• Journal of Chest Surgery
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• v.18 no.3
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• pp.470-473
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• 1985

We performed clinical analysis about 20 cases of pulmonary parenchymal and intrabronchial hamartoma in Korea by literatures of the Korean Journal of Thoracic and Cardiovascular Surgical Society during 8 years from September 1976 to September 1984 and in addition to our hospital experienced 4 cases of pulmonary parenchymal hamartoma during same periods. 1] There were no cases below second decades. 2] Patients of pulmonary parenchymal hamartoma were asymptomatic, but patients of intrabronchial hamartoma were symptomatic [dyspnea & frequent upper respiratory tract infections]. 3] Pulmonary parenchymal hamartoma were confirmed by removal of mass, but intrabronchial hamartoma were confirmed by bronchoscopic biopsy. 4] There were no malignant changes in both type of pulmonary hamartoma.

• Journal of Chest Surgery
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• v.26 no.7
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• pp.568-570
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• 1993

Pulmonary sequestration is a congenital malformation in which a mass of pulmonary tissue is detached from the normal lung and receives its blood supply from a systemic arterys from the thoracic aorta or the abdominal aorta, or occasionally from an intercostal artery. We have experienced the three cases of the intralobar pulmonary sequestration. In the first case a 5 year old male was admitted of productive cough and abdominal distension, and chest film showed pneumonic infiltration in RLL. Second case was 26 year old male patient complaining Rt. chest discomfort and hemoptysis and chest X-ray revealed infiltration in Rt. LLF. Third case was 26 year old male patient whose complaint was hemoptysis. Chest x-ray showed hazy density in Lt. lower lung field. In the all cases, the aortograms were performed and the confirmed diagnosis was intralobar pulmonary seqeustration.

• Tuberculosis and Respiratory Diseases
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• v.55 no.4
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• pp.408-412
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• 2003

Pulmonary blastoma is a rare primary lung neoplasm composed of a mixture of immature mesenchyme and epithelium that morphologically mimics embryonal pulmonary structure. Microscopically, tumors could be divided into two classes; those composed solely of malignant glands of epithelial components (well-differentiated fetal adenocarcinoma) and those with biphasic appearance. A 51-year-old man was admitted with left sided pneumothorax. After closed thoracostomy, chest X-ray showed a circular mass in the left lower zone. The tumor was diagnosed as adenocarcinoma as a result of percutaneous needle aspiration biopsy, and left lower lobectomy was performed. The patient was diagnosed as having biphasic pulmonary blastoma on postoperative histological assessment. This case is the first reported patient with biphasic pulmonary blastoma detected by pneumothorax.

• Journal of Chest Surgery
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• v.22 no.5
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• pp.845-850
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• 1989

Intralobar pulmonary sequestration is rare congenital lung disease characterized by a cystic portion of the lung that derives its arterial blood supply though aberrant vessel directly of systemic circulation. Intralobar pulmonary sequestration is usually contained within the visceral pleura of a pulmonary lobe and its venous drainage to the pulmonary venous system. We experienced a case of pulmonary sequestration postoperatively confirmed. The patient was 48-year-old female whose complaints were cough and left chest pain. Chest film showed large homogenous opacity in left lower lung field. By operation, adult fist sized mass at the lower lobe were noted. An aberrant artery, measuring 1.0 cm. in diameter and 2.0 cm. in length, arose from the descending thoracic aorta just above the diaphragm. The anomalous systemic artery was ligatures and resection, and associated with left middle, lower bilobectomy was done. The postoperative course was uneventful, and 10 days later discharged.

• Tuberculosis and Respiratory Diseases
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• v.67 no.2
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• pp.131-134
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• 2009

Pulmonary papillomas are rare benign epithelial neoplasms arising in bronchial surface epithelium. They are categorized by a variety of cell types including squamous, glandular, and mixed squamous and glandular type. Among them, glandular papilloma is extremely rare and has not been reported in Korea. The patient was a 52 year-old man presenting with a 4-months' history of recurrent hemoptysis. Bronchofiberoscopy revealed a whitish, glistening, and polypoid mass lesion at the proximal bronchus in the basal segment of the left lower lung. Bronchoscopic biopsy was performed; papillary fronds lined by ciliated or nonciliated pseudostratified columnar epithelium were noted on histologic findings. We present the first case of glandular papilloma in Korea. Two years later, the patient visited our hospital again due to hemoptysis. On follow-up bronchoscopy, a mass that had been found previously showed an increase in size.

• Tuberculosis and Respiratory Diseases
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• v.51 no.5
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• pp.453-461
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• 2001

Pulmonary carcinosarcoma(Sarcomatoid carcinoma of the lung) is a rare pulmonary malignancy, which is defined as having an admixture of both carcinomatous and sarcomatous components. Pulmonary carcinosarcoma occurs most frequently in males between 50 and 80 years of age. It predominantly affects the upper lobe and/or the principal bronchi, and is associated with a history of smoking. Here, we report a case of pulmonary carcinosarcoma with a left lobe atelectasis due to an endobronchial mass in a 56-year-old male. After a left pneumonectomy, the pathologic stage was IIb ($T_3N_0M_0$). Four months later, an abdominal mass was observed and exploratory laparotomy revealed metastases of the pulmonary carcinosarcoma to the pelvic cavity.

• Journal of Chest Surgery
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• v.20 no.2
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• pp.423-426
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• 1987

Intrathoracic teratomas are unusual but intrapulmonary teratoma constitutes one of the rarities of medicine. A case is presented of pulmonary teratoma in which the initial clue was hemoptysis with intra-pulmonary mass. Left upper lobectomy was done. We would like to describe this case of extremely rare tumor.

• Journal of Chest Surgery
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• v.27 no.11
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• pp.961-964
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• 1994

The pulmonary sequestration is an uncommon congenital anomaly characterized by the presence of nonfunctioning lung tissue supplied by aberrant artery from the aorta or its branches and usually has no communication with the normal bronchial tree. The patient was 35 year old female and had no specific complaints. The lung mass was found incidentally and was continned to be intralobar pulmonary sequestration by aotography whitch showed aberrant blood supply from thoracic aorta at the T. vertebra level. The right lower lobectomy was done.

• Journal of Chest Surgery
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• v.9 no.2
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• pp.139-142
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• 1976

A 33 year old male patient was admitted with 20 years history of recurrent hemoptysis. On clinical examination, mild left chest discomfortness and foul odored sputum with occasional rusty hemoptysis were principal complaints noted. Chest X-ray film revealed moderately advanced active tuberculosis lesion on both upper lung fields, and hen-egg sized mass surrounded with linear crescent of air shadow in a cavity on his left upper lung field. On left thoracotomy, dense pleural adhesions on left apicoposterior segmental surface with multiple lymphnode enlargements were noted, and the soft encapsulated mass of $5{\times}5{\times}8cm$ was localized in the apicoposterior segment of the left upper lobe. Apicoposterior segment with anterior segment of the left upper lobe was resected. Cavity was opened to find a rusty grayish colored, fragile mass, which was confirmed as "fungus ball" of aspergillosis by histological section slide with Gomori staining. The authors report one case of pulmonary aspergilloma superinfected with previous long standing pulmonary tbc.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.1
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• pp.45-54
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• 2017

Our study aims to determine the metabolism and excretion of novel pulmonary-targeting docetaxel liposome (DTX-LP) using the in vitro and in vivo animal experimental models. The metabolism and excretion of DTX-LP and intravenous DTX (DTX-IN) in New Zealand rabbits were determined with ultra-performance liquid chromatography tandem mass spectrometry. We found DTX-LP and DTX-IN were similarly degraded in vitro by liver homogenates and microsomes, but not metabolized by lung homogenates. Ultra-performance liquid chromatography tandem mass spectrometry identified two shared DTX metabolites. The unconfirmed metabolite $M_{un}$ differed structurally from all DTX metabolites identified to date. DTX-LP likewise had a similar in vivo metabolism to DTX-IN. Conversely, DTX-LP showed significantly diminished excretion in rabbit feces or urine, approximately halving the cumulative excretion rates compared to DTX-IN. Liposomal delivery of DTX did not alter the in vitro or in vivo drug metabolism. Delayed excretion of pulmonary-targeting DTX-LP may greatly enhance the therapeutic efficacy and reduce the systemic toxicity in the chemotherapy of non-small cell lung cancer. The identification of $M_{un}$ may further suggest an alternative species-specific metabolic pathway.