• 대한전기학회:학술대회논문집
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• 대한전기학회 1988년도 전기.전자공학 학술대회 논문집
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• pp.705-708
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• 1988

Ultrasound Doppler Diagnostic System utilizes the Doppler effect for measurement of blood velocity. The sign of the Doppler frequency shift represents blood flow direction. Pulsed Doppler System uses Phase detector and zerocrossing method to produce simultaneous independent audio and velocity signals for forward and reverse blood flow direction in the time domain, had been fabricated. But time-domain analyzing such as audio evaluation and zerocrossing detection for instantaneous and mean frequency measurement doesn't, provide both an accurate and quantitative result. Therefore, it is necessary to adopt frequency domain technique to improve system performance. In this paper, we describe a unit which is composed of Pulsed Doppler System and real-time spectrum analyzer (installed TMS 32010 DSP Chip). This unit shows time-dependent spectrum variation and mean velocity of blood Signal.

• The Korean Journal of Pain
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• 제25권1호
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• pp.52-54
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• 2012

Trigger point injection treatment is an effective and widely applied treatment for myofascial pain syndrome. The trapezius muscle frequently causes myofascial pain in neck area. We herein report a case in which direct pulsed radiofrequency (RF) treatment was applied to the trapezius muscle. We observed that the RF treatment produced continuous pain relief when the effective duration of trigger point injection was temporary in myofascial pain.

• The Korean Journal of Pain
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• 제27권3호
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• pp.290-293
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• 2014

Amputation neuroma can cause very serious, intractable pain. Many treatment modalities are suggested for painful neuroma. Pharmacologic treatment shows a limited effect on eliminating the pain, and surgical treatment has a high recurrence rate. We applied pulsed radiofrequency treatment at the neuroma stalk under ultrasonography guidance. The long-term outcome was very successful, prompting us to report this case.

• 대한의용생체공학회:의공학회지
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• 제6권1호
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• pp.47-54
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• 1985

In this paper, clutter in ultrasound pulsed Doppler system is analyzed mathematically. And stationary canceler which reduce the clutter is designed. The operating characteristics of the stationary canceler is investigated in body (in vivo) by audio signal and spectrum analyzer.

• 한국의학물리학회지:의학물리
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• 제5권1호
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• pp.25-39
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• 1994

심장 벽의 운동속도와 혈관내 혈구의 유속을 측정하기 위해, 단일 채널 3.1MHz 펄스 도플러 속도계를 제작하였다. 도플러 속도계에 사용된 초음파 펄스의 폭과 펄스 반복주파수(PRF)는 각각 1$\mu$s과 6kHz이고, 후방 산란된 반향신호의 도플러 편이는 완전간섭성(coherent) 복조방식을 이용하여 위상 측정기에 감지된다. 위상 측정기의 출력신호로부터 레인지 게이트와 샘플 홀더, 대역여파기를 이용하여 작은 영역내에 있는 초음파 산란체의 평균속도에 해당하는 도플러 신호가 얻어진다. 도플러 신호의 평균 주파수는 영점교차의 카운터에 의해 측정되며 시간의 함수로 산란체의 순간 속도를 디스플레이한다. 채널 수와 거리 분해능을 증가시키면 혈관내의 혈류속도 분포도와 총 유량 그리고 혈류가속도를 측정할 수 있다.

• 대한수의학회지
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• 제37권3호
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• pp.661-668
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• 1997

Portal blood flow was measured with pulsed doppler ultrasound in thirty normal dogs. In normal dogs, the average portal blood flow velocity was $17.03{\pm}1.75cm/sec$ and the average portal blood flow was $41.59{\pm}10.10ml/min/kg$. The incident angle between the doppler beam and the portal vein averaged $65^{\circ}$. The average portal vein sectional area was $0.41{\pm}0.14cm^2$. The Congestion index was $0.0245{\pm}0.0081cm{\cdot}sec$. Conclusively, the spectral doppler ultrasonography was quick, non-invasive and simple diagnostic method in circulatory disorders of liver.

• Physical Therapy Rehabilitation Science
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• 제3권1호
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• pp.33-37
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• 2014

Objective: Low intensity pulsed ultrasound (LIPUS) has been shown to accelerate cell proliferation and tissue healing in both animal models and clinical trials. However, details of the clinical effects of LIPUS have not been well characterized. The aim of this study was to investigate the effect of LIPUS on mitogen-activated protein kinase (MAPK) activation in rat articular chondrocytes. Design: Cross-sectional study. Methods: Chondrocyte were cultured in six well cell culture plates for 72 hours at $37^{\circ}C$ with 5% $CO_2$, and then exposed to LIPUS at 1.5 MHz frequency and $30-mW/cm^2$ power. Changes in chondrocyte activities were evaluated in response to oxydative stress in dose-dependent (0 and 300 uM) and time-dependent (0-24 hr) manner. The cell viability were analyzed using MTT [3-(4.5-dimethylthiazol-2-yl)-2.5 diphenyltetrazolium bromide]. The expression of p38 MAPK was measured using western blotting. Results: Oxidative stress was induced in rat chondrocytes using hydrogen peroxide ($H_2O_2$). The cell viability was decreased in chondrocytes after the $H_2O_2$ dose and time-dependent treatment. The p38 MAPK phosphorylation occurred at a significantly increased rate after $H_2O_2$ treated (p<0.05). Expression of p38 MAPK was decreased in the p38 inhibitor groups compared with the oxidative stress-induced chondrocyte damage via the p38 MAPK signaling pathways (p<0.05). Conclusions: It could be concluded that LIPUS can inhibit oxidative stress-induced chondrocyte damage via the p38 MAPK signaling pathways.

• Physical Therapy Rehabilitation Science
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• 제2권1호
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• pp.21-26
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• 2013

Objective: The aim of this study was to investigate the effect of therapeutic ultrasound (US) of cell viability and inflammatory cytokine in rat articular chondrocyte cultures stimulated with lipopolysaccharide (LPS). Design: One group pretest-posttest design. Methods: Cultured chondrocytes were treated with US and/or LPS and assessed for viability, Tumor necrosis factor $(TNF)-{\alpha}$ and Interleukin (IL)-1 production. Results: Oxidative stress was induced in rat chondrocytes with LPS. The cell viability was decreased in chondrocytes after treatment with LPS. The viability revealed that low-intensity pulsed ultrasound (LIPUS) exerted no significant cytotoxicity in the rat chondrocyte. LIPUS inhibited decreased cell viability in the presence of LPS ($30{\mu}g/ml$) in a intensity dependent pattern at LIPUS (p<0.05). $TNF-{\alpha}$ production in the presence of LPS was also inhibited in a dose dependent manner (p<0.05 from $30mW/cm^2$). IL-1 production in the presence of LPS was inhibited as well (p<0.05 from $7.5mW/cm^2$). Conclusions: Our results demonstrate that US was the anti-inflammatory effect of chondrocytes. LIPUS may exert its anti inflammatory effects through inhibition of $TNF-{\alpha}$ and IL-1 synthesis. These results suggest that US have potential for use as a pain relief and reduce the articular destruction.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.149-158
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• 2007

To investigate the permeability of lidocaine, percutaneous absorption studies were performed using excised hairless mouse skin and the penetration of lidocaine via the skin was determined. To increase the skin permeation of lidocine, the effects of $Labrasol^{(R)}$, $Labrafil^{(R)}$, $Labrafac^{(R)}$ and $Transcutol^{(R)}$ were investigated. The skin permeation of lidocaine was increased when $Labrasol^{(R)}$ and $Transcutol^{(R)}$ were used as permeation enhancer. To evaluate the influence of ultrasound, various factors such as application modes (continuous mode and pulsed mode), frequency (1.0 and 3.0 MHz) and intensity (1.0, 1.5 and 2.0 w/$cm^2$) were investigated with lidocaine hydrogel. The pronounced effect of ultrasound on the skin permeation of lidocaine was observed at all ultrasound energy levels. The influence of frequency having an effect on skin permeation rate was higher in the case of using 1 MHz, 2.0 w/$cm^2$ and continuous treatment. As the intensity of ultrasound increased, the permeation of lidocaine was accelerated. The in vivo anesthetic effects were evaluated by two aspects as mechanical threshold and electrical threshold. Six healthy volunteers consented to the randomized, double-blind, and cross-over designed study in each group. In each subject, 3 groups were adapted such as K group (ultrasound with gel base only), L group (lidocaine gel) and B group (ultrasound with lidocaine gel). In conclusion, lidocaine was potent anesthetic which could be block pain threshold effectively. And ultrasound could accelerate the skin penetration of lidocaine. The phonophoretic delivery system could be a good candidate for lidocaine as a local anaesthetic to improve the skin permeation and in vivo anaesthetic effect.

• 대한의용생체공학회:의공학회지
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• 제16권2호
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• pp.183-190
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• 1995

The use of ultrasound pulsed Doppler systems has become increasingly popular due to the advantages of easy measurements of blood velocity, volume blood blow, and irregularities of the circulatory system. However, the 2-D Doppler systems have several problems, such as range ambiguity, low signal to noise ratio, and slow frame rate. The mean frequency aliasing problem originating from the pulse repetition frequency is one of major limitations in pulsed Doppler systems. A conventional approach to resolve this problem is tracking the mean frequency close to and beyond the Nyquist frequency along the temporal axis. In this paper, a new concept of tracking the mean frequency along the spatial axis is proposed. The proposed technique is fault tolerant by nature and more suitable for multi gate and 2-D Doppler system than conventional methods.