• The Journal of Internal Korean Medicine
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• v.37 no.1
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• pp.90-108
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• 2016

Objectives: This study aimed to learn what should be considered in the Guidelines of Clinical Trials with Herbal Medicinal Products for Gastroesophageal Reflux Disease (GERD) by analyzing the existing guidelines and clinical trials.Methods: The development committee searched the existing guidelines for herbal medicinal products or GERD. Then, clinical trials related to GERD using herbal medicine were selected. The chosen trials were analyzed in terms of their inclusion and exclusion of participants, intervention, comparators, outcome, and trial design. Then, we compared the results of the analysis according to the regulations and guidelines of the Ministry of Food and Drug Safety to suggest the issues that we will have to consider when developing the Guidelines of Clinical Trials with Herbal Medicinal Products for Gastroesophageal Reflux Disease (GERD).Results: As a result, few guidelines for GERD and clinical trials with herbal medicinal products were located in the national institution homepage. In addition, 8 articles were found using the following combination of search terms: “Gastroesophageal reflux disease”, “GERD”, “herbal medicine”, “herbal therapy”, “Korean Medicine”, “Traditional Chinese Medicine”, and “TCM”. Even though all trials had their own unique research questions, all studies were performed using a randomization method. Most trials included participants with reflux esophagitis, but two trials targeted proton pump inhibitor-refractory GERD. The type of intervention varied, such as decoction, granules, and capsules. Additionally, individualized herbal medicines were used in two studies. Comparators were diverse, such as placebo, Western medicine, and electro-acupuncture. The most frequently used outcome for efficacy was the effectiveness rate. In addition, the outcome for evaluating quality of life, esophageal mucosa and pressure, esophageal acid reflux, and recurrence rates were used. Safety was investigated by recording adverse events and carrying out laboratory tests.Conclusions: We identified some issues by reviewing the existing guidelines and comparing them with clinical trials for GERD and herbal medicinal products. These results will be utilized for developing the Guidelines of Clinical Trials with Herbal Medicinal Products for Gastroesophageal Reflux Disease (GERD).

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.2
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• pp.15-21
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• 2011

In this paper, an energy management circuit for solar energy harvesting system is designed in $0.35{\mu}m$ CMOS technology. The solar energy management system consists of an ISC(Integrated Solar Cell), a voltage booster, and an MPPT(Maximum Power Point Tracker) control unit. The ISC generates an open circuit voltage of 0.5V and a short circuit current of $15{\mu}A$. The voltage booster provides the following circuit with a supply voltage about 1.5V. The MPPT control unit turns on the pMOS switch to provide the load with power while the ISC operates at MPP. The SEMU(Solar Energy Management Unit) area is $360{\mu}m{\times}490{\mu}m$ including pads. The ISC area is $500{\mu}m{\times}2000{\mu}m$. Experimental results show that the designed SEMU performs proper MPPT control for solar energy harvested from the ISC. The measured MPP voltage range is about 370mV∼420mV.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.44 no.2
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• pp.19-24
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• 2007

With recent advancement of high-speed, multi-gigabit data transmission capabilities, serial links have been more widely adopted in industry than parallel links. Since the parallel link design forces its transmitter to transmit both the data and the clock to the receiver at the same time, it leads to hardware's intricacy during high-speed data transmission, large power consumption, and high cost. Meanwhile, the serial links allows the transmitter to transmit data only with no synchronized clock information. For the purpose, clock and data recovery circuit becomes a very crucial key block. In this paper, a 5.4Gbps half-rate bang-bang CDR is designed for the applications of high-speed graphic DRAM interface. The CDR consists of a half-rate bang-bang phase detector, a current-mirror charge-pump, a 2nd-order loop filter, and a 4-stage differential ring-type VCO. The PD automatically retimes and demultiplexes the data, generating two 2.7Gb/s sequences. The proposed circuit is realized in 66㎚ CMOS process. With input pseudo-random bit sequences (PRBS) of $2^{13}-1$, the post-layout simulations show 10psRMS clock jitter and $40ps_{p-p}$ retimed data jitter characteristics, and also the power dissipation of 80mW from a single 1.8V supply.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.1
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• pp.512-520
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• 2020

Recently, the applications of the standing column well (SCW) ground heat exchanger (GHX) have increased significantly in Korea as a heat transfer mechanism of ground source heat pump systems (GSHP) because of its high heat capacity and efficiency. Among the various design and operating parameters, bleeding was found to be the most important parameter for improving the thermal performance, such as ground thermal conductivity and borehole thermal resistance. In this study, a bleeding analysis model was developed using the thermal response test data, and the effects of bleeding rates and bleeding locations on the thermal performance of anSCW were investigated. The results show that, when the ground water flows into the top of anSCW, the time variation of circulating water temperature decreased with increasing bleeding rate, and the ground thermal conductivity increases by as much as 179% with a 30% bleeding rate. When the ground water flows into the bottom of the SCW, the circulating water temperatures become almost constant after the increase in the beginning time because the circulating water exchanges heat with the ground structure before mixing with the ground water at the bottom.

• Journal of IKEEE
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• v.24 no.3
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• pp.859-866
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• 2020

This paper proposes a 2-ch DC-DC converter with a wide-input voltage range from 2.9V~5.6V for wearable AMOLED displays. For positive voltage V_POS, a boost converter is designed using an over-charged voltage permissible circuit (OPC) which generates a normal output voltage even if over-input voltage is applied, and a SPWM-PWM dual mode with 3-segmented power transistors to improve efficiency at light load. For negative voltage V_NEG, a 0.5x regulated inverting charge pump is designed to increase power efficiency. The proposed DC-DC converter was designed using a 0.18-㎛ BCDMOS process. Simulation results show that the proposed DC-DC converter generates V_POS voltages of 4.6 V and V_NEG voltage of -0.6V~-2.3V for input voltage of 2.9V to 5.6V. In addition, it has power efficiency of 49%~92%, output ripple voltage has less than 20 mV for load current range of 1 mA~70 mA.

• Applied Chemistry for Engineering
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• v.18 no.1
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• pp.29-35
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• 2007

Recently, due to narrow margin on design factor of flue gas desulfurization (FGD) systems or aging of systems, some problems such as decrease of $SO_2$ removal efficiency and difficulty on coping with unstable state are arising on FGD systems. On this study, to cope with these problems several methods such as adjustment of reagent pH, inlet $SO_2$ concentration, variation of units of operation pump, installation of liquid distribution ring (LDR) were attempted to increase the $SO_2$ removal using spray type simulated FGD system. Also, sulfite and Al/Fx ion effects on limestone blinding were experimented. When three absorber recirculation pumps were operated, $SO_2$ removal was increased by 12% in comparison with that of two pumps operation. $SO_2$ removal was increased by 2~7% after installation of LDR. Dissolved oxygen increased up to 0.5 ppm and limestone binding effect was alleviated after injection of dibasic acid (DBA) with the concentration of 500 and 1,000 ppm. When $Al^{3+}$ and $F^-$ ions were coexisting, the dissolution rate of limestone was decreased by 20%.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2004.03a
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• pp.216-227
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• 2004

A new cavitating model by using bubble size distribution based on bubbles-mass has been proposed. Both liquid and vapor phases are treated with Eulerian framework as a mixture containing minute cavitating bubbles. In addition vapor phase consists of various sizes of vapor bubbles, which are distributed to classes based on their mass. The bubble number-density for each class was solved by considering the change of the bubble-mass due to phase change as well as generation of new bubbles due to heterogeneous nucleation. In this method, the bubble-mass is treated as an independent variable, and the other dependent variables are solved in spatial coordinates and bubble-mass coordinate. Firstly, we employed this method to calculate bubble nucleation and growth in stationary super-heated liquid nitrogen, and bubble collapse in stationary sub-cooled one. In the case of bubble growth in super-heated liquid, bubble number-density of the smallest class based on its mass is increased due to the nucleation. These new bubbles grow with time, and the bubbles shift to larger class. Therefore void fraction of each class is increased due to the growth in the whole class. On the other hand, in the case of bubble collapse in sub-cooled liquid, the existing bubbles are contracted, and then they shift to smaller class. It finally becomes extinct at the smallest one. Secondly, the present method is applied to a cavitating flow around NACA00l5 foil. Liquid nitrogen and liquid oxygen are employed as working fluids. Cavitation number, $\sigma$, is fixed at 0.15, inlet velocities are changed at 5, 10, 20 and 50m/s. Inlet temperatures are 90K in case of liquid nitrogen, and 90K and 1l0K in case of liquid oxygen. 110K of oxygen is corresponding to the 90K of nitrogen because of the same relative temperature to the critical one, $T_{r}$=$T/T_c^{+}$. Cavitating flow around the NACA0015 foils was properly analyzed by using bubble size distribution. Finally, the method is applied to a cavitating flow in an inducer of the LE-7A hydrogen turbo-pump. This inducer has 3 spiral foils. However, for simplicity, 2D calculation was carried out in an unrolled channel at 0.9R cross-section. The channel moves against the fluid at a peripheral velocity corresponding to the inducer revolutions. Total inlet pressure, $Pt_{in}$, is set at l00KPa, because cavitation is not generated at a design point, $Pt_{in}$=260KPa. The bubbles occur upstream of the foils and collapse between them. Cavitating flow in the inducer was successfully predicted by using the bubble size distribution.

• Journal of the Korean Institute of Gas
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• v.20 no.6
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• pp.65-72
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• 2016

ORC system was designed and constructed for utilizing the heat of the exhaust gas and coolant released from the gas engine which was modified to use natural gas as a fuel. In this paper the components of the ORC system were designed and manufactured based on measured data of the gas engine. The components are composed of two plate heat exchanger, the 5kW-class expander and multi stage centrifugal pump. The thermodynamic performance of the ORC system was analyzed by using the electric heater. Also, the developed ORC system was implemented to modified natural gas engine. Two gas engines were used to supply heat to the ORC system. As a result of test bench, when the heat source temperature is $110^{\circ}C$ expander shaft power, the pressure ratio and cycle efficiency is 5.22kW, 7.41, 9.09%. As a result of field test, when the heat source temperature is $86^{\circ}C$ expander shaft power, the pressure ratio and cycle efficiency is 2kW, 3.75, 6.45%.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.28-35
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• 2016

The in-situ thermal response test for the design of a ground heat exchanger of geothermal heat pumps have difficulty in predicting the outlet temperature according to the variation of conditions due to the expense and time. This paper suggests a 3-D CFD analysis method to predict the heat transfer performance of vertical type ground heat exchanger, which is mostly used in national, and the outlet temperature and the slope of two in-situ thermal response tests were compared to test the proposed CFD reliability. The results of CFD analysis showed that the outlet temperature was predicted to within $0.5^{\circ}C$ of the actual value and the slope was predicted to within 1.6%. The reliability of the CFD analysis method was confirmed using this process, and the outlet temperature prediction of the two in-situ thermal response tests was obtained by changing ${\pm}20%$ of the flow rate and the effective thermal conductivity conditions, respectively. The results of CFD analysis showed that the outlet temperature of Case 1 was 28.0 (-20%) and $29.6^{\circ}C$ (+20%) for the flow rate variation and $29.6^{\circ}C$ (-20%) and $28.0^{\circ}C$ (+20%) for the effective thermal conductivity variation, and the outlet temperature of Case 2 was 28.4 (-20%) and $29.8^{\circ}C$ (+20%) for the flow rate variation and $29.7^{\circ}C$(-20%) and $28.4^{\circ}C$(+20%) for the effective thermal conductivity variation.

• Journal of The Korean Society of Agricultural Engineers
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• v.60 no.5
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• pp.115-124
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• 2018

Resilience has been widely used in various fields including design and operation of infrastructures. The resilient infrastructures not only reduce the damage scale of various disasters but also reduce the time and cost required for restoration. However, resilience rarely applied to promote efficient management of agricultural infrastructures. Recently, drought is an aggravating disaster by climate change and need countermeasures. Therefore, we tried to demonstrate evaluating measures in case of drought under consideration of resilience. This study applied the robustness-cost index (RCI) to evaluate alternative solution of the supply problem of a large agricultural reservoir under drought conditions. Four structural alternatives were selected to estimate the robustness index (RI) and the cost index (CI) to obtain the RCI values. Structural alternatives are classified into temporary measures and permanent measures. Temporary measures include the development of a tube wells and the installation of the portable pump, while the permanent measures include the installation of a pumping stations and the pumping water to the reservoir (Yeongsan River-Naju reservoir). RCI values were higher in permanent measures than those of temporary measures. Initial storage of the reservoir also affected RCI values of the drought measures. Permanent measures installation and management of early stage of the reservoir storage shortage was identified as the most resilient system.