• Tuberculosis and Respiratory Diseases
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• 제77권3호
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• pp.105-110
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• 2014

Venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis, is an important cause of morbidity and mortality. The aim of this review is to summarize the findings from clinically important publications over the last year in the area of VTE. In this review, we discuss 11 randomized controlled trials published from March 2013 to April 2014. The COAG and the EU-PACT trials indicate that pharmacogenetic testing has either no usefulness in the initial dosing of vitamin K antagonists or marginal usefulness in the Caucasian population. Recent clinical trials with novel oral anticoagulants (NOACs) have demonstrated that the efficacy and safety of rivaroxaban, apixaban, edoxaban, and dabigatran are not inferior to those of conventional anticoagulants for the treatment of VTE. The PEITHO and ULTIMA trials suggested that rescue thrombolysis or catheter-directed thrombolysis may maximize the clinical benefits and minimize the bleeding risk. Lastly, riociguat has a proven efficacy in treating chronic thromboembolic pulmonary hypertension. In the future, NOACs, riociguat, and catheter-directed thrombolysis have the potential to revolutionize the management of patients with VTE.

• Tuberculosis and Respiratory Diseases
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• 제85권4호
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• pp.361-363
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• 2022

• Tuberculosis and Respiratory Diseases
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• 제80권2호
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• pp.153-158
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• 2017

Background: Recently, increased levels of high-mobility group box 1 protein (HMGB1) have been identified in various inflammatory conditions and infections. However, no studies have evaluated the HMGB1 level in nontuberculous mycobacterial (NTM) lung disease, and compared it to mycobacterial lung disease. Methods: A total of 60 patients newly diagnosed with NTM lung disease, 44 culture-positive pulmonary tuberculosis (TB) patients, and 34 healthy controls, were included in this study. The serum HMGB1 concentrations were quantified using HMGB1 enzyme-linked immunosorbent assay kits. Results: Serum HMGB1 level in patients with pulmonary TB or NTM lung disease, was significantly lower than that of the healthy controls. In addition, the serum HMGB1 level in TB patients was significantly lower than patients with NTM lung disease. However, the levels in NTM patient subgroups did not differ according to the causative species, disease progression, and disease phenotype. Conclusion: Although low levels of serum HMGB1 has the potential to be a marker of mycobacterial lung disease, these levels were unable to differentiate disease progression and disease phenotype in NTM lung diseases.

• Tuberculosis and Respiratory Diseases
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• 제71권1호
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• pp.37-45
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• 2011

Background: Pulmonary emphysema (PE) is major cause of obstructive pulmonary function impairment (OPFI), which is diagnosed by spirometry. PE by high resolution CT is known to be correlated with OPFI. Recently, low dose CT (LDCT) has been increasingly used for screening interstitial lung diseases including PE. The aim of this study was to evaluate OPFI risks of subjects with PE detected by LDCT compared with those detected by simple digital radiography (SDR). Methods: LDCT and spirometry were administered to 266 inorganic dust exposed retired workers, from May 30, 2007 to August 31, 2008. This study was approved by our institutional review board and informed consent was obtained. OPFI risk was defined as less than 0.7 of forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), and relative risk (RR) of OPFI of PE was calculated by multiple logistic regression analysis. Results: Of the 266 subjects, PE was found in 28 subjects (10.5%) by LDCT and in 11 subjects (4.1%) by SDR; agreement was relatively low (kappa value=0.32, p<0.001). FEV1 and FEV1/FVC were significantly different between PE and no PE groups determined by either SDR or LDCT. The differences between groups were larger when the groups were divided by the findings of SDR. When PE was present in either LDCT or SDR assays, the RRs of OPFI were 2.34 and 8.65, respectively. Conclusion: LDCT showed significantly higher sensitivity than SDR for detecting PE, especially low grade PE, in which pulmonary function is not affected. As a result, the OPFI risks in the PE group by LDCT was lower than that in the PE group by SDR.

• Tuberculosis and Respiratory Diseases
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• 제66권2호
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• pp.116-121
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• 2009

연구배경: 쯔쯔가무시병, 렙토스피라병, 신증후출혈열은 우리나라에서 흔한 급성열성질환으로 최근 발병과 유행성의 보고가 있음에도 불구하고 열성질환에 있어서 폐침범에 대한 연구는 부족한 상태이다. 열성질환에 있어서 폐합병증이 있을 때 임상적으로 더 심한 경과를 보이고 CRP 수치도 더 높게 측정되는 경우가 있어 입원 시 측정한 CRP값이 조기에 적극적인 치료 대상에 대한 예측인자가 될 수 있는지 알아보고자 하였다. 방 법: 2002년 1월부터 2008년 5월까지 한림대학교 춘천성심병원에서 혈청학적 검사에서 양성이거나 임상적으로 진단을 받았던 환자를 대상으로 후향적 연구를 하였다. 결 과: 총 105명의 환자가 대상이 되었고 쯔쯔가무시병 63명(63%), 신증후출혈열 32명(30.5%), 렙토스피라병 10명(9.5%)이었고 폐침범은 42명(40%)에서 관찰되었으며 폐부종 20명(19%), 가슴막삼출 20명(19%), 간질폐렴 2명(2%)이었다. CRP는 평균 8.87${\pm}$7.29 mg/dl였고 20 mg/dl 이상의 높은 값을 보였던 환자도 8명 있었고 폐침범 중 간질폐렴 형태에서 가장 높은 평균값을 보였다(p=0.027). 폐합병증을 보였던 환자군에서 임상적으로 심한 경과를 보였으며 중환자실 입원치료와 인공호흡기 치료를 동반하고 있었고 더 높은 CRP값을 보였다(p=0.0073). 결 론: 급성열성질환에 있어서 폐합병증을 보인 군에서 더 높은 CPR 수치가 측정되었으며 입원 시 CRP측정을 통해 조기에 더 적극적인 치료가 필요한 환자군을 선택할 수 있고 폐침범에 의한 사망률과 치명률의 감소에도 도움이 될 것으로 추정된다.

• Tuberculosis and Respiratory Diseases
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• 제76권2호
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• pp.53-58
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• 2014

Chronic obstructive pulmonary disease (COPD) is a common airway disease that has considerable impact on disease burdens and mortality rates. A large number of articles on COPD are published within the last few years. Many aspects on COPD ranging from risk factors to management have continued to be fertile fields of investigation. This review summarizes 6 clinical articles with regards to the risk factors, phenotype, assessment, exacerbation, management and prognosis of patients with COPD which were being published last year in major medical journals.

• Tuberculosis and Respiratory Diseases
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• 제85권3호
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• pp.279-282
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• 2022

• Tuberculosis and Respiratory Diseases
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• 제86권1호
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• pp.67-69
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• 2023

• Tuberculosis and Respiratory Diseases
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• 제87권3호
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• pp.411-413
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• 2024

• Journal of Yeungnam Medical Science
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• 제37권4호
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• pp.253-261
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• 2020

Bronchoscopy has evolved over the past few decades and has been used by respiratory physicians to diagnose various airway and lung diseases. With the popularization of medical check-ups and growing interest in health, early diagnosis of lung diseases is essential. With the development of endobronchial ultrasound, ultrathin bronchoscopy, and electromagnetic navigational bronchoscopy, bronchoscopy has been able to widen its scope in diagnosing pulmonary diseases. In this review, we have described the brief history, role, and complications of bronchoscopy used in diagnosing pulmonary lesions, from simple flexible bronchoscopy to bronchoscopy combined with several up-to-date technologies.