• Title/Summary/Keyword: Pulmonaran

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Studies on Constituents of the Higher Fungi of Korea(XXXVIII) - Antitumor Components Extracted from Cultured Mycelia of Pleurotus pulmonarius - (한국산(韓國産) 고등(高等) 균류(菌類)의 성분(成分) 연구(硏究)(제38보)(第38報) -조개느타리버섯의 항암(抗癌) 성분(成分)-)

  • Lee, Kyung-Lim;Lee, Chong-Ock;Kim, Ha-Won;Kim, Jung-Woo;Kim, Sung-Won;Choi, Eung-Chil;Kim, Byong-Kak
    • The Korean Journal of Mycology
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    • v.13 no.1
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    • pp.11-21
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    • 1985

  • Antitumor components were obtained from the cultured mycelia of Pleurotus pulmonarius by ethanol precipitation. The protein-bound polysaccharide was subjected to DEAE-­Sephadex column chromatography and Sephadex G-200 gel filtration. The antitumor fraction $C_1$ was isolated. The inhibition ratio of fraction $C_1$ was 81.8 % in the doses of 10 mg/kg/day for 10 days. The antitumor fraction $C_1$ consisted of a polysaccharide and a protein. The protein-moiety was composed of 14 amino acids. From the peritoneal cell populations in the mice given antitumor fraction $C_1$, the injection of the fraction caused the influx of peritoneal macrophages at two days when compared with those of soluble starch. This was named pulmonaran after its species name.

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