• Journal of Chest Surgery
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• 제45권1호
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• pp.56-59
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• 2012

Aspergillus is a ubiquitous fungus and can cause many levels of disease severity. Chronic necrotizing aspergillosis is a rare disease and few cases have been reported in Korea. We experienced a case of pleural aspergillosis that was treated successfully with medical and surgical interventions. The 52-year-old man who was diagnosed with chronic necrotizing pulmonary aspergillosis underwent surgical treatment including a lobectomy, decortication, and myoplasty. The patient was also medically treated with amphotericin B followed by voriconazole. Pleural irrigation with amphotericin B was also performed. A multi-dimensional approach should be considered for treating chronic necrotizing pulmonary aspergillosis.

• Tuberculosis and Respiratory Diseases
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• 제38권3호
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• pp.317-323
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• 1991

Pulmonary mucormycosis is an uncommon opportunistic fungal infection associated with diabetis mellitus, leukemia, lymphoma & other debilitating diseases. Their clinical presentations depend on the associated underlying disorders. Generally patients with leukemia and lymphoma often have rapidly progressive clinical course, and may cause diffuse parenchymal disease refractory to medical and surgical therapies. However, some diabetics with pulmonary mucormycosis have a striking tendency to develop a localized endobronchial disease in major airway which is amenable to therapy with surgery and Amphotericin B. We have experienced a case of endobronchial mucormycosis complicating lung abscess associated with diabetic ketoacidosis, which was cured without specific antifungal therapy or surgery. A brief review of the literature was given.

• 한국임상수의학회지
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• 제11권1호
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• pp.339-341
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• 1994

45두의 브로일러 중 2두에서 배양과 직접 현미경 검사에 의해 폐 접합균증이 진단되었다. 폐의 병변부를 Sabouraud 배지에 접종하고 37$^{\circ}C$에서 배양하여 Absidia corymbifera가 분리되었다. 폐조직으로 squash표본을 만들어 직접 현미경 검사를 한 결과 폭이 넓고, 격벽이 없으며, 분지를 나타내는 접합균형 균사를 나타내었다. 감염된 폐조직의 PAS 염색 날인표본에서도 이와 비슷한 균요소가 발견되었다. 닭장의 흙과 닭똥으로부터 고농도의 A. corymbifera가 증명되었는데 이것은 이 브로일러균에서 환경이 감염원이었던 것을 제시하는 것으로 판단된다. 닭의 폐렴 감별진단에 있어서 접합균류도 고려할 것이 강력히 주장되었다.

• Journal of Oral Medicine and Pain
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• 제39권1호
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• pp.29-33
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• 2014

Mucormycosis is a rare but fatal fungal infection with low survival rate in immune-compromised patients. It is caused by a fungus belonging to the Mucoraceae family of the Zygomycetes class. Mucormycosis is classified as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, disseminated, and miscellaneous types according to its clinical manifestations. Early diagnosis and treatment along with correction of the underlying medical condition is important for favorable results. This case presentation describes mucormycosis involving the anterior maxillary region in a leukemic patient with prolonged neutropenia. The patient benefited from a timely biopsy and immediate treatment with amphotericin B, and was successfully managed with an interdisciplinary team approach consisting of dental and several medical specialists.

• Tuberculosis and Respiratory Diseases
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• 제46권2호
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• pp.266-272
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• 1999

콕시디오이데스진균증 토착 지역인 미국 애리조나 피닉스 지역을 여행한 과거력이 있는 국내 거주 75세 여자 환자에서 무증상의 고립성 폐결절로 악성종양을 의심하여 폐절제술을 시행한 결과 콕시디오이도마로 진단된 1예를 국내에서 처음 경험하였기에 보고 하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제42권4호
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• pp.317-325
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• 2007

Objective : The purpose of the study was to determine the clinical effects of anterior radical debridement on a series of patients with spontaneous spinal infection. Methods : We retrospectively analyzed the clinical characteristics of 32 patients who underwent surgical treatment from January 2000 to December 2005 in our department. The average follow-up Period was 33.4 months (range, 6 to 87 months). Thirty-two patients presented with the following : 23 cases with pyogenic spondylitis, eight with tuberculous spondylitis and one with fungal spondylitis. The indications for surgery were intractable pain, failure of medical management, neurological impairment with or without an associated abscess, vertebral destruction causing spinal instability and/or segmental kyphosis. Results : The study included 15 (46.9%) males and 17 (53.1%) females ranging in age from 26 to 75 years (mean, 53.1 years). Diabetes mellitus (DM) and pulmonary Tbc were the most common predisposing factors for pyogenic spondylitis and tuberculous spondylitis. Staphylococcus aureus (13%) was the main organism isolated. The most prevalent location was the lumbar spine (75%). Changes in the pain score, Frankel's classification, and laboratory parameters demonstrated a significant clinical improvement in all patients. However, there were recurrent infections in two patients with tuberculous spondylitis and inappropriate debridement and intolerance of medication and noncompliance. Autologous rib, iliac bone and allograft(fibular) were performed in most patients. However, 10 patients were grafted using a titanium mesh cage after anterior radical debridement. There were no recurrent infections in the 10 cases using the mesh cage with radical debridement. Conclusion : The findings of this study indicate that surgery based on appropriate surgical indications is effective for the control of spinal infection and prevention of recurrence with anterior radical debridement, proper drug use and abscess drainage.

• Tuberculosis and Respiratory Diseases
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• 제43권1호
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• pp.102-107
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• 1996

본 환자는 평소 건강하던 38세 남자환자로 기침의 증상과 X-선상 우측폐에 경화소견을 보인 예였다. CT 유도하 세침 흡인 생검법에 의한 세균학적검사와 조직 검사로 C. neoformans에 의한 폐효모균증으로 진단하여, 6주간 fluconazole 사용후 증상은 소실되었고, X-선상 많이 호전되어 현재 추적 관찰중에 있다.

• Tuberculosis and Respiratory Diseases
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• 제66권3호
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• pp.220-224
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• 2009

콕시디오이데스 진균증은 미국 남서부 지역의 풍토병으로 알려져 있고 국내 발병 사례가 적으므로 진단에 혼선과 지연을 초래할 수 있다. 따라서 풍토지역 거주력이나 여행력을 문진하는 것이 매우 중요하고 호산구 증다증을 동반할 경우 콕시디오이데스 진균증을 감별질환의 한 가지로 생각해야 할 것이다. 또한 의심이 되는 경우 적극적인 조직검사 및 엄격한 보호아래 시행되는 배양검사를 통한 진단과 치료가 필요하겠다. 저자들은 C.immitis 풍토지역인 미국 애리조나 주에서 거주 후 입국한 정상 면역력환자에서 다발성 폐경화 및 폐문부 림프절 비대 소견을 보여 조직 검사와 기관지세척액 및 폐조직배양검사를 통하여 폐 콕시디오이데스 진균증으로 진단한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한후두음성언어의학회지
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• 제27권1호
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• pp.5-10
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• 2016

Variable systemic diseases affect larynx and vocal fold and result in voice change. Asthma and chronic obstructive pulmonary disease make increase of intra-abdomimal pressure followed by reflux of gastric acid, which stimulate vagal-bronchopulomary reflex aggravating cough and respiratory disturbance. Fungal laryngitis in the general population is extremely rare, but can occur in immunocompromised AIDS patients. Although, initially, empirical antifungal therapy for candidiasis is often given without biopsy, diagnostic direct laryngoscopy and biopsy is imperative if a substantial clinical response is not rapidly achieved. In the highly active anti-retroviral therapy era, HIV-positive patients are living longer and are at higher risk for developing non-AIDS-defining malignancies. The incidence of head and neck cancer (HNC) which is related with human papilloma virus infection has increased. The survival is significantly lower among the AIDS-HNC patients with CD4 counts ${\leq}200cells/{\mu}L$. Rheumatoid arthritis (RA) cause voice disturbance by developing cricoarytenoid joints fixation or nodule on vocal fold. Post-menopausal voice disorder (PMVD) is caused by decreased secretion of estrogen-progesterone resulting in decrease of fundamental frequency (F0). Hormonal replacement therapy is helpful to reduce F0 decrease. RA and PMVD result in slight voice change, but it could crucial in professional voice user.

• Mycobiology
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• 제39권1호
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• pp.40-44
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• 2011

Aspergillus fumigatus is associated with invasive disease aspergillosis in immunocompromised individuals. The major aim of this study was to investigate the biochemical and immunological responses of male Wistar rats against A. fumigatus experimentally-induced pulmonary fungal infection. Nostril experimental exposure of male Wistar rats to a high dose of A. fumigatus freeze-dried preparation for only 24 hr resulted in a significant increase in levels of catalase, nitric oxide and lipid peroxide in lung homogenates, compared to those of the control animals. However, the oxidative status of the lungs of rats challenged with killed fungus did not change significantly, except for the stimulation in the level of lipid peroxide. IgG level was significantly elevated only in rats that received two low doses of fungus, compared to unexposed animals (p < 0.005). Examining the lung of rats exposed to A. fumigatus revealed no abnormal changes, except for pus in bronchial lumen spaces and per bronchial inflammation. Histologically, large numbers of granuloma cells were evident in the lungs of challenged rats, while no granuloma formation was evident in the lungs of rats exposed to killed fungus.