• 지식경영연구
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• 제18권4호
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• pp.63-96
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• 2017

In a competitive organizational environment, members view completing tasks to perfection without mistakes as the requirement for success and good evaluation from others. However, unrealistically strong perfectionism can have negative effects on members' psychological states and organizational performance. This study focuses on evaluative concerns perfectionism, the negative aspect of perfectionism, based on positive psychology theory to explore the positive mechanism that comes into place in the process of strengthening organization members' resilience. For this purpose, we performed a moderated moderation analysis to investigate whether the moderating effect of leaders' social support (primary moderator) is moderated by their emotional intelligence (secondary moderator). To verify our research model, we conducted a two-part survey of 252 employees in various industries with a time interval to minimize the common method bias. Job rank and positive affectivity were set as control variables to identify the clear causal relationship among variables. Our findings showed that first, evaluative concerns perfectionism reduced resilience; second, leaders' social support positively moderated the relationship between evaluative concerns perfectionism and resilience; and third, the leaders' emotional intelligence positively moderated the two-way interaction between evaluative concerns perfectionism and the leaders' social support, confirming a moderated moderation. Our findings suggest the need for leaders to assume multidimensional roles to enhance the positive traits of organization members, especially in today's complex business environment. The implications of our findings are further discussed in relation to knowledge management and the development of organization members who exhibit evaluative concerns perfectionism, along with suggestions for future research.

• The Korean Journal of Pain
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• 제23권2호
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• pp.99-108
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• 2010

Chronic pain is a multifactorial condition with both physical and psychological symptoms, and it affects around 20% of the population in the developed world. In spite of outstanding advances in pain management over the past decades, chronic pain remains a significant problem. This article provides a mechanism- and evidence-based approach to improve the outcome for pharmacologic management of chronic pain. The usual approach to treat mild to moderate pain is to start with a nonopioid analgesic. If this is inadequate, and if there is an element of sleep deprivation, then it is reasonable to add an antidepressant with analgesic qualities. If there is a component of neuropathic pain or fibromyalgia, then a trial with one of the gabapentinoids is appropriate. If these steps are inadequate, then an opioid analgesic may be added. For moderate to severe pain, one would initiate an earlier trial of a long term opioid. Skeletal muscle relaxants and topicals may also be appropriate as single agents or in combination. Meanwhile, the steps of pharmacologic treatments for neuropathic pain include (1) certain antidepressants (tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors), calcium channel ${\alpha}2-{\delta}$ ligands (gabapentin and pregabalin) and topical lidocaine, (2) opioid analgesics and tramadol (for first-line use in selected clinical circumstances) and (3) certain other antidepressant and antiepileptic medications (topical capsaicin, mexiletine, and N-methyl-d-aspartate receptor antagonists). It is essential to have a thorough understanding about the different pain mechanisms of chronic pain and evidence-based multi-mechanistic treatment. It is also essential to increase the individualization of treatment.

• 한국멀티미디어학회논문지
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• 제14권3호
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• pp.378-391
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• 2011

본 논문에서는 입력장치로 들어오는 수많은 시각정보 중 현 시점에서 가장 유용하다고 생각되는 정보를 인간의 상향식 주의시각에 기반하여 선택하는 시각정보 선택기법에 대해 소개한다. 제안하는 시스템은 색상, 명도, 방위, 형태 등 저수준의 공간특징 외에 시간특징으로서 움직임 정보와 3차원 정보인 깊이 정보를 추가적으로 사용함으로써 기존방법에 비해 정보 선택의 정확도를 높혔다. 움직임 정보 추출 시 발생할 수 있는 노이즈를 제거하기 위해 인간의 움직임 인지에 대한 연구결과를 이용하는 새로운 접근법을 사용하였으며, 입력 영상 내 객체들이 부분적으로 겹쳐있다거나 동일한 현저도를 가지고 있을 때에도 현저한 영역을 제대로 선택해낼 수 있도록 깊이 정보를 사용하여 유의미한 영역을 선별하고 우선순위를 부여하였다. 실험결과를 통해 제안하는 방법이 기존의 방법에 비해 높은 정확도를 가짐을 확인할 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제8권6호
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• pp.295-300
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• 2004

Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 $(50 {\mu}M)$, an NMDA receptor antagonist. Whereas bath application of 5-HT $(10 {\mu}M)$ inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine $(PCA,\;10{\mu}M)$, for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and $10 {\mu}M)$ suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.

• 한국교육논총
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• 제40권1호
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• pp.81-108
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• 2019

본 연구의 목적은 고등학생을 대상으로 하여 자신의 인지나 정서, 행동을 조절할 수 있는 능력인 자기통제력과 소비선택 행동에 기준이 되는 각각의 가치소비패턴이 심리적 기제로서 주관적 행복감과 어떠한 차이를 보이는지 알아보는 것이다. 이를 위해 충청북도 C시에 소재하는 일반계 남녀 고등학생 400명을 대상으로 자기통제력과 가치소비 및 주관적 행복감에 대한 질문지 조사를 실시하여 자료를 수집하였다. 자료 분석은 SPSS 21.0 통계프로그램을 사용하였고, 기술통계, 빈도분석, 독립표본 t-검정을 실시하였다. 본 연구의 주요결과는 다음과 같다. 첫째, 고등학생의 자기통제력 수준에 따른 주관적 행복감은 유의한 차이를 보였다. 이는 자기통제력 수준이 높은 집단일수록 주관적 행복감이 높게 나타났음을 의미한다. 둘째, 고등학생의 가치소비 수준에 따른 주관적 행복감은 유의한 차이를 보였다. 이는 가치소비 수준이 높은 집단일수록 주관적 행복감이 높게 나타났음을 의미한다.

• 생물정신의학
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• 제23권3호
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• pp.108-115
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• 2016

Aggression and aggressive behaviors, often explained as harmful social interaction with the intention of hurting or inflicting damage upon another, have been considered as an adaptive mechanism from the evolutionary psychological point of view. However, various studies on aggression and aggressive behaviors have been done with psychopathological approach as the extreme aggressive behaviors may harm themselves and others at the same time. Recently, researchers have attempted to explain aggression in terms of neurobiological substrates rather than based on traditional psychopathological and/or behavioral concept. In this regard, there have been findings of differences in neurotransmitters and their receptors, and genetic polymorphisms. In this review article, we provide a brief overview of the literature about seven most frequently reported neurotransmitters including neurohormones (serotonin, norepinephrine, dopamine, gamma-aminobutyric acid, nitric oxide, oxytocin and vasopressin) and an associated enzyme (monoamine oxidase A), which are known to be related with aggression and aggressive behaviors.

• 정보교육학회논문지
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• 제12권1호
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• pp.57-63
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• 2008

본 연구는 인간의 자아표현 욕구와 창조적 욕구로 인해 자신을 대체할 산물들을 끊임없이 만들어 내는 과정에서 중요하게 작용되는 자기노출이라는 심리를 이용하여 아바타와 학습자의 얼굴을 합성하는 증강가상을 통하여 가상세계에서의 현실감을 부여함으로써 학습자의 몰입을 유도하여 그 교육적 효과를 증대하고자 하였다. 이를 실증하기 위하여 컴퓨터기반으로 콘텐츠를 개발한 후, 로봇 콘텐츠로써의 활용을 위해 컨버팅하고 자동 로딩을 통한 학습자의 사진을 아바타와 합성시켰다. 실험 결과 자기노출 기반 콘텐츠의 효과는 모든 집단의 경우에서 학습에 대한 집중도에는 긍정적인 영향을 주었으며, 학업성취도에는 유의미하지는 않지만 긍정적 효과를 가지는 것으로 나타났다. 이는 교육용 로봇을 활용한 자기노출 개념 적용에 대하여 긍정적인 결과라고 보여지는데, 보다 유의미한 결과를 얻기 위해서는 단순히 사진을 찍어 로딩하는 증강가상보다는 얼굴검출을 통한 실시간 증강가상과 같은 증강가상 효과의 증대가 필요하다고 하겠다.

• 대한의용생체공학회:의공학회지
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• 제15권4호
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• pp.383-388
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• 1994

일정한 단속 주파수(triggering frequency)를 지닌 청각자극의 반송 주파수(carrier ferquency, pure tone)를 1kHz에서 3kHz까지 0.5kHz단위로 증가시키면서, 이에 반응하는 뇌전위를 디지탈 EEG측정장치를 이용하여 총 7초 동안 1kHz의 sampling frequency로 컴퓨터로 전송하였다. 먼저 신호의 pseudo-phase space분석을 통해 뇌전위의 진폭특성을 파악하였다. 이러한 해석은 생리학적으로 밝져진 소리의 반송주파수와 소리의 크기 인지사이의 상관관계와 잘 일치함이 확인되었다. 또한 이 신호외 Lyapunov exponent 분석을 통해 신호의 발산 특성을 물리적으로 파악하고, 이러한 특성을 이미 여러가지 접근법에 의해 밝혀져 있는 생리학적 실험결과와 관련지어 해석함으로써 반송 주파수에 반응하는 뇌의 mechanism을 뇌전위 측정에 의해서 검출이 가능함을 확인할 수 있었다.

• Archives of Plastic Surgery
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• 제43권4호
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• pp.344-351
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• 2016

Background Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by xerosis, ultraviolet light sensitivity, and cutaneous dyspigmentation. Due to defects in their DNA repair mechanism, genetic mutations and carcinogenesis inevitably occurs in almost all patients. In these patients, reconstruction of cutaneous malignancies in the head and neck area is associated with some challenges such as likelihood of recurrence and an aggressive clinical course. The aim of this study is to discuss the therapeutic options and challenges commonly seen during the course of treatment. Methods Between 2005 and 2015, 11 XP patients with head and neck cutaneous malignancies were included in this study. Demographic data and treatment options of the patients were evaluated. Results The mean age of the patients was 32 years (range, 10-43) (4 males, 7 females). The most common tumor type and location were squamous cell carcinoma (6 patients) and the orbital region (4 patients), respectively. Free tissue transfer was the most commonly performed surgical intervention (4 patients). The average number of surgical procedures was 5.5 (range, 1-25). Six patients were siblings with each other, 5 patients had local recurrences, and one patient was lost to follow-up. Conclusions Although genetic components of the disease have been elucidated, there is no definitive treatment algorithm. Early surgical intervention and close follow-up are the gold standard modalities due to the tendency toward rapid tumor growth and possible recurrence. Treatment must be individualized for each patient. In addition, the psychological aspect of the disease is an important issue for both patients and families.

• 대한수의학회지
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• 제44권3호
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• pp.389-397
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• 2004

The therapeutic efficacy of xylamine in the field of psychological medicine has been recognized for years and the drug is used to treat depression and some other conditions, but little is known about its mechanism of action on vascular system. Therefore, the present study was designed to investigate the influence of xylamine on the contractile responses of isolated rat thoracic arteries to phenylephrine(PE) and potassium chloride(KCl). Xylamine produced a concentration-dependent relaxation in PE-precontracted endothelium intact(+E) rat aortic rings, but not in a KCl-precontracted aortic rings. Also, xylamine inhibited the PE-induced contraction in concentration-dependent manner, but not in the high KCl-induced contraction in +E rings. This concentration-dependent inhibition was suppressed by the removal of the endothelium (-E). The inhibitory effects of xylamine($0.3{\mu}M$) on the PE-induced contractions were suppressed by N(G)-nitro-L-arginine(L-NNA), N(omega)-nitro-L-arginine methyl ester(L-NAME), aminoguanidine, dexamethasone, methylene blue, 1H-[1,2,4]oxadiazolo [4,3-a]quinoxalin-1-one(ODQ), indomethacin, ryanodine, tetrabutylammonium(TBA), lidocaine, procaine and 0 mM extracellular $Na^+$, but not by 2-nitro-4-carboxyphenyl-n,n-diphenylcarbamate(NCDC), lithium, nifedipine, verapamil, 0 mM extracellular $Ca^{2+}$, glibenclamide and clotrimazole. These findings suggest that xylamine could act as a vasorelaxant and direct inhibitor of arterial contraction. This vasorelaxation involves an endothelial nitric oxide (NO)/cGMP (guanosine 3',5'-cyclic monophosphate) pathway or cyclooxygenase system, and an interference with $Ca^{2+}$ release, TBA-sensitive $Ca^{2+}$-activated $K^+$ channels and $Na^+$$ channels.