experimental studies, including proton pump inhibitor, arsenic trioxide, and other natural compounds. Taken together, we suggest that modulation of SHP-1/STAT3 signaling axis may present a new way for treatment of gastric cancer, and development of effective SHP-1 inducer may be an important task in the future search field of gastric cancer.

• Archives of Pharmacal Research
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• v.28 no.10
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• pp.1196-1202
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• 2005

Omeprazole (OMP) is a proton pump inhibitor used as an oral treatment for acid-related gastrointestinal disorders. In the liver, it is primarily metabolized by cytochrome P-450 (CYP450) isoenzymes such as CYP2C19 and CYP3A4. 5-Hyroxyomeprazole (5-OHOMP) and omeprazole sulfone (OMP-SFN) are the two major metabolites of OMP in human. Cimetidine (CMT) inhibits the breakdown of drugs metabolized by CYP450 and reduces, the clearance of coad-ministered drug resulted from both the CMT binding to CYP450 and the decreased hepatic blood flow due to CMT. Phenobarbital (PB) induces drug metabolism in laboratory animals and human. PB induction mainly involves mammalian CYP forms in gene families 2B and 3A. PB has been widely used as a prototype inducer for biochemical investigations of drug metabolism and the enzymes catalyzing this metabolism, as well as for genetic, pharmacological, and toxicological investigations. In order to investigate the influence of CMT and PB on the metabolite kinetics of OMP, we intravenously administered OMP (30 mg/kg) to rats intraperitoneally pretreated with normal saline (5 mL/kg), CMT (100 mg/kg) or PB (75 mg/kg) once a day for four days, and compared the pharmacokinetic parameters of OMP. The systemic clearance ($CL_{t}$) of OMP was significantly (p<0.05) decreased in CMT-pretreated rats and significantly (p<0.05) increased in PB-pretreated rats. These results indicate that CMT inhibits the OMP metabolism due to both decreased hepatic blood flow and inhibited enzyme activity of CYP2C19 and 3A4 and that PB increases the OMP metabolism due to stimulation of the liver blood flow and/or bile flow, due not to induction of the enzyme activity of CYP3A4.