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Dietary Fiber Modulates Colon Cell Proliferation by Altering Luminal Concentrations of Short-Chain Fatty Acids

  • Kim, Dong-Yeon;Park, Mi-Young;Lee, Jung-Hee
    • Nutritional Sciences
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    • 제5권4호
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    • pp.175-183
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    • 2002
  • To compare the effects of various types of dietary fiber on microbial production of short-chain fatty acids (SCFA) and on colon cell proliferation which is used as an intermediate biomarker for colon carcinogenesis, groups of 10 male Sprague-Dawley rats were fed one of four fiber-supplemented diets (6% cellulose, 6% pectin, 6% polydextrose, and a mixture of 3% cellulose and 3% polydextrose) for three weeks. As a control, a fiber-free diet was fed to a separate group of 10 rats. Cell proliferation was measured by in vivo incorporation of bromodeoxyuridine into DNA in the proximal and distal colon, respectively. Luminal concentrations of SCFA were measured by gas chromatography. Dietary fiber significantly influenced microbial production of SCFA in the colon; pectin supplementation produced the highest concentrations of luminal SCFA in both the proximal and distal colon (p<0.05). The degree of individual SCFA production was characterized by a relatively higher increase in butyrate production by the pectin-supplemented diet, and in propionate production by the polydextrose-supplemented diet, resulting in alterations of the molar ratios of acetate, propionate and butyrate. There were significant differences in colon cell proliferation among the diet groups; the pectin-supplemented diet produced a significantly higher effect on cell proliferation of distal colonic epithelial cells (p<0.05), and the polydextrose-supplemented diet produced an intermediate effect compared to the fiber-free or cellulose-supplemented diet. Increased cell proliferation was correlated to increased luminal concentrations of butyrate in the proximal colon and to increased luminal concentrations of propionate and butyrate in the distal colon (p<0.05). Therefore, these data suggest that dietary fiber may modulate colon cell proliferation by altering luminal SCFA concentrations, particularly butyrate and perhaps propionate. In addition, the present study is the first finding that has demonstrated a relative increase in colon cell proliferation due to supplementation with polydextrose, suggesting that the overuse of this artificially synthesized polysaccharide in food processing technology needs to be carefully evaluated from the public health point of view.

한의사의 간접구 이용실태에 대한 조사 연구 (Survey on the Status of Utilization of mediate Moxibustion by Korean Medicine Doctor)

  • 이은경;한승준;정명수
    • 대한예방한의학회지
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    • 제17권2호
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    • pp.105-127
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    • 2013
  • Objectives : We examined the use of the moxibustion through survey on Korean Medicine Doctors (KMDs) on preparation of universal moxa product standard by fully reflecting opinions of practitioners and the industry. Methods : The questionnaire is composed of 25 questions including use of indirect moxa, side effects, complaints and improvements, general characteristics and so on, and were responded by 1,588 KMDs. For statistics, frequency analysis, chi-square analysis, T-test and ANOVA were conducted using SPSS 12.0 for windows, and the significance level was 0.05. Results : In this research, 91% of the responded KMDs was using moxibustion, and the proportion of using mediate moxibustion was shown as 63.2%. They used mediate moxibustion for side effects of direct moxa method such as risk of burn, ease of use, control of stimulation and so on. And it was mostly being conducted to women and 40 ages. Most respondents gave moxibustion treatments for the purpose of thermal stimulation on acupoint to musculoskeletal diseases. Most respondents were treating 1~2 pieces of moxibustion to patients by moxibustion points to those of 1~2 regions every time within 10 minutes. Regarding the frequency of side effects of mediate moxibustion, within 3% of respondents had experienced side effects, and the types were burn, flare and itchiness, odor and smoke. The dissatisfaction of mediate moxibustion products was moderate(2.00 out of 5 point scale), and went up public health doctors, the younger ages and the shorter clinical experience. Complaints on mediate moxibustion products were serious odor, poor attachment, risk of burn etc. Regarding ways to improve mediate moxibustion, the expansion of moxibustion's insurance cost carne out highest, followed by preparation of manual on efficacy, strengthening of training, acquiring evidence on efficacy, diversification of specifications, safety improvement, quality improvement of mediate moxibustion products. Conclusions: Many KMDs use for ease of use and give moxibustion treatments for thermal stimulation but they complain about safety, efficacy and quality of mediate moxibustion. After this it is considered that we have to elevate therapeutic effect through the improvement of mediate moxibustion products.

미용관련교육기관의 교육서비스 품질이 재등록 의도에 미치는 영향 (Effects of the Education Service Quality of Beauty Educational Institutions on Re-Registration)

  • 이경희;안종숙
    • 패션비즈니스
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    • 제18권4호
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    • pp.168-179
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    • 2014
  • Everyone has the desire to be well shaped. Modern people in the $21^{st}$ century utilize their external appearance as a tool to express their personalities and social activities for the improvement of cultural life and the acceleration of information transfer. The expression of beauty is a method of communication from the view point of creation in addition to the exchange of meaning & value, and it has become a method of image transfer due to the increased desire for a better appearance. The beauty industry was established in 1948 by the execution of the 1st hairdresser's license test, and has been developed in full scale through the enactment of the public health control act. Therefore, beauty education is currently qualitatively and quantitatively developed, and the educational role of the beauty institute has expanded to include training beauty professionals. Private beauty institutes provide students with beauty related education in preparation for the national technical qualification examinations or private beauty association tests. These beauty education opportunities enable aspiring beauticians to attend various beauty competition events and acquire a sense of accomplishment. The purpose of this study was to determine how the quality of the beauty educational institutes affects the re-registration rate, and to analyze the effect of the beauty educational institutes quality on the intention of re-registrations using a survey. The study results show that variables such as 'lecture satisfaction', 'internal environment satisfaction', 'facility satisfaction', and 'tuition satisfaction' are significantly related to the rate of re-registrations, with 'lectures satisfaction' especially having the largest influence on re-registration.

창원시 건강증진 시범학교 일부 아동의 식습관 , 체격지수 , 혈액성상에 관한 연구 (A Study of the Relation between Food Habits , Anthropometric and Clinical Data in a Health Promoting Elementary School in Changwon)

  • 이갑연;주정;이부옥
    • 대한영양사협회학술지
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    • 제7권4호
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    • pp.331-348
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    • 2001
  • The purpose of this study was to obtain basic data for nutrition education of the children in a health promoting elementry school. The data was collected by a questionaire of food habits, and anthropometric measurement and biochemical test in comparison with obesity index. The study subjects were boys and girls aged 10 to 12 years who participated in the “99 Children Nutrition Camp”. The average obesity index was 1.7$\pm$21.6% in boys and -11.4$\pm$12.6% in girls. After school, major leisure items were significnatly different by gender but both boys and girls played mainly computer game. In concern for body image and eating habits, girls had more concern and girls had attempted weight control more than boys. 80.2% of subjects had prejudice for special food, especially, all subjects in the severely underweight group had prejudice. But this tendency was significantly decreased with the increasing obesity index. The lowest preferency was for vegetables(64.4%). The tendency of prejudice of subjects was higher whose mother are thirties than those of subjects whose mother are in fourties. The serum GOT and GPT values were significantly higher in overweight and obese group than the other groups. The only serum T-chol was significantly higher in boys than in girls. The number of risk factors related to coronary heart disease(CHD) based on coresponding criteria of TG, T-chol, HDL-chol, and LDL-chol was not increased significantly with the degree of obesity index. The results indicated the need of nutritional management for the children. At a point of view, to educate children early who are able to change food habits and life-styles means to help heathy growth and to deliver up heathy adults. Active nutrition education for both children and mothers will be recommended with joint participation of nutritionists in community public health center and elementary school.

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편평족 달리기 시 충격 쇼크의 성분과 흡수 (Impact Shock Components and Attenuation in Flat Foot Running)

  • 류지선;임가영
    • 한국운동역학회지
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    • 제25권3호
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    • pp.283-291
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    • 2015
  • Objective : The purpose of this study was to determine the differences in the head and tibial acceleration signal magnitudes, and their powers and shock attenuations between flat-footed and normal-footed running. Methods : Ten flat-footed and ten normal-footed subjects ran barefoot on a treadmill with a force plate at 3.22m/s averaged from their preferred running speed using heel-toe running pattern while the head and tibial acceleration in the vertical axis data was collected. The accelerometers were sampled at 2000 Hz and voltage was set at 100 mv, respectively. The peak magnitudes of the head and tibial acceleration signals in time domain were calculated. The power spectral density(PSD) of each signal in the frequency domain was also calculated. In addition to that, shock attenuation was calculated by a transfer function of the head PSD relative to the tibia PSD. A one-way analysis of variance was used to determine the difference in time and frequency domain acceleration variables between the flat-footed and normal-footed groups running. Results : Peaks of the head and tibial acceleration signals were significantly greater during flat-footed group running than normal-footed group running(p<.05). PSDs of the tibial acceleration signal in the lower and higher frequency range were significantly greater during flat-footed running(p<.05), but PSDs of the head acceleration signal were not statistically different between the two groups. Flat-footed group running resulted in significantly greater shock attenuation for the higher frequency ranges compared with normal-footed group running(p<.05). Conclusion : The difference in impact shock magnitude and frequency content between flat-footed and normal-footed group during running suggested that the body had different ability to control impact shock from acceleration. It might be conjectured that flat-footed running was more vulnerable to potential injury than normal-footed running from an impact shock point of view.

고령 건설기술자를 활용한 소규모공사의 공사관리방법 개선방안 (A Study on the Improving Management Method for the Small Projects applying Senior Construction Engineer)

  • 송진우;정용식;이상범
    • 한국건축시공학회지
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    • 제5권2호
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    • pp.115-121
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    • 2005
  • The building below standard scales to be built only by constructive report to authorities. Construction law 8 illustrates that supervision should be deployed in all the construction sites at the building which is found to have more than 3 floors and also to have more than loom of total squares in especially outside area of city plan zone. Such a small construction is have a important and the most basic meaning. Many problems were found to occur in all the constructive places which were out of the limit of this law. The construction sites were found to be controlled by public official's visiting without supervisors and designers of architecture. Technique of construction in architecture was found to be not different from that of 1980. The security of employees in construction on sites has a serious problem. Because of choosing ail the materials of the building without a reasonable point. All the building were found to have a law material about inside and outside aspects. The purpose of this study are to examine existing law about a small project and than to analyze the situation of constructive control through questionnaires and interviews with all the supervisors. Based on the data base of engineers who had a great experience in construction sites, The purpose of this study is also to suggest and advise the method of controlling all the items in architecture through on and off line.

브롬화 난연제의 환경오염도 관리 방안 (Monitoring of Brominated Flame Retardants (BFRs) for the management of Their Contamination in Environments)

  • 김용범;이상훈;정용
    • 환경영향평가
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    • 제14권2호
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    • pp.83-96
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    • 2005
  • Brominated flame retardants have the market share of 40%, comparing others because of their low cost and highly effective retardation against the flame. However, their toxic effects in human and properties of the accumulation in the environments have been issued among the international organization such as EU, OECD and etc. It, therefore, was surveyed the classification, toxic effects, and the usage of Brominated flame retardants, the trends for their managements in the world and Korea, and their contaminated levels in Korean Peninsula. In addition, the management directions for them were proposed. Penta, octa, and deca-BDE among brominated retardants will seem to be prohibited by the regulation as a flame retardants for plastics in Europe because of their toxic effects. Although Penta and Octa BDEs was used marginally in Korea, deca-BDE was 27% of brominated flame retardants (49,050 ton) which had been used in 2002. However, risk assessment for brominated retardants might not launched in Korea, yet. These reports demonstrate that toxic brominated retardants such as PBDEs will be assessed for their usage and the level of contamination in the environment in the area of the point sources like the industrial areas, incinerators and etc. However, the law to regulate the hazardous chemicals seems not to be dictated the monitoring of their contamination in the environment. We, therefore, suggest how to evaluate and to monitor the toxic contaminants with EIA (Environmental Impact Assessment) and LCA (Life Cycle Assessment) system. Further, to establish the management system of BFRs (such as the monitering of contamination levels in environments, life cycle assessment, and risk assessment for the toxic chemicals), It can be recommended the law to deal with the method analyzing chemicals will be established, which contains QA/QC (Quality Assurance and Quality Control) to evaluate the analytic capability of the companies to prepare EIS (Environment Impact Statement) or other institutes for analyzing chemicals.

정보취약계층을 위한 도서관 서비스 활성화 방안에 관한 연구 (A Study on Revitalization of Library Service for the Alienated Class)

  • 남영준
    • 한국문헌정보학회지
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    • 제41권4호
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    • pp.49-68
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    • 2007
  • 이 연구에서는 우리나라 공공 도서관에서 적극적으로 수용해야할 정보취약계층에 대한 정보서비스 확산을 위해 필요한 개념과 기본적인 정보서비스 전략을 제안하였다. 공공도서관은 정보취약계층을 크게 장애인과 생활보호대상자, 노인 등으로 구분하여 각 계층의 특성을 고려한 정보서비스를 제공하여야 한다. 이들을 위한 정보서비스는 시설적 배려와 제도적 배려, 기기적 배려로 구분할 수 있다. 시설적 배려는 Information Commons 전략에 따라 정보화 기기와 시설이 통합된 공간에서 참고사서에 의해 협업하는 공간의 배치를 고려한다. 제도적 배려는 도서관에서 이용자 교육과 외부 전문가와의 협업교육을 수행하고, 정보취약계층별에 따른 개인화된 서비스를 제공해야 한다. 기기적 배려는 장애인을 위해 개발된 기기수준과 같이 다른 정보취약계층의 특성을 고려해야 한다.

테러대응 관련 법제의 국가별 비교 연구 (Comparative Study on Major Nations's Related Legislation for Counter-terrorism)

  • 권정훈
    • 한국콘텐츠학회논문지
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    • 제10권1호
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    • pp.343-352
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    • 2010
  • 각국의 테러대응 관련 법제들을 비교 분석해 본 결과, 테러환경에 능동적으로 대처하기 위해서는 현행의 법령적 근거보다는 상위의 법률적 체제가 필요함이 사료된다. 그리고 상위법에서는 다음의 몇 가지 사항에 대한 구체적인 규정이 포함되어야 할 것이다. 첫째, 테러혐의자의 감시와 관련한 '통신비밀보호법'의 근거에 의해서는 테러정보의 수집 및 감시활동이 불가능하기 때문에 국민의 생명과 재산을 보호하는 국가의 의무적 차원에서 볼 때, 심도 있는 논의가 필요하다. 둘째, '출입국관리법'에 의한 현행 법규로는 테러대응의 관리에 부족한 점이 지적되고 있기 때문에 이를 보완하여 대응 관리해야 한다. 셋째, 현행 '특정금융거래정보의 보고 및 이용 등에 관한 법률'로는 테러자금의 차단이 불가능하기 때문에 테러조직의 자금 차단과 처벌 근거를 마련해야 한다. 넷째, 테러범죄의 처벌은 통상적인 형벌에 의거하고 있는데, 테러행위와 테러단체를 확연히 구분하여 처벌규정을 마련해야 할 것이다. 다섯째, 국가중요시설 및 다중이용시설의 보호를 강화하기 위한 민간경비시스템의 활용이 필요할 것이다.

군수품 정부품질보증 위험성 평가제도 개선을 위한 제언 (Proposal for Government Quality Assurance Risk Assessment System for Military Supplies)

  • 안남수
    • 품질경영학회지
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    • 제51권2호
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    • pp.155-170
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    • 2023
  • Purpose: Nowadays, the risk assessment system is widely used in many industrial and public areas to reduce the possible risks. The system is used to determine the priorities of the government quality assurance works in Defense Agency for Technology and Quality. However, as the risk assessment system is used for other purposes, there are some items that need improvement, and in this study, we propose improvement plans by benchmarking the risk assessment systems of other institutions. Methods: In this paper, first, the procedures of risk assessment system used in many industrial sites were reviewed, and how each institution specialized and applied the system. Afterwards, by benchmarking various risk assessment systems, an improvement plan on how to operate the risk assessment system in the case of government quality assurance for centrally procured military supplies was presented, and practical application cases were presented to prove the usefulness of the improvement plan. Results: The proposed risk assessment system differs from the existing system in five major aspects. First, inputs, outputs, and key performance indicators were specified from the systematic point of view. Second, risk analysis was analyzed in four dimensions: probability of occurrence, impact, detection difficulty. Third, risk mitigation measures were classified, control, transfer, and sharing. Fourth, the risk mitigation measures were realized through document verification, product verification, process verification, and quality system evaluation. Finally, risk mitigation measures were implemented and the effectiveness of the risk mitigation measures was evaluated through effectiveness evaluation. Conclusions: In order for the risk assessment procedure proposed in this study to be applied to actual work, it is necessary to obtain the consent of the person involved in the work due to the increased time for risk identification and preparation of the government quality assurance log, and a change in the information system that performs the actual work is required. Therefore, the authors of this study plan to actively perform internal seminar presentations and work improvement suggestions to apply these research outputs to actual work.