• Journal of Chest Surgery
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• 제32권3호
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• pp.318-321
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• 1999

폐 절제수술후 나머지 폐엽의 뒤틀림은 드문 합병증 중의 하나이다. 저자들은 50세 좌상엽에 진균종을 가진 남자 환자에서 좌상엽의 폐엽 절제술 후 좌하엽의 뒤틀림(torsion)에 의한 폐경색이 발생하여 수술후 2일째 남아있는 좌하엽 절제수술을 시행하였으며 23일간의 인공호흡기 치료와 92일간의 영양공급 및 물리치료가 필요하였다. 폐엽절제술 후 남아 있는 폐의 뒤틀림에 의한 폐경색은 적절한 치료에도 불구하 \ulcorner사망률이 22%에 이르기 때문에 정확한 진단과 신속한 치료가 가장 중요하다.

• Journal of Chest Surgery
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• 제30권9호
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• pp.941-944
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• 1997

폐경색은 임상적으로나 방사선학적으로 폐암, 폐출혈, 울혈성 무기폐, 단순괴사와 감별이 힘든 질환으로 흉부외상과 관련되어 보고된 예는 없다. 환자는 45세 남자로 약 3주전 흉부외상에 의한 우측의 다발성 늑골골절과 쇄골골절로 치료를 받아오 다가 증상이 점점 악화되어 본원에 전원된 후 우상엽 절제술을 받았으며, 조직검사 결과 폐경 색으로 진 단되었다. 전원 당시 흉부의 컴퓨터 단층활영상 우상엽에 거대한 종괴음영이 있었고, 양측 폐야에 5개 정도의 작 은 결절상 음영이 있었으나 폐 생검에서 암세포는 발견되지 않았고, 우상엽 절제술 당시 대부분의 작은 결절들은 자연 소실되어 있었다 절제된 우상엽에서 육안적으로 인지되는 혈전은 보이지 않았고, 조직검사상 주로 폐동맥의 분지인 0.6 ∼2.0 mm 정도의 근형 동맥들이 혈전에 의해 폐쇄되어 있었으며 일부는 더 진행하여 기질화를 보이거나 혈류의 재소통이 이루어진 곳도 관찰되었다.

• Journal of Chest Surgery
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• 제39권5호
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• pp.403-406
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• 2006

폐경색은 폐동맥의 폐색으로 인해 발생하며 기관지내 세균오염에 의해 폐감염이 흔하게 속발하며 이는 폐농양, 농흉 그리고 기관지 흉막루 등을 일으켜 결국 패혈증에 이르게 할 수 있다. 이러한 이유로 조기 진단이 중요하며 감염 조절을 위해 폐절제 등을 조기에 고려해야 한다. 67세 남자가 호흡곤란을 주소로 응급실에 내원하였다. 흉부 전산화 단층 촬영에서 좌하엽에 침윤성 병변과 소량의 흉수 그리고 늑막 비후가 관찰되었다. 폐색전은 하엽 폐동맥에서 상엽 폐동맥까지 자라나 있었다. 출혈성 경색이 완연한 좌하엽은 절제되었고 좌주폐동맥을 열어 나머지 폐색전을 제거하였다. 수술 후 15개월간 추적 관찰하고 있으며 폐색전이나 폐경색의 재발은 보이지 않았다.

• Tuberculosis and Respiratory Diseases
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• 제45권3호
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• pp.654-660
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• 1998

Pulmonary embolism is one of the moot common acute pulmonary disease in the adult general hospital population However, the disease is still frequently unsuspected and underdiagnosed due to the nonspecificity of both clinical findings and laboratory tests. The chest radiography in a patient suspected acute pulmonary embolism do not provide adequate information to establish or exclude the diagnosis of pulmonary embolism. Even in the case of infarction, there is no pathognomonic clues on the chest film. Rarely infarction presents unusual roentgenologic manifestation such as lobar consolidation, coin lesion, multinodular opacity, or massive pleural effusion Especially, lobar consolidation in pulmonary embolism might mislead into the diagnosis of pneumonia. We experienced a case of pulmonary embolism presenting lobar consolidation in a 62 years old woman, originated from deep vein thrombosis. She took a compression stocking and underwent anticoagulant therapy with excellent outcome.

• Tuberculosis and Respiratory Diseases
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• 제73권4호
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• pp.231-233
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• 2012

Tadalafil is a phosphodiesterase-5 inhibitor (PDE5I), which is widely used to treat erectile dysfunction. Although PDE5Is have excellent safety profiles, and most of the side effects are mild, rare serious adverse events have been reported in association with PDE5Is. Thrombosis is one of those events, and a few previous reports have suggested the association of PDE5Is with thrombosis. We report the case of a 61-year-old male who developed pulmonary embolism combined with pulmonary infarction directly after taking tadalafil. Both the patient and the physician suspected tadalafil as the culprit drug, as the patient was in an otherwise healthy condition. However, after extensive evaluation, we noticed that factor VIII levels were elevated. Prior reports suggesting the association between thrombosis and PDEIs either lack complete information on coagulation factors, or show inconsistencies in their results. Physicians should operate caution prior to accepting the diagnosis of adverse drug reaction.

• Journal of Chest Surgery
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• 제36권10호
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• pp.776-779
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• 2003

기침과 고열을 주소로 8세 남아가 전원되었으며, 과거력상 출생시 작은 크기의 심실 중격결손이 있었다. 심장 초음파 검사상 삼첨판에 10${\times}$6mm 크기의 우종이 있었고 심실중격결손 및 중등도의 삼천판 폐쇄부전이 발견되었다. 혈액 균배양 검사에서는 메티씰린 저항성 황색포도구균이 나왔다. 충분한 항생제 치료에도 불구하고 열이 조절되지 않았으며 폐경색이 진행되었다. 정중 흉골 절개하에 혈전제거술 및 우측폐하엽 절제술을 먼저 시행하였으며, 체외순환 하에 우종제거술, 삼첨판 재건술 및 심실중격결손 폐쇄술을 시행하였다.

• Journal of Korean Neurosurgical Society
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• 제43권2호
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• pp.90-96
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• 2008

Objective: Delayed ischemic deficit or cerebral infarction is the leading cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). The purpose of this study is to reassess the prognostic impact of intraoperative elements, including factors related to surgery and anesthesia, on the development of cerebral infarction in patients with ruptured cerebral aneurysms. Methods: Variables related to surgery and anesthesia as well as predetermined factors were all evaluated via a retrospective study on 398 consecutive patients who underwent early microsurgery for ruptured cerebral aneurysms in the last 7 years. Patients were dichotomized as following; good clinical grade (Hunt-Hess grade I to III) and poor clinical grade (IV and V). The end-point events were cerebral infarctions and the clinical outcomes were measured at postoperative 6 months. Results: The occurrence of cerebral infarction was eminent when there was an intraoperative rupture, prolonged temporary clipping and retraction time, intraoperative hypotension, or decreased $O_2$ saturation, but there was no statistical significance between the two different clinical groups. Besides the Fisher Grade, multiple logistic regression analyses showed that temporary clipping time, hypotension, and low $O_2$ saturation had odds ratios of 1.574, 3.016, and 1.528, respectively. Cerebral infarction and outcome had a meaningful correlation (${\gamma}$=0.147, p=0.038). Conclusion: This study results indicate that early surgery for poor grade SAH patients carries a significant risk of ongoing ischemic complication due to the brain's vulnerability or accompanying cardio-pulmonary dysfunction. Thus, these patients should be approached very cautiously to overcome any anticipated intraoperative threat by concerted efforts with neuro-anesthesiologist in point to point manner.

• Tuberculosis and Respiratory Diseases
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• 제77권6호
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• pp.274-278
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• 2014

Antiphospholipid syndrome (APS) is an acquired systemic autoimmune disorder characterized by a combination of clinical criteria, including vascular thrombosis or pregnancy morbidity and elevated antiphospholipid antibody titers. It is one of the causes of deep vein thrombosis and pulmonary embolism that can be critical due to the mortality risk. Overall recurrence of thromboembolism is very low with adequate anticoagulation prophylaxis. The most effective treatment to prevent recurrent thrombosis is long-term anticoagulation. We report on a 17-year-old male with APS, who manifested blue toe syndrome, deep vein thrombosis, pulmonary thromboembolism, and cerebral infarction despite adequate long-term anticoagulation therapy.

• Journal of Chest Surgery
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• 제20권1호
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• pp.139-147
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• 1987

in general rapid and complete resolution of pulmonary emboli, even massive, is the natural history. However, rarely, the emboli do not resolve but rather became fibrotic organization and densely adherent to the arterial wall, therefore, may lead to significant clinical disability. In patients with chronic pulmonary embolism, medical management usually has little effect and only surgical treatment can offer improvement. The case was 30-year-old man who had admission to the Hanyang University Hospital due to fall-down from 11th floor 407 days before operation and then transferred to our department for surgical management under the diagnosis of chronic pulmonary embolism, Pulmonary angiogram demonstrated multifocal thromboembolism with infarction and lung scans showed no improvement in spite of anticoagulant and thrombolytic therapy. At median sternotomy for pulmonary artery thromboembolectomy, the well organized and multiple septic emboli could be removed by gallstone forceps. But reoperation of left upper lobectomy was performed because of the repeated hemoptysis and suspicious pulmonary arterio-bronchial fistula 19 days postoperatively. Despite of ventilatory support and drug treatment, the patient died due to right heart failure associated with cor pulmonale 27 days after first operation. Discussion of the operative and perioperative problems are offered.

• The Korean Journal of Physiology and Pharmacology
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• 제26권2호
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• pp.87-94
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• 2022

Myocardial infarction promotes cardiac remodeling and myocardial fibrosis, thus leading to cardiac dysfunction or heart failure. Peiminine has been regarded as a traditional anti-fibrotic Chinese medicine in pulmonary fibrosis. However, the role of peiminine in myocardial infarction-induced myocardial injury and fibrosis remained elusive. Firstly, rat model of myocardial infarction was established using ligation of the left coronary artery, which were then intraperitoneally injected with 2 or 5 mg/kg peiminine once a day for 4 weeks. Echocardiography and haemodynamic evaluation results showed that peiminine treatment reduced left ventricular end-diastolic pressure, and enhanced maximum rate of increase/decrease of left ventricle pressure (± dP/dt max) and left ventricular systolic pressure, which ameliorate the cardiac function. Secondly, myocardial infarction-induced myocardial injury and infarct size were also attenuated by peiminine. Moreover, peiminine inhibited myocardial infarction-induced increase of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α production, as well as the myocardial cell apoptosis, in the rats. Thirdly, peiminine also decreased the myocardial fibrosis related protein expression including collagen I and collagen III. Lastly, peiminine reduced the expression of p38 and phosphorylation of extracellular signal-regulated kinase 1/2 in rat model of myocardial infarction. In conclusion, peiminine has a cardioprotective effect against myocardial infarction-induced myocardial injury and fibrosis, which can be attributed to the inactivation of mitogen-activated protein kinase pathway.