• 대한한의학회지
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• 제20권3호
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• pp.36-44
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• 1999

Objectives: It has been well known that electroacupuncture(EA) has an analgesic effect and there is a pain control system in the central nervous system(CNS). The pain control system is composed of three major nuclei, which are periaqueductal gray(PAG), raphe nuclei, and the pain inhibitory complex located in the spinal cord. It has been suggested that the analgesic effect of EA might be the result of activation of the pain control system in the CNS. However, there may be a possibility that other nuclei are also involved in this pain modulation. Thus, we investigated whether the posterior intralaminar thalamic nuclei (PTIN) are involved in the pain modulation. Methods: To measure the level of pain, the jaw opening reflex (JOR) was used as a pain index. The magnitude of JOR is estimated by averaging the area of 10 successive responses. JOR was evoked by tooth-pulp stimulation with bipolar electrode carrying stimulus with the following parameters: intensity ranging from 420uA to 680ulA, 0.3ms duration of square pulse, and 0.5 Hz. Hapkog($LI_4$) and Taechung ($LR_3$) were the chosen acupoints. The Hapkog point was stimulated ipsilaterally at 5V, 3 Hz, for 15min in total, and the Taechung was stimulated at 2-3 V, 3 Hz, and for a total of 15 or 30 minutes. Different intensities of stimulation were given the PITN; one was given at $300{\mu}A$ and the other was at 500uA. The position stimulated in these nuclei by Paxinos Atlas was AP; from bregma $-4.0{\sim}-4.3mm,\;L; 0.5{\sim}1.8mm,\;D;\;4.8{\sim}6.3mm$. Results: The Hapkog point had a significant analgesic effect (P<0.05). However, the Taechung point had no effect. Both types of stimulation in the PITN did not reveal any analgesic effects. Conclusions: From these results, it was suggested that the posterior intralaminar thalamic nuclei are not involved in the modulation of pain.

• 한국전문물리치료학회지
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• 제18권1호
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• pp.83-92
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• 2011

Osteoarthritis is a degenerative joint disease and is led to physical disability. Yet the development of effective disease-modifying treatments has lagged. In this study, I examined the effect of physical therapeutic intervention through microcurrent stimulation and attempt to find which degree of intensity, either 25 ${\mu}A$ or 500 ${\mu}A$ with a regular 5 pps pulse, is more effective in the osteoarthritis. Osteoarthritis was induced with a mixture of 2% carrageenan and 2% kaolin in 26 male Sprague-Dawley rats. The mixture (0.1 $m{\ell}$) was injected into the intra-articular capsule of knee joint once a week for three weeks. Five animals did not show degenerative changes by radiological findings and excluded in the following experiment. Osteoarthritic animals were randomly divided into 3 groups ($n_1$, $n_2$, $n_3$=7/each): untreated, treated with 25 ${\mu}A$, treated with 500 ${\mu}A$. All experimental groups received microcurrent stimulation for four weeks (15 min/day, 5 days/week). The ethological inspection of foot print analysis on the walking corridor was accomplished every week. Histological preparations and immunohistochemical staining with insulin-like growth factor-1 were also done in the articular cartilages. All of these parameters were compared with those of osteoarthritic control group (n=7). The ethological inspection of foot print analysis revealed that changes of walking track (paw width) and stride length was significantly increased in both experimental groups. The better results were observed in experimental group treated with 25 ${\mu}A$ intensity without significance than group treated with 500 ${\mu}A$. Histological preparations disclosed that routine hyaline cartilage of articular surface were altered to fibrous cartilage in untreated group and experimental group treated with 500 ${\mu}A$ intensity. But a little changes were seen in experimental group treated with 25 ${\mu}A$ intensity. Immunolocalization of insulin-like growth factor-1 was simultaneously decreased according to the duration of osteoarthritis, and did not show significant difference among the groups. In this study discovered that the microcurrent stimulation, especially 25 ${\mu}A$ intensity, had a positive effect by the ethological inspection, histological and immunohistochemical stainings. These results suggest that microcurrent stimulation with low-intensity might be effective in the promotion of healing process for the osteoarthritis.

• International Journal of Oral Biology
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• 제31권4호
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• pp.113-118
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• 2006

In the primary sensory neuron of the mesencephalic trigeminal nucleus (MTN), the peripheral axon supplies a large number of annulospiral endings surrounding intrafusal fibers encapsulated in single muscle spindles while the central axon sends only a few number of synapses onto single ${\alpha}-motoneurons({\alpha}-MNs)$. Therefore, the ${\alpha}-{\gamma}$ linkage is thought to be very crucial in the jaw-closing movement. Spike activity in a ${\gamma}-motoneuron\;({\gamma}-MN)$ would induce a large number of impulses in single peripheral axons by activating many intrafusal fibers simultaneously, subsequently causing an activation of ${\alpha}-MNs$ in spite of the small number of synapses. Thus, the activity of ${\gamma}-MNs$ may be vital for modulation of jaw-closing movements. Independently of such a spindle activity modulated by ${\gamma}-MNs$, somatic depolarization in MTN neurons is known to trigger the oscillatory spike activity. Nevertheless, the trafficking of these spikes arising from the two distinct sources of MTN neurons is not well understood. In this short review, switching among multiple functional modes of MTN neurons is discussed. Subsequently, it will be discussed which mode can support the ${\alpha}-{\gamma}$ linkage. In our most recent study, simultaneous patch-clamp recordings from the soma and axon hillock revealed a spike-back-propagation from the spike-initiation site in the stem axon to the soma in response to a somatic current pulse. The persistent $Na^+$ current was found to be responsible for the spike-initiation in the stem axon, the activation threshold of which was lower than those of soma spikes. Somatic inputs or impulses arising from the sensory ending, whichever trigger spikes in the stem axon first, would be forwarded through the central axon to the target synapse. We also demonstrated that at hyperpolarized membrane potentials, 4-AP-sensitive $K^+$ current ($IK_{4-AP}$) exerts two opposing effects on spikes depending on their origins; the suppression of spike initiation by increasing the apparent electrotonic distance between the soma and the spike-initiation site, and the facilitation of axonal spike invasion at higher frequencies by decreasing the spike duration and the refractory period. Through this mechanism, the spindle activity caused by ${\gamma}-MNs$ would be safely forwarded to ${\alpha}-MNs$. Thus, soma spikes shaped differentially by this $IK_{4-AP}$ depending on their origins would reflect which one of the two inputs was forwarded to the target synapses.

• 생물정신의학
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• 제3권1호
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• pp.102-108
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• 1996

본 연구는 한국인의 우울증 환자에서 moclobemide가 효과적이며 안전하게 사용될 수 있음을 입증하였으며, 투약 방법으로 초기 권장량인 1일 300mg을 2회 분복시키는 방법이 추천될 수 있음을 확인하였다.

• 대한간호학회지
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• 제21권3호
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• pp.268-280
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• 1991

The nursing intervention for the prevention of the pulmonary complication and of the function lowering of pulmonary ventilation which emerge with high generation frequency during the nursing of operation patient is necessary for performing the qualitative nursing for operation patient. So, this researcher tried this study so as to obtain the data which can be utilized for the trial of nursing intervention, by grasping the effect that the deep breathing with Incentive Spirometer has on the function of pulmonary ventilation, analysing the factor to have influence on the function of pulmonary ventilation, and applying the effective method of deep breathing to the clinic. By making 42 patients who underwent the operation of upper abdomen after admitting G Hospital in Seoul from Mar. 7, 1991 to Apr.30, 1991 as the object, they were classified into the experiment group that the deep breathing was made with the use of Incentive Spiromenter and the comparison group that the deep breathing exercise was made without the use of Incentive Spirometer. And then, by measuring Tidal Volume and Forced Vital Capacity with Respirometer and $O_2$ Saturation with Pulse Oximeter at preoperation postoperation 24 hours, 72 hours, and 120 hours data were collected. The collected data were analyzed with of, average, standard deviation, x$^2$-test, t-test and ANOVA by SPSS. The result of this study is as follows : 1. As for the hypothesis that the function of pulmonary ventilation at postoperation 24 hours, 72 hours and 120 hours will be better in the experiment group that the deep breathing was made with the use of Incentive Spirometer, in comparison with the comparison group that deep breathing was made without the use of Incentive Spirometer, experiment group and comparison group didn't show the significant difference in Tidal Volume, Foreced Vital Capacity and $O_2$ Saturation at postoperation 24 hours and 72 hours. But experiment group and comparison group showed the significant difference in Tidal Volume at postoperation 120 hours (p＜0.01). So, this hypothesis was supported partially. 2. The variables that there were the significant differences about the function of pulmonary ventilation in experiment group at postoperation 24 hours stastically were smoking existence (p＜0.05), and the variables that there were not significant differences about the function of pulmonary ventilation were distinction of sex, age, anesthetic duration, smoking extent, body weight, surface area of body, existence of narcotic use, regular exercise existence, and past experience existence of respiratory disease. As above result, it appeared that the method of deep breathing with the use of the Incentive Spirometer is more effective for the function recovery of pulmonary ventilation, in comparison with the deep breathing without use of Incentive Spirometer and that smoking existence was the factor to have influence on the function of pulmonary ventilation. In the aspect of clinic, the trial of nursing intervention of deep breathing with use of Incentive Spirometer is expected. And, in the aspect of study, the study through various operative site patients about the effect of Incentive Spirometer use at the clinic will have to be confirmed.

• 대한소아치과학회지
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• 제32권3호
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• pp.499-508
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• 2005

Flumazenil의 투여 방법에 따른 혈중 농도와 midazolam에 의해 유도된 진정 상태의 환원 효과를 평가하기 위해 23-25세의 학생을 대상으로 비강으로 midazolam을 투여하여 진정시킨 후 flumazenil을 비강내과 정맥내를 통하여 투여한 다음 액체크로마토그래피(HPLC)를 사용하여 시간 경과에 따른 혈중 농도의 변화와 함께 생징후 및 진정 정도를 측정하여 flumazenil의 길항 효과를 다각적으로 분석, 평가하여 다음과 같은 결과를 얻었다. 1. Midazolam에 의한 진정 상태에서 flumazenil의 투여시 수축기 및 이완기 혈압, 동맥혈 산소포화도 등의 생징후는 변화가 없었으나 맥박은 일시적인 상승이 있었다(P<0.05). 2. Flumazenil은 비강내 투여 및 정맥내 투여 등 투여 방법에 관계없이 midazolam에 의한 진정 상태를 일시적으로 환원시키며 투여 방법에 따른 발현 시간의 차이는 없으나 환원 정도와 지속 시간은 정맥내 투여에서 크게 나타났다(P<0.05). 3. Flumazenil의 비강내 투여는 최고 혈중 농도에 2분, 정맥내 투여는 4분 후에 각각 도달하므로써 흡수 속도는 비강내 투여와 정맥내 투여의 차이가 크지 않았다. 4. Flumazenil의 투여 후 수 분 동안 midazolam의 혈중 농도가 일시적으로 상승하였다(P<0.05). 이상의 결과를 종합하여 보면 flumazenil은 midazolam에 의한 진정 상태에서 생징후의 변화에 영향을 미치지 않으며 진정의 정도를 감소시키는 효과가 있고, 특히 비강내 투여는 정맥내 투여와 발현 시간에 있어서 차이가 없는 것으로 나타나 임상적으로 midazolam에 의한 부작용 발현시 응급 처치법으로 유용하게 사용할 수 있을 것으로 사료된다.

• 마이크로전자및패키징학회지
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• 제16권1호
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• pp.33-38
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• 2009

전자 기기 제품들이 소형화 및 휴대화 되면서 낙하충격 신뢰성에 대한 관심이 높아지고 있다. 본 연구에서는 대표적인 무연솔더인 Sn-3.0Ag-0.5Cu 솔더를 이용하여 ENIG (Electroless Nickel Iimmersion Gold), OSP (Organic Solderability Preservative) 표면 처리와 등온 시효 시험 (High Temperature Storage test)에 따른 보드 레벨 패키지 (board level package)의 낙하충격 신뢰성 (drop reliability) 시험을 수행하였다. 또한 충격 조건을 변화시켜 시편에 가해지는 가속도 (G:acceleration)와 충격 지속 시간 (pulse duration)에 따른 신뢰성을 평가하였다. 기판의 strain측정 결과 중앙 부위가 가장 응력이 컸으며, 충격가속도에 비례하여 응력이 증가하였다. 시효 처리 전에는 OSP처리된 기판이 다소 우수한 신뢰성을 보였지만, 시효 처리후에는 ENIG기판에서 신뢰성이 우수하였고, 반대로 OSP는 감소하는 경향을 보였다. OSP의 경우 과도한 금속간화합물 (intermetallic compound)의 성장으로 인해 접합 계면에서 취성파괴 (brittle fracture)가 일어난 것을 관찰할 수 있었다.

• 조명전기설비학회논문지
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• 제13권1호
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• pp.1-8
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• 1999

최근 들어 레이저를 이용한 방전 제어 기술에 대한 관심이 여러 분야에서 고조되고 있다. 특히, 레이저의 우수한 특성 때문에 Electro-Discharge Machining(EDM)분야에서 각광을 받고 있다. 본 연구에서는 펄스형 Nd:TAG 레이저를 이용해서 방전 가공 장치에 적용될 수 있는 방전 유도 기술에 관한 기초 데이터의 확보를 위한 실험이 수행되었다. 레이저에 의한 직류 발전 유도 실험의 동작 압력의 범위는 0.2~20 torr였다. 진공조 내의 압력 P와 전극간의 거리 d에 따른 최소 직류 레이저 방전 유도 전압 $V_{G.min}$을 측정하였으며, $V_{G.min}$이 자연 방전전압 VND보다 훨씬 낮고 P.d값에 따른 $V_{G.min}$이 $V_{ND}$와 유사한 경향을 가짐을 확인하였다. 그리고 레이저 출력 에너지 $E_{out}$은 플래쉬램프의 전류 펄스폭 $t_p$가 증가함에 따라 감소하고 $t_p$값이 증가할수록 $V_{G.min}$은 방전 지속 시간 동안에 조사되는 광자량이 감소하기 때문에 더 높아짐을 알 수 있었다. 또한 레이저에 의한 방전 유도 가능범위와 레이저 출력에 따른 방전 유도 특성을 조사하였다.

• 한국통신학회논문지
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• 제26권11B호
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• pp.1501-1509
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• 2001

최근 들어 무선 통신 시스템의 급격한 증가로 인해, 한정된 주파수 자원의 효과적인 배분이 큰 문제로 대두되고 있으며, 이의 근본적인 해결 방안으로서, 초광대역 시간도약 임펄스 라디오 시스템이 많은 관심을 모으고 있다. 임펄스 라디오 시스템은 PPM 변조된 데이터를 1 nsec 이하의 매우 짧은 펄스폭을 갖는 가우시안 모노사이클 펄스를 사용하여 전송한다. 따라서 전송 신호는 매우 낮은 전력의 수 GHz에 이르는 초광대역 스펙트럼을 갖게 되며, 기존의 통신 시스템에 거의 간섭을 미치지 않는 것으로 알려져 있다. 본 논문의 목적은 임펄스 라디오 신호의 다중 경로 전파 특성을 파악하고 다중 경로 환경에서 상관기를 사용하는 수신기의 성능을 평가하는데 있다. 이러한 목적을 위하여 본 논문에서는 결정론적인 2-path 모델과 Saleh와 Valenzuela의 통계적 실내 다중 경로 모델을 고려하였다. 2-path 모델에 대하여 이상적인 기준 파형을 사용하는 상관기의 출력이 간접 경로의 지연 시간과 PPM 이진 데이터의 시간 지연의 상대적 차와 간접 경로의 경로 이득에 의존함을 보이고 모의 실험을 통하여 두 모델에 대한 임펄스 라디오의 비트 오율 특성을 관측하였다. 모의 실험 결과에 의하면 임펄스 라디오의 성능은 간접 경로의 지연 시간과 PPM 이진 데이터의 시간 지연의 상대적 차에 따라서 변하는 것이 관측되었다. 또한 기존의 AWGN (additive white Gaussian noise) 채널 환경에서 사용되는 기준 파형을 다중 경로 채널에서 적용할 수 없음을 관측하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제8권1호
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• pp.7-15
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• 2004

Nitric oxide (NO) system has been implicated in a wide range of physiological functions in the nervous system. However, the role of NO in regulating the neural activity in the gustatory zone of nucleus tractus solitarius (NTS) has not been established. The present study was aimed to investigate the role of NO in the gustatory NTS neurons. Sprague-Dawley rats, weighing about 50 g, were used. Whole cell patch recording and immunohistochemistry were done to determine the electrophysiological characteristics of the rostral gustatory nucleus of the tractus solitaries and distribution of NO synthases (NOS). Neuronal NOS (nNOS) immunoreactivity was strongly detected along the solitary tract extending from rostral to caudal medulla. Resting membrane potentials of NTS neurons were $-49.2{\pm}2\;mV$ and action potential amplitudes were $68.5{\pm}2\;mV$ with a mean duration measured at half amplitude of $1.7{\pm}0.3\;ms$. Input resistance, determined from the response to a 150 ms, -100 pA hyperpolarizing current pulse, was $385{\pm}15\;M{\Omega}$, Superfusion of SNAP or SNP, NO donors, produced either hyperpolarization (68%), depolarization (5%), or no effect (27%). The hyperpolarization was mostly accompanied by a decrease in input resistance. The hyperpolarization caused by SNAP or SNP increased the time to initiate the first action potential, and decreased the number of action potentials elicited by current injection. SNP or SNAP also markedly decreased the number of firing neural discharges of the spontaneous NTS neural activity under zero current. Superfusion of L-NAME, a NOS inhibitor, slightly depolarized the membrane potential and increased the firing rate of NTS neurons induced by current injection. ODQ, a soluble guanylate cyclase inhibitor, ameliorated the SNAP-induced changes in membrane potential, input resistance and firing rates. 8-Br-cGMP, a non-degradable cell-permeable cGMP, hyperpolarized the membrane potential and decreased the number of action potentials. It is suggested that NO in the gustatory NTS has an inhibitory role on the neural activity of NTS through activating soluble guanylate cyclase.